A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds

Autores
Cumashi, Albana; Ushakova, Natalia A.; Preobrazhenskaya, Marina E.; D'Incecco, Armida; Piccoli, Antonio; Totani, Licia; Tinari, Nicola; Morozevich, Galina E.; Berman, Albert E.; Bilan, María; Usov, Anatolii I.; Ustyuzhanina, Nadezhda E.; Grachev, Alexey A.; Sanderson, Craig J.; Kelly, Maeve; Rabinovich, Gabriel Adrián; Iacobelli, Stefano; Nifantiev, Nikolay E.
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The anti-inflammatory, antiangiogenic, anticoagulant, and antiadhesive properties of fucoidans obtained from nine species of brown algae were studied in order to examine the influence of fucoidan origin and composition on their biological activities. All fucoidans inhibited leucocyte recruitment in an inflammation model in rats, and neither the content of fucose and sulfate nor other structural features of their polysaccharide backbones significantly affected the efficacy of fucoidans in this model. In vitro evaluation of P-selectin-mediated neutrophil adhesion to platelets under flow conditions revealed that only polysaccharides from Laminaria saccharina, L. digitata, Fucus evanescens, F. serratus, F. distichus, F. spiralis, and Ascophyllum nodosum could serve as P-selectin inhibitors. All fucoidans, except that from Cladosiphon okamuranus carrying substantial levels of 2-O-alpha-D-glucuronopyranosyl branches in the linear (1-->3)-linked poly-alpha-fucopyranoside chain, exhibited anticoagulant activity as measured by activated partial thromboplastin time whereas only fucoidans from L. saccharina, L. digitata, F. serratus, F. distichus, and F. evanescens displayed strong antithrombin activity in a platelet aggregation test. The last fucoidans potently inhibited human umbilical vein endothelial cell (HUVEC) tubulogenesis in vitro and this property correlated with decreased levels of plasminogen-activator inhibitor-1 in HUVEC supernatants, suggesting a possible mechanism of fucoidan-induced inhibition of tubulogenesis. Finally, fucoidans from L. saccharina, L. digitata, F. serratus, F. distichus, and F. vesiculosus strongly blocked MDA-MB-231 breast carcinoma cell adhesion to platelets, an effect which might have critical implications in tumor metastasis. The data presented herein provide a new rationale for the development of potential drugs for thrombosis, inflammation, and tumor progression.
Fil: Cumashi, Albana. Universita degli Studi G. D Annunzio; Italia
Fil: Ushakova, Natalia A.. Academia Rusa de Ciencias Médicas; Rusia
Fil: Preobrazhenskaya, Marina E.. Academia Rusa de Ciencias Médicas; Rusia
Fil: D'Incecco, Armida. Universita degli Studi G. D Annunzio; Italia
Fil: Piccoli, Antonio. Consorzio Mario Negri Sud; Italia
Fil: Totani, Licia. Consorzio Mario Negri Sud; Italia
Fil: Tinari, Nicola. Universita degli Studi G. D Annunzio; Italia
Fil: Morozevich, Galina E.. Academia Rusa de Ciencias Médicas; Rusia
Fil: Berman, Albert E.. Academia Rusa de Ciencias Médicas; Rusia
Fil: Bilan, María. Academia Rusa de Ciencias; Rusia
Fil: Usov, Anatolii I.. Academia Rusa de Ciencias; Rusia
Fil: Ustyuzhanina, Nadezhda E.. Academia Rusa de Ciencias; Rusia
Fil: Grachev, Alexey A.. Academia Rusa de Ciencias; Rusia
Fil: Sanderson, Craig J.. Scottish Association for Marine Sciences; Reino Unido
Fil: Kelly, Maeve. Scottish Association for Marine Sciences; Reino Unido
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Iacobelli, Stefano. Universita degli Studi G. D Annunzio; Italia
Fil: Nifantiev, Nikolay E.. Academia Rusa de Ciencias; Rusia
Materia
Fucoidan
Brown Algae
Blood Coagulation
Inflammation
Angiogenesis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/29419
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/29419
