The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models

Autores
Paulino, Érica Tex; Ribeiro de Lima, Monique; Viçosa, Alessandra Lifsitch; Hooper da Silva, Cleber; Salomon, Claudio Javier; Real, Daniel Andres; Leonardi, Darío; Mello Silva, Clélia Christina; Almeida de Moraes Neto, Antonio Henrique
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Schistosomiasis is a widely distributed parasitic disease and one of the most important neglected tropical diseases globally, for which Praziquantel® (PZQ) is the only available treatment. In this context, tests with new PZQ formulations become relevant for disease control. This study evaluated the effects of PZQ treatment in the prepatent phase of schistosomiasis using two formulations: nanoencapsulated (PZQ-NANO) and active pharmaceutical ingredient (PZQ-API). Five experimental groups were established, for which the following serological parameters were evaluated: ALT, AST, ALP, and TP. Animals treated with PZQ-API at 15 and 30 days post-infection showed decreased eggs per gram of feces (EPG) compared to untreated infected animals. The same animals showed reductions of 63.6 and 65.1%, respectively, at 60 days post-infection. Animals treated with PZQ-NANO experienced no significant changes in EPG at any time of observation. Animals treated with either PZQ-API or PZQ-NANO had higher ALT and AST levels in the patent period (60 and 90 days post-infection). Treatment with PZQ, either API or NANO, at 15 days post-infection reduced AST, ALT, and TP levels. It is concluded that prepatent treatment with PZQ-API can reduce the parasite load of infected animals and that treatment at 15 days post-infection can prevent increased serum levels of ALT, AST, and TP.
Fil: Paulino, Érica Tex. Fundación Oswaldo Cruz; Brasil
Fil: Ribeiro de Lima, Monique. Fundación Oswaldo Cruz; Brasil
Fil: Viçosa, Alessandra Lifsitch. Fundación Oswaldo Cruz; Brasil
Fil: Hooper da Silva, Cleber. Fundación Oswaldo Cruz; Brasil
Fil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Real, Daniel Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Mello Silva, Clélia Christina. Fundación Oswaldo Cruz; Brasil
Fil: Almeida de Moraes Neto, Antonio Henrique. Fundación Oswaldo Cruz; Brasil
Materia
NANOENCAPSULATED
PRAZIQUANTEL (PZQ)
PREPATENT INFECTION
SCHISTOSOMA MANSONI (S. MANSONI)
SCHISTOSOMIASIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/216535
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine ModelsPaulino, Érica TexRibeiro de Lima, MoniqueViçosa, Alessandra LifsitchHooper da Silva, CleberSalomon, Claudio JavierReal, Daniel AndresLeonardi, DaríoMello Silva, Clélia ChristinaAlmeida de Moraes Neto, Antonio HenriqueNANOENCAPSULATEDPRAZIQUANTEL (PZQ)PREPATENT INFECTIONSCHISTOSOMA MANSONI (S. MANSONI)SCHISTOSOMIASIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Schistosomiasis is a widely distributed parasitic disease and one of the most important neglected tropical diseases globally, for which Praziquantel® (PZQ) is the only available treatment. In this context, tests with new PZQ formulations become relevant for disease control. This study evaluated the effects of PZQ treatment in the prepatent phase of schistosomiasis using two formulations: nanoencapsulated (PZQ-NANO) and active pharmaceutical ingredient (PZQ-API). Five experimental groups were established, for which the following serological parameters were evaluated: ALT, AST, ALP, and TP. Animals treated with PZQ-API at 15 and 30 days post-infection showed decreased eggs per gram of feces (EPG) compared to untreated infected animals. The same animals showed reductions of 63.6 and 65.1%, respectively, at 60 days post-infection. Animals treated with PZQ-NANO experienced no significant changes in EPG at any time of observation. Animals treated with either PZQ-API or PZQ-NANO had higher ALT and AST levels in the patent period (60 and 90 days post-infection). Treatment with PZQ, either API or NANO, at 15 days post-infection reduced AST, ALT, and TP levels. It is concluded that prepatent treatment with PZQ-API can reduce the parasite load of infected animals and that treatment at 15 days post-infection can prevent increased serum levels of ALT, AST, and TP.Fil: Paulino, Érica Tex. Fundación Oswaldo Cruz; BrasilFil: Ribeiro de Lima, Monique. Fundación Oswaldo Cruz; BrasilFil: Viçosa, Alessandra Lifsitch. Fundación Oswaldo Cruz; BrasilFil: Hooper da Silva, Cleber. Fundación Oswaldo Cruz; BrasilFil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Real, Daniel Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Mello Silva, Clélia Christina. Fundación Oswaldo Cruz; BrasilFil: Almeida de Moraes Neto, Antonio Henrique. Fundación Oswaldo Cruz; BrasilFrontiers Media2022-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/216535Paulino, Érica Tex; Ribeiro de Lima, Monique; Viçosa, Alessandra Lifsitch; Hooper da Silva, Cleber; Salomon, Claudio Javier; et al.; The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models; Frontiers Media; Frontiers in Public Health; 10; 5-2022; 1-102296-2565CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fpubh.2022.848633info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fpubh.2022.848633/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:14:05Zoai:ri.conicet.gov.ar:11336/216535instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:14:06.164CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models
title The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models
spellingShingle The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models
Paulino, Érica Tex
NANOENCAPSULATED
PRAZIQUANTEL (PZQ)
PREPATENT INFECTION
SCHISTOSOMA MANSONI (S. MANSONI)
SCHISTOSOMIASIS
