Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats

Autores
Cecchini, Maria Eugenia; Roma, Dardo Andrés; Magnago, Franco; Vilchez, Maria Laura; Varea, María Cristina; Torreta, María Elena; Aiassa, Delia Elba; Mañas, Fernando Javier
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Epidemiological evidence indicates that flaxseed reduces oxidative stress and cholesterol levels in blood. In this study we evaluated the lipid profile, oxidation of plasma lipids and genetic damage in goats fed on a diet supplemented with flaxseed. Thirteen adult male goats were split in two experimental groups; one of them was fed on a conventional diet of alfalfa and ground corn and the other group was fed on the same diet supplemented with 5% of flaxseed. Blood samples were obtained every 7 days to quantify the Thiobarbituric Acid-Reactive Substances (TBARs), total cholesterol, HDL, LDL and triacylglycerols. Additionally, 3 blood samples and 3 oral mucosa samples were taken to each animal every 15 days to perform comet assay and micronucleus test. Flaxseed supplementation produces a remarkable antioxidant effect in plasma in a three months period that could explain the antigenotoxic effect determined through both micronucleus test and comet assay. In addition, we also found a reduction of LDL/HDL ratio and cholesterol levels in animals supplemented with flaxseed.
Fil: Cecchini, Maria Eugenia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Roma, Dardo Andrés. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Magnago, Franco. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina
Fil: Vilchez, Maria Laura. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Varea, María Cristina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Torreta, María Elena. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Aiassa, Delia Elba. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Mañas, Fernando Javier. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Materia
ANTIOXIDANT
DNA PROTECTION
FLAXSEED
GOATS
LIPID PROFILE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/138454
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/138454
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goatsCecchini, Maria EugeniaRoma, Dardo AndrésMagnago, FrancoVilchez, Maria LauraVarea, María CristinaTorreta, María ElenaAiassa, Delia ElbaMañas, Fernando JavierANTIOXIDANTDNA PROTECTIONFLAXSEEDGOATSLIPID PROFILEhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Epidemiological evidence indicates that flaxseed reduces oxidative stress and cholesterol levels in blood. In this study we evaluated the lipid profile, oxidation of plasma lipids and genetic damage in goats fed on a diet supplemented with flaxseed. Thirteen adult male goats were split in two experimental groups; one of them was fed on a conventional diet of alfalfa and ground corn and the other group was fed on the same diet supplemented with 5% of flaxseed. Blood samples were obtained every 7 days to quantify the Thiobarbituric Acid-Reactive Substances (TBARs), total cholesterol, HDL, LDL and triacylglycerols. Additionally, 3 blood samples and 3 oral mucosa samples were taken to each animal every 15 days to perform comet assay and micronucleus test. Flaxseed supplementation produces a remarkable antioxidant effect in plasma in a three months period that could explain the antigenotoxic effect determined through both micronucleus test and comet assay. In addition, we also found a reduction of LDL/HDL ratio and cholesterol levels in animals supplemented with flaxseed.Fil: Cecchini, Maria Eugenia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Roma, Dardo Andrés. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Magnago, Franco. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; ArgentinaFil: Vilchez, Maria Laura. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaFil: Varea, María Cristina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Torreta, María Elena. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Aiassa, Delia Elba. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; ArgentinaFil: Mañas, Fernando Javier. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; ArgentinaScience Publications2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/138454Cecchini, Maria Eugenia; Roma, Dardo Andrés; Magnago, Franco; Vilchez, Maria Laura; Varea, María Cristina; et al.; Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats; Science Publications; American Journal of Animal and Veterinary Sciences; 13; 2; 2018; 51-581557-45551557-4563CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3844/ajavsp.2018.51.58info:eu-repo/semantics/altIdentifier/url/https://thescipub.com/abstract/10.3844/ajavsp.2018.51.58info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:03Zoai:ri.conicet.gov.ar:11336/138454instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:03.682CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats
title Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats
spellingShingle Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats
Cecchini, Maria Eugenia
ANTIOXIDANT
DNA PROTECTION
