Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria

Autores
Vizoso Pinto, María Guadalupe; Villena, Julio Cesar; Rodriguez, Ana Virginia; Kitazawa, Haruki; Salva, Maria Susana; Alvarez, Gladis Susana
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The female genital tract (FGT) has unique characteristics, which have evolved to adequately carry on its vital function of reproduction. Thus, on the one hand the FGT has to be tolerogenic enough not to reject the allogeneic sperm and fetus in order to ensure procreation and; on the other hand it should be reactive enough for clearing viral, bacterial, fungal and parasitic pathogens. To increase complexity, there is a constant exposure of mucosal cells to an endogenous microbiota [1-3], and to the direct and indirect action of sexual hormones (estradiol and progesterone) [4]. The immunity of the FGT has not been studied as extensively as the immunity of the gut, and the antiviral response at this important mucosal site is even less understood. In line with this, immune modulation by lactic acid bacteria (LAB) offers a brand new field of research. In this review, we discuss some recent advances in the understanding of viral infections at the FGT, the use of TLR-ligands as possible therapeutic tools, and the hallmarks during the infection process, which may be used for modulation of the antiviral responses using immunobiotic and/or recombinant LAB expressing viral antigens.
Fil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Rodriguez, Ana Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Kitazawa, Haruki. Tohoku University; Japón
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Bioquimica Clinica Aplicada. Catedra de Bioquimica Clinica I; Argentina
Materia
MUCOSAL IMMUNITY
TLR
FEMALE GENITAL TRACT
IMMUNOBIOTIC
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/2563
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/2563
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteriaVizoso Pinto, María GuadalupeVillena, Julio CesarRodriguez, Ana VirginiaKitazawa, HarukiSalva, Maria SusanaAlvarez, Gladis SusanaMUCOSAL IMMUNITYTLRFEMALE GENITAL TRACTIMMUNOBIOTIChttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The female genital tract (FGT) has unique characteristics, which have evolved to adequately carry on its vital function of reproduction. Thus, on the one hand the FGT has to be tolerogenic enough not to reject the allogeneic sperm and fetus in order to ensure procreation and; on the other hand it should be reactive enough for clearing viral, bacterial, fungal and parasitic pathogens. To increase complexity, there is a constant exposure of mucosal cells to an endogenous microbiota [1-3], and to the direct and indirect action of sexual hormones (estradiol and progesterone) [4]. The immunity of the FGT has not been studied as extensively as the immunity of the gut, and the antiviral response at this important mucosal site is even less understood. In line with this, immune modulation by lactic acid bacteria (LAB) offers a brand new field of research. In this review, we discuss some recent advances in the understanding of viral infections at the FGT, the use of TLR-ligands as possible therapeutic tools, and the hallmarks during the infection process, which may be used for modulation of the antiviral responses using immunobiotic and/or recombinant LAB expressing viral antigens.Fil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); ArgentinaFil: Rodriguez, Ana Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); ArgentinaFil: Kitazawa, Haruki. Tohoku University; JapónFil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); ArgentinaFil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Bioquimica Clinica Aplicada. Catedra de Bioquimica Clinica I; ArgentinaSciTechnol2013-10-28info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/2563Vizoso Pinto, María Guadalupe; Villena, Julio Cesar; Rodriguez, Ana Virginia; Kitazawa, Haruki; Salva, Maria Susana; et al.; Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria; SciTechnol; Journal of Immunological Techniques in Infectious Diseases; 2; 28-10-2013; 1-92325-9752enginfo:eu-repo/semantics/altIdentifier/url/http://www.scitechnol.com/infectious-diseases-immunological-techniques.phpinfo:eu-repo/semantics/altIdentifier/doi/10.4172/2329-9541.1000120info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:39Zoai:ri.conicet.gov.ar:11336/2563instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:40.181CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria
title Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria
spellingShingle Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria
Vizoso Pinto, María Guadalupe
MUCOSAL IMMUNITY
TLR
FEMALE GENITAL TRACT
IMMUNOBIOTIC
title_short Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria
title_full Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria
title_fullStr Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria
