Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers

Autores
Grippo, Lucía Daniela; Reidel, Ivana Gabriela; García, María Inés; Streu, Alexis; Müller, Diana María; Veaute, Carolina Melania Isabel
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules.
Fil: Grippo, Lucía Daniela. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Química Aplicada.; Argentina. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; Argentina
Fil: Reidel, Ivana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; Argentina
Fil: García, María Inés. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; Argentina
Fil: Streu, Alexis. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Química Aplicada.; Argentina. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; Argentina
Fil: Müller, Diana María. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Química Aplicada.; Argentina
Fil: Veaute, Carolina Melania Isabel. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; Argentina
Materia
ADJUVANTS
DNA
GEMINI LIPOPEPTIDES
IMMUNOSTIMULANTS
VACCINES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/174942
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/174942
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriersGrippo, Lucía DanielaReidel, Ivana GabrielaGarcía, María InésStreu, AlexisMüller, Diana MaríaVeaute, Carolina Melania IsabelADJUVANTSDNAGEMINI LIPOPEPTIDESIMMUNOSTIMULANTSVACCINEShttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules.Fil: Grippo, Lucía Daniela. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Química Aplicada.; Argentina. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; ArgentinaFil: Reidel, Ivana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; ArgentinaFil: García, María Inés. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; ArgentinaFil: Streu, Alexis. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Química Aplicada.; Argentina. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; ArgentinaFil: Müller, Diana María. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Química Aplicada.; ArgentinaFil: Veaute, Carolina Melania Isabel. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; ArgentinaKorean Vaccine Society2020-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/174942Grippo, Lucía Daniela; Reidel, Ivana Gabriela; García, María Inés; Streu, Alexis; Müller, Diana María; et al.; Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers; Korean Vaccine Society; Clinical and Experimental Vaccine Research; 9; 2; 7-2020; 159-1632287-36512287-366XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://ecevr.org/DOIx.php?id=10.7774/cevr.2020.9.2.159info:eu-repo/semantics/altIdentifier/doi/10.7774/cevr.2020.9.2.159info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:45Zoai:ri.conicet.gov.ar:11336/174942instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:45.861CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
title Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
spellingShingle Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
Grippo, Lucía Daniela
ADJUVANTS
DNA
GEMINI LIPOPEPTIDES
IMMUNOSTIMULANTS
VACCINES
title_short Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
title_full Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
title_fullStr Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
title_full_unstemmed Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
title_sort Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers
dc.creator.none.fl_str_mv Grippo, Lucía Daniela
Reidel, Ivana Gabriela
García, María Inés
Streu, Alexis
Müller, Diana María
Veaute, Carolina Melania Isabel
author Grippo, Lucía Daniela
author_facet Grippo, Lucía Daniela
Reidel, Ivana Gabriela
García, María Inés
Streu, Alexis
Müller, Diana María
Veaute, Carolina Melania Isabel
author_role author
author2 Reidel, Ivana Gabriela
García, María Inés
Streu, Alexis
Müller, Diana María
Veaute, Carolina Melania Isabel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ADJUVANTS
DNA
GEMINI LIPOPEPTIDES
IMMUNOSTIMULANTS
VACCINES
topic ADJUVANTS
DNA
GEMINI LIPOPEPTIDES
IMMUNOSTIMULANTS
VACCINES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules.
Fil: Grippo, Lucía Daniela. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Química Aplicada.; Argentina. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; Argentina
Fil: Reidel, Ivana Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe; Argentina. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; Argentina
Fil: García, María Inés. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; Argentina
Fil: Streu, Alexis. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Química Aplicada.; Argentina. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; Argentina
Fil: Müller, Diana María. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Química Aplicada.; Argentina
Fil: Veaute, Carolina Melania Isabel. Universidad Nacional del Litoral. Facultad de Bioquimica y Ciencias Biologicas. Laboratorio de Inmunologia Experimental.; Argentina
description The design of subunit vaccines requires new adjuvant systems. We designed and synthesized new lipopeptides (cysteine-based) of low molecular weight with different hydrophobic chains that dimerize becoming gemini lipopeptides. They were characterized and their adjuvant capacity was tested in mice by the inoculation of a protein antigen formulated with the lipopeptides, with and without the addition of CpG-oligodeoxynucleotides. Formulations were able to induce an immune response and produced no adverse effects. An adjuvant ability is described for the first time for this type of molecules.
publishDate 2020
dc.date.none.fl_str_mv 2020-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/174942
Grippo, Lucía Daniela; Reidel, Ivana Gabriela; García, María Inés; Streu, Alexis; Müller, Diana María; et al.; Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers; Korean Vaccine Society; Clinical and Experimental Vaccine Research; 9; 2; 7-2020; 159-163
2287-3651
2287-366X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/174942
identifier_str_mv Grippo, Lucía Daniela; Reidel, Ivana Gabriela; García, María Inés; Streu, Alexis; Müller, Diana María; et al.; Gemini lipopeptides as vaccine adjuvants: a new role for these versatile carriers; Korean Vaccine Society; Clinical and Experimental Vaccine Research; 9; 2; 7-2020; 159-163
2287-3651
2287-366X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://ecevr.org/DOIx.php?id=10.7774/cevr.2020.9.2.159
info:eu-repo/semantics/altIdentifier/doi/10.7774/cevr.2020.9.2.159
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Korean Vaccine Society
publisher.none.fl_str_mv Korean Vaccine Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269715697762304
score 13.13397

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