Do galectins serve as soluble ligands for immune checkpoint receptors?
- Autores
- Torres, Nicolás; Baudou, Federico Gastón; Scheidegger, Marco Adrian; D'alotto Moreno, Tomas; Rabinovich, Gabriel Adrián
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Galectins are a family of soluble glycan-binding proteins containing one or two highly conserved carbohydrate recognition domains (CRDs) that preferentially bind to lactosamine (LacNac; Galβ1-4NAcGlc) structures present on different cell surface receptors and the extracellular matrix. Unlike other lectins such as C-type lectin receptors and sialic acid-binding immunoglobulin-type lectins (Siglecs), which are mostly transmembrane proteins, galectins are synthesized as cytosolic proteins, reside in the cytosol or nucleus for much of their lifetime, and are released into the extracellular medium through non-classical secretory mechanisms bypassing the endoplasmic reticulum (ER)-Golgi system.
Fil: Torres, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Argentina de la Empresa; Argentina
Fil: Baudou, Federico Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Nacional de Luján; Argentina
Fil: Scheidegger, Marco Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: D'alotto Moreno, Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina - Materia
-
GALECTINS
ESCAPE
IMMUNE CHECKPOINT INHIBITOR
TUMOR MICROENVIRONMENT
IMMUNOSUPPRESSION
NEOPLASMS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/238299
Ver los metadatos del registro completo
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Do galectins serve as soluble ligands for immune checkpoint receptors?Torres, NicolásBaudou, Federico GastónScheidegger, Marco AdrianD'alotto Moreno, TomasRabinovich, Gabriel AdriánGALECTINSESCAPEIMMUNE CHECKPOINT INHIBITORTUMOR MICROENVIRONMENTIMMUNOSUPPRESSIONNEOPLASMShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Galectins are a family of soluble glycan-binding proteins containing one or two highly conserved carbohydrate recognition domains (CRDs) that preferentially bind to lactosamine (LacNac; Galβ1-4NAcGlc) structures present on different cell surface receptors and the extracellular matrix. Unlike other lectins such as C-type lectin receptors and sialic acid-binding immunoglobulin-type lectins (Siglecs), which are mostly transmembrane proteins, galectins are synthesized as cytosolic proteins, reside in the cytosol or nucleus for much of their lifetime, and are released into the extracellular medium through non-classical secretory mechanisms bypassing the endoplasmic reticulum (ER)-Golgi system.Fil: Torres, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Argentina de la Empresa; ArgentinaFil: Baudou, Federico Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Nacional de Luján; ArgentinaFil: Scheidegger, Marco Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: D'alotto Moreno, Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; ArgentinaBioMed Central2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/238299Torres, Nicolás; Baudou, Federico Gastón; Scheidegger, Marco Adrian; D'alotto Moreno, Tomas; Rabinovich, Gabriel Adrián; Do galectins serve as soluble ligands for immune checkpoint receptors?; BioMed Central; Journal for ImmunoTherapy of Cancer; 12; 4; 4-2024; 1-42051-1426CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://jitc.bmj.com/content/12/4/e008984info:eu-repo/semantics/altIdentifier/doi/10.1136/jitc-2024-008984info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:33Zoai:ri.conicet.gov.ar:11336/238299instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:33.559CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Do galectins serve as soluble ligands for immune checkpoint receptors? |
title |
Do galectins serve as soluble ligands for immune checkpoint receptors? |
spellingShingle |
Do galectins serve as soluble ligands for immune checkpoint receptors? Torres, Nicolás GALECTINS ESCAPE IMMUNE CHECKPOINT INHIBITOR TUMOR MICROENVIRONMENT IMMUNOSUPPRESSION NEOPLASMS |
title_short |
Do galectins serve as soluble ligands for immune checkpoint receptors? |
title_full |