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweedsCumashi, AlbanaUshakova, Natalia A.Preobrazhenskaya, Marina E.D'Incecco, ArmidaPiccoli, AntonioTotani, LiciaTinari, NicolaMorozevich, Galina E.Berman, Albert E.Bilan, MaríaUsov, Anatolii I.Ustyuzhanina, Nadezhda E.Grachev, Alexey A.Sanderson, Craig J.Kelly, MaeveRabinovich, Gabriel AdriánIacobelli, StefanoNifantiev, Nikolay E.FucoidanBrown AlgaeBlood CoagulationInflammationAngiogenesishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The anti-inflammatory, antiangiogenic, anticoagulant, and antiadhesive properties of fucoidans obtained from nine species of brown algae were studied in order to examine the influence of fucoidan origin and composition on their biological activities. All fucoidans inhibited leucocyte recruitment in an inflammation model in rats, and neither the content of fucose and sulfate nor other structural features of their polysaccharide backbones significantly affected the efficacy of fucoidans in this model. In vitro evaluation of P-selectin-mediated neutrophil adhesion to platelets under flow conditions revealed that only polysaccharides from Laminaria saccharina, L. digitata, Fucus evanescens, F. serratus, F. distichus, F. spiralis, and Ascophyllum nodosum could serve as P-selectin inhibitors. All fucoidans, except that from Cladosiphon okamuranus carrying substantial levels of 2-O-alpha-D-glucuronopyranosyl branches in the linear (1-->3)-linked poly-alpha-fucopyranoside chain, exhibited anticoagulant activity as measured by activated partial thromboplastin time whereas only fucoidans from L. saccharina, L. digitata, F. serratus, F. distichus, and F. evanescens displayed strong antithrombin activity in a platelet aggregation test. The last fucoidans potently inhibited human umbilical vein endothelial cell (HUVEC) tubulogenesis in vitro and this property correlated with decreased levels of plasminogen-activator inhibitor-1 in HUVEC supernatants, suggesting a possible mechanism of fucoidan-induced inhibition of tubulogenesis. Finally, fucoidans from L. saccharina, L. digitata, F. serratus, F. distichus, and F. vesiculosus strongly blocked MDA-MB-231 breast carcinoma cell adhesion to platelets, an effect which might have critical implications in tumor metastasis. The data presented herein provide a new rationale for the development of potential drugs for thrombosis, inflammation, and tumor progression.Fil: Cumashi, Albana. Universita degli Studi G. D Annunzio; ItaliaFil: Ushakova, Natalia A.. Academia Rusa de Ciencias Médicas; RusiaFil: Preobrazhenskaya, Marina E.. Academia Rusa de Ciencias Médicas; RusiaFil: D'Incecco, Armida. Universita degli Studi G. D Annunzio; ItaliaFil: Piccoli, Antonio. Consorzio Mario Negri Sud; ItaliaFil: Totani, Licia. Consorzio Mario Negri Sud; ItaliaFil: Tinari, Nicola. Universita degli Studi G. D Annunzio; ItaliaFil: Morozevich, Galina E.. Academia Rusa de Ciencias Médicas; RusiaFil: Berman, Albert E.. Academia Rusa de Ciencias Médicas; RusiaFil: Bilan, María. Academia Rusa de Ciencias; RusiaFil: Usov, Anatolii I.. Academia Rusa de Ciencias; RusiaFil: Ustyuzhanina, Nadezhda E.. Academia Rusa de Ciencias; RusiaFil: Grachev, Alexey A.. Academia Rusa de Ciencias; RusiaFil: Sanderson, Craig J.. Scottish Association for Marine Sciences; Reino UnidoFil: Kelly, Maeve. Scottish Association for Marine Sciences; Reino UnidoFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Iacobelli, Stefano. Universita degli Studi G. D Annunzio; ItaliaFil: Nifantiev, Nikolay E.. Academia Rusa de Ciencias; RusiaOxford Univ Press Inc2007-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/29419Cumashi, Albana; Ushakova, Natalia A.; Preobrazhenskaya, Marina E.; D'Incecco, Armida; Piccoli, Antonio; et al.; A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds; Oxford Univ Press Inc; Glycobiology; 17; 5; 2-2007; 541-5520959-66581460-2423CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/glycob/article-lookup/doi/10.1093/glycob/cwm014info:eu-repo/semantics/altIdentifier/doi/10.1093/glycob/cwm014info:eu-repo/semantics/altIdentifier/url/http://europepmc.org/abstract/med/17296677info:eu-repo/semantics/altIdentifier/pmid/17296677info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:48:11Zoai:ri.conicet.gov.ar:11336/29419instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:48:12.254CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
title A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
spellingShingle A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
Cumashi, Albana
Fucoidan
Brown Algae
Blood Coagulation
Inflammation
Angiogenesis
title_short A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
title_full A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
title_fullStr A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
title_full_unstemmed A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
title_sort A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds
dc.creator.none.fl_str_mv Cumashi, Albana
Ushakova, Natalia A.
