FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival

Autores
Amezcua Vesely, Maria Carolina; Schwartz, Marc; Bermejo, Daniela Andrea; Montes, Carolina Lucia; Cautivo, Kelly M.; Kalergis, Alexis M.; Rawlings, David J.; Acosta Rodriguez, Eva Virginia; Gruppi, Adriana
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
B1 cells produce most natural Abs in unimmunized mice and play a key role in the response to thymus-independent Ags and microbial infection. Enlargement of B1 cell number in mice is often associated with autoimmunity. However, the factors that control peripheral B1 cell survival remain poorly characterized. Mice lacking the inhibitory receptor FcgRIIb exhibit a massive expansion in peritoneal B1 cells, implicating this receptor in B1 cell homeostasis. In this study, we show that peritoneal B1 cells express the highest levels of FcgRIIb among B cell subsets and are highly susceptible to FcgRIIb-mediated apoptosis. B1 cells upregulate FcgRIIb in response to innate signals, including CpG, and the B cell homeostatic cytokine BAFF efficiently protects activated B1 cells from FcgRIIb-mediated apoptosis via receptor downregulation. BAFF-transgenic mice manifest an expansion of peritoneal B1 cells that express lower levels of FcgRIIb and exhibit reduced susceptibility to apoptosis. Whereas both peritoneal B1 cells from wild-type and BAFF-transgenic mice immunized with CpG exhibit an increase in FcgRIIb levels, this change is blunted in BAFF-transgenic animals. Our combined results demonstrate that FcgRIIb controls peritoneal B1 cell survival and this program can be modulated by the BAFF signaling axis.
Fil: Amezcua Vesely, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Schwartz, Marc. Seattle Children’s Research Institute; Estados Unidos
Fil: Bermejo, Daniela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Montes, Carolina Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Cautivo, Kelly M.. Pontificia Universidad Católica de Chile; Chile
Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile
Fil: Rawlings, David J.. Seattle Children’s Research Institute; Estados Unidos
Fil: Acosta Rodriguez, Eva Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Materia
B1 cell
Peritoneum
Apoptosis
Fc receptor
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/269496
Acceder
id CONICETDig_3a0c78e5a3e206001ab13d201393a92e
oai_identifier_str oai:ri.conicet.gov.ar:11336/269496
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell SurvivalAmezcua Vesely, Maria CarolinaSchwartz, MarcBermejo, Daniela AndreaMontes, Carolina LuciaCautivo, Kelly M.Kalergis, Alexis M.Rawlings, David J.Acosta Rodriguez, Eva VirginiaGruppi, AdrianaB1 cellPeritoneumApoptosisFc receptorhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3B1 cells produce most natural Abs in unimmunized mice and play a key role in the response to thymus-independent Ags and microbial infection. Enlargement of B1 cell number in mice is often associated with autoimmunity. However, the factors that control peripheral B1 cell survival remain poorly characterized. Mice lacking the inhibitory receptor FcgRIIb exhibit a massive expansion in peritoneal B1 cells, implicating this receptor in B1 cell homeostasis. In this study, we show that peritoneal B1 cells express the highest levels of FcgRIIb among B cell subsets and are highly susceptible to FcgRIIb-mediated apoptosis. B1 cells upregulate FcgRIIb in response to innate signals, including CpG, and the B cell homeostatic cytokine BAFF efficiently protects activated B1 cells from FcgRIIb-mediated apoptosis via receptor downregulation. BAFF-transgenic mice manifest an expansion of peritoneal B1 cells that express lower levels of FcgRIIb and exhibit reduced susceptibility to apoptosis. Whereas both peritoneal B1 cells from wild-type and BAFF-transgenic mice immunized with CpG exhibit an increase in FcgRIIb levels, this change is blunted in BAFF-transgenic animals. Our combined results demonstrate that FcgRIIb controls peritoneal B1 cell survival and this program can be modulated by the BAFF signaling axis.Fil: Amezcua Vesely, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Schwartz, Marc. Seattle Children’s Research Institute; Estados UnidosFil: Bermejo, Daniela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Montes, Carolina Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Cautivo, Kelly M.. Pontificia Universidad Católica de Chile; ChileFil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; ChileFil: Rawlings, David J.. Seattle Children’s Research Institute; Estados UnidosFil: Acosta Rodriguez, Eva Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaFil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; ArgentinaAmerican Association of Immunologists2012-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/269496Amezcua Vesely, Maria Carolina; Schwartz, Marc; Bermejo, Daniela Andrea; Montes, Carolina Lucia; Cautivo, Kelly M.; et al.; FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival; American Association of Immunologists; Journal of Immunology; 188; 10; 4-2012; 4792-48000022-1767CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jimmunol/article-abstract/188/10/4792/7981703info:eu-repo/semantics/altIdentifier/doi/10.4049/jimmunol.1102070info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:05:32Zoai:ri.conicet.gov.ar:11336/269496instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:05:32.809CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival
title FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival
spellingShingle FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival
Amezcua Vesely, Maria Carolina
B1 cell
Peritoneum
Apoptosis
Fc receptor
title_short FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival
title_full FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival
title_fullStr FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival
title_full_unstemmed FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival
title_sort FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival
dc.creator.none.fl_str_mv Amezcua Vesely, Maria Carolina
Schwartz, Marc
Bermejo, Daniela Andrea
Montes, Carolina Lucia
Cautivo, Kelly M.
