Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries

Autores
Perrone, Sofía; Zubeldia Brenner, Lautaro; Gazza, Elías; Demarchi, Gianina; Baccarini, Leticia Cecilia; Baricalla, Agustín; Mertens, Freya; Luque, Guillermina Maria; Vankelecom, Hugo; Berner, Silvia; Becu, Damasia; Cristina, Silvia Carolina
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Pituitary adenomas are among the most frequent intracranial neoplasms andtreatment depends on tumor subtype and clinical features. Unfortunately, nonresponder cases occur, then new molecular targets are needed.Notch system component expression and activation data are scarce in pituitarytumorigenesis, we therefore aimed to characterize Notch system in pituitary tumors of different histotype. In human pituitary adenomas we showed NOTCH1-4 receptors, JAGGED1 ligand and HES1 target gene expression with positive correlations between NOTCH1,2,4 and HES1, and NOTCH3 and JAGGED1 denoting Notch system activation in a subset of tumors. Importantly, NOTCH3 positive cells were higher in corticotropinomas and somatotropinomas compared to non functioning adenomas. In accordance, Notch activation was evidenced in AtT20 tumor corticotropes, with higher levels of NOTCH1-3 active domains, Jagged1 and Hes1 compared to normal pituitary.In the prolactinoma cell lines GH3 and MMQ, in vivo GH3 tumors and normalglands, Notch system activation was lower than in corticotropes. In MMQ cells only the NOTCH2 active domain was increased, whereas NOTCH1 active domain was higher in GH3 tumors. High levels of Jagged1 and Dll1 were found solely in GH3 cells, and Hes1, Hey1 and Hey2 were expressed in a model dependent pattern.Prolactinomas harbored by lacDrd2KO mice expressed high levels of NOTCH1active domain and reduced Hes1.We show a differential expression of Notch system components in tumoral andnormal pituitaries and specific Notch system involvement depending on adenomahistotype, with higher activation in corticotropinomas. These data suggest thattargeting Notch pathway may benefit non responder pituitary adenomas.
Fil: Perrone, Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Zubeldia Brenner, Lautaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Gazza, Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Demarchi, Gianina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Baccarini, Leticia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Baricalla, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Mertens, Freya. Katholikie Universiteit Leuven; Bélgica
Fil: Luque, Guillermina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Vankelecom, Hugo. Katholikie Universiteit Leuven; Bélgica
Fil: Berner, Silvia. Clinica Santa Isabel; Argentina
Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Cristina, Silvia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Materia
NOTCH
PITUITARY
CORTICOTROPINOMA
PROLACTINOMA
JAGGED1
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/63597
Acceder
id CONICETDig_2ef6d3c7a4980ab104bd3c482ea05555
oai_identifier_str oai:ri.conicet.gov.ar:11336/63597
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitariesPerrone, SofíaZubeldia Brenner, LautaroGazza, ElíasDemarchi, GianinaBaccarini, Leticia CeciliaBaricalla, AgustínMertens, FreyaLuque, Guillermina MariaVankelecom, HugoBerner, SilviaBecu, DamasiaCristina, Silvia CarolinaNOTCHPITUITARYCORTICOTROPINOMAPROLACTINOMAJAGGED1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Pituitary adenomas are among the most frequent intracranial neoplasms andtreatment depends on tumor subtype and clinical features. Unfortunately, nonresponder cases occur, then new molecular targets are needed.Notch system component expression and activation data are scarce in pituitarytumorigenesis, we therefore aimed to characterize Notch system in pituitary tumors of different histotype. In human pituitary adenomas we showed NOTCH1-4 receptors, JAGGED1 ligand and HES1 target gene expression with positive correlations between NOTCH1,2,4 and HES1, and NOTCH3 and JAGGED1 denoting Notch system activation in a subset of tumors. Importantly, NOTCH3 positive cells were higher in corticotropinomas and somatotropinomas compared to non functioning adenomas. In accordance, Notch activation was evidenced in AtT20 tumor corticotropes, with higher levels of NOTCH1-3 active domains, Jagged1 and Hes1 compared to normal pituitary.In the prolactinoma cell lines GH3 and MMQ, in vivo GH3 tumors and normalglands, Notch system activation was lower than in corticotropes. In MMQ cells only the NOTCH2 active domain was increased, whereas NOTCH1 active domain was higher in GH3 tumors. High levels of Jagged1 and Dll1 were found solely in GH3 cells, and Hes1, Hey1 and Hey2 were expressed in a model dependent pattern.Prolactinomas harbored by lacDrd2KO mice expressed high levels of NOTCH1active domain and reduced Hes1.We show a differential expression of Notch system components in tumoral andnormal pituitaries and specific