Multidose pharmacokinetic study of azithromycin in pneumonic foals

Autores
Rivulgo, Virginia Margarita; Fumuso, Elida Ana; Sparo, Mónica Delfina; Landoni, Maria Fabiana; Sanchez Bruni, Sergio Fabian
Año de publicación
2009
Idioma
inglés
Tipo de recurso
documento de conferencia
Estado
versión publicada
Descripción
Azithromycin (AZM) is an azalide antibiotic commonly used in Human and Veterinary Medicine, for the treatment of respiratory diseases. Rhodococcus equi is an intracellular facultative Gram positive pathogen that provokes pneumonia in foals. Pharmacokinetics (PK) of AZM in diseased foals has not been still described. The main goal of this study was to evaluate the plasma PK of AZM in a multiple dose regimen in experimentally challenged R. equi -foals-infection model of pneumonia. Five foals of 42 days old were inoculated by intratracheal endoscopy, with 25 mL of a 103 R. equi 103+ strain solution. When the disease developed, foals were treated orally with 10 mg/kg of AZM q 24 h for 6 days. Blood samples were obtained from jugular vein. Samples were frozen up to analysis by bioassay method using Kocuria Rhizophila. Cmax was obtained at 2 hours after the first and latest administration. Comparison between values of AUC 0-24 (14.0 ± 2.95 μg.h/ml) and AUC 120-144 (18.0 ± 5.00 μg.h/ml) showed no statistical difference. These values pointed out that the steady state was not attained, being 6 days of treatment insufficient to obtain clinical and bacteriological cure.
Fil: Rivulgo, Virginia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Fumuso, Elida Ana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Sparo, Mónica Delfina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Landoni, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Farmacología, Farmacotecnia y Terapéutica; Argentina
Fil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
LXI Reunión Anual de Sociedad Argentina de Farmacología Experimental
Rosario
Argentina
Sociedad Argentina de Farmacología Experimental
Materia
AZYTROMYCIN
FOALS
RODOCOCCUS EQUI
PHARMACOKINETICS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/264146
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/264146
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Multidose pharmacokinetic study of azithromycin in pneumonic foalsRivulgo, Virginia MargaritaFumuso, Elida AnaSparo, Mónica DelfinaLandoni, Maria FabianaSanchez Bruni, Sergio FabianAZYTROMYCINFOALSRODOCOCCUS EQUIPHARMACOKINETICShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Azithromycin (AZM) is an azalide antibiotic commonly used in Human and Veterinary Medicine, for the treatment of respiratory diseases. Rhodococcus equi is an intracellular facultative Gram positive pathogen that provokes pneumonia in foals. Pharmacokinetics (PK) of AZM in diseased foals has not been still described. The main goal of this study was to evaluate the plasma PK of AZM in a multiple dose regimen in experimentally challenged R. equi -foals-infection model of pneumonia. Five foals of 42 days old were inoculated by intratracheal endoscopy, with 25 mL of a 103 R. equi 103+ strain solution. When the disease developed, foals were treated orally with 10 mg/kg of AZM q 24 h for 6 days. Blood samples were obtained from jugular vein. Samples were frozen up to analysis by bioassay method using Kocuria Rhizophila. Cmax was obtained at 2 hours after the first and latest administration. Comparison between values of AUC 0-24 (14.0 ± 2.95 μg.h/ml) and AUC 120-144 (18.0 ± 5.00 μg.h/ml) showed no statistical difference. These values pointed out that the steady state was not attained, being 6 days of treatment insufficient to obtain clinical and bacteriological cure.Fil: Rivulgo, Virginia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Fumuso, Elida Ana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Sparo, Mónica Delfina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaFil: Landoni, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Farmacología, Farmacotecnia y Terapéutica; ArgentinaFil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; ArgentinaLXI Reunión Anual de Sociedad Argentina de Farmacología ExperimentalRosarioArgentinaSociedad Argentina de Farmacología ExperimentalSociedad Argentina de Farmacología Experimental2009info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/conferenceObjectReuniónBookhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/264146Multidose pharmacokinetic study of azithromycin in pneumonic foals; LXI Reunión Anual de Sociedad Argentina de Farmacología Experimental; Rosario; Argentina; 2009; 32-32CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:11:58Zoai:ri.conicet.gov.ar:11336/264146instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:11:58.4CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Multidose pharmacokinetic study of azithromycin in pneumonic foals
title Multidose pharmacokinetic study of azithromycin in pneumonic foals
spellingShingle Multidose pharmacokinetic study of azithromycin in pneumonic foals
Rivulgo, Virginia Margarita
AZYTROMYCIN
FOALS
RODOCOCCUS EQUI
PHARMACOKINETICS
title_short Multidose pharmacokinetic study of azithromycin in pneumonic foals
title_full Multidose pharmacokinetic study of azithromycin in pneumonic foals
title_fullStr Multidose pharmacokinetic study of azithromycin in pneumonic foals
title_full_unstemmed Multidose pharmacokinetic study of azithromycin in pneumonic foals
