P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice

Autores
Stachon, Peter; Peikert, Alexander; Michel, Nathaly Anto; Hergeth, Sonja; Marchini, Timoteo Oscar; Wolf, Dennis; Dufner, Bianca; Hoppe, Natalie; Ayata, Cemil Korcan; Grimm, Melanie; Cicko, Sanja; Schulte, Lisa; Reinöhl, Jochen; Von Zur Muhlen, Constantin; Bode, Christoph; Idzko, Marco; Zirlik, Andreas
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective - Nucleotides such as ATP, ADP, UTP, and UDP serve as proinflammatory danger signals via purinergic receptors on their release to the extracellular space by activated or dying cells. UDP binds to the purinergic receptor Y6 (P2Y6) and propagates vascular inflammation by inducing the expression of chemokines such as monocyte chemoattractant protein 1, interleukin-8, or its mouse homologsCCL1 (chemokine [C-C motif] ligand 1)/keratinocyte chemokine, CXCL2 (chemokine [C-X-C motif] ligand 2)/macrophage inflammatory protein 2, and CXCL5 (chemokine [C-X-C motif] ligand 5)/LIX, and adhesion molecules such as vascular cell adhesion molecule 1 and intercellular cell adhesion molecule 1. Thus, P2Y6 contributes to leukocyte recruitment and inflammation in conditions such as allergic asthma or sepsis. Because atherosclerosis is a chronic inflammatory disease driven by leukocyte recruitment to the vessel wall, we hypothesized a role of P2Y6 in atherogenesis.
Fil: Stachon, Peter. Universität Freiburg; Alemania
Fil: Peikert, Alexander. Universität Freiburg; Alemania
Fil: Michel, Nathaly Anto. Universität Freiburg; Alemania
Fil: Hergeth, Sonja. Universität Freiburg; Alemania
Fil: Marchini, Timoteo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universität Freiburg; Alemania
Fil: Wolf, Dennis. Universität Freiburg; Alemania
Fil: Dufner, Bianca. Universität Freiburg; Alemania
Fil: Hoppe, Natalie. Universität Freiburg; Alemania
Fil: Ayata, Cemil Korcan. Universität Freiburg; Alemania
Fil: Grimm, Melanie. Universität Freiburg; Alemania
Fil: Cicko, Sanja. Universität Freiburg; Alemania
Fil: Schulte, Lisa. Universität Freiburg; Alemania
Fil: Reinöhl, Jochen. Universität Freiburg; Alemania
Fil: Von Zur Muhlen, Constantin. Universität Freiburg; Alemania
Fil: Bode, Christoph. Universität Freiburg; Alemania
Fil: Idzko, Marco. Universität Freiburg; Alemania
Fil: Zirlik, Andreas. Universität Freiburg; Alemania
Materia
ATHEROSCLEROSIS
INFLAMMATION
P2Y6 RECEPTOR
RECEPTORS, PURINERGIC P2
URIDINE DIPHOSPHATE
VASCULAR CELL ADHESION MOLECULE-1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67036
Acceder
id CONICETDig_358c62833800782a2198152a157e8546
oai_identifier_str oai:ri.conicet.gov.ar:11336/67036
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling P2Y6 deficiency limits vascular inflammation and atherosclerosis in miceStachon, PeterPeikert, AlexanderMichel, Nathaly AntoHergeth, SonjaMarchini, Timoteo OscarWolf, DennisDufner, BiancaHoppe, NatalieAyata, Cemil KorcanGrimm, MelanieCicko, SanjaSchulte, LisaReinöhl, JochenVon Zur Muhlen, ConstantinBode, ChristophIdzko, MarcoZirlik, AndreasATHEROSCLEROSISINFLAMMATIONP2Y6 RECEPTORRECEPTORS, PURINERGIC P2URIDINE DIPHOSPHATEVASCULAR CELL ADHESION MOLECULE-1https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective - Nucleotides such as ATP, ADP, UTP, and UDP serve as proinflammatory danger signals via purinergic receptors on their release to the extracellular space by activated or dying cells. UDP binds to the purinergic receptor Y6 (P2Y6) and propagates vascular inflammation by inducing the expression of chemokines such as monocyte chemoattractant protein 1, interleukin-8, or its mouse homologsCCL1 (chemokine [C-C motif] ligand 1)/keratinocyte chemokine, CXCL2 (chemokine [C-X-C motif] ligand 2)/macrophage inflammatory protein 2, and CXCL5 (chemokine [C-X-C motif] ligand 5)/LIX, and adhesion molecules such as vascular cell adhesion molecule 1 and intercellular cell adhesion molecule 1. Thus, P2Y6 contributes to leukocyte recruitment and inflammation in conditions such as allergic asthma or sepsis. Because atherosclerosis is a chronic inflammatory disease driven by leukocyte recruitment to the vessel wall, we hypothesized a role of P2Y6 in atherogenesis.Fil: Stachon, Peter. Universität Freiburg; AlemaniaFil: Peikert, Alexander. Universität Freiburg; AlemaniaFil: Michel, Nathaly Anto. Universität Freiburg; AlemaniaFil: Hergeth, Sonja. Universität Freiburg; AlemaniaFil: Marchini, Timoteo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universität Freiburg; AlemaniaFil: Wolf, Dennis. Universität Freiburg; AlemaniaFil: Dufner, Bianca. Universität Freiburg; AlemaniaFil: Hoppe, Natalie. Universität Freiburg; AlemaniaFil: Ayata, Cemil Korcan. Universität Freiburg; AlemaniaFil: Grimm, Melanie. Universität Freiburg; AlemaniaFil: Cicko, Sanja. Universität Freiburg; AlemaniaFil: Schulte, Lisa. Universität Freiburg; AlemaniaFil: Reinöhl, Jochen. Universität Freiburg; AlemaniaFil: Von Zur Muhlen, Constantin. Universität Freiburg; AlemaniaFil: Bode, Christoph. Universität Freiburg; AlemaniaFil: Idzko, Marco. Universität Freiburg; AlemaniaFil: Zirlik, Andreas. Universität Freiburg; AlemaniaLippincott Williams2014-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67036Stachon, Peter; Peikert, Alexander; Michel, Nathaly Anto; Hergeth, Sonja; Marchini, Timoteo Oscar; et al.; P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice; Lippincott Williams; Arteriosclerosis, Thrombosis, and Vascular Biology; 34; 10; 10-2014; 2237-22451079-5642CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1161/ATVBAHA.114.303585info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.303585info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:48:59Zoai:ri.conicet.gov.ar:11336/67036instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:00.2CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice
title P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice
spellingShingle P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice
Stachon, Peter
ATHEROSCLEROSIS
INFLAMMATION
P2Y6 RECEPTOR
RECEPTORS, PURINERGIC P2
URIDINE DIPHOSPHATE
VASCULAR CELL ADHESION MOLECULE-1
title_short P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice
title_full P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice
title_fullStr P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice
title_full_unstemmed P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice
title_sort P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice
dc.creator.none.fl_str_mv Stachon, Peter
Peikert, Alexander
Michel, Nathaly Anto
Hergeth, Sonja
Marchini, Timoteo Oscar
Wolf, Dennis
Dufner, Bianca
Hoppe, Natalie
Ayata, Cemil Korcan
Grimm, Melanie
Cicko, Sanja
Schulte, Lisa
Reinöhl, Jochen
Von Zur Muhlen, Constantin
Bode, Christoph
Idzko, Marco
Zirlik, Andreas
author Stachon, Peter
author_facet Stachon, Peter
Peikert, Alexander
Michel, Nathaly Anto
Hergeth, Sonja
Marchini, Timoteo Oscar
Wolf, Dennis
Dufner, Bianca
Hoppe, Natalie
Ayata, Cemil Korcan
Grimm, Melanie
Cicko, Sanja
Schulte, Lisa
Reinöhl, Jochen
Von Zur Muhlen, Constantin
Bode, Christoph
Idzko, Marco
Zirlik, Andreas
author_role author
author2 Peikert, Alexander
Michel, Nathaly Anto
Hergeth, Sonja
Marchini, Timoteo Oscar
Wolf, Dennis
Dufner, Bianca
Hoppe, Natalie
Ayata, Cemil Korcan
Grimm, Melanie
Cicko, Sanja
Schulte, Lisa
Reinöhl, Jochen
Von Zur Muhlen, Constantin
Bode, Christoph
Idzko, Marco
Zirlik, Andreas
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ATHEROSCLEROSIS
INFLAMMATION
P2Y6 RECEPTOR
RECEPTORS, PURINERGIC P2
URIDINE DIPHOSPHATE
VASCULAR CELL ADHESION MOLECULE-1
topic ATHEROSCLEROSIS
INFLAMMATION
P2Y6 RECEPTOR
RECEPTORS, PURINERGIC P2
URIDINE DIPHOSPHATE
VASCULAR CELL ADHESION MOLECULE-1
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective - Nucleotides such as ATP, ADP, UTP, and UDP serve as proinflammatory danger signals via purinergic receptors on their release to the extracellular space by activated or dying cells. UDP binds to the purinergic receptor Y6 (P2Y6) and propagates vascular inflammation by inducing the expression of chemokines such as monocyte chemoattractant protein 1, interleukin-8, or its mouse homologsCCL1 (chemokine [C-C motif] ligand 1)/keratinocyte chemokine, CXCL2 (chemokine [C-X-C motif] ligand 2)/macrophage inflammatory protein 2, and CXCL5 (chemokine [C-X-C motif] ligand 5)/LIX, and adhesion molecules such as vascular cell adhesion molecule 1 and intercellular cell adhesion molecule 1. Thus, P2Y6 contributes to leukocyte recruitment and inflammation in conditions such as allergic asthma or sepsis. Because atherosclerosis is a chronic inflammatory disease driven by leukocyte recruitment to the vessel wall, we hypothesized a role of P2Y6 in atherogenesis.