Notch system involvement depending on adenomahistotype, with higher activation in corticotropinomas. These data suggest thattargeting Notch pathway may benefit non responder pituitary adenomas.Fil: Perrone, Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Zubeldia Brenner, Lautaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Gazza, Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Demarchi, Gianina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Baccarini, Leticia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Baricalla, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaFil: Mertens, Freya. Katholikie Universiteit Leuven; BélgicaFil: Luque, Guillermina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Vankelecom, Hugo. Katholikie Universiteit Leuven; BélgicaFil: Berner, Silvia. Clinica Santa Isabel; ArgentinaFil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Cristina, Silvia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; ArgentinaImpact Journals LLC2017-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/63597Perrone, Sofía; Zubeldia Brenner, Lautaro; Gazza, Elías; Demarchi, Gianina; Baccarini, Leticia Cecilia; et al.; Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries; Impact Journals LLC; Oncotarget; 8; 34; 7-2017; 57072-570881949-25531949-2553CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=19046&pubmed-linkout=1info:eu-repo/semantics/altIdentifier/doi/10.18632/oncotarget.19046info:eu-repo/semantics/altIdentifier/pmid/28915655info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:01:17Zoai:ri.conicet.gov.ar:11336/63597instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:01:18.271CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries
title Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries
spellingShingle Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries
Perrone, Sofía
NOTCH
PITUITARY
CORTICOTROPINOMA
PROLACTINOMA
JAGGED1
title_short Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries
title_full Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries
title_fullStr Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries
title_full_unstemmed Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries
title_sort Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries
dc.creator.none.fl_str_mv Perrone, Sofía
Zubeldia Brenner, Lautaro
Gazza, Elías
Demarchi, Gianina
Baccarini, Leticia Cecilia
Baricalla, Agustín
Mertens, Freya
Luque, Guillermina Maria
Vankelecom, Hugo
Berner, Silvia
Becu, Damasia
Cristina, Silvia Carolina
author Perrone, Sofía
author_facet Perrone, Sofía
Zubeldia Brenner, Lautaro
Gazza, Elías
Demarchi, Gianina
Baccarini, Leticia Cecilia
Baricalla, Agustín
Mertens, Freya
Luque, Guillermina Maria
Vankelecom, Hugo
Berner, Silvia
Becu, Damasia
Cristina, Silvia Carolina
author_role author
author2 Zubeldia Brenner, Lautaro
Gazza, Elías
Demarchi, Gianina
Baccarini, Leticia Cecilia
Baricalla, Agustín
Mertens, Freya
Luque, Guillermina Maria
Vankelecom, Hugo
Berner, Silvia
Becu, Damasia
Cristina, Silvia Carolina
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NOTCH
PITUITARY
CORTICOTROPINOMA
PROLACTINOMA
JAGGED1
topic NOTCH
PITUITARY
CORTICOTROPINOMA
PROLACTINOMA
JAGGED1
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Pituitary adenomas are among the most frequent intracranial neoplasms andtreatment depends on tumor subtype and clinical features. Unfortunately, nonresponder cases occur, then new molecular targets are needed.Notch system component expression and activation data are scarce in pituitarytumorigenesis, we therefore aimed to characterize Notch system in pituitary tumors of different histotype. In human pituitary adenomas we showed NOTCH1-4 receptors, JAGGED1 ligand and HES1 target gene expression with positive correlations between NOTCH1,2,4 and HES1, and NOTCH3 and JAGGED1 denoting Notch system activation in a subset of tumors. Importantly, NOTCH3 positive cells were higher in corticotropinomas and somatotropinomas compared to non functioning adenomas. In accordance, Notch activation was evidenced in AtT20 tumor corticotropes, with higher levels of NOTCH1-3 active domains, Jagged1 and Hes1 compared to normal pituitary.In the prolactinoma cell lines GH3 and MMQ, in vivo GH3 tumors and normalglands, Notch system activation was lower than in corticotropes. In MMQ cells only the NOTCH2 active domain was increased, whereas NOTCH1 active domain was higher in GH3 tumors. High levels of Jagged1 and Dll1 were found solely in GH3 cells, and Hes1, Hey1 and Hey2 were expressed in a model dependent pattern.Prolactinomas harbored by lacDrd2KO mice expressed high levels of NOTCH1active domain and reduced Hes1.We show a differential expression of Notch system components in tumoral andnormal pituitaries and specific Notch system involvement depending on adenomahistotype, with higher activation in corticotropinomas. These data suggest thattargeting Notch pathway may benefit non responder pituitary adenomas.
