The dicrotic notch analyzed by a numerical model

Autores
Politi, Teresa; Ghigo, Arthur; Fernández, Juan Manuel Francisco; Khelifa, Ismaïl; Gaudric, Julien; Fullana, José María; Lagrée, Pierre Yves
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Divergent concepts on the origin of the dicrotic notch are widespread in medical literature and education. Since most medical textbooks explain the origin of the dicrotic notch as caused by the aortic valve closure itself, this is commonly transmitted in medical physiology courses. We present clinical data and numerical simulations to demonstrate that reflected pressure waves could participate as one of the causes of the dicrotic notch. Our experimental data from continuous arterial pressure measurements from adult patients undergoing vascular surgery suggest that isolated changes in peripheral vascular resistance using an intravenous bolus of phenylephrine (a selective alpha 1-receptor agonist and thus a potent vasoconstrictor) modify the dicrotic notch. We then explore the mechanisms behind this phenomenon by using a numerical model based on integrated axisymmetric Navier-Stokes equations to compute the hemodynamic flow. Our model illustrates clearly how modifications in peripheral artery resistance may result in changes in the amplitude of the dicrotic notch by modifying reflected pressure waves. We believe that this could be a useful tool in teaching medical physiology courses.
Fil: Politi, Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Ghigo, Arthur. Universite de Paris VI; Francia
Fil: Fernández, Juan Manuel Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Khelifa, Ismaïl. Hôpitaux Universitaires La Pitié-Salpêtrière; Francia
Fil: Gaudric, Julien. Hôpitaux Universitaires La Pitié-Salpêtrière; Francia. Universite de Paris VI; Francia
Fil: Fullana, José María. Universite de Paris VI; Francia
Fil: Lagrée, Pierre Yves. Universite de Paris VI; Francia
Materia
Dicrotic Notch
Medical Physiology
Numerical Model
Reflection Wave
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47435
Acceder
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network_name_str CONICET Digital (CONICET)
spelling The dicrotic notch analyzed by a numerical modelPoliti, TeresaGhigo, ArthurFernández, Juan Manuel FranciscoKhelifa, IsmaïlGaudric, JulienFullana, José MaríaLagrée, Pierre YvesDicrotic NotchMedical PhysiologyNumerical ModelReflection Wavehttps://purl.org/becyt/ford/1.2https://purl.org/becyt/ford/1Divergent concepts on the origin of the dicrotic notch are widespread in medical literature and education. Since most medical textbooks explain the origin of the dicrotic notch as caused by the aortic valve closure itself, this is commonly transmitted in medical physiology courses. We present clinical data and numerical simulations to demonstrate that reflected pressure waves could participate as one of the causes of the dicrotic notch. Our experimental data from continuous arterial pressure measurements from adult patients undergoing vascular surgery suggest that isolated changes in peripheral vascular resistance using an intravenous bolus of phenylephrine (a selective alpha 1-receptor agonist and thus a potent vasoconstrictor) modify the dicrotic notch. We then explore the mechanisms behind this phenomenon by using a numerical model based on integrated axisymmetric Navier-Stokes equations to compute the hemodynamic flow. Our model illustrates clearly how modifications in peripheral artery resistance may result in changes in the amplitude of the dicrotic notch by modifying reflected pressure waves. We believe that this could be a useful tool in teaching medical physiology courses.Fil: Politi, Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Ghigo, Arthur. Universite de Paris VI; FranciaFil: Fernández, Juan Manuel Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; ArgentinaFil: Khelifa, Ismaïl. Hôpitaux Universitaires La Pitié-Salpêtrière; FranciaFil: Gaudric, Julien. Hôpitaux Universitaires La Pitié-Salpêtrière; Francia. Universite de Paris VI; FranciaFil: Fullana, José María. Universite de Paris VI; FranciaFil: Lagrée, Pierre Yves. Universite de Paris VI; FranciaPergamon-Elsevier Science Ltd2016-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47435Politi, Teresa; Ghigo, Arthur; Fernández, Juan Manuel Francisco; Khelifa, Ismaïl; Gaudric, Julien; et al.; The dicrotic notch analyzed by a numerical model; Pergamon-Elsevier Science Ltd; Computers In Biology And Medicine; 72; 5-2016; 54-640010-4825CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.compbiomed.2016.03.005info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0010482516300592info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:37:40Zoai:ri.conicet.gov.ar:11336/47435instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:37:40.683CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The dicrotic notch analyzed by a numerical model
title The dicrotic notch analyzed by a numerical model
spellingShingle The dicrotic notch analyzed by a numerical model
Politi, Teresa
Dicrotic Notch
Medical Physiology
