Role of TGF-β1 in the behavior disorders

Autores
Depino, Amaicha Mara
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Transforming growth factor 1 (TGF-β1) is an anti-inflammatory cytokine that is expressed in different regions of the mammalian brain, and at all developmental ages. This cytokine can modulate neuron differentiation and survival, and also participate in the tissular response to injury. Based on clinical evidence, different approaches have been used to study the role of TGF-β1 on modulating brain function and behavior. Here, we review evidence showing a role of TGF-β1 in circadian rhythms, locomotion, sociability and depression-related behaviors. For these behaviors, suprachiamatic, hippocampal and cerebellar expression of TGF-β1 have been manipulated. Further studies are required to extend these results to other brain regions and different behaviors, but so far evidence points to a role of TGF-β1 on behavior disorders such as schizophrenia, depression and autism.
Fil: Depino, Amaicha Mara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
Materia
AUTISM
DEPRESSION-RELATED BEHAVIOR
LOCOMOTION
NEUROGENESIS
SOCIABILITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/84967
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Role of TGF-β1 in the behavior disordersDepino, Amaicha MaraAUTISMDEPRESSION-RELATED BEHAVIORLOCOMOTIONNEUROGENESISSOCIABILITYhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Transforming growth factor 1 (TGF-β1) is an anti-inflammatory cytokine that is expressed in different regions of the mammalian brain, and at all developmental ages. This cytokine can modulate neuron differentiation and survival, and also participate in the tissular response to injury. Based on clinical evidence, different approaches have been used to study the role of TGF-β1 on modulating brain function and behavior. Here, we review evidence showing a role of TGF-β1 in circadian rhythms, locomotion, sociability and depression-related behaviors. For these behaviors, suprachiamatic, hippocampal and cerebellar expression of TGF-β1 have been manipulated. Further studies are required to extend these results to other brain regions and different behaviors, but so far evidence points to a role of TGF-β1 on behavior disorders such as schizophrenia, depression and autism.Fil: Depino, Amaicha Mara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; ArgentinaIOS Press2015-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/84967Depino, Amaicha Mara; Role of TGF-β1 in the behavior disorders; IOS Press; Advances in Neuroimmune Biology; 6; 1; 11-2015; 19-231878-948X1878-9498CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3233/NIB-150105info:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/advances-in-neuroimmune-biology/nib150105info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:53:38Zoai:ri.conicet.gov.ar:11336/84967instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:53:39.214CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Role of TGF-β1 in the behavior disorders
title Role of TGF-β1 in the behavior disorders
spellingShingle Role of TGF-β1 in the behavior disorders
Depino, Amaicha Mara
AUTISM
DEPRESSION-RELATED BEHAVIOR
LOCOMOTION
NEUROGENESIS
SOCIABILITY
title_short Role of TGF-β1 in the behavior disorders
title_full Role of TGF-β1 in the behavior disorders
title_fullStr Role of TGF-β1 in the behavior disorders
title_full_unstemmed Role of TGF-β1 in the behavior disorders
title_sort Role of TGF-β1 in the behavior disorders
dc.creator.none.fl_str_mv Depino, Amaicha Mara
author Depino, Amaicha Mara
author_facet Depino, Amaicha Mara
author_role author
dc.subject.none.fl_str_mv AUTISM
DEPRESSION-RELATED BEHAVIOR
LOCOMOTION
NEUROGENESIS
SOCIABILITY
topic AUTISM
DEPRESSION-RELATED BEHAVIOR
LOCOMOTION
NEUROGENESIS
SOCIABILITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Transforming growth factor 1 (TGF-β1) is an anti-inflammatory cytokine that is expressed in different regions of the mammalian brain, and at all developmental ages. This cytokine can modulate neuron differentiation and survival, and also participate in the tissular response to injury. Based on clinical evidence, different approaches have been used to study the role of TGF-β1 on modulating brain function and behavior. Here, we review evidence showing a role of TGF-β1 in circadian rhythms, locomotion, sociability and depression-related behaviors. For these behaviors, suprachiamatic, hippocampal and cerebellar expression of TGF-β1 have been manipulated. Further studies are required to extend these results to other brain regions and different behaviors, but so far evidence points to a role of TGF-β1 on behavior disorders such as schizophrenia, depression and autism.
Fil: Depino, Amaicha Mara. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Fisiología, Biología Molecular y Neurociencias. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Fisiología, Biología Molecular y Neurociencias; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Fisiología, Biología Molecular y Celular; Argentina
description Transforming growth factor 1 (TGF-β1) is an anti-inflammatory cytokine that is expressed in different regions of the mammalian brain, and at all developmental ages. This cytokine can modulate neuron differentiation and survival, and also participate in the tissular response to injury. Based on clinical evidence, different approaches have been used to study the role of TGF-β1 on modulating brain function and behavior. Here, we review evidence showing a role of TGF-β1 in circadian rhythms, locomotion, sociability and depression-related behaviors. For these behaviors, suprachiamatic, hippocampal and cerebellar expression of TGF-β1 have been manipulated. Further studies are required to extend these results to other brain regions and different behaviors, but so far evidence points to a role of TGF-β1 on behavior disorders such as schizophrenia, depression and autism.
publishDate 2015
dc.date.none.fl_str_mv 2015-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/84967
Depino, Amaicha Mara; Role of TGF-β1 in the behavior disorders; IOS Press; Advances in Neuroimmune Biology; 6; 1; 11-2015; 19-23
1878-948X
1878-9498
CONICET Digital
CONICET
url http://hdl.handle.net/11336/84967
identifier_str_mv Depino, Amaicha Mara; Role of TGF-β1 in the behavior disorders; IOS Press; Advances in Neuroimmune Biology; 6; 1; 11-2015; 19-23
1878-948X
1878-9498
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3233/NIB-150105
info:eu-repo/semantics/altIdentifier/url/https://content.iospress.com/articles/advances-in-neuroimmune-biology/nib150105
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv IOS Press
publisher.none.fl_str_mv IOS Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.22299

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