Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America

Autores
Padula, Paula Julieta; Colavecchia, Silvia Beatriz; Martinez, Valeria Paula; Gonzalez Della Valle, M. O.; Edelstein, Andres Ivan; Miguel, S. D. L.; Russi, J.; Riquelme, J. Mora; Colucci, N.; Almirón, M.; Rabinovich, Roberto Daniel
Año de publicación
2000
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Since 1995 when the first case of hantavirus pulmonary syndrome (HPS) was reported in Patagonia, there have been more than 400 cases of HPS reported in five countries in South America. The first case of HPS was associated with Andes (AND) virus. In this study, we report on the genetic diversity, geographical distribution, and serological features of hantavirus infection in six countries in South America based on 87 HPS cases from Argentina, Bolivia, Chile, Paraguay, and Uruguay. An early immunoglobulin M (IgM), IgA, and IgG humoral response was observed in almost all HPS cases. The IgM response appears to peak 1 or 2 days after the onset of symptoms. Peak IgG antibody titers occur mostly after the first week. Low IgG titers or the absence of IgG was associated with higher mortality rates. The IgA response peaks around day 15 and then rapidly decreases. The results of phylogenetic analysis based on partial M-fragment G1- and G2-encoding sequences showed that HPS cases from the five countries were infected with viruses related to AND or Laguna Negra (LN) virus. Within AND virus-infected persons, at least five major genetic lineages were found; one lineage was detected in Uruguayan and Argentinean cases from both sides of the Rio de la Plata river. Two Paraguayan patients were infected with a virus different from LN virus. According to the results of phylogenetic analyses, this virus probably belongs to a distinct lineage related more closely to the AND virus than to the LN virus, suggesting that there is probably an Oligoryzomys-borne viral variant circulating in Paraguay. These studies may contribute to a better understanding of hantavirus human infection in South America.
Fil: Padula, Paula Julieta. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Colavecchia, Silvia Beatriz. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Martinez, Valeria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Gonzalez Della Valle, M. O.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Edelstein, Andres Ivan. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Miguel, S. D. L.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Russi, J.. Ministerio de Salud Pública; Uruguay
Fil: Riquelme, J. Mora. Ministerio de Salud Pública; Chile
Fil: Colucci, N.. Ministerio de Salud Pública y Bienestar Social; Paraguay
Fil: Almirón, M.. Universidad Nacional de Asunción; Paraguay
Fil: Rabinovich, Roberto Daniel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Materia
Hantavirus
Genetic Diversity
South America
Serology
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/44719
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/44719
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South AmericaPadula, Paula JulietaColavecchia, Silvia BeatrizMartinez, Valeria PaulaGonzalez Della Valle, M. O.Edelstein, Andres IvanMiguel, S. D. L.Russi, J.Riquelme, J. MoraColucci, N.Almirón, M.Rabinovich, Roberto DanielHantavirusGenetic DiversitySouth AmericaSerologyhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Since 1995 when the first case of hantavirus pulmonary syndrome (HPS) was reported in Patagonia, there have been more than 400 cases of HPS reported in five countries in South America. The first case of HPS was associated with Andes (AND) virus. In this study, we report on the genetic diversity, geographical distribution, and serological features of hantavirus infection in six countries in South America based on 87 HPS cases from Argentina, Bolivia, Chile, Paraguay, and Uruguay. An early immunoglobulin M (IgM), IgA, and IgG humoral response was observed in almost all HPS cases. The IgM response appears to peak 1 or 2 days after the onset of symptoms. Peak IgG antibody titers occur mostly after the first week. Low IgG titers or the absence of IgG was associated with higher mortality rates. The IgA response peaks around day 15 and then rapidly decreases. The results of phylogenetic analysis based on partial M-fragment G1- and G2-encoding sequences showed that HPS cases from the five countries were infected with viruses related to AND or Laguna Negra (LN) virus. Within AND virus-infected persons, at least five major genetic lineages were found; one lineage was detected in Uruguayan and Argentinean cases from both sides of the Rio de la Plata river. Two Paraguayan patients were infected with a virus different from LN virus. According to the results of phylogenetic analyses, this virus probably belongs to a distinct lineage related more closely to the AND virus than to the LN virus, suggesting that there is probably an Oligoryzomys-borne viral variant circulating in Paraguay. These studies may contribute to a better understanding of hantavirus human infection in South America.Fil: Padula, Paula Julieta. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Colavecchia, Silvia Beatriz. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Martinez, Valeria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Gonzalez Della Valle, M. O.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Edelstein, Andres Ivan. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Miguel, S. D. L.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaFil: Russi, J.. Ministerio de Salud Pública; UruguayFil: Riquelme, J. Mora. Ministerio de Salud Pública; ChileFil: Colucci, N.. Ministerio de Salud Pública y Bienestar Social; ParaguayFil: Almirón, M.. Universidad Nacional de Asunción; ParaguayFil: Rabinovich, Roberto Daniel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; ArgentinaAmerican Society for Microbiology2000-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/44719Padula, Paula Julieta; Colavecchia, Silvia Beatriz; Martinez, Valeria Paula; Gonzalez Della Valle, M. O.; Edelstein, Andres Ivan; et al.; Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America; American Society for Microbiology; Journal of Clinical Microbiology; 38; 8; 8-2000; 3029-30350095-11371098-660XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jcm.asm.org/content/38/8/3029.full.pdf+htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-05-06T16:56:44Zoai:ri.conicet.gov.ar:11336/44719instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-05-06 16:56:45.264CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America
title Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America
spellingShingle Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America
Padula, Paula Julieta
Hantavirus
Genetic Diversity
South America
Serology
title_short Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America
title_full Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America
title_fullStr Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America
title_full_unstemmed Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America
title_sort Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America
dc.creator.none.fl_str_mv Padula, Paula Julieta
Colavecchia, Silvia Beatriz
Martinez, Valeria Paula
Gonzalez Della Valle, M. O.