title_full_unstemmed Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria
title_sort Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria
dc.creator.none.fl_str_mv Vizoso Pinto, María Guadalupe
Villena, Julio Cesar
Rodriguez, Ana Virginia
Kitazawa, Haruki
Salva, Maria Susana
Alvarez, Gladis Susana
author Vizoso Pinto, María Guadalupe
author_facet Vizoso Pinto, María Guadalupe
Villena, Julio Cesar
Rodriguez, Ana Virginia
Kitazawa, Haruki
Salva, Maria Susana
Alvarez, Gladis Susana
author_role author
author2 Villena, Julio Cesar
Rodriguez, Ana Virginia
Kitazawa, Haruki
Salva, Maria Susana
Alvarez, Gladis Susana
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv MUCOSAL IMMUNITY
TLR
FEMALE GENITAL TRACT
IMMUNOBIOTIC
topic MUCOSAL IMMUNITY
TLR
FEMALE GENITAL TRACT
IMMUNOBIOTIC
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The female genital tract (FGT) has unique characteristics, which have evolved to adequately carry on its vital function of reproduction. Thus, on the one hand the FGT has to be tolerogenic enough not to reject the allogeneic sperm and fetus in order to ensure procreation and; on the other hand it should be reactive enough for clearing viral, bacterial, fungal and parasitic pathogens. To increase complexity, there is a constant exposure of mucosal cells to an endogenous microbiota [1-3], and to the direct and indirect action of sexual hormones (estradiol and progesterone) [4]. The immunity of the FGT has not been studied as extensively as the immunity of the gut, and the antiviral response at this important mucosal site is even less understood. In line with this, immune modulation by lactic acid bacteria (LAB) offers a brand new field of research. In this review, we discuss some recent advances in the understanding of viral infections at the FGT, the use of TLR-ligands as possible therapeutic tools, and the hallmarks during the infection process, which may be used for modulation of the antiviral responses using immunobiotic and/or recombinant LAB expressing viral antigens.
Fil: Vizoso Pinto, María Guadalupe. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Rodriguez, Ana Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Kitazawa, Haruki. Tohoku University; Japón
Fil: Salva, Maria Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina
Fil: Alvarez, Gladis Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Tucumán. Centro de Referencia Para Lactobacilos (i); Argentina. Universidad Nacional de Tucuman. Facultad de Bioquimica, Quimica y Farmacia. Instituto de Bioquimica Clinica Aplicada. Catedra de Bioquimica Clinica I; Argentina
description The female genital tract (FGT) has unique characteristics, which have evolved to adequately carry on its vital function of reproduction. Thus, on the one hand the FGT has to be tolerogenic enough not to reject the allogeneic sperm and fetus in order to ensure procreation and; on the other hand it should be reactive enough for clearing viral, bacterial, fungal and parasitic pathogens. To increase complexity, there is a constant exposure of mucosal cells to an endogenous microbiota [1-3], and to the direct and indirect action of sexual hormones (estradiol and progesterone) [4]. The immunity of the FGT has not been studied as extensively as the immunity of the gut, and the antiviral response at this important mucosal site is even less understood. In line with this, immune modulation by lactic acid bacteria (LAB) offers a brand new field of research. In this review, we discuss some recent advances in the understanding of viral infections at the FGT, the use of TLR-ligands as possible therapeutic tools, and the hallmarks during the infection process, which may be used for modulation of the antiviral responses using immunobiotic and/or recombinant LAB expressing viral antigens.
publishDate 2013
dc.date.none.fl_str_mv 2013-10-28
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/2563
Vizoso Pinto, María Guadalupe; Villena, Julio Cesar; Rodriguez, Ana Virginia; Kitazawa, Haruki; Salva, Maria Susana; et al.; Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria; SciTechnol; Journal of Immunological Techniques in Infectious Diseases; 2; 28-10-2013; 1-9
2325-9752
url http://hdl.handle.net/11336/2563
identifier_str_mv Vizoso Pinto, María Guadalupe; Villena, Julio Cesar; Rodriguez, Ana Virginia; Kitazawa, Haruki; Salva, Maria Susana; et al.; Modulation of mucosal antiviral immune response at the female genital tract by immunobiotic lactic acid bacteria; SciTechnol; Journal of Immunological Techniques in Infectious Diseases; 2; 28-10-2013; 1-9
2325-9752
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.scitechnol.com/infectious-diseases-immunological-techniques.php
info:eu-repo/semantics/altIdentifier/doi/10.4172/2329-9541.1000120
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv SciTechnol
publisher.none.fl_str_mv SciTechnol
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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