A global research priority agenda to advance public health responses to fatty liver disease

• Autores: Lazarus, Jeffrey V.; Mark, Henry E.; Allen, Alina M.; Arab, Juan Pablo; Carrieri, Patrizia; Noureddin, Mazen; Alazawi, William; Alkhouri, Naim; Alqahtani, Saleh A.; Arrese, Marco; Bataller, Ramon; Berg, Thomas; Brennan, Paul N.; Burra, Patrizia; Castro Narro, Graciela E.; Cortez Pinto, Helena; Cusi, Kenneth; Dedes, Nikos; Duseja, Ajay; Francque, Sven M.; Hagström, Hannes; Huang, Terry T. K.; Wajcman, Dana Ivancovsky; Valenti, Luca; Zelber-Sagi, Shira; Schattenberg, Jörn M.; Wong, Vincent Wai-Sun; Younossi, Zobair M.; Zheng, Kenneth I.; Sookoian, Silvia Cristina
• Año de publicación: 2023
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: DELPHI METHOD; GLOBAL HEALTH; NAFLD/NASH; NON-COMMUNICABLE DISEASE (NCD); STEATOTIC LIVER DISEASE
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

Background & aims: An estimated 38% of adults worldwide have non-alcoholic fatty liver disease (NAFLD). From individual impacts to widespread public health and economic consequences, the implications of this disease are profound. This study aimed to develop an aligned, prioritised fatty liver disease research agenda for the global health community. Methods: Nine co-chairs drafted initial research priorities, subsequently reviewed by 40 core authors and debated during a threeday in-person meeting. Following a Delphi methodology, over two rounds, a large panel (R1 n = 344, R2 n = 288) reviewed the priorities, via Qualtrics XM, indicating agreement using a four-point Likert-scale and providing written feedback. The core group revised the draft priorities between rounds. In R2, panellists also ranked the priorities within six domains: epidemiology, models of care, treatment and care, education and awareness, patient and community perspectives, and leadership and public health policy. Results: The consensus-built fatty liver disease research agenda encompasses 28 priorities. The mean percentage of ‘agree’ responses increased from 78.3 in R1 to 81.1 in R2. Five priorities received unanimous combined agreement (‘agree’ + ‘somewhat agree’); the remaining 23 priorities had >90% combined agreement. While all but one of the priorities exhibited at least a supermajority of agreement (>66.7% ‘agree’), 13 priorities had <80% ‘agree’, with greater reliance on ‘somewhat agree’ to achieve >90% combined agreement. Conclusions: Adopting this multidisciplinary consensus-built research priorities agenda can deliver a step-change in addressing fatty liver disease, mitigating against its individual and societal harms and proactively altering its natural history through prevention, identification, treatment, and care. This agenda should catalyse the global health community’s efforts to advance and accelerate responses to this widespread and fast-growing public health threat.
Fil: Lazarus, Jeffrey V.. City University of New York; Estados Unidos. Universidad de Barcelona; España
Fil: Mark, Henry E.. European Association for the Study of the Liver; Suiza
Fil: Allen, Alina M.. Mayo Clinic; Estados Unidos
Fil: Arab, Juan Pablo. Pontificia Universidad Católica de Chile; Chile. Western University; Canadá
Fil: Carrieri, Patrizia. Inserm; Francia. Sciences Economiques & Sociales de la Santé & Traitement de l’Information Médicale; Francia
Fil: Noureddin, Mazen. Houston Methodist Hospital; Estados Unidos
Fil: Alazawi, William. Queen Mary University of London; Estados Unidos
Fil: Alkhouri, Naim. Arizona Liver Health; Estados Unidos
Fil: Alqahtani, Saleh A.. King Faisal Specialist Hospital And Research Centre; Arabia Saudita
Fil: Arrese, Marco. Universidad Católica de Chile; Chile. Pontificia Universidad Católica de Chile; Chile
Fil: Bataller, Ramon. Universidad de Barcelona; España
Fil: Berg, Thomas. Universitat Leipzig; Alemania
Fil: Brennan, Paul N.. University of Dundee; Reino Unido
Fil: Burra, Patrizia. Università di Padova; Italia
Fil: Castro Narro, Graciela E.. Instituto Nacional de la Nutrición Salvador Zubiran; México. Fundacion Clinica Medica Sur; México. Asociación Latinoamericana Para El Estudio del Hígado; Chile
Fil: Cortez Pinto, Helena. Universidade Nova de Lisboa; Portugal
Fil: Cusi, Kenneth. University of Florida; Estados Unidos
Fil: Dedes, Nikos. Greek Patients Association; Grecia
Fil: Duseja, Ajay. Postgraduate Institute of Medical Education and Research; India
Fil: Francque, Sven M.. Universiteit Antwerp; Bélgica
Fil: Hagström, Hannes. Karolinska Huddinge Hospital. Karolinska Institutet; Suecia
Fil: Huang, Terry T. K.. City University of New York; Estados Unidos
Fil: Wajcman, Dana Ivancovsky. Universidad de Barcelona; España
Fil: Valenti, Luca. Università degli Studi di Milano; Italia
Fil: Zelber-Sagi, Shira. University Of Haifa; Israel. Universitat Tel Aviv; Israel
Fil: Schattenberg, Jörn M.. Johannes Gutenberg Universitat Mainz; Alemania
Fil: Wong, Vincent Wai-Sun. Chinese University Of Hong Kong; Hong Kong
Fil: Younossi, Zobair M.. Universiteit Antwerp; Bélgica
Fil: Zheng, Kenneth I.. Universiteit Antwerp; Bélgica
Fil: Sookoian, Silvia Cristina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentina. Universidad Abierta Interamericana; Argentina