Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus

Autores
Couto, Juan Blas Marcos; Adolfi, Federico; Sedeño, Lucas; Salles, Alejo; Canales Johnson, Andrés; Alvarez Abut, Pablo; García Cordero, Indira Ruth; Pietto, Marcos Luis; Bekinschtein, Tristán Andrés; Sigman, Mariano; Manes, Facundo Francisco; Ibáñez Barassi, Agustín Mariano
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Interoception is the moment-to-moment sensing of the physiological condition of the body. The multimodal sources of interoception can be classified into two different streams of afferents: an internal pathway of signals arising from core structures (i.e., heart, blood vessels, and bronchi) and an external pathway of body-mapped sensations (i.e., chemosensation and pain) arising from peripersonal space. This study examines differential processing along these streams within the insular cortex (IC) and their subcortical tracts connecting frontotemporal networks. Two rare patients presenting focal lesions of the IC (insular lesion, IL) or its subcortical tracts (subcortical lesion, SL) were tested. Internally generated interoceptive streams were assessed through a heartbeat detection (HBD) task, while those externally triggered were tapped via taste, smell, and pain recognition tasks. A differential pattern was observed. The IC patient showed impaired internal signal processing while the SL patient exhibited external perception deficits. Such selective deficits remained even when comparing each patient with a group of healthy controls and a group of brain-damaged patients. These outcomes suggest the existence of distinguishable interoceptive streams. Results are discussed in relation with neuroanatomical substrates, involving a fronto-insulo-temporal network for interoceptive and cognitive contextual integration.
Fil: Couto, Juan Blas Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; Chile
Fil: Adolfi, Federico. Universidad Favaloro; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; Chile
Fil: Salles, Alejo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Fil: Canales Johnson, Andrés. Universidad Diego Portales; Chile. Cognition and Brain Sciences Unit; Reino Unido
Fil: Alvarez Abut, Pablo. Universidad Favaloro; Argentina
Fil: García Cordero, Indira Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Pietto, Marcos Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Cambridge; Reino Unido
Fil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Torcuato Di Tella; Argentina
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Centre of Excellence in Cognition and its Disorders; Australia
Fil: Ibáñez Barassi, Agustín Mariano. Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Diego Portales; Chile. Universidad Favaloro; Argentina. Universidad Autónoma del Caribe; Colombia
Materia
EXTEROCEPTION
INTEROCEPTION
INTEROCEPTIVE AWARENESS
INTEROCEPTIVE SENSITIVITY
LESION
PERIPERSONAL SPACE
STROKE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/52314
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieusCouto, Juan Blas MarcosAdolfi, FedericoSedeño, LucasSalles, AlejoCanales Johnson, AndrésAlvarez Abut, PabloGarcía Cordero, Indira RuthPietto, Marcos LuisBekinschtein, Tristán AndrésSigman, MarianoManes, Facundo FranciscoIbáñez Barassi, Agustín MarianoEXTEROCEPTIONINTEROCEPTIONINTEROCEPTIVE AWARENESSINTEROCEPTIVE SENSITIVITYLESIONPERIPERSONAL SPACESTROKEhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Interoception is the moment-to-moment sensing of the physiological condition of the body. The multimodal sources of interoception can be classified into two different streams of afferents: an internal pathway of signals arising from core structures (i.e., heart, blood vessels, and bronchi) and an external pathway of body-mapped sensations (i.e., chemosensation and pain) arising from peripersonal space. This study examines differential processing along these streams within the insular cortex (IC) and their subcortical tracts connecting frontotemporal networks. Two rare patients presenting focal lesions of the IC (insular lesion, IL) or its subcortical tracts (subcortical lesion, SL) were tested. Internally generated interoceptive streams were assessed through a heartbeat detection (HBD) task, while those externally triggered were tapped via taste, smell, and pain recognition tasks. A differential pattern was observed. The IC patient showed impaired internal signal processing while the SL patient exhibited external perception deficits. Such selective deficits remained even when comparing each patient with a group of healthy controls and a group of brain-damaged patients. These outcomes suggest the existence of distinguishable interoceptive streams. Results are discussed in relation with neuroanatomical substrates, involving a fronto-insulo-temporal network for interoceptive and cognitive contextual integration.Fil: Couto, Juan Blas Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; ChileFil: Adolfi, Federico. Universidad Favaloro; ArgentinaFil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; ChileFil: Salles, Alejo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; ArgentinaFil: Canales Johnson, Andrés. Universidad Diego Portales; Chile. Cognition and Brain Sciences Unit; Reino UnidoFil: Alvarez Abut, Pablo. Universidad Favaloro; ArgentinaFil: García Cordero, Indira Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Pietto, Marcos Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; ArgentinaFil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Cambridge; Reino UnidoFil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Torcuato Di Tella; ArgentinaFil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Centre of Excellence in Cognition and its Disorders; AustraliaFil: Ibáñez Barassi, Agustín Mariano. Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Diego Portales; Chile. Universidad Favaloro; Argentina. Universidad Autónoma del Caribe; ColombiaFrontiers Media S.A.2015-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/52314Couto, Juan Blas Marcos; Adolfi, Federico; Sedeño, Lucas; Salles, Alejo; Canales Johnson, Andrés; et al.; Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus; Frontiers Media S.A.; Frontiers in Psychology; 6; 5-2015; 1-171664-1078CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fpsyg.2015.00503info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fpsyg.2015.00503/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:36:23Zoai:ri.conicet.gov.ar:11336/52314instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:36:23.508CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus
title Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus
spellingShingle Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus
Couto, Juan Blas Marcos
EXTEROCEPTION
INTEROCEPTION
INTEROCEPTIVE AWARENESS
INTEROCEPTIVE SENSITIVITY
LESION
PERIPERSONAL SPACE
STROKE
title_short Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus
title_full Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus
title_fullStr Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus
title_full_unstemmed Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus
title_sort Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus
dc.creator.none.fl_str_mv Couto, Juan Blas Marcos
Adolfi, Federico
Sedeño, Lucas
Salles, Alejo
Canales Johnson, Andrés
Alvarez Abut, Pablo
García Cordero, Indira Ruth
Pietto, Marcos Luis
Bekinschtein, Tristán Andrés
Sigman, Mariano
Manes, Facundo Francisco
Ibáñez Barassi, Agustín Mariano
author Couto, Juan Blas Marcos
author_facet Couto, Juan Blas Marcos
Adolfi, Federico
Sedeño, Lucas
Salles, Alejo
Canales Johnson, Andrés
Alvarez Abut, Pablo
García Cordero, Indira Ruth
Pietto, Marcos Luis
Bekinschtein, Tristán Andrés
Sigman, Mariano
Manes, Facundo Francisco
Ibáñez Barassi, Agustín Mariano
author_role author
author2 Adolfi, Federico
Sedeño, Lucas
Salles, Alejo
Canales Johnson, Andrés
Alvarez Abut, Pablo
García Cordero, Indira Ruth
Pietto, Marcos Luis
Bekinschtein, Tristán Andrés
Sigman, Mariano
Manes, Facundo Francisco
Ibáñez Barassi, Agustín Mariano
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv EXTEROCEPTION
INTEROCEPTION
INTEROCEPTIVE AWARENESS
INTEROCEPTIVE SENSITIVITY
LESION
PERIPERSONAL SPACE
STROKE
topic EXTEROCEPTION
INTEROCEPTION
INTEROCEPTIVE AWARENESS
INTEROCEPTIVE SENSITIVITY
LESION
PERIPERSONAL SPACE
STROKE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Interoception is the moment-to-moment sensing of the physiological condition of the body. The multimodal sources of interoception can be classified into two different streams of afferents: an internal pathway of signals arising from core structures (i.e., heart, blood vessels, and bronchi) and an external pathway of body-mapped sensations (i.e., chemosensation and pain) arising from peripersonal space. This study examines differential processing along these streams within the insular cortex (IC) and their subcortical tracts connecting frontotemporal networks. Two rare patients presenting focal lesions of the IC (insular lesion, IL) or its subcortical tracts (subcortical lesion, SL) were tested. Internally generated interoceptive streams were assessed through a heartbeat detection (HBD) task, while those externally triggered were tapped via taste, smell, and pain recognition tasks. A differential pattern was observed. The IC patient showed impaired internal signal processing while the SL patient exhibited external perception deficits. Such selective deficits remained even when comparing each patient with a group of healthy controls and a group of brain-damaged patients. These outcomes suggest the existence of distinguishable interoceptive streams. Results are discussed in relation with neuroanatomical substrates, involving a fronto-insulo-temporal network for interoceptive and cognitive contextual integration.
