Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors

Autores
Maggini, Julian; Raiden, Silvina Claudia; Salamone, Gabriela Veronica; Trevani, Analía Silvina; Geffner, Jorge Raúl
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
As a key component of the innate immune response, neutrophils play a major role in host protection against bacterial and fungi infections. Neutrophils are short-lived phagocytic cells and, as a first line of defense against host insult, they are rapidly and massively recruited from the circulation into inflammatory sites, where the expression of their apoptotic program can be regulated by a number of agents such as cytokines, pathogens and environmental stressors. Apoptosis of neutrophils is central to homoeostasis and the resolution of inflammation. Recent studies have highlighted the complex convergence of different pathways in the regulation of neutrophil survival. This review focuses on the mechanisms involved in the induction and regulation of neutrophil apoptosis.
Fil: Maggini, Julian. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Raiden, Silvina Claudia. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salamone, Gabriela Veronica. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Trevani, Analía Silvina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Geffner, Jorge Raúl. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Apoptosis
Extrinsic Pathway
Fas
Intrinsic Pathway
Mitochondria
Neutrophils
Review
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/55359
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressorsMaggini, JulianRaiden, Silvina ClaudiaSalamone, Gabriela VeronicaTrevani, Analía SilvinaGeffner, Jorge RaúlApoptosisExtrinsic PathwayFasIntrinsic PathwayMitochondriaNeutrophilsReviewhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3As a key component of the innate immune response, neutrophils play a major role in host protection against bacterial and fungi infections. Neutrophils are short-lived phagocytic cells and, as a first line of defense against host insult, they are rapidly and massively recruited from the circulation into inflammatory sites, where the expression of their apoptotic program can be regulated by a number of agents such as cytokines, pathogens and environmental stressors. Apoptosis of neutrophils is central to homoeostasis and the resolution of inflammation. Recent studies have highlighted the complex convergence of different pathways in the regulation of neutrophil survival. This review focuses on the mechanisms involved in the induction and regulation of neutrophil apoptosis.Fil: Maggini, Julian. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; ArgentinaFil: Raiden, Silvina Claudia. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Salamone, Gabriela Veronica. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Trevani, Analía Silvina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Geffner, Jorge Raúl. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFrontiers in Bioscience2009-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/55359Maggini, Julian; Raiden, Silvina Claudia; Salamone, Gabriela Veronica; Trevani, Analía Silvina; Geffner, Jorge Raúl; Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors; Frontiers in Bioscience; Frontiers in Bioscience; 14; 6; 1-2009; 2372-23851093-9946CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2741/3384info:eu-repo/semantics/altIdentifier/url/http://www.bioscience.org/2009/v14/af/3384/list.htminfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:24:56Zoai:ri.conicet.gov.ar:11336/55359instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:24:56.295CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors
title Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors
spellingShingle Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors
Maggini, Julian
Apoptosis
Extrinsic Pathway
Fas
Intrinsic Pathway
Mitochondria
Neutrophils
Review
title_short Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors
title_full Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors
title_fullStr Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors
title_full_unstemmed Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors
title_sort Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors
dc.creator.none.fl_str_mv Maggini, Julian
Raiden, Silvina Claudia
Salamone, Gabriela Veronica
Trevani, Analía Silvina
Geffner, Jorge Raúl
author Maggini, Julian
author_facet Maggini, Julian
Raiden, Silvina Claudia
Salamone, Gabriela Veronica
Trevani, Analía Silvina
Geffner, Jorge Raúl
author_role author
author2 Raiden, Silvina Claudia
Salamone, Gabriela Veronica
Trevani, Analía Silvina
Geffner, Jorge Raúl
author2_role author
author
author
author
dc.subject.none.fl_str_mv Apoptosis
Extrinsic Pathway
Fas
Intrinsic Pathway
Mitochondria
Neutrophils
Review
topic Apoptosis
Extrinsic Pathway
Fas
Intrinsic Pathway
Mitochondria
Neutrophils
Review
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv As a key component of the innate immune response, neutrophils play a major role in host protection against bacterial and fungi infections. Neutrophils are short-lived phagocytic cells and, as a first line of defense against host insult, they are rapidly and massively recruited from the circulation into inflammatory sites, where the expression of their apoptotic program can be regulated by a number of agents such as cytokines, pathogens and environmental stressors. Apoptosis of neutrophils is central to homoeostasis and the resolution of inflammation. Recent studies have highlighted the complex convergence of different pathways in the regulation of neutrophil survival. This review focuses on the mechanisms involved in the induction and regulation of neutrophil apoptosis.
Fil: Maggini, Julian. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina
Fil: Raiden, Silvina Claudia. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Salamone, Gabriela Veronica. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Trevani, Analía Silvina. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Geffner, Jorge Raúl. Academia Nacional de Medicina de Buenos Aires. Instituto de Investigaciones Hematológicas "Mariano R. Castex"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description As a key component of the innate immune response, neutrophils play a major role in host protection against bacterial and fungi infections. Neutrophils are short-lived phagocytic cells and, as a first line of defense against host insult, they are rapidly and massively recruited from the circulation into inflammatory sites, where the expression of their apoptotic program can be regulated by a number of agents such as cytokines, pathogens and environmental stressors. Apoptosis of neutrophils is central to homoