Structures of Two Streptococcal Superantigens Bound to TCR β Chains Reveal Diversity in the Architecture of T Cell Signaling Complexes

• Autores: Sundberg, Eric J.; Li, Hongmin; Llera, Andrea Sabina; McCormick, John K.; Tormo, José; Schlievert, Patrick M.; Karjalainen, Klaus; Mariuzza, Roy A.
• Año de publicación: 2002
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: Superantigen; T Cell Receptor
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Superantigens (SAGs) crosslink MHC class II and TCR molecules, resulting in an overstimulation of T cells associated with human disease. SAGs interact with several different surfaces on MHC molecules, necessitating the formation of multiple distinct MHC-SAG-TCR ternary signaling complexes. Variability in SAG-TCR binding modes could also contribute to the structural heterogeneity of SAG-dependent signaling complexes. We report crystal structures of the streptococcal SAGs SpeA and SpeC in complex with their corresponding TCR beta chain ligands that reveal distinct TCR binding modes. The SpeC-TCR beta chain complex structure, coupled with the recently determined SpeC-HLA-DR2a complex structure, provides a model for a novel T cell signaling complex that precludes direct TCR-MHC interactions. Thus, highly efficient T cell activation may be achieved through structurally diverse strategies of TCR ligation.
Fil: Sundberg, Eric J.. University of Maryland; Estados Unidos
Fil: Li, Hongmin. University of Maryland; Estados Unidos
Fil: Llera, Andrea Sabina. University of Maryland; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina
Fil: McCormick, John K.. University of Minnesota; Estados Unidos
Fil: Tormo, José. University of Maryland; Estados Unidos. Universidad Autónoma de Madrid; España
Fil: Schlievert, Patrick M.. University of Minnesota; Estados Unidos
Fil: Karjalainen, Klaus. Basel Institute for Immunology; Suiza
Fil: Mariuzza, Roy A.. University of Maryland; Estados Unidos