Kalergis, Alexis M.
Rawlings, David J.
Acosta Rodriguez, Eva Virginia
Gruppi, Adriana
author Amezcua Vesely, Maria Carolina
author_facet Amezcua Vesely, Maria Carolina
Schwartz, Marc
Bermejo, Daniela Andrea
Montes, Carolina Lucia
Cautivo, Kelly M.
Kalergis, Alexis M.
Rawlings, David J.
Acosta Rodriguez, Eva Virginia
Gruppi, Adriana
author_role author
author2 Schwartz, Marc
Bermejo, Daniela Andrea
Montes, Carolina Lucia
Cautivo, Kelly M.
Kalergis, Alexis M.
Rawlings, David J.
Acosta Rodriguez, Eva Virginia
Gruppi, Adriana
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv B1 cell
Peritoneum
Apoptosis
Fc receptor
topic B1 cell
Peritoneum
Apoptosis
Fc receptor
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv B1 cells produce most natural Abs in unimmunized mice and play a key role in the response to thymus-independent Ags and microbial infection. Enlargement of B1 cell number in mice is often associated with autoimmunity. However, the factors that control peripheral B1 cell survival remain poorly characterized. Mice lacking the inhibitory receptor FcgRIIb exhibit a massive expansion in peritoneal B1 cells, implicating this receptor in B1 cell homeostasis. In this study, we show that peritoneal B1 cells express the highest levels of FcgRIIb among B cell subsets and are highly susceptible to FcgRIIb-mediated apoptosis. B1 cells upregulate FcgRIIb in response to innate signals, including CpG, and the B cell homeostatic cytokine BAFF efficiently protects activated B1 cells from FcgRIIb-mediated apoptosis via receptor downregulation. BAFF-transgenic mice manifest an expansion of peritoneal B1 cells that express lower levels of FcgRIIb and exhibit reduced susceptibility to apoptosis. Whereas both peritoneal B1 cells from wild-type and BAFF-transgenic mice immunized with CpG exhibit an increase in FcgRIIb levels, this change is blunted in BAFF-transgenic animals. Our combined results demonstrate that FcgRIIb controls peritoneal B1 cell survival and this program can be modulated by the BAFF signaling axis.
Fil: Amezcua Vesely, Maria Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Schwartz, Marc. Seattle Children’s Research Institute; Estados Unidos
Fil: Bermejo, Daniela Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Montes, Carolina Lucia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Cautivo, Kelly M.. Pontificia Universidad Católica de Chile; Chile
Fil: Kalergis, Alexis M.. Pontificia Universidad Católica de Chile; Chile
Fil: Rawlings, David J.. Seattle Children’s Research Institute; Estados Unidos
Fil: Acosta Rodriguez, Eva Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
Fil: Gruppi, Adriana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones en Bioquímica Clínica e Inmunología; Argentina
description B1 cells produce most natural Abs in unimmunized mice and play a key role in the response to thymus-independent Ags and microbial infection. Enlargement of B1 cell number in mice is often associated with autoimmunity. However, the factors that control peripheral B1 cell survival remain poorly characterized. Mice lacking the inhibitory receptor FcgRIIb exhibit a massive expansion in peritoneal B1 cells, implicating this receptor in B1 cell homeostasis. In this study, we show that peritoneal B1 cells express the highest levels of FcgRIIb among B cell subsets and are highly susceptible to FcgRIIb-mediated apoptosis. B1 cells upregulate FcgRIIb in response to innate signals, including CpG, and the B cell homeostatic cytokine BAFF efficiently protects activated B1 cells from FcgRIIb-mediated apoptosis via receptor downregulation. BAFF-transgenic mice manifest an expansion of peritoneal B1 cells that express lower levels of FcgRIIb and exhibit reduced susceptibility to apoptosis. Whereas both peritoneal B1 cells from wild-type and BAFF-transgenic mice immunized with CpG exhibit an increase in FcgRIIb levels, this change is blunted in BAFF-transgenic animals. Our combined results demonstrate that FcgRIIb controls peritoneal B1 cell survival and this program can be modulated by the BAFF signaling axis.
publishDate 2012
dc.date.none.fl_str_mv 2012-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/269496
Amezcua Vesely, Maria Carolina; Schwartz, Marc; Bermejo, Daniela Andrea; Montes, Carolina Lucia; Cautivo, Kelly M.; et al.; FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival; American Association of Immunologists; Journal of Immunology; 188; 10; 4-2012; 4792-4800
0022-1767
CONICET Digital
CONICET
url http://hdl.handle.net/11336/269496
identifier_str_mv Amezcua Vesely, Maria Carolina; Schwartz, Marc; Bermejo, Daniela Andrea; Montes, Carolina Lucia; Cautivo, Kelly M.; et al.; FcγRIIb and BAFF Differentially Regulate Peritoneal B1 Cell Survival; American Association of Immunologists; Journal of Immunology; 188; 10; 4-2012; 4792-4800
0022-1767
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/jimmunol/article-abstract/188/10/4792/7981703
info:eu-repo/semantics/altIdentifier/doi/10.4049/jimmunol.1102070
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Association of Immunologists
publisher.none.fl_str_mv American Association of Immunologists
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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