Do galectins serve as soluble ligands for immune checkpoint receptors? |
title_fullStr |
Do galectins serve as soluble ligands for immune checkpoint receptors? |
title_full_unstemmed |
Do galectins serve as soluble ligands for immune checkpoint receptors? |
title_sort |
Do galectins serve as soluble ligands for immune checkpoint receptors? |
dc.creator.none.fl_str_mv |
Torres, Nicolás Baudou, Federico Gastón Scheidegger, Marco Adrian D'alotto Moreno, Tomas Rabinovich, Gabriel Adrián |
author |
Torres, Nicolás |
author_facet |
Torres, Nicolás Baudou, Federico Gastón Scheidegger, Marco Adrian D'alotto Moreno, Tomas Rabinovich, Gabriel Adrián |
author_role |
author |
author2 |
Baudou, Federico Gastón Scheidegger, Marco Adrian D'alotto Moreno, Tomas Rabinovich, Gabriel Adrián |
author2_role |
author author author author |
dc.subject.none.fl_str_mv |
GALECTINS ESCAPE IMMUNE CHECKPOINT INHIBITOR TUMOR MICROENVIRONMENT IMMUNOSUPPRESSION NEOPLASMS |
topic |
GALECTINS ESCAPE IMMUNE CHECKPOINT INHIBITOR TUMOR MICROENVIRONMENT IMMUNOSUPPRESSION NEOPLASMS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Galectins are a family of soluble glycan-binding proteins containing one or two highly conserved carbohydrate recognition domains (CRDs) that preferentially bind to lactosamine (LacNac; Galβ1-4NAcGlc) structures present on different cell surface receptors and the extracellular matrix. Unlike other lectins such as C-type lectin receptors and sialic acid-binding immunoglobulin-type lectins (Siglecs), which are mostly transmembrane proteins, galectins are synthesized as cytosolic proteins, reside in the cytosol or nucleus for much of their lifetime, and are released into the extracellular medium through non-classical secretory mechanisms bypassing the endoplasmic reticulum (ER)-Golgi system. Fil: Torres, Nicolás. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Argentina de la Empresa; Argentina Fil: Baudou, Federico Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad Nacional de Luján; Argentina Fil: Scheidegger, Marco Adrian. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: D'alotto Moreno, Tomas. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Rabinovich, Gabriel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina |
description |
Galectins are a family of soluble glycan-binding proteins containing one or two highly conserved carbohydrate recognition domains (CRDs) that preferentially bind to lactosamine (LacNac; Galβ1-4NAcGlc) structures present on different cell surface receptors and the extracellular matrix. Unlike other lectins such as C-type lectin receptors and sialic acid-binding immunoglobulin-type lectins (Siglecs), which are mostly transmembrane proteins, galectins are synthesized as cytosolic proteins, reside in the cytosol or nucleus for much of their lifetime, and are released into the extracellular medium through non-classical secretory mechanisms bypassing the endoplasmic reticulum (ER)-Golgi system. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-04 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/238299 Torres, Nicolás; Baudou, Federico Gastón; Scheidegger, Marco Adrian; D'alotto Moreno, Tomas; Rabinovich, Gabriel Adrián; Do galectins serve as soluble ligands for immune checkpoint receptors?; BioMed Central; Journal for ImmunoTherapy of Cancer; 12; 4; 4-2024; 1-4 2051-1426 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/238299 |
identifier_str_mv |
Torres, Nicolás; Baudou, Federico Gastón; Scheidegger, Marco Adrian; D'alotto Moreno, Tomas; Rabinovich, Gabriel Adrián; Do galectins serve as soluble ligands for immune checkpoint receptors?; BioMed Central; Journal for ImmunoTherapy of Cancer; 12; 4; 4-2024; 1-4 2051-1426 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://jitc.bmj.com/content/12/4/e008984 info:eu-repo/semantics/altIdentifier/doi/10.1136/jitc-2024-008984 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
BioMed Central |
publisher.none.fl_str_mv |
BioMed Central |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842270049145978880 |
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13.13397 |