Fil: Stachon, Peter. Universität Freiburg; Alemania
Fil: Peikert, Alexander. Universität Freiburg; Alemania
Fil: Michel, Nathaly Anto. Universität Freiburg; Alemania
Fil: Hergeth, Sonja. Universität Freiburg; Alemania
Fil: Marchini, Timoteo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universität Freiburg; Alemania
Fil: Wolf, Dennis. Universität Freiburg; Alemania
Fil: Dufner, Bianca. Universität Freiburg; Alemania
Fil: Hoppe, Natalie. Universität Freiburg; Alemania
Fil: Ayata, Cemil Korcan. Universität Freiburg; Alemania
Fil: Grimm, Melanie. Universität Freiburg; Alemania
Fil: Cicko, Sanja. Universität Freiburg; Alemania
Fil: Schulte, Lisa. Universität Freiburg; Alemania
Fil: Reinöhl, Jochen. Universität Freiburg; Alemania
Fil: Von Zur Muhlen, Constantin. Universität Freiburg; Alemania
Fil: Bode, Christoph. Universität Freiburg; Alemania
Fil: Idzko, Marco. Universität Freiburg; Alemania
Fil: Zirlik, Andreas. Universität Freiburg; Alemania
description Objective - Nucleotides such as ATP, ADP, UTP, and UDP serve as proinflammatory danger signals via purinergic receptors on their release to the extracellular space by activated or dying cells. UDP binds to the purinergic receptor Y6 (P2Y6) and propagates vascular inflammation by inducing the expression of chemokines such as monocyte chemoattractant protein 1, interleukin-8, or its mouse homologsCCL1 (chemokine [C-C motif] ligand 1)/keratinocyte chemokine, CXCL2 (chemokine [C-X-C motif] ligand 2)/macrophage inflammatory protein 2, and CXCL5 (chemokine [C-X-C motif] ligand 5)/LIX, and adhesion molecules such as vascular cell adhesion molecule 1 and intercellular cell adhesion molecule 1. Thus, P2Y6 contributes to leukocyte recruitment and inflammation in conditions such as allergic asthma or sepsis. Because atherosclerosis is a chronic inflammatory disease driven by leukocyte recruitment to the vessel wall, we hypothesized a role of P2Y6 in atherogenesis.
publishDate 2014
dc.date.none.fl_str_mv 2014-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67036
Stachon, Peter; Peikert, Alexander; Michel, Nathaly Anto; Hergeth, Sonja; Marchini, Timoteo Oscar; et al.; P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice; Lippincott Williams; Arteriosclerosis, Thrombosis, and Vascular Biology; 34; 10; 10-2014; 2237-2245
1079-5642
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67036
identifier_str_mv Stachon, Peter; Peikert, Alexander; Michel, Nathaly Anto; Hergeth, Sonja; Marchini, Timoteo Oscar; et al.; P2Y6 deficiency limits vascular inflammation and atherosclerosis in mice; Lippincott Williams; Arteriosclerosis, Thrombosis, and Vascular Biology; 34; 10; 10-2014; 2237-2245
1079-5642
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1161/ATVBAHA.114.303585
info:eu-repo/semantics/altIdentifier/url/https://www.ahajournals.org/doi/10.1161/ATVBAHA.114.303585
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Lippincott Williams
publisher.none.fl_str_mv Lippincott Williams
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268948411711488
score 13.13397

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