Mouse models of altered gonadotrophin action: insight into male reproductive disorders

Autores
Jonas, Kim C.; Oduwole, Olayiwola O.; Peltoketo, Hellevi; Rulli, Susana Beatriz; Huhtaniemi, Ilpo T.
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The advent of technologies to genetically manipulate the mouse genome has revolutionised research approaches, providing a unique platform to study the causality of reproductive disorders in vivo. With the relative ease of generating genetically modified (GM) mouse models, the last two decades have yielded multiple loss-of-function and gain-of-function mutation mouse models to explore the role of gonadotrophins and their receptors in reproductive pathologies. This work has provided key insights into the molecular mechanisms underlying reproductive disorders with altered gonadotrophin action, revealing the fundamental roles of these pituitary hormones and their receptors in the hypothalamic–pituitary–gonadal axis. This review will describe GM mouse models of gonadotrophins and their receptors with enhanced or diminished actions, specifically focusing on the male. We will discuss the mechanistic insights gained from these models into male reproductive disorders, and the relationship and understanding provided into male human reproductive disorders originating from altered gonadotrophin action.
Fil: Jonas, Kim C.. Imperial College London; Reino Unido
Fil: Oduwole, Olayiwola O.. Imperial College London; Reino Unido
Fil: Peltoketo, Hellevi . University of Oulu; Finlandia
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Huhtaniemi, Ilpo T. . Imperial College London; Reino Unido. University of Turku; Finlandia
Materia
GONADOTROPHIN
REPRODUCTION
MALE
MOUSE MODELS
INFERTILITY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/6446
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/6446
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mouse models of altered gonadotrophin action: insight into male reproductive disordersJonas, Kim C.Oduwole, Olayiwola O.Peltoketo, Hellevi Rulli, Susana BeatrizHuhtaniemi, Ilpo T. GONADOTROPHINREPRODUCTIONMALEMOUSE MODELSINFERTILITYhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The advent of technologies to genetically manipulate the mouse genome has revolutionised research approaches, providing a unique platform to study the causality of reproductive disorders in vivo. With the relative ease of generating genetically modified (GM) mouse models, the last two decades have yielded multiple loss-of-function and gain-of-function mutation mouse models to explore the role of gonadotrophins and their receptors in reproductive pathologies. This work has provided key insights into the molecular mechanisms underlying reproductive disorders with altered gonadotrophin action, revealing the fundamental roles of these pituitary hormones and their receptors in the hypothalamic–pituitary–gonadal axis. This review will describe GM mouse models of gonadotrophins and their receptors with enhanced or diminished actions, specifically focusing on the male. We will discuss the mechanistic insights gained from these models into male reproductive disorders, and the relationship and understanding provided into male human reproductive disorders originating from altered gonadotrophin action.Fil: Jonas, Kim C.. Imperial College London; Reino UnidoFil: Oduwole, Olayiwola O.. Imperial College London; Reino UnidoFil: Peltoketo, Hellevi . University of Oulu; FinlandiaFil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); ArgentinaFil: Huhtaniemi, Ilpo T. . Imperial College London; Reino Unido. University of Turku; FinlandiaBioscientifica2014-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/6446Jonas, Kim C.; Oduwole, Olayiwola O.; Peltoketo, Hellevi ; Rulli, Susana Beatriz; Huhtaniemi, Ilpo T. ; Mouse models of altered gonadotrophin action: insight into male reproductive disorders; Bioscientifica; Reproduction; 148; 4; 1-10-2014; R63-R701470-16261741-7899enginfo:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/altIdentifier/doi/10.1530/REP-14-0302info:eu-repo/semantics/altIdentifier/pmid/25030890info:eu-repo/semantics/altIdentifier/url/http://www.reproduction-online.org/content/148/4/R63info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:00:31Zoai:ri.conicet.gov.ar:11336/6446instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:00:31.541CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mouse models of altered gonadotrophin action: insight into male reproductive disorders
title Mouse models of altered gonadotrophin action: insight into male reproductive disorders
spellingShingle Mouse models of altered gonadotrophin action: insight into male reproductive disorders
Jonas, Kim C.
