Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil
- Autores
- Dropa, Milena; Ghiglione, Barbara; Matté, Maria Helena; Balsalobre, Livia Carminato; Lincopan, Nilton; Matté, Glavur Rogério; Gutkind, Gabriel Osvaldo; Power, Pablo
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- CTX-M-131 is a natural Asp240Gly variant from the CTX-M-2 group detected in a Providencia rettgeri clinical strain from Brazil. Molecular analysis showed that blaCTX-M-131 was inserted in a complex class 1 integron harbored by a 112-kb plasmid, which has not been previously described as a platform for CTX-M-encoding genes with the Asp240Gly mutation. Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime.
Fil: Dropa, Milena. Universidade de Sao Paulo; Brasil
Fil: Ghiglione, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Matté, Maria Helena. Universidade de Sao Paulo; Brasil
Fil: Balsalobre, Livia Carminato. Universidade de Sao Paulo; Brasil
Fil: Lincopan, Nilton. Universidade de Sao Paulo; Brasil
Fil: Matté, Glavur Rogério. Universidade de Sao Paulo; Brasil
Fil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Power, Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina - Materia
-
Ctx-M-131
Asp240gly
Providencia Rettgeri - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/38773
Ver los metadatos del registro completo
id |
CONICETDig_39f725b244f230a95582720fbdbafa74 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/38773 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, BrazilDropa, MilenaGhiglione, BarbaraMatté, Maria HelenaBalsalobre, Livia CarminatoLincopan, NiltonMatté, Glavur RogérioGutkind, Gabriel OsvaldoPower, PabloCtx-M-131Asp240glyProvidencia Rettgerihttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1CTX-M-131 is a natural Asp240Gly variant from the CTX-M-2 group detected in a Providencia rettgeri clinical strain from Brazil. Molecular analysis showed that blaCTX-M-131 was inserted in a complex class 1 integron harbored by a 112-kb plasmid, which has not been previously described as a platform for CTX-M-encoding genes with the Asp240Gly mutation. Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime.Fil: Dropa, Milena. Universidade de Sao Paulo; BrasilFil: Ghiglione, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Matté, Maria Helena. Universidade de Sao Paulo; BrasilFil: Balsalobre, Livia Carminato. Universidade de Sao Paulo; BrasilFil: Lincopan, Nilton. Universidade de Sao Paulo; BrasilFil: Matté, Glavur Rogério. Universidade de Sao Paulo; BrasilFil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Power, Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaAmerican Society for Microbiology2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/38773Dropa, Milena; Ghiglione, Barbara; Matté, Maria Helena; Balsalobre, Livia Carminato; Lincopan, Nilton; et al.; Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 59; 3; 3-2015; 1815-18170066-4804CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/59/3/1815.fullinfo:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.04116-14info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:57:27Zoai:ri.conicet.gov.ar:11336/38773instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:57:27.436CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil |
title |
Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil |
spellingShingle |
Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil Dropa, Milena Ctx-M-131 Asp240gly Providencia Rettgeri |
title_short |
Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil |
title_full |
Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil |
title_fullStr |
Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil |
title_full_unstemmed |
Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil |
title_sort |
Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil |
dc.creator.none.fl_str_mv |
Dropa, Milena Ghiglione, Barbara Matté, Maria Helena Balsalobre, Livia Carminato Lincopan, Nilton Matté, Glavur Rogério Gutkind, Gabriel Osvaldo Power, Pablo |
author |
Dropa, Milena |
author_facet |
Dropa, Milena Ghiglione, Barbara Matté, Maria Helena Balsalobre, Livia Carminato Lincopan, Nilton Matté, Glavur Rogério Gutkind, Gabriel Osvaldo Power, Pablo |
author_role |
author |
author2 |
Ghiglione, Barbara Matté, Maria Helena Balsalobre, Livia Carminato Lincopan, Nilton Matté, Glavur Rogério Gutkind, Gabriel Osvaldo Power, Pablo |
author2_role |
author author author author author author author |
dc.subject.none.fl_str_mv |
Ctx-M-131 Asp240gly Providencia Rettgeri |
topic |
Ctx-M-131 Asp240gly Providencia Rettgeri |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
CTX-M-131 is a natural Asp240Gly variant from the CTX-M-2 group detected in a Providencia rettgeri clinical strain from Brazil. Molecular analysis showed that blaCTX-M-131 was inserted in a complex class 1 integron harbored by a 112-kb plasmid, which has not been previously described as a platform for CTX-M-encoding genes with the Asp240Gly mutation. Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime. Fil: Dropa, Milena. Universidade de Sao Paulo; Brasil Fil: Ghiglione, Barbara. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Matté, Maria Helena. Universidade de Sao Paulo; Brasil Fil: Balsalobre, Livia Carminato. Universidade de Sao Paulo; Brasil Fil: Lincopan, Nilton. Universidade de Sao Paulo; Brasil Fil: Matté, Glavur Rogério. Universidade de Sao Paulo; Brasil Fil: Gutkind, Gabriel Osvaldo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina Fil: Power, Pablo. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina |
description |
CTX-M-131 is a natural Asp240Gly variant from the CTX-M-2 group detected in a Providencia rettgeri clinical strain from Brazil. Molecular analysis showed that blaCTX-M-131 was inserted in a complex class 1 integron harbored by a 112-kb plasmid, which has not been previously described as a platform for CTX-M-encoding genes with the Asp240Gly mutation. Steady-state kinetic parameters showed that the enzyme has a typical cefotaximase catalytic profile and an enhanced activity against ceftazidime. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/38773 Dropa, Milena; Ghiglione, Barbara; Matté, Maria Helena; Balsalobre, Livia Carminato; Lincopan, Nilton; et al.; Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 59; 3; 3-2015; 1815-1817 0066-4804 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/38773 |
identifier_str_mv |
Dropa, Milena; Ghiglione, Barbara; Matté, Maria Helena; Balsalobre, Livia Carminato; Lincopan, Nilton; et al.; Molecular and biochemical characterization of CTX-M-131, a natural Asp240Gly variant derived from CTX-M-2, produced by a Providencia rettgeri clinical strain in São Paulo, Brazil; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 59; 3; 3-2015; 1815-1817 0066-4804 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://aac.asm.org/content/59/3/1815.full info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.04116-14 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1846083113490317312 |
score |
13.22299 |