Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms

Autores
Cury, R. G.; Galhardoni, R.; Fonoff, E. T.; Pérez Lloret, Santiago; Santos Ghilardi, Maria Gabriela dos; Barbosa, E. R.; Teixeira, M. J.; Ciampi de Andrade, Daniel
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pain and sensory abnormalities are present in a large proportion of Parkinson disease (PD) patients and have a significant negative impact in quality of life. It remains undetermined whether pain occurs secondary to motor impairment and to which extent it can be relieved by improvement of motor symptoms. The aim of this review was to examine the current knowledge on the mechanisms behind sensory changes and pain in PD and to assess the modulatory effects of motor treatment on these sensory abnormalities. A comprehensive literature search was performed. We selected studies investigating sensory changes and pain in PD and the effects of levodopa administration and deep brain stimulation (DBS) on these symptoms. PD patients have altered sensory and pain thresholds in the off-medication state. Both levodopa and DBS improve motor symptoms (i.e.: bradykinesia, tremor) and change sensory abnormalities towards normal levels. However, there is no direct correlation between sensory/pain changes and motor improvement, suggesting that motor and non-motor symptoms do not necessarily share the same mechanisms. Whether dopamine and DBS have a real antinociceptive effect or simply a modulatory effect in pain perception remain uncertain. These data may provide useful insights into a mechanism-based approach to pain in PD, pointing out the role of the dopaminergic system in pain perception and the importance of the characterization of different pain syndromes related to PD before specific treatment can be instituted.
Fil: Cury, R. G.. Universidade de Sao Paulo; Brasil
Fil: Galhardoni, R.. Universidade de Sao Paulo; Brasil
Fil: Fonoff, E. T.. Universidade de Sao Paulo; Brasil
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Santos Ghilardi, Maria Gabriela dos. Universidade de Sao Paulo; Brasil
Fil: Barbosa, E. R.. Universidade de Sao Paulo; Brasil
Fil: Teixeira, M. J.. Universidade de Sao Paulo; Brasil
Fil: Ciampi de Andrade, Daniel. Universidade de Sao Paulo; Brasil
Materia
Enfermedad de Parkinson
Dolor
Estimación Cerebral Profunda
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/39009
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptomsCury, R. G.Galhardoni, R.Fonoff, E. T.Pérez Lloret, SantiagoSantos Ghilardi, Maria Gabriela dosBarbosa, E. R.Teixeira, M. J.Ciampi de Andrade, DanielEnfermedad de ParkinsonDolorEstimación Cerebral Profundahttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Pain and sensory abnormalities are present in a large proportion of Parkinson disease (PD) patients and have a significant negative impact in quality of life. It remains undetermined whether pain occurs secondary to motor impairment and to which extent it can be relieved by improvement of motor symptoms. The aim of this review was to examine the current knowledge on the mechanisms behind sensory changes and pain in PD and to assess the modulatory effects of motor treatment on these sensory abnormalities. A comprehensive literature search was performed. We selected studies investigating sensory changes and pain in PD and the effects of levodopa administration and deep brain stimulation (DBS) on these symptoms. PD patients have altered sensory and pain thresholds in the off-medication state. Both levodopa and DBS improve motor symptoms (i.e.: bradykinesia, tremor) and change sensory abnormalities towards normal levels. However, there is no direct correlation between sensory/pain changes and motor improvement, suggesting that motor and non-motor symptoms do not necessarily share the same mechanisms. Whether dopamine and DBS have a real antinociceptive effect or simply a modulatory effect in pain perception remain uncertain. These data may provide useful insights into a mechanism-based approach to pain in PD, pointing out the role of the dopaminergic system in pain perception and the importance of the characterization of different pain syndromes related to PD before specific treatment can be instituted.Fil: Cury, R. G.. Universidade de Sao Paulo; BrasilFil: Galhardoni, R.. Universidade de Sao Paulo; BrasilFil: Fonoff, E. T.. Universidade de Sao Paulo; BrasilFil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; ArgentinaFil: Santos Ghilardi, Maria Gabriela dos. Universidade de Sao Paulo; BrasilFil: Barbosa, E. R.. Universidade de Sao Paulo; BrasilFil: Teixeira, M. J.. Universidade de Sao Paulo; BrasilFil: Ciampi de Andrade, Daniel. Universidade de Sao Paulo; BrasilElsevier2016-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/39009Cury, R. G.; Galhardoni, R.; Fonoff, E. T.; Pérez Lloret, Santiago; Santos Ghilardi, Maria Gabriela dos; et al.; Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms; Elsevier; European Journal of Pain; 20; 2; 2-2016; 151-1651090-3801CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/ejp.745info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ejp.745/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:00Zoai:ri.conicet.gov.ar:11336/39009instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:01.057CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms
title Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms
spellingShingle Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms
Cury, R. G.
Enfermedad de Parkinson
Dolor
Estimación Cerebral Profunda
title_short Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms
title_full Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms
title_fullStr Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms
title_full_unstemmed Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms
title_sort Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms
dc.creator.none.fl_str_mv Cury, R. G.