GONADOTROPHIN
REPRODUCTION
MALE
MOUSE MODELS
INFERTILITY
title_short Mouse models of altered gonadotrophin action: insight into male reproductive disorders
title_full Mouse models of altered gonadotrophin action: insight into male reproductive disorders
title_fullStr Mouse models of altered gonadotrophin action: insight into male reproductive disorders
title_full_unstemmed Mouse models of altered gonadotrophin action: insight into male reproductive disorders
title_sort Mouse models of altered gonadotrophin action: insight into male reproductive disorders
dc.creator.none.fl_str_mv Jonas, Kim C.
Oduwole, Olayiwola O.
Peltoketo, Hellevi
Rulli, Susana Beatriz
Huhtaniemi, Ilpo T.
author Jonas, Kim C.
author_facet Jonas, Kim C.
Oduwole, Olayiwola O.
Peltoketo, Hellevi
Rulli, Susana Beatriz
Huhtaniemi, Ilpo T.
author_role author
author2 Oduwole, Olayiwola O.
Peltoketo, Hellevi
Rulli, Susana Beatriz
Huhtaniemi, Ilpo T.
author2_role author
author
author
author
dc.subject.none.fl_str_mv GONADOTROPHIN
REPRODUCTION
MALE
MOUSE MODELS
INFERTILITY
topic GONADOTROPHIN
REPRODUCTION
MALE
MOUSE MODELS
INFERTILITY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The advent of technologies to genetically manipulate the mouse genome has revolutionised research approaches, providing a unique platform to study the causality of reproductive disorders in vivo. With the relative ease of generating genetically modified (GM) mouse models, the last two decades have yielded multiple loss-of-function and gain-of-function mutation mouse models to explore the role of gonadotrophins and their receptors in reproductive pathologies. This work has provided key insights into the molecular mechanisms underlying reproductive disorders with altered gonadotrophin action, revealing the fundamental roles of these pituitary hormones and their receptors in the hypothalamic–pituitary–gonadal axis. This review will describe GM mouse models of gonadotrophins and their receptors with enhanced or diminished actions, specifically focusing on the male. We will discuss the mechanistic insights gained from these models into male reproductive disorders, and the relationship and understanding provided into male human reproductive disorders originating from altered gonadotrophin action.
Fil: Jonas, Kim C.. Imperial College London; Reino Unido
Fil: Oduwole, Olayiwola O.. Imperial College London; Reino Unido
Fil: Peltoketo, Hellevi . University of Oulu; Finlandia
Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental (i); Argentina
Fil: Huhtaniemi, Ilpo T. . Imperial College London; Reino Unido. University of Turku; Finlandia
description The advent of technologies to genetically manipulate the mouse genome has revolutionised research approaches, providing a unique platform to study the causality of reproductive disorders in vivo. With the relative ease of generating genetically modified (GM) mouse models, the last two decades have yielded multiple loss-of-function and gain-of-function mutation mouse models to explore the role of gonadotrophins and their receptors in reproductive pathologies. This work has provided key insights into the molecular mechanisms underlying reproductive disorders with altered gonadotrophin action, revealing the fundamental roles of these pituitary hormones and their receptors in the hypothalamic–pituitary–gonadal axis. This review will describe GM mouse models of gonadotrophins and their receptors with enhanced or diminished actions, specifically focusing on the male. We will discuss the mechanistic insights gained from these models into male reproductive disorders, and the relationship and understanding provided into male human reproductive disorders originating from altered gonadotrophin action.
publishDate 2014
dc.date.none.fl_str_mv 2014-10-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/6446
Jonas, Kim C.; Oduwole, Olayiwola O.; Peltoketo, Hellevi ; Rulli, Susana Beatriz; Huhtaniemi, Ilpo T. ; Mouse models of altered gonadotrophin action: insight into male reproductive disorders; Bioscientifica; Reproduction; 148; 4; 1-10-2014; R63-R70
1470-1626
1741-7899
url http://hdl.handle.net/11336/6446
identifier_str_mv Jonas, Kim C.; Oduwole, Olayiwola O.; Peltoketo, Hellevi ; Rulli, Susana Beatriz; Huhtaniemi, Ilpo T. ; Mouse models of altered gonadotrophin action: insight into male reproductive disorders; Bioscientifica; Reproduction; 148; 4; 1-10-2014; R63-R70
1470-1626
1741-7899
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/
info:eu-repo/semantics/altIdentifier/doi/10.1530/REP-14-0302
info:eu-repo/semantics/altIdentifier/pmid/25030890
info:eu-repo/semantics/altIdentifier/url/http://www.reproduction-online.org/content/148/4/R63
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bioscientifica
publisher.none.fl_str_mv Bioscientifica
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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