Fil: Perrone, Sofía. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Zubeldia Brenner, Lautaro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Gazza, Elías. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Demarchi, Gianina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Baccarini, Leticia Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Baricalla, Agustín. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
Fil: Mertens, Freya. Katholikie Universiteit Leuven; Bélgica
Fil: Luque, Guillermina Maria. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Vankelecom, Hugo. Katholikie Universiteit Leuven; Bélgica
Fil: Berner, Silvia. Clinica Santa Isabel; Argentina
Fil: Becu, Damasia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
Fil: Cristina, Silvia Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires. Universidad Nacional del Noroeste de la Provincia de Buenos Aires. Centro de Investigaciones y Transferencia del Noroeste de la Provincia de Buenos Aires; Argentina
description Pituitary adenomas are among the most frequent intracranial neoplasms andtreatment depends on tumor subtype and clinical features. Unfortunately, nonresponder cases occur, then new molecular targets are needed.Notch system component expression and activation data are scarce in pituitarytumorigenesis, we therefore aimed to characterize Notch system in pituitary tumors of different histotype. In human pituitary adenomas we showed NOTCH1-4 receptors, JAGGED1 ligand and HES1 target gene expression with positive correlations between NOTCH1,2,4 and HES1, and NOTCH3 and JAGGED1 denoting Notch system activation in a subset of tumors. Importantly, NOTCH3 positive cells were higher in corticotropinomas and somatotropinomas compared to non functioning adenomas. In accordance, Notch activation was evidenced in AtT20 tumor corticotropes, with higher levels of NOTCH1-3 active domains, Jagged1 and Hes1 compared to normal pituitary.In the prolactinoma cell lines GH3 and MMQ, in vivo GH3 tumors and normalglands, Notch system activation was lower than in corticotropes. In MMQ cells only the NOTCH2 active domain was increased, whereas NOTCH1 active domain was higher in GH3 tumors. High levels of Jagged1 and Dll1 were found solely in GH3 cells, and Hes1, Hey1 and Hey2 were expressed in a model dependent pattern.Prolactinomas harbored by lacDrd2KO mice expressed high levels of NOTCH1active domain and reduced Hes1.We show a differential expression of Notch system components in tumoral andnormal pituitaries and specific Notch system involvement depending on adenomahistotype, with higher activation in corticotropinomas. These data suggest thattargeting Notch pathway may benefit non responder pituitary adenomas.
publishDate 2017
dc.date.none.fl_str_mv 2017-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/63597
Perrone, Sofía; Zubeldia Brenner, Lautaro; Gazza, Elías; Demarchi, Gianina; Baccarini, Leticia Cecilia; et al.; Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries; Impact Journals LLC; Oncotarget; 8; 34; 7-2017; 57072-57088
1949-2553
1949-2553
CONICET Digital
CONICET
url http://hdl.handle.net/11336/63597
identifier_str_mv Perrone, Sofía; Zubeldia Brenner, Lautaro; Gazza, Elías; Demarchi, Gianina; Baccarini, Leticia Cecilia; et al.; Notch system is differentially expressed and activated in pituitary adenomas of distinct histotype, tumor cell lines and normal pituitaries; Impact Journals LLC; Oncotarget; 8; 34; 7-2017; 57072-57088
1949-2553
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path[]=19046&pubmed-linkout=1
info:eu-repo/semantics/altIdentifier/doi/10.18632/oncotarget.19046
info:eu-repo/semantics/altIdentifier/pmid/28915655
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Impact Journals LLC
publisher.none.fl_str_mv Impact Journals LLC
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269688585781248
score 13.13397

Publicaciones similares