title_short The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models
title_full The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models
title_fullStr The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models
title_full_unstemmed The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models
title_sort The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models
dc.creator.none.fl_str_mv Paulino, Érica Tex
Ribeiro de Lima, Monique
Viçosa, Alessandra Lifsitch
Hooper da Silva, Cleber
Salomon, Claudio Javier
Real, Daniel Andres
Leonardi, Darío
Mello Silva, Clélia Christina
Almeida de Moraes Neto, Antonio Henrique
author Paulino, Érica Tex
author_facet Paulino, Érica Tex
Ribeiro de Lima, Monique
Viçosa, Alessandra Lifsitch
Hooper da Silva, Cleber
Salomon, Claudio Javier
Real, Daniel Andres
Leonardi, Darío
Mello Silva, Clélia Christina
Almeida de Moraes Neto, Antonio Henrique
author_role author
author2 Ribeiro de Lima, Monique
Viçosa, Alessandra Lifsitch
Hooper da Silva, Cleber
Salomon, Claudio Javier
Real, Daniel Andres
Leonardi, Darío
Mello Silva, Clélia Christina
Almeida de Moraes Neto, Antonio Henrique
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NANOENCAPSULATED
PRAZIQUANTEL (PZQ)
PREPATENT INFECTION
SCHISTOSOMA MANSONI (S. MANSONI)
SCHISTOSOMIASIS
topic NANOENCAPSULATED
PRAZIQUANTEL (PZQ)
PREPATENT INFECTION
SCHISTOSOMA MANSONI (S. MANSONI)
SCHISTOSOMIASIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Schistosomiasis is a widely distributed parasitic disease and one of the most important neglected tropical diseases globally, for which Praziquantel® (PZQ) is the only available treatment. In this context, tests with new PZQ formulations become relevant for disease control. This study evaluated the effects of PZQ treatment in the prepatent phase of schistosomiasis using two formulations: nanoencapsulated (PZQ-NANO) and active pharmaceutical ingredient (PZQ-API). Five experimental groups were established, for which the following serological parameters were evaluated: ALT, AST, ALP, and TP. Animals treated with PZQ-API at 15 and 30 days post-infection showed decreased eggs per gram of feces (EPG) compared to untreated infected animals. The same animals showed reductions of 63.6 and 65.1%, respectively, at 60 days post-infection. Animals treated with PZQ-NANO experienced no significant changes in EPG at any time of observation. Animals treated with either PZQ-API or PZQ-NANO had higher ALT and AST levels in the patent period (60 and 90 days post-infection). Treatment with PZQ, either API or NANO, at 15 days post-infection reduced AST, ALT, and TP levels. It is concluded that prepatent treatment with PZQ-API can reduce the parasite load of infected animals and that treatment at 15 days post-infection can prevent increased serum levels of ALT, AST, and TP.
Fil: Paulino, Érica Tex. Fundación Oswaldo Cruz; Brasil
Fil: Ribeiro de Lima, Monique. Fundación Oswaldo Cruz; Brasil
Fil: Viçosa, Alessandra Lifsitch. Fundación Oswaldo Cruz; Brasil
Fil: Hooper da Silva, Cleber. Fundación Oswaldo Cruz; Brasil
Fil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Real, Daniel Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Mello Silva, Clélia Christina. Fundación Oswaldo Cruz; Brasil
Fil: Almeida de Moraes Neto, Antonio Henrique. Fundación Oswaldo Cruz; Brasil
description Schistosomiasis is a widely distributed parasitic disease and one of the most important neglected tropical diseases globally, for which Praziquantel® (PZQ) is the only available treatment. In this context, tests with new PZQ formulations become relevant for disease control. This study evaluated the effects of PZQ treatment in the prepatent phase of schistosomiasis using two formulations: nanoencapsulated (PZQ-NANO) and active pharmaceutical ingredient (PZQ-API). Five experimental groups were established, for which the following serological parameters were evaluated: ALT, AST, ALP, and TP. Animals treated with PZQ-API at 15 and 30 days post-infection showed decreased eggs per gram of feces (EPG) compared to untreated infected animals. The same animals showed reductions of 63.6 and 65.1%, respectively, at 60 days post-infection. Animals treated with PZQ-NANO experienced no significant changes in EPG at any time of observation. Animals treated with either PZQ-API or PZQ-NANO had higher ALT and AST levels in the patent period (60 and 90 days post-infection). Treatment with PZQ, either API or NANO, at 15 days post-infection reduced AST, ALT, and TP levels. It is concluded that prepatent treatment with PZQ-API can reduce the parasite load of infected animals and that treatment at 15 days post-infection can prevent increased serum levels of ALT, AST, and TP.
publishDate 2022
dc.date.none.fl_str_mv 2022-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/216535
Paulino, Érica Tex; Ribeiro de Lima, Monique; Viçosa, Alessandra Lifsitch; Hooper da Silva, Cleber; Salomon, Claudio Javier; et al.; The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models; Frontiers Media; Frontiers in Public Health; 10; 5-2022; 1-10
2296-2565
CONICET Digital
CONICET
url http://hdl.handle.net/11336/216535
identifier_str_mv Paulino, Érica Tex; Ribeiro de Lima, Monique; Viçosa, Alessandra Lifsitch; Hooper da Silva, Cleber; Salomon, Claudio Javier; et al.; The Effect of Different Formulations of Praziquantel in Reducing Worms in the Prepatent Period of Schistosomiasis in Murine Models; Frontiers Media; Frontiers in Public Health; 10; 5-2022; 1-10
2296-2565
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fpubh.2022.848633
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fpubh.2022.848633/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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