Fil: Couto, Juan Blas Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; Chile
Fil: Adolfi, Federico. Universidad Favaloro; Argentina
Fil: Sedeño, Lucas. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Universidad Diego Portales; Chile
Fil: Salles, Alejo. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina
Fil: Canales Johnson, Andrés. Universidad Diego Portales; Chile. Cognition and Brain Sciences Unit; Reino Unido
Fil: Alvarez Abut, Pablo. Universidad Favaloro; Argentina
Fil: García Cordero, Indira Ruth. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Pietto, Marcos Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina
Fil: Bekinschtein, Tristán Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. University of Cambridge; Reino Unido
Fil: Sigman, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Torcuato Di Tella; Argentina
Fil: Manes, Facundo Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Favaloro; Argentina. Centre of Excellence in Cognition and its Disorders; Australia
Fil: Ibáñez Barassi, Agustín Mariano. Centre of Excellence in Cognition and its Disorders; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Diego Portales; Chile. Universidad Favaloro; Argentina. Universidad Autónoma del Caribe; Colombia
description Interoception is the moment-to-moment sensing of the physiological condition of the body. The multimodal sources of interoception can be classified into two different streams of afferents: an internal pathway of signals arising from core structures (i.e., heart, blood vessels, and bronchi) and an external pathway of body-mapped sensations (i.e., chemosensation and pain) arising from peripersonal space. This study examines differential processing along these streams within the insular cortex (IC) and their subcortical tracts connecting frontotemporal networks. Two rare patients presenting focal lesions of the IC (insular lesion, IL) or its subcortical tracts (subcortical lesion, SL) were tested. Internally generated interoceptive streams were assessed through a heartbeat detection (HBD) task, while those externally triggered were tapped via taste, smell, and pain recognition tasks. A differential pattern was observed. The IC patient showed impaired internal signal processing while the SL patient exhibited external perception deficits. Such selective deficits remained even when comparing each patient with a group of healthy controls and a group of brain-damaged patients. These outcomes suggest the existence of distinguishable interoceptive streams. Results are discussed in relation with neuroanatomical substrates, involving a fronto-insulo-temporal network for interoceptive and cognitive contextual integration.
publishDate 2015
dc.date.none.fl_str_mv 2015-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/52314
Couto, Juan Blas Marcos; Adolfi, Federico; Sedeño, Lucas; Salles, Alejo; Canales Johnson, Andrés; et al.; Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus; Frontiers Media S.A.; Frontiers in Psychology; 6; 5-2015; 1-17
1664-1078
CONICET Digital
CONICET
url http://hdl.handle.net/11336/52314
identifier_str_mv Couto, Juan Blas Marcos; Adolfi, Federico; Sedeño, Lucas; Salles, Alejo; Canales Johnson, Andrés; et al.; Disentangling interoception: Insights from focal strokes affecting the perception of external and internal milieus; Frontiers Media S.A.; Frontiers in Psychology; 6; 5-2015; 1-17
1664-1078
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fpsyg.2015.00503
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fpsyg.2015.00503/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media S.A.
publisher.none.fl_str_mv Frontiers Media S.A.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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