Preobrazhenskaya, Marina E.
D'Incecco, Armida
Piccoli, Antonio
Totani, Licia
Tinari, Nicola
Morozevich, Galina E.
Berman, Albert E.
Bilan, María
Usov, Anatolii I.
Ustyuzhanina, Nadezhda E.
Grachev, Alexey A.
Sanderson, Craig J.
Kelly, Maeve
Rabinovich, Gabriel Adrián
Iacobelli, Stefano
Nifantiev, Nikolay E.
author Cumashi, Albana
author_facet Cumashi, Albana
Ushakova, Natalia A.
Preobrazhenskaya, Marina E.
D'Incecco, Armida
Piccoli, Antonio
Totani, Licia
Tinari, Nicola
Morozevich, Galina E.
Berman, Albert E.
Bilan, María
Usov, Anatolii I.
Ustyuzhanina, Nadezhda E.
Grachev, Alexey A.
Sanderson, Craig J.
Kelly, Maeve
Rabinovich, Gabriel Adrián
Iacobelli, Stefano
Nifantiev, Nikolay E.
author_role author
author2 Ushakova, Natalia A.
Preobrazhenskaya, Marina E.
D'Incecco, Armida
Piccoli, Antonio
Totani, Licia
Tinari, Nicola
Morozevich, Galina E.
Berman, Albert E.
Bilan, María
Usov, Anatolii I.
Ustyuzhanina, Nadezhda E.
Grachev, Alexey A.
Sanderson, Craig J.
Kelly, Maeve
Rabinovich, Gabriel Adrián
Iacobelli, Stefano
Nifantiev, Nikolay E.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Fucoidan
Brown Algae
Blood Coagulation
Inflammation
Angiogenesis
topic Fucoidan
Brown Algae
Blood Coagulation
Inflammation
Angiogenesis
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The anti-inflammatory, antiangiogenic, anticoagulant, and antiadhesive properties of fucoidans obtained from nine species of brown algae were studied in order to examine the influence of fucoidan origin and composition on their biological activities. All fucoidans inhibited leucocyte recruitment in an inflammation model in rats, and neither the content of fucose and sulfate nor other structural features of their polysaccharide backbones significantly affected the efficacy of fucoidans in this model. In vitro evaluation of P-selectin-mediated neutrophil adhesion to platelets under flow conditions revealed that only polysaccharides from Laminaria saccharina, L. digitata, Fucus evanescens, F. serratus, F. distichus, F. spiralis, and Ascophyllum nodosum could serve as P-selectin inhibitors. All fucoidans, except that from Cladosiphon okamuranus carrying substantial levels of 2-O-alpha-D-glucuronopyranosyl branches in the linear (1-->3)-linked poly-alpha-fucopyranoside chain, exhibited anticoagulant activity as measured by activated partial thromboplastin time whereas only fucoidans from L. saccharina, L. digitata, F. serratus, F. distichus, and F. evanescens displayed strong antithrombin activity in a platelet aggregation test. The last fucoidans potently inhibited human umbilical vein endothelial cell (HUVEC) tubulogenesis in vitro and this property correlated with decreased levels of plasminogen-activator inhibitor-1 in HUVEC supernatants, suggesting a possible mechanism of fucoidan-induced inhibition of tubulogenesis. Finally, fucoidans from L. saccharina, L. digitata, F. serratus, F. distichus, and F. vesiculosus strongly blocked MDA-MB-231 breast carcinoma cell adhesion to platelets, an effect which might have critical implications in tumor metastasis. The data presented herein provide a new rationale for the development of potential drugs for thrombosis, inflammation, and tumor progression.