Numerical Model
Reflection Wave
title_short The dicrotic notch analyzed by a numerical model
title_full The dicrotic notch analyzed by a numerical model
title_fullStr The dicrotic notch analyzed by a numerical model
title_full_unstemmed The dicrotic notch analyzed by a numerical model
title_sort The dicrotic notch analyzed by a numerical model
dc.creator.none.fl_str_mv Politi, Teresa
Ghigo, Arthur
Fernández, Juan Manuel Francisco
Khelifa, Ismaïl
Gaudric, Julien
Fullana, José María
Lagrée, Pierre Yves
author Politi, Teresa
author_facet Politi, Teresa
Ghigo, Arthur
Fernández, Juan Manuel Francisco
Khelifa, Ismaïl
Gaudric, Julien
Fullana, José María
Lagrée, Pierre Yves
author_role author
author2 Ghigo, Arthur
Fernández, Juan Manuel Francisco
Khelifa, Ismaïl
Gaudric, Julien
Fullana, José María
Lagrée, Pierre Yves
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Dicrotic Notch
Medical Physiology
Numerical Model
Reflection Wave
topic Dicrotic Notch
Medical Physiology
Numerical Model
Reflection Wave
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.2
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Divergent concepts on the origin of the dicrotic notch are widespread in medical literature and education. Since most medical textbooks explain the origin of the dicrotic notch as caused by the aortic valve closure itself, this is commonly transmitted in medical physiology courses. We present clinical data and numerical simulations to demonstrate that reflected pressure waves could participate as one of the causes of the dicrotic notch. Our experimental data from continuous arterial pressure measurements from adult patients undergoing vascular surgery suggest that isolated changes in peripheral vascular resistance using an intravenous bolus of phenylephrine (a selective alpha 1-receptor agonist and thus a potent vasoconstrictor) modify the dicrotic notch. We then explore the mechanisms behind this phenomenon by using a numerical model based on integrated axisymmetric Navier-Stokes equations to compute the hemodynamic flow. Our model illustrates clearly how modifications in peripheral artery resistance may result in changes in the amplitude of the dicrotic notch by modifying reflected pressure waves. We believe that this could be a useful tool in teaching medical physiology courses.
Fil: Politi, Teresa. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Ghigo, Arthur. Universite de Paris VI; Francia
Fil: Fernández, Juan Manuel Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Fisiología y Biofísica Bernardo Houssay. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Fisiología y Biofísica Bernardo Houssay; Argentina
Fil: Khelifa, Ismaïl. Hôpitaux Universitaires La Pitié-Salpêtrière; Francia
Fil: Gaudric, Julien. Hôpitaux Universitaires La Pitié-Salpêtrière; Francia. Universite de Paris VI; Francia
Fil: Fullana, José María. Universite de Paris VI; Francia
Fil: Lagrée, Pierre Yves. Universite de Paris VI; Francia
description Divergent concepts on the origin of the dicrotic notch are widespread in medical literature and education. Since most medical textbooks explain the origin of the dicrotic notch as caused by the aortic valve closure itself, this is commonly transmitted in medical physiology courses. We present clinical data and numerical simulations to demonstrate that reflected pressure waves could participate as one of the causes of the dicrotic notch. Our experimental data from continuous arterial pressure measurements from adult patients undergoing vascular surgery suggest that isolated changes in peripheral vascular resistance using an intravenous bolus of phenylephrine (a selective alpha 1-receptor agonist and thus a potent vasoconstrictor) modify the dicrotic notch. We then explore the mechanisms behind this phenomenon by using a numerical model based on integrated axisymmetric Navier-Stokes equations to compute the hemodynamic flow. Our model illustrates clearly how modifications in peripheral artery resistance may result in changes in the amplitude of the dicrotic notch by modifying reflected pressure waves. We believe that this could be a useful tool in teaching medical physiology courses.
publishDate 2016
dc.date.none.fl_str_mv 2016-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47435
Politi, Teresa; Ghigo, Arthur; Fernández, Juan Manuel Francisco; Khelifa, Ismaïl; Gaudric, Julien; et al.; The dicrotic notch analyzed by a numerical model; Pergamon-Elsevier Science Ltd; Computers In Biology And Medicine; 72; 5-2016; 54-64
0010-4825
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47435
identifier_str_mv Politi, Teresa; Ghigo, Arthur; Fernández, Juan Manuel Francisco; Khelifa, Ismaïl; Gaudric, Julien; et al.; The dicrotic notch analyzed by a numerical model; Pergamon-Elsevier Science Ltd; Computers In Biology And Medicine; 72; 5-2016; 54-64
0010-4825
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.compbiomed.2016.03.005
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0010482516300592
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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