FLAXSEED
GOATS
LIPID PROFILE
title_short Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats
title_full Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats
title_fullStr Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats
title_full_unstemmed Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats
title_sort Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats
dc.creator.none.fl_str_mv Cecchini, Maria Eugenia
Roma, Dardo Andrés
Magnago, Franco
Vilchez, Maria Laura
Varea, María Cristina
Torreta, María Elena
Aiassa, Delia Elba
Mañas, Fernando Javier
author Cecchini, Maria Eugenia
author_facet Cecchini, Maria Eugenia
Roma, Dardo Andrés
Magnago, Franco
Vilchez, Maria Laura
Varea, María Cristina
Torreta, María Elena
Aiassa, Delia Elba
Mañas, Fernando Javier
author_role author
author2 Roma, Dardo Andrés
Magnago, Franco
Vilchez, Maria Laura
Varea, María Cristina
Torreta, María Elena
Aiassa, Delia Elba
Mañas, Fernando Javier
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANTIOXIDANT
DNA PROTECTION
FLAXSEED
GOATS
LIPID PROFILE
topic ANTIOXIDANT
DNA PROTECTION
FLAXSEED
GOATS
LIPID PROFILE
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv Epidemiological evidence indicates that flaxseed reduces oxidative stress and cholesterol levels in blood. In this study we evaluated the lipid profile, oxidation of plasma lipids and genetic damage in goats fed on a diet supplemented with flaxseed. Thirteen adult male goats were split in two experimental groups; one of them was fed on a conventional diet of alfalfa and ground corn and the other group was fed on the same diet supplemented with 5% of flaxseed. Blood samples were obtained every 7 days to quantify the Thiobarbituric Acid-Reactive Substances (TBARs), total cholesterol, HDL, LDL and triacylglycerols. Additionally, 3 blood samples and 3 oral mucosa samples were taken to each animal every 15 days to perform comet assay and micronucleus test. Flaxseed supplementation produces a remarkable antioxidant effect in plasma in a three months period that could explain the antigenotoxic effect determined through both micronucleus test and comet assay. In addition, we also found a reduction of LDL/HDL ratio and cholesterol levels in animals supplemented with flaxseed.
Fil: Cecchini, Maria Eugenia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Roma, Dardo Andrés. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Magnago, Franco. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina
Fil: Vilchez, Maria Laura. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
Fil: Varea, María Cristina. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Torreta, María Elena. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Aiassa, Delia Elba. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales; Argentina
Fil: Mañas, Fernando Javier. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba; Argentina
description Epidemiological evidence indicates that flaxseed reduces oxidative stress and cholesterol levels in blood. In this study we evaluated the lipid profile, oxidation of plasma lipids and genetic damage in goats fed on a diet supplemented with flaxseed. Thirteen adult male goats were split in two experimental groups; one of them was fed on a conventional diet of alfalfa and ground corn and the other group was fed on the same diet supplemented with 5% of flaxseed. Blood samples were obtained every 7 days to quantify the Thiobarbituric Acid-Reactive Substances (TBARs), total cholesterol, HDL, LDL and triacylglycerols. Additionally, 3 blood samples and 3 oral mucosa samples were taken to each animal every 15 days to perform comet assay and micronucleus test. Flaxseed supplementation produces a remarkable antioxidant effect in plasma in a three months period that could explain the antigenotoxic effect determined through both micronucleus test and comet assay. In addition, we also found a reduction of LDL/HDL ratio and cholesterol levels in animals supplemented with flaxseed.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/138454
Cecchini, Maria Eugenia; Roma, Dardo Andrés; Magnago, Franco; Vilchez, Maria Laura; Varea, María Cristina; et al.; Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats; Science Publications; American Journal of Animal and Veterinary Sciences; 13; 2; 2018; 51-58
1557-4555
1557-4563
CONICET Digital
CONICET
url http://hdl.handle.net/11336/138454
identifier_str_mv Cecchini, Maria Eugenia; Roma, Dardo Andrés; Magnago, Franco; Vilchez, Maria Laura; Varea, María Cristina; et al.; Effects of flaxseed supplementation on lipid metabolism, oxidative balance and genetic damage in goats; Science Publications; American Journal of Animal and Veterinary Sciences; 13; 2; 2018; 51-58
1557-4555
1557-4563
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3844/ajavsp.2018.51.58
info:eu-repo/semantics/altIdentifier/url/https://thescipub.com/abstract/10.3844/ajavsp.2018.51.58
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Science Publications
publisher.none.fl_str_mv Science Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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