Fil: Cumashi, Albana. Universita degli Studi G. D Annunzio; Italia
Fil: Ushakova, Natalia A.. Academia Rusa de Ciencias Médicas; Rusia
Fil: Preobrazhenskaya, Marina E.. Academia Rusa de Ciencias Médicas; Rusia
Fil: D'Incecco, Armida. Universita degli Studi G. D Annunzio; Italia
Fil: Piccoli, Antonio. Consorzio Mario Negri Sud; Italia
Fil: Totani, Licia. Consorzio Mario Negri Sud; Italia
Fil: Tinari, Nicola. Universita degli Studi G. D Annunzio; Italia
Fil: Morozevich, Galina E.. Academia Rusa de Ciencias Médicas; Rusia
Fil: Berman, Albert E.. Academia Rusa de Ciencias Médicas; Rusia
Fil: Bilan, María. Academia Rusa de Ciencias; Rusia
Fil: Usov, Anatolii I.. Academia Rusa de Ciencias; Rusia
Fil: Ustyuzhanina, Nadezhda E.. Academia Rusa de Ciencias; Rusia
Fil: Grachev, Alexey A.. Academia Rusa de Ciencias; Rusia
Fil: Sanderson, Craig J.. Scottish Association for Marine Sciences; Reino Unido
Fil: Kelly, Maeve. Scottish Association for Marine Sciences; Reino Unido
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina
Fil: Iacobelli, Stefano. Universita degli Studi G. D Annunzio; Italia
Fil: Nifantiev, Nikolay E.. Academia Rusa de Ciencias; Rusia
description The anti-inflammatory, antiangiogenic, anticoagulant, and antiadhesive properties of fucoidans obtained from nine species of brown algae were studied in order to examine the influence of fucoidan origin and composition on their biological activities. All fucoidans inhibited leucocyte recruitment in an inflammation model in rats, and neither the content of fucose and sulfate nor other structural features of their polysaccharide backbones significantly affected the efficacy of fucoidans in this model. In vitro evaluation of P-selectin-mediated neutrophil adhesion to platelets under flow conditions revealed that only polysaccharides from Laminaria saccharina, L. digitata, Fucus evanescens, F. serratus, F. distichus, F. spiralis, and Ascophyllum nodosum could serve as P-selectin inhibitors. All fucoidans, except that from Cladosiphon okamuranus carrying substantial levels of 2-O-alpha-D-glucuronopyranosyl branches in the linear (1-->3)-linked poly-alpha-fucopyranoside chain, exhibited anticoagulant activity as measured by activated partial thromboplastin time whereas only fucoidans from L. saccharina, L. digitata, F. serratus, F. distichus, and F. evanescens displayed strong antithrombin activity in a platelet aggregation test. The last fucoidans potently inhibited human umbilical vein endothelial cell (HUVEC) tubulogenesis in vitro and this property correlated with decreased levels of plasminogen-activator inhibitor-1 in HUVEC supernatants, suggesting a possible mechanism of fucoidan-induced inhibition of tubulogenesis. Finally, fucoidans from L. saccharina, L. digitata, F. serratus, F. distichus, and F. vesiculosus strongly blocked MDA-MB-231 breast carcinoma cell adhesion to platelets, an effect which might have critical implications in tumor metastasis. The data presented herein provide a new rationale for the development of potential drugs for thrombosis, inflammation, and tumor progression.
publishDate 2007
dc.date.none.fl_str_mv 2007-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/29419
Cumashi, Albana; Ushakova, Natalia A.; Preobrazhenskaya, Marina E.; D'Incecco, Armida; Piccoli, Antonio; et al.; A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds; Oxford Univ Press Inc; Glycobiology; 17; 5; 2-2007; 541-552
0959-6658
1460-2423
CONICET Digital
CONICET
url http://hdl.handle.net/11336/29419
identifier_str_mv Cumashi, Albana; Ushakova, Natalia A.; Preobrazhenskaya, Marina E.; D'Incecco, Armida; Piccoli, Antonio; et al.; A comparative study of the anti-inflammatory, anticoagulant, antiangiogenic, and antiadhesive activities of nine different fucoidans from brown seaweeds; Oxford Univ Press Inc; Glycobiology; 17; 5; 2-2007; 541-552
0959-6658
1460-2423
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/glycob/article-lookup/doi/10.1093/glycob/cwm014
info:eu-repo/semantics/altIdentifier/doi/10.1093/glycob/cwm014
info:eu-repo/semantics/altIdentifier/url/http://europepmc.org/abstract/med/17296677
info:eu-repo/semantics/altIdentifier/pmid/17296677
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Oxford Univ Press Inc
publisher.none.fl_str_mv Oxford Univ Press Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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