Large-scale signatures of unconsciousness are consistent with a departure from critical dynamics

Authors
Tagliazucchi, Enzo Rodolfo; Chialvo, Dante Renato; Siniatchkin, Michael; Amico, Enrico; Brichant, Jean Francois; Bonhomme, Vincent; Noirhomme, Quentin; Laufs, Helmut; Laureys, Steven
Publication Year
2016
Language
English
Format
article
Status
Published version
Description
Loss of cortical integration and changes in the dynamics of electrophysiological brain signals characterize the transition from wakefulness towards unconsciousness. In this study, we arrive at a basic model explaining these observations based on the theory of phase transitions in complex systems. We studied the link between spatial and temporal correlations of large-scale brain activity recorded with functional magnetic resonance imaging during wakefulness, propofol-induced sedation and loss of consciousness and during the subsequent recovery. We observed that during unconsciousness activity in frontothalamic regions exhibited a reduction of long-range temporal correlations and a departure of functional connectivity from anatomical constraints. A model of a system exhibiting a phase transition reproduced our findings, as well as the diminished sensitivity of the cortex to external perturbations during unconsciousness. This framework unifies different observations about brain activity during unconsciousness and predicts that the principles we identified are universal and independent from its causes.
Fil: Tagliazucchi, Enzo Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Christian Albrechts University zu Kiel; Alemania. Goethe Universitat Frankfurt; Alemania
Fil: Chialvo, Dante Renato. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Siniatchkin, Michael. Christian Albrechts University zu Kiel; Alemania
Fil: Amico, Enrico. Université de Liège; Bélgica
Fil: Brichant, Jean Francois. Université de Liège; Bélgica
Fil: Bonhomme, Vincent. Université de Liège; Bélgica
Fil: Noirhomme, Quentin. Université de Liège; Bélgica
Fil: Laufs, Helmut. Goethe Universitat Frankfurt; Alemania
Fil: Laureys, Steven. Université de Liège; Bélgica
Subject
ANAESTHESIA
COMPLEX SYSTEMS
CONSCIOUSNESS
FMRI
PHASE TRANSITIONS
Otras Ciencias Físicas
Ciencias Físicas
CIENCIAS NATURALES Y EXACTAS
Access level
Restricted access
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/52509