title_sort Multidose pharmacokinetic study of azithromycin in pneumonic foals
dc.creator.none.fl_str_mv Rivulgo, Virginia Margarita
Fumuso, Elida Ana
Sparo, Mónica Delfina
Landoni, Maria Fabiana
Sanchez Bruni, Sergio Fabian
author Rivulgo, Virginia Margarita
author_facet Rivulgo, Virginia Margarita
Fumuso, Elida Ana
Sparo, Mónica Delfina
Landoni, Maria Fabiana
Sanchez Bruni, Sergio Fabian
author_role author
author2 Fumuso, Elida Ana
Sparo, Mónica Delfina
Landoni, Maria Fabiana
Sanchez Bruni, Sergio Fabian
author2_role author
author
author
author
dc.subject.none.fl_str_mv AZYTROMYCIN
FOALS
RODOCOCCUS EQUI
PHARMACOKINETICS
topic AZYTROMYCIN
FOALS
RODOCOCCUS EQUI
PHARMACOKINETICS
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Azithromycin (AZM) is an azalide antibiotic commonly used in Human and Veterinary Medicine, for the treatment of respiratory diseases. Rhodococcus equi is an intracellular facultative Gram positive pathogen that provokes pneumonia in foals. Pharmacokinetics (PK) of AZM in diseased foals has not been still described. The main goal of this study was to evaluate the plasma PK of AZM in a multiple dose regimen in experimentally challenged R. equi -foals-infection model of pneumonia. Five foals of 42 days old were inoculated by intratracheal endoscopy, with 25 mL of a 103 R. equi 103+ strain solution. When the disease developed, foals were treated orally with 10 mg/kg of AZM q 24 h for 6 days. Blood samples were obtained from jugular vein. Samples were frozen up to analysis by bioassay method using Kocuria Rhizophila. Cmax was obtained at 2 hours after the first and latest administration. Comparison between values of AUC 0-24 (14.0 ± 2.95 μg.h/ml) and AUC 120-144 (18.0 ± 5.00 μg.h/ml) showed no statistical difference. These values pointed out that the steady state was not attained, being 6 days of treatment insufficient to obtain clinical and bacteriological cure.
Fil: Rivulgo, Virginia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Fumuso, Elida Ana. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Sparo, Mónica Delfina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
Fil: Landoni, Maria Fabiana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina. Universidad Nacional de La Plata. Facultad de Ciencias Veterinarias. Departamento de Ciencias Básicas. Cátedra de Farmacología, Farmacotecnia y Terapéutica; Argentina
Fil: Sanchez Bruni, Sergio Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional del Centro de la Provincia de Buenos Aires. Facultad de Ciencias Veterinarias. Departamento de Fisiopatología. Laboratorio de Farmacología; Argentina
LXI Reunión Anual de Sociedad Argentina de Farmacología Experimental
Rosario
Argentina
Sociedad Argentina de Farmacología Experimental
description Azithromycin (AZM) is an azalide antibiotic commonly used in Human and Veterinary Medicine, for the treatment of respiratory diseases. Rhodococcus equi is an intracellular facultative Gram positive pathogen that provokes pneumonia in foals. Pharmacokinetics (PK) of AZM in diseased foals has not been still described. The main goal of this study was to evaluate the plasma PK of AZM in a multiple dose regimen in experimentally challenged R. equi -foals-infection model of pneumonia. Five foals of 42 days old were inoculated by intratracheal endoscopy, with 25 mL of a 103 R. equi 103+ strain solution. When the disease developed, foals were treated orally with 10 mg/kg of AZM q 24 h for 6 days. Blood samples were obtained from jugular vein. Samples were frozen up to analysis by bioassay method using Kocuria Rhizophila. Cmax was obtained at 2 hours after the first and latest administration. Comparison between values of AUC 0-24 (14.0 ± 2.95 μg.h/ml) and AUC 120-144 (18.0 ± 5.00 μg.h/ml) showed no statistical difference. These values pointed out that the steady state was not attained, being 6 days of treatment insufficient to obtain clinical and bacteriological cure.
publishDate 2009
dc.date.none.fl_str_mv 2009
dc.type.none.fl_str_mv info:eu-repo/semantics/publishedVersion
info:eu-repo/semantics/conferenceObject
Reunión
Book
http://purl.org/coar/resource_type/c_5794
info:ar-repo/semantics/documentoDeConferencia
status_str publishedVersion
format conferenceObject
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/264146
Multidose pharmacokinetic study of azithromycin in pneumonic foals; LXI Reunión Anual de Sociedad Argentina de Farmacología Experimental; Rosario; Argentina; 2009; 32-32
CONICET Digital
CONICET
url http://hdl.handle.net/11336/264146
identifier_str_mv Multidose pharmacokinetic study of azithromycin in pneumonic foals; LXI Reunión Anual de Sociedad Argentina de Farmacología Experimental; Rosario; Argentina; 2009; 32-32
CONICET Digital
CONICET
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language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://aafeargentina.org/congresos-aafe/
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rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
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application/pdf
dc.publisher.none.fl_str_mv Sociedad Argentina de Farmacología Experimental
publisher.none.fl_str_mv Sociedad Argentina de Farmacología Experimental
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instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
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repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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