Edelstein, Andres Ivan
Miguel, S. D. L.
Russi, J.
Riquelme, J. Mora
Colucci, N.
Almirón, M.
Rabinovich, Roberto Daniel
author Padula, Paula Julieta
author_facet Padula, Paula Julieta
Colavecchia, Silvia Beatriz
Martinez, Valeria Paula
Gonzalez Della Valle, M. O.
Edelstein, Andres Ivan
Miguel, S. D. L.
Russi, J.
Riquelme, J. Mora
Colucci, N.
Almirón, M.
Rabinovich, Roberto Daniel
author_role author
author2 Colavecchia, Silvia Beatriz
Martinez, Valeria Paula
Gonzalez Della Valle, M. O.
Edelstein, Andres Ivan
Miguel, S. D. L.
Russi, J.
Riquelme, J. Mora
Colucci, N.
Almirón, M.
Rabinovich, Roberto Daniel
author2_role author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Hantavirus
Genetic Diversity
South America
Serology
topic Hantavirus
Genetic Diversity
South America
Serology
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Since 1995 when the first case of hantavirus pulmonary syndrome (HPS) was reported in Patagonia, there have been more than 400 cases of HPS reported in five countries in South America. The first case of HPS was associated with Andes (AND) virus. In this study, we report on the genetic diversity, geographical distribution, and serological features of hantavirus infection in six countries in South America based on 87 HPS cases from Argentina, Bolivia, Chile, Paraguay, and Uruguay. An early immunoglobulin M (IgM), IgA, and IgG humoral response was observed in almost all HPS cases. The IgM response appears to peak 1 or 2 days after the onset of symptoms. Peak IgG antibody titers occur mostly after the first week. Low IgG titers or the absence of IgG was associated with higher mortality rates. The IgA response peaks around day 15 and then rapidly decreases. The results of phylogenetic analysis based on partial M-fragment G1- and G2-encoding sequences showed that HPS cases from the five countries were infected with viruses related to AND or Laguna Negra (LN) virus. Within AND virus-infected persons, at least five major genetic lineages were found; one lineage was detected in Uruguayan and Argentinean cases from both sides of the Rio de la Plata river. Two Paraguayan patients were infected with a virus different from LN virus. According to the results of phylogenetic analyses, this virus probably belongs to a distinct lineage related more closely to the AND virus than to the LN virus, suggesting that there is probably an Oligoryzomys-borne viral variant circulating in Paraguay. These studies may contribute to a better understanding of hantavirus human infection in South America.
Fil: Padula, Paula Julieta. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Colavecchia, Silvia Beatriz. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Martinez, Valeria Paula. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Gonzalez Della Valle, M. O.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Edelstein, Andres Ivan. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Miguel, S. D. L.. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
Fil: Russi, J.. Ministerio de Salud Pública; Uruguay
Fil: Riquelme, J. Mora. Ministerio de Salud Pública; Chile
Fil: Colucci, N.. Ministerio de Salud Pública y Bienestar Social; Paraguay
Fil: Almirón, M.. Universidad Nacional de Asunción; Paraguay
Fil: Rabinovich, Roberto Daniel. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud “Dr. C. G. Malbrán”; Argentina
description Since 1995 when the first case of hantavirus pulmonary syndrome (HPS) was reported in Patagonia, there have been more than 400 cases of HPS reported in five countries in South America. The first case of HPS was associated with Andes (AND) virus. In this study, we report on the genetic diversity, geographical distribution, and serological features of hantavirus infection in six countries in South America based on 87 HPS cases from Argentina, Bolivia, Chile, Paraguay, and Uruguay. An early immunoglobulin M (IgM), IgA, and IgG humoral response was observed in almost all HPS cases. The IgM response appears to peak 1 or 2 days after the onset of symptoms. Peak IgG antibody titers occur mostly after the first week. Low IgG titers or the absence of IgG was associated with higher mortality rates. The IgA response peaks around day 15 and then rapidly decreases. The results of phylogenetic analysis based on partial M-fragment G1- and G2-encoding sequences showed that HPS cases from the five countries were infected with viruses related to AND or Laguna Negra (LN) virus. Within AND virus-infected persons, at least five major genetic lineages were found; one lineage was detected in Uruguayan and Argentinean cases from both sides of the Rio de la Plata river. Two Paraguayan patients were infected with a virus different from LN virus. According to the results of phylogenetic analyses, this virus probably belongs to a distinct lineage related more closely to the AND virus than to the LN virus, suggesting that there is probably an Oligoryzomys-borne viral variant circulating in Paraguay. These studies may contribute to a better understanding of hantavirus human infection in South America.
publishDate 2000
dc.date.none.fl_str_mv 2000-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/44719
Padula, Paula Julieta; Colavecchia, Silvia Beatriz; Martinez, Valeria Paula; Gonzalez Della Valle, M. O.; Edelstein, Andres Ivan; et al.; Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America; American Society for Microbiology; Journal of Clinical Microbiology; 38; 8; 8-2000; 3029-3035
0095-1137
1098-660X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/44719
identifier_str_mv Padula, Paula Julieta; Colavecchia, Silvia Beatriz; Martinez, Valeria Paula; Gonzalez Della Valle, M. O.; Edelstein, Andres Ivan; et al.; Genetic diversity, distribution, and serological features of hantavirus infection in five countries in South America; American Society for Microbiology; Journal of Clinical Microbiology; 38; 8; 8-2000; 3029-3035
0095-1137
1098-660X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jcm.asm.org/content/38/8/3029.full.pdf+html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.1485815

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