Do galectins serve as soluble ligands for immune checkpoint receptors?

Autores
Torres, Nicolás; Baudou, Federico Gastón; Scheidegger, Marco Adrian; D'alotto Moreno, Tomas; Rabinovich, Gabriel Adrián
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Galectins are a family of soluble glycan-binding proteins containing one or two highly conserved carbohydrate recognition domains (CRDs) that preferentially bind to lactosamine (LacNac; Galβ1-4NAcGlc) structures present on different cell surface receptors and the extracellular matrix. Unlike other lectins such as C-type lectin receptors and sialic acid-binding immunoglobulin-type lectins (Siglecs), which are mostly transmembrane proteins, galectins are synthesized as cytosolic proteins, reside in the cytosol or nucleus for much of their lifetime, and are released into the extracellular medium through non-classical secretory mechanisms bypassing the endoplasmic reticulum (ER)-Golgi system.
Fil: Torres, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Argentina de la Empresa; Argentina
Fil: Baudou, Federico Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Nacional de Luján; Argentina
Fil: Scheidegger, Marco Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: D'alotto Moreno, Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
Materia
GALECTINS
ESCAPE
IMMUNE CHECKPOINT INHIBITOR
TUMOR MICROENVIRONMENT
IMMUNOSUPPRESSION
NEOPLASMS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/238299
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Do galectins serve as soluble ligands for immune checkpoint receptors?Torres, NicolásBaudou, Federico GastónScheidegger, Marco AdrianD'alotto Moreno, TomasRabinovich, Gabriel AdriánGALECTINSESCAPEIMMUNE CHECKPOINT INHIBITORTUMOR MICROENVIRONMENTIMMUNOSUPPRESSIONNEOPLASMShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Galectins are a family of soluble glycan-binding proteins containing one or two highly conserved carbohydrate recognition domains (CRDs) that preferentially bind to lactosamine (LacNac; Galβ1-4NAcGlc) structures present on different cell surface receptors and the extracellular matrix. Unlike other lectins such as C-type lectin receptors and sialic acid-binding immunoglobulin-type lectins (Siglecs), which are mostly transmembrane proteins, galectins are synthesized as cytosolic proteins, reside in the cytosol or nucleus for much of their lifetime, and are released into the extracellular medium through non-classical secretory mechanisms bypassing the endoplasmic reticulum (ER)-Golgi system.Fil: Torres, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Argentina de la Empresa; ArgentinaFil: Baudou, Federico Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Nacional de Luján; ArgentinaFil: Scheidegger, Marco Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: D'alotto Moreno, Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaBioMed Central2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/238299Torres, Nicolás; Baudou, Federico Gastón; Scheidegger, Marco Adrian; D'alotto Moreno, Tomas; Rabinovich, Gabriel Adrián; Do galectins serve as soluble ligands for immune checkpoint receptors?; BioMed Central; Journal for ImmunoTherapy of Cancer; 12; 4; 4-2024; 1-42051-1426CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jitc.bmj.com/content/12/4/e008984info:eu-repo/semantics/altIdentifier/doi/10.1136/jitc-2024-008984info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:37:25Zoai:ri.conicet.gov.ar:11336/238299instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:37:26.167CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Do galectins serve as soluble ligands for immune checkpoint receptors?
title Do galectins serve as soluble ligands for immune checkpoint receptors?
spellingShingle Do galectins serve as soluble ligands for immune checkpoint receptors?
Torres, Nicolás
GALECTINS
ESCAPE
IMMUNE CHECKPOINT INHIBITOR
TUMOR MICROENVIRONMENT
IMMUNOSUPPRESSION
NEOPLASMS
title_short Do galectins serve as soluble ligands for immune checkpoint receptors?
title_full Do galectins serve as soluble ligands for immune checkpoint receptors?
title_fullStr Do galectins serve as soluble ligands for immune checkpoint receptors?
title_full_unstemmed Do galectins serve as soluble ligands for immune checkpoint receptors?
title_sort Do galectins serve as soluble ligands for immune checkpoint receptors?
dc.creator.none.fl_str_mv Torres, Nicolás
Baudou, Federico Gastón
Scheidegger, Marco Adrian
D'alotto Moreno, Tomas
Rabinovich, Gabriel Adrián
author Torres, Nicolás
author_facet Torres, Nicolás
Baudou, Federico Gastón
Scheidegger, Marco Adrian
D'alotto Moreno, Tomas
Rabinovich, Gabriel Adrián
author_role author
author2 Baudou, Federico Gastón
Scheidegger, Marco Adrian
D'alotto Moreno, Tomas
Rabinovich, Gabriel Adrián
author2_role author
author
author
author
dc.subject.none.fl_str_mv GALECTINS
ESCAPE
IMMUNE CHECKPOINT INHIBITOR
TUMOR MICROENVIRONMENT
IMMUNOSUPPRESSION
NEOPLASMS
topic GALECTINS
ESCAPE
IMMUNE CHECKPOINT INHIBITOR
TUMOR MICROENVIRONMENT
IMMUNOSUPPRESSION
NEOPLASMS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Galectins are a family of soluble glycan-binding proteins containing one or two highly conserved carbohydrate recognition domains (CRDs) that preferentially bind to lactosamine (LacNac; Galβ1-4NAcGlc) structures present on different cell surface receptors and the extracellular matrix. Unlike other lectins such as C-type lectin receptors and sialic acid-binding immunoglobulin-type lectins (Siglecs), which are mostly transmembrane proteins, galectins are synthesized as cytosolic proteins, reside in the cytosol or nucleus for much of their lifetime, and are released into the extracellular medium through non-classical secretory mechanisms bypassing the endoplasmic reticulum (ER)-Golgi system.
Fil: Torres, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Argentina de la Empresa; Argentina
Fil: Baudou, Federico Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Nacional de Luján; Argentina
Fil: Scheidegger, Marco Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: D'alotto Moreno, Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina
description Galectins are a family of soluble glycan-binding proteins containing one or two highly conserved carbohydrate recognition domains (CRDs) that preferentially bind to lactosamine (LacNac; Galβ1-4NAcGlc) structures present on different cell surface receptors and the extracellular matrix. Unlike other lectins such as C-type lectin receptors and sialic acid-binding immunoglobulin-type lectins (Siglecs), which are mostly transmembrane proteins, galectins are synthesized as cytosolic proteins, reside in the cytosol or nucleus for much of their lifetime, and are released into the extracellular medium through non-classical secretory mechanisms bypassing the endoplasmic reticulum (ER)-Golgi system.
publishDate 2024
dc.date.none.fl_str_mv 2024-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/238299
Torres, Nicolás; Baudou, Federico Gastón; Scheidegger, Marco Adrian; D'alotto Moreno, Tomas; Rabinovich, Gabriel Adrián; Do galectins serve as soluble ligands for immune checkpoint receptors?; BioMed Central; Journal for ImmunoTherapy of Cancer; 12; 4; 4-2024; 1-4
2051-1426
CONICET Digital
CONICET
url http://hdl.handle.net/11336/238299
identifier_str_mv Torres, Nicolás; Baudou, Federico Gastón; Scheidegger, Marco Adrian; D'alotto Moreno, Tomas; Rabinovich, Gabriel Adrián; Do galectins serve as soluble ligands for immune checkpoint receptors?; BioMed Central; Journal for ImmunoTherapy of Cancer; 12; 4; 4-2024; 1-4
2051-1426
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://jitc.bmj.com/content/12/4/e008984
info:eu-repo/semantics/altIdentifier/doi/10.1136/jitc-2024-008984
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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