Galhardoni, R.
Fonoff, E. T.
Pérez Lloret, Santiago
Santos Ghilardi, Maria Gabriela dos
Barbosa, E. R.
Teixeira, M. J.
Ciampi de Andrade, Daniel
author Cury, R. G.
author_facet Cury, R. G.
Galhardoni, R.
Fonoff, E. T.
Pérez Lloret, Santiago
Santos Ghilardi, Maria Gabriela dos
Barbosa, E. R.
Teixeira, M. J.
Ciampi de Andrade, Daniel
author_role author
author2 Galhardoni, R.
Fonoff, E. T.
Pérez Lloret, Santiago
Santos Ghilardi, Maria Gabriela dos
Barbosa, E. R.
Teixeira, M. J.
Ciampi de Andrade, Daniel
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Enfermedad de Parkinson
Dolor
Estimación Cerebral Profunda
topic Enfermedad de Parkinson
Dolor
Estimación Cerebral Profunda
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Pain and sensory abnormalities are present in a large proportion of Parkinson disease (PD) patients and have a significant negative impact in quality of life. It remains undetermined whether pain occurs secondary to motor impairment and to which extent it can be relieved by improvement of motor symptoms. The aim of this review was to examine the current knowledge on the mechanisms behind sensory changes and pain in PD and to assess the modulatory effects of motor treatment on these sensory abnormalities. A comprehensive literature search was performed. We selected studies investigating sensory changes and pain in PD and the effects of levodopa administration and deep brain stimulation (DBS) on these symptoms. PD patients have altered sensory and pain thresholds in the off-medication state. Both levodopa and DBS improve motor symptoms (i.e.: bradykinesia, tremor) and change sensory abnormalities towards normal levels. However, there is no direct correlation between sensory/pain changes and motor improvement, suggesting that motor and non-motor symptoms do not necessarily share the same mechanisms. Whether dopamine and DBS have a real antinociceptive effect or simply a modulatory effect in pain perception remain uncertain. These data may provide useful insights into a mechanism-based approach to pain in PD, pointing out the role of the dopaminergic system in pain perception and the importance of the characterization of different pain syndromes related to PD before specific treatment can be instituted.
Fil: Cury, R. G.. Universidade de Sao Paulo; Brasil
Fil: Galhardoni, R.. Universidade de Sao Paulo; Brasil
Fil: Fonoff, E. T.. Universidade de Sao Paulo; Brasil
Fil: Pérez Lloret, Santiago. Pontificia Universidad Católica Argentina ; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Cardiológicas; Argentina
Fil: Santos Ghilardi, Maria Gabriela dos. Universidade de Sao Paulo; Brasil
Fil: Barbosa, E. R.. Universidade de Sao Paulo; Brasil
Fil: Teixeira, M. J.. Universidade de Sao Paulo; Brasil
Fil: Ciampi de Andrade, Daniel. Universidade de Sao Paulo; Brasil
description Pain and sensory abnormalities are present in a large proportion of Parkinson disease (PD) patients and have a significant negative impact in quality of life. It remains undetermined whether pain occurs secondary to motor impairment and to which extent it can be relieved by improvement of motor symptoms. The aim of this review was to examine the current knowledge on the mechanisms behind sensory changes and pain in PD and to assess the modulatory effects of motor treatment on these sensory abnormalities. A comprehensive literature search was performed. We selected studies investigating sensory changes and pain in PD and the effects of levodopa administration and deep brain stimulation (DBS) on these symptoms. PD patients have altered sensory and pain thresholds in the off-medication state. Both levodopa and DBS improve motor symptoms (i.e.: bradykinesia, tremor) and change sensory abnormalities towards normal levels. However, there is no direct correlation between sensory/pain changes and motor improvement, suggesting that motor and non-motor symptoms do not necessarily share the same mechanisms. Whether dopamine and DBS have a real antinociceptive effect or simply a modulatory effect in pain perception remain uncertain. These data may provide useful insights into a mechanism-based approach to pain in PD, pointing out the role of the dopaminergic system in pain perception and the importance of the characterization of different pain syndromes related to PD before specific treatment can be instituted.
publishDate 2016
dc.date.none.fl_str_mv 2016-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/39009
Cury, R. G.; Galhardoni, R.; Fonoff, E. T.; Pérez Lloret, Santiago; Santos Ghilardi, Maria Gabriela dos; et al.; Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms; Elsevier; European Journal of Pain; 20; 2; 2-2016; 151-165
1090-3801
CONICET Digital
CONICET
url http://hdl.handle.net/11336/39009
identifier_str_mv Cury, R. G.; Galhardoni, R.; Fonoff, E. T.; Pérez Lloret, Santiago; Santos Ghilardi, Maria Gabriela dos; et al.; Sensory abnormalities and pain in Parkinson disease and its modulation by treatment of motor symptoms; Elsevier; European Journal of Pain; 20; 2; 2-2016; 151-165
1090-3801
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/ejp.745
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/ejp.745/abstract
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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