In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes

Autores
Parente, Juliana Elena; Naso, Luciana Gissella; Jori, Khalil; Franca, Carlos Alberto; da Costa Ferreira, Ana Maria; Williams, Patricia Ana María; Ferrer, Evelina Gloria
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the course of our research of vanadium-containing complexes, two oxidovanadium complexes containing vanadium(V) and (IV) core with 4-aminobenzoic acid and/or peroxo anion as ligands were synthesized and characterized by elemental analysis, conductivity measurements, thermogravimetric analysis, and spectroscopies.(([VO(O 2 )(C 7 H 6 NO 2 )(H 2 O)] . H 2 O, [VO(C 7 H 6 NO 2 ) 2 H 2 O]) were supported by experimental data and theoretical studies (Density functional theory, DFT). The complexes were evaluated in vitro as phosphatase inhibitors (alkaline and acid enzymes) being considered as potential pharmaceutical agents under over-expression of those biochemical markers.The effect achieved was then analysed through FTIR spectroscopy. Changes in the finger print substrate bands as well as induced conformational changes on phosphatases enzymes secondary structure were further examined. Eventually albumin interactions experimentswere performed in order to derive their bioavailability.
Fil: Parente, Juliana Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Jori, Khalil. Universidad Nacional de La Plata; Argentina
Fil: Franca, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: da Costa Ferreira, Ana Maria. Universidade de Sao Paulo; Brasil
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Materia
vanadium
complexes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/127837
Acceder
id CONICETDig_378ef5ebce35199dca8e603e18823b86
oai_identifier_str oai:ri.conicet.gov.ar:11336/127837
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexesParente, Juliana ElenaNaso, Luciana GissellaJori, KhalilFranca, Carlos Albertoda Costa Ferreira, Ana MariaWilliams, Patricia Ana MaríaFerrer, Evelina Gloriavanadiumcomplexeshttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1In the course of our research of vanadium-containing complexes, two oxidovanadium complexes containing vanadium(V) and (IV) core with 4-aminobenzoic acid and/or peroxo anion as ligands were synthesized and characterized by elemental analysis, conductivity measurements, thermogravimetric analysis, and spectroscopies.(([VO(O 2 )(C 7 H 6 NO 2 )(H 2 O)] . H 2 O, [VO(C 7 H 6 NO 2 ) 2 H 2 O]) were supported by experimental data and theoretical studies (Density functional theory, DFT). The complexes were evaluated in vitro as phosphatase inhibitors (alkaline and acid enzymes) being considered as potential pharmaceutical agents under over-expression of those biochemical markers.The effect achieved was then analysed through FTIR spectroscopy. Changes in the finger print substrate bands as well as induced conformational changes on phosphatases enzymes secondary structure were further examined. Eventually albumin interactions experimentswere performed in order to derive their bioavailability.Fil: Parente, Juliana Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Jori, Khalil. Universidad Nacional de La Plata; ArgentinaFil: Franca, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: da Costa Ferreira, Ana Maria. Universidade de Sao Paulo; BrasilFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaRoyal Society of Chemistry2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/127837Parente, Juliana Elena; Naso, Luciana Gissella; Jori, Khalil; Franca, Carlos Alberto; da Costa Ferreira, Ana Maria; et al.; In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes; Royal Society of Chemistry; New Journal of Chemistry; 45; 5-2019; 1-171144-0546CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2019/NJ/C9NJ01638Dinfo:eu-repo/semantics/altIdentifier/doi/10.1039/C9NJ01638Dinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:04:09Zoai:ri.conicet.gov.ar:11336/127837instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:04:09.613CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes
title In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes
spellingShingle In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes
Parente, Juliana Elena
vanadium
complexes
title_short In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes
title_full In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes
title_fullStr In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes
title_full_unstemmed In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes
title_sort In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes
dc.creator.none.fl_str_mv Parente, Juliana Elena
Naso, Luciana Gissella
Jori, Khalil
Franca, Carlos Alberto
da Costa Ferreira, Ana Maria
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author Parente, Juliana Elena
author_facet Parente, Juliana Elena
Naso, Luciana Gissella
Jori, Khalil
Franca, Carlos Alberto
da Costa Ferreira, Ana Maria
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author_role author
author2 Naso, Luciana Gissella
Jori, Khalil
Franca, Carlos Alberto
da Costa Ferreira, Ana Maria
Williams, Patricia Ana María
Ferrer, Evelina Gloria
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv vanadium
complexes
topic vanadium
complexes
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In the course of our research of vanadium-containing complexes, two oxidovanadium complexes containing vanadium(V) and (IV) core with 4-aminobenzoic acid and/or peroxo anion as ligands were synthesized and characterized by elemental analysis, conductivity measurements, thermogravimetric analysis, and spectroscopies.(([VO(O 2 )(C 7 H 6 NO 2 )(H 2 O)] . H 2 O, [VO(C 7 H 6 NO 2 ) 2 H 2 O]) were supported by experimental data and theoretical studies (Density functional theory, DFT). The complexes were evaluated in vitro as phosphatase inhibitors (alkaline and acid enzymes) being considered as potential pharmaceutical agents under over-expression of those biochemical markers.The effect achieved was then analysed through FTIR spectroscopy. Changes in the finger print substrate bands as well as induced conformational changes on phosphatases enzymes secondary structure were further examined. Eventually albumin interactions experimentswere performed in order to derive their bioavailability.
Fil: Parente, Juliana Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Jori, Khalil. Universidad Nacional de La Plata; Argentina
Fil: Franca, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: da Costa Ferreira, Ana Maria. Universidade de Sao Paulo; Brasil
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
description In the course of our research of vanadium-containing complexes, two oxidovanadium complexes containing vanadium(V) and (IV) core with 4-aminobenzoic acid and/or peroxo anion as ligands were synthesized and characterized by elemental analysis, conductivity measurements, thermogravimetric analysis, and spectroscopies.(([VO(O 2 )(C 7 H 6 NO 2 )(H 2 O)] . H 2 O, [VO(C 7 H 6 NO 2 ) 2 H 2 O]) were supported by experimental data and theoretical studies (Density functional theory, DFT). The complexes were evaluated in vitro as phosphatase inhibitors (alkaline and acid enzymes) being considered as potential pharmaceutical agents under over-expression of those biochemical markers.The effect achieved was then analysed through FTIR spectroscopy. Changes in the finger print substrate bands as well as induced conformational changes on phosphatases enzymes secondary structure were further examined. Eventually albumin interactions experimentswere performed in order to derive their bioavailability.
publishDate 2019
dc.date.none.fl_str_mv 2019-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/127837
Parente, Juliana Elena; Naso, Luciana Gissella; Jori, Khalil; Franca, Carlos Alberto; da Costa Ferreira, Ana Maria; et al.; In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes; Royal Society of Chemistry; New Journal of Chemistry; 45; 5-2019; 1-17
1144-0546
CONICET Digital
CONICET
url http://hdl.handle.net/11336/127837
identifier_str_mv Parente, Juliana Elena; Naso, Luciana Gissella; Jori, Khalil; Franca, Carlos Alberto; da Costa Ferreira, Ana Maria; et al.; In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes; Royal Society of Chemistry; New Journal of Chemistry; 45; 5-2019; 1-17
1144-0546
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2019/NJ/C9NJ01638D
info:eu-repo/semantics/altIdentifier/doi/10.1039/C9NJ01638D
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782388031455232
score 12.982451

Publicaciones similares