In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes
- Autores
- Parente, Juliana Elena; Naso, Luciana Gissella; Jori, Khalil; Franca, Carlos Alberto; da Costa Ferreira, Ana Maria; Williams, Patricia Ana María; Ferrer, Evelina Gloria
- Año de publicación
- 2019
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- In the course of our research of vanadium-containing complexes, two oxidovanadium complexes containing vanadium(V) and (IV) core with 4-aminobenzoic acid and/or peroxo anion as ligands were synthesized and characterized by elemental analysis, conductivity measurements, thermogravimetric analysis, and spectroscopies.(([VO(O 2 )(C 7 H 6 NO 2 )(H 2 O)] . H 2 O, [VO(C 7 H 6 NO 2 ) 2 H 2 O]) were supported by experimental data and theoretical studies (Density functional theory, DFT). The complexes were evaluated in vitro as phosphatase inhibitors (alkaline and acid enzymes) being considered as potential pharmaceutical agents under over-expression of those biochemical markers.The effect achieved was then analysed through FTIR spectroscopy. Changes in the finger print substrate bands as well as induced conformational changes on phosphatases enzymes secondary structure were further examined. Eventually albumin interactions experimentswere performed in order to derive their bioavailability.
Fil: Parente, Juliana Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Jori, Khalil. Universidad Nacional de La Plata; Argentina
Fil: Franca, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: da Costa Ferreira, Ana Maria. Universidade de Sao Paulo; Brasil
Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina - Materia
-
vanadium
complexes - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/127837
Ver los metadatos del registro completo
id |
CONICETDig_378ef5ebce35199dca8e603e18823b86 |
---|---|
oai_identifier_str |
oai:ri.conicet.gov.ar:11336/127837 |
network_acronym_str |
CONICETDig |
repository_id_str |
3498 |
network_name_str |
CONICET Digital (CONICET) |
spelling |
In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexesParente, Juliana ElenaNaso, Luciana GissellaJori, KhalilFranca, Carlos Albertoda Costa Ferreira, Ana MariaWilliams, Patricia Ana MaríaFerrer, Evelina Gloriavanadiumcomplexeshttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1In the course of our research of vanadium-containing complexes, two oxidovanadium complexes containing vanadium(V) and (IV) core with 4-aminobenzoic acid and/or peroxo anion as ligands were synthesized and characterized by elemental analysis, conductivity measurements, thermogravimetric analysis, and spectroscopies.(([VO(O 2 )(C 7 H 6 NO 2 )(H 2 O)] . H 2 O, [VO(C 7 H 6 NO 2 ) 2 H 2 O]) were supported by experimental data and theoretical studies (Density functional theory, DFT). The complexes were evaluated in vitro as phosphatase inhibitors (alkaline and acid enzymes) being considered as potential pharmaceutical agents under over-expression of those biochemical markers.The effect achieved was then analysed through FTIR spectroscopy. Changes in the finger print substrate bands as well as induced conformational changes on phosphatases enzymes secondary structure were further examined. Eventually albumin interactions experimentswere performed in order to derive their bioavailability.Fil: Parente, Juliana Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Jori, Khalil. Universidad Nacional de La Plata; ArgentinaFil: Franca, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: da Costa Ferreira, Ana Maria. Universidade de Sao Paulo; BrasilFil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaRoyal Society of Chemistry2019-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/127837Parente, Juliana Elena; Naso, Luciana Gissella; Jori, Khalil; Franca, Carlos Alberto; da Costa Ferreira, Ana Maria; et al.; In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes; Royal Society of Chemistry; New Journal of Chemistry; 45; 5-2019; 1-171144-0546CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2019/NJ/C9NJ01638Dinfo:eu-repo/semantics/altIdentifier/doi/10.1039/C9NJ01638Dinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:31:43Zoai:ri.conicet.gov.ar:11336/127837instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:31:43.999CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes |
title |
In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes |
spellingShingle |
In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes Parente, Juliana Elena vanadium complexes |
title_short |
In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes |
title_full |
In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes |
title_fullStr |
In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes |
title_full_unstemmed |
In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes |
title_sort |
In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes |
dc.creator.none.fl_str_mv |
Parente, Juliana Elena Naso, Luciana Gissella Jori, Khalil Franca, Carlos Alberto da Costa Ferreira, Ana Maria Williams, Patricia Ana María Ferrer, Evelina Gloria |
author |
Parente, Juliana Elena |
author_facet |
Parente, Juliana Elena Naso, Luciana Gissella Jori, Khalil Franca, Carlos Alberto da Costa Ferreira, Ana Maria Williams, Patricia Ana María Ferrer, Evelina Gloria |
author_role |
author |
author2 |
Naso, Luciana Gissella Jori, Khalil Franca, Carlos Alberto da Costa Ferreira, Ana Maria Williams, Patricia Ana María Ferrer, Evelina Gloria |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
vanadium complexes |
topic |
vanadium complexes |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.7 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
In the course of our research of vanadium-containing complexes, two oxidovanadium complexes containing vanadium(V) and (IV) core with 4-aminobenzoic acid and/or peroxo anion as ligands were synthesized and characterized by elemental analysis, conductivity measurements, thermogravimetric analysis, and spectroscopies.(([VO(O 2 )(C 7 H 6 NO 2 )(H 2 O)] . H 2 O, [VO(C 7 H 6 NO 2 ) 2 H 2 O]) were supported by experimental data and theoretical studies (Density functional theory, DFT). The complexes were evaluated in vitro as phosphatase inhibitors (alkaline and acid enzymes) being considered as potential pharmaceutical agents under over-expression of those biochemical markers.The effect achieved was then analysed through FTIR spectroscopy. Changes in the finger print substrate bands as well as induced conformational changes on phosphatases enzymes secondary structure were further examined. Eventually albumin interactions experimentswere performed in order to derive their bioavailability. Fil: Parente, Juliana Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina Fil: Naso, Luciana Gissella. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina Fil: Jori, Khalil. Universidad Nacional de La Plata; Argentina Fil: Franca, Carlos Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina Fil: da Costa Ferreira, Ana Maria. Universidade de Sao Paulo; Brasil Fil: Williams, Patricia Ana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina Fil: Ferrer, Evelina Gloria. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina |
description |
In the course of our research of vanadium-containing complexes, two oxidovanadium complexes containing vanadium(V) and (IV) core with 4-aminobenzoic acid and/or peroxo anion as ligands were synthesized and characterized by elemental analysis, conductivity measurements, thermogravimetric analysis, and spectroscopies.(([VO(O 2 )(C 7 H 6 NO 2 )(H 2 O)] . H 2 O, [VO(C 7 H 6 NO 2 ) 2 H 2 O]) were supported by experimental data and theoretical studies (Density functional theory, DFT). The complexes were evaluated in vitro as phosphatase inhibitors (alkaline and acid enzymes) being considered as potential pharmaceutical agents under over-expression of those biochemical markers.The effect achieved was then analysed through FTIR spectroscopy. Changes in the finger print substrate bands as well as induced conformational changes on phosphatases enzymes secondary structure were further examined. Eventually albumin interactions experimentswere performed in order to derive their bioavailability. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/127837 Parente, Juliana Elena; Naso, Luciana Gissella; Jori, Khalil; Franca, Carlos Alberto; da Costa Ferreira, Ana Maria; et al.; In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes; Royal Society of Chemistry; New Journal of Chemistry; 45; 5-2019; 1-17 1144-0546 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/127837 |
identifier_str_mv |
Parente, Juliana Elena; Naso, Luciana Gissella; Jori, Khalil; Franca, Carlos Alberto; da Costa Ferreira, Ana Maria; et al.; In vitro experiments and infrared spectroscopy analysis of acid and alkaline phosphatase inhibition by vanadium complexes; Royal Society of Chemistry; New Journal of Chemistry; 45; 5-2019; 1-17 1144-0546 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2019/NJ/C9NJ01638D info:eu-repo/semantics/altIdentifier/doi/10.1039/C9NJ01638D |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society of Chemistry |
publisher.none.fl_str_mv |
Royal Society of Chemistry |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1844614328707186688 |
score |
13.070432 |