Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans
- Autores
- D'almeida, Romina Elisa; Alberto, Maria Rosa; Morgan, Phillip; Sedensky, Margaret; Isla, Maria Ines
- Año de publicación
- 2015
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Zuccagnia punctata Cav. (Fabaceae), commonly called jarilla macho or pus-pus, is being used in traditional medicine as an antiseptic, anti-inflammatory and to relieve muscle and bone pain. The aim of this work was to study the anthelmintic effects of three structurally related flavonoids present in aerial parts of Z. punctata Cav. The biological activity of the flavonoids 7-hydroxyflavanone (HF), 3,7-dihydroxyflavone (DHF) and 2′,4′-dihydroxychalcone (DHC) was examined in the free-living nematode Caenorhabditis elegans. Our results showed that among the assayed flavonoids, only DHC showed an anthelmintic effect and alteration of egg hatching and larval development processes in C. elegans. DHC was able to kill 50% of adult nematodes at a concentration of 17 μg/mL. The effect on larval development was observed after 48 h in the presence of 25 and 50 μg/mL DHC, where 33.4 and 73.4% of nematodes remained in the L3 stage or younger. New therapeutic drugs with good efficacy against drug-resistant nematodes are urgently needed. Therefore, DHC, a natural compound present in Z. punctata, is proposed as a potential anthelmintic drug.
Fil: D'almeida, Romina Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina
Fil: Morgan, Phillip. University of Washington; Estados Unidos
Fil: Sedensky, Margaret. University of Washington; Estados Unidos
Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina - Materia
-
2″,4″-Dihydroxychalcone
3,7-Dihydroxyflavone
7-Hydroxyflavanone
Anthelmintic Effect
Caenorhabditis Elegans - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/40333
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/40333 |
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network_name_str |
CONICET Digital (CONICET) |
spelling |
Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegansD'almeida, Romina ElisaAlberto, Maria RosaMorgan, PhillipSedensky, MargaretIsla, Maria Ines2″,4″-Dihydroxychalcone3,7-Dihydroxyflavone7-HydroxyflavanoneAnthelmintic EffectCaenorhabditis Eleganshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Zuccagnia punctata Cav. (Fabaceae), commonly called jarilla macho or pus-pus, is being used in traditional medicine as an antiseptic, anti-inflammatory and to relieve muscle and bone pain. The aim of this work was to study the anthelmintic effects of three structurally related flavonoids present in aerial parts of Z. punctata Cav. The biological activity of the flavonoids 7-hydroxyflavanone (HF), 3,7-dihydroxyflavone (DHF) and 2′,4′-dihydroxychalcone (DHC) was examined in the free-living nematode Caenorhabditis elegans. Our results showed that among the assayed flavonoids, only DHC showed an anthelmintic effect and alteration of egg hatching and larval development processes in C. elegans. DHC was able to kill 50% of adult nematodes at a concentration of 17 μg/mL. The effect on larval development was observed after 48 h in the presence of 25 and 50 μg/mL DHC, where 33.4 and 73.4% of nematodes remained in the L3 stage or younger. New therapeutic drugs with good efficacy against drug-resistant nematodes are urgently needed. Therefore, DHC, a natural compound present in Z. punctata, is proposed as a potential anthelmintic drug.Fil: D'almeida, Romina Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaFil: Morgan, Phillip. University of Washington; Estados UnidosFil: Sedensky, Margaret. University of Washington; Estados UnidosFil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; ArgentinaDe Gruyter2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/40333D'almeida, Romina Elisa; Alberto, Maria Rosa; Morgan, Phillip; Sedensky, Margaret; Isla, Maria Ines; Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans; De Gruyter; Acta Parasitologica; 60; 1; 3-2015; 164-1721230-2821CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1515/ap-2015-0023info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/ap.2015.60.issue-1/ap-2015-0023/ap-2015-0023.xmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:03:38Zoai:ri.conicet.gov.ar:11336/40333instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:03:38.641CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans |
title |
Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans |
spellingShingle |
Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans D'almeida, Romina Elisa 2″,4″-Dihydroxychalcone 3,7-Dihydroxyflavone 7-Hydroxyflavanone Anthelmintic Effect Caenorhabditis Elegans |
title_short |
Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans |
title_full |
Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans |
title_fullStr |
Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans |
title_full_unstemmed |
Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans |
title_sort |
Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans |
dc.creator.none.fl_str_mv |
D'almeida, Romina Elisa Alberto, Maria Rosa Morgan, Phillip Sedensky, Margaret Isla, Maria Ines |
author |
D'almeida, Romina Elisa |
author_facet |
D'almeida, Romina Elisa Alberto, Maria Rosa Morgan, Phillip Sedensky, Margaret Isla, Maria Ines |
author_role |
author |
author2 |
Alberto, Maria Rosa Morgan, Phillip Sedensky, Margaret Isla, Maria Ines |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
2″,4″-Dihydroxychalcone 3,7-Dihydroxyflavone 7-Hydroxyflavanone Anthelmintic Effect Caenorhabditis Elegans |
topic |
2″,4″-Dihydroxychalcone 3,7-Dihydroxyflavone 7-Hydroxyflavanone Anthelmintic Effect Caenorhabditis Elegans |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Zuccagnia punctata Cav. (Fabaceae), commonly called jarilla macho or pus-pus, is being used in traditional medicine as an antiseptic, anti-inflammatory and to relieve muscle and bone pain. The aim of this work was to study the anthelmintic effects of three structurally related flavonoids present in aerial parts of Z. punctata Cav. The biological activity of the flavonoids 7-hydroxyflavanone (HF), 3,7-dihydroxyflavone (DHF) and 2′,4′-dihydroxychalcone (DHC) was examined in the free-living nematode Caenorhabditis elegans. Our results showed that among the assayed flavonoids, only DHC showed an anthelmintic effect and alteration of egg hatching and larval development processes in C. elegans. DHC was able to kill 50% of adult nematodes at a concentration of 17 μg/mL. The effect on larval development was observed after 48 h in the presence of 25 and 50 μg/mL DHC, where 33.4 and 73.4% of nematodes remained in the L3 stage or younger. New therapeutic drugs with good efficacy against drug-resistant nematodes are urgently needed. Therefore, DHC, a natural compound present in Z. punctata, is proposed as a potential anthelmintic drug. Fil: D'almeida, Romina Elisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina Fil: Alberto, Maria Rosa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina Fil: Morgan, Phillip. University of Washington; Estados Unidos Fil: Sedensky, Margaret. University of Washington; Estados Unidos Fil: Isla, Maria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto de Química del Noroeste. Universidad Nacional de Tucumán. Facultad de Bioquímica, Química y Farmacia. Instituto de Química del Noroeste; Argentina |
description |
Zuccagnia punctata Cav. (Fabaceae), commonly called jarilla macho or pus-pus, is being used in traditional medicine as an antiseptic, anti-inflammatory and to relieve muscle and bone pain. The aim of this work was to study the anthelmintic effects of three structurally related flavonoids present in aerial parts of Z. punctata Cav. The biological activity of the flavonoids 7-hydroxyflavanone (HF), 3,7-dihydroxyflavone (DHF) and 2′,4′-dihydroxychalcone (DHC) was examined in the free-living nematode Caenorhabditis elegans. Our results showed that among the assayed flavonoids, only DHC showed an anthelmintic effect and alteration of egg hatching and larval development processes in C. elegans. DHC was able to kill 50% of adult nematodes at a concentration of 17 μg/mL. The effect on larval development was observed after 48 h in the presence of 25 and 50 μg/mL DHC, where 33.4 and 73.4% of nematodes remained in the L3 stage or younger. New therapeutic drugs with good efficacy against drug-resistant nematodes are urgently needed. Therefore, DHC, a natural compound present in Z. punctata, is proposed as a potential anthelmintic drug. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-03 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/40333 D'almeida, Romina Elisa; Alberto, Maria Rosa; Morgan, Phillip; Sedensky, Margaret; Isla, Maria Ines; Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans; De Gruyter; Acta Parasitologica; 60; 1; 3-2015; 164-172 1230-2821 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/40333 |
identifier_str_mv |
D'almeida, Romina Elisa; Alberto, Maria Rosa; Morgan, Phillip; Sedensky, Margaret; Isla, Maria Ines; Effect of structurally related flavonoids from Zuccagnia punctata Cav. on Caenorhabditis elegans; De Gruyter; Acta Parasitologica; 60; 1; 3-2015; 164-172 1230-2821 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1515/ap-2015-0023 info:eu-repo/semantics/altIdentifier/url/https://www.degruyter.com/view/j/ap.2015.60.issue-1/ap-2015-0023/ap-2015-0023.xml |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
De Gruyter |
publisher.none.fl_str_mv |
De Gruyter |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846083179268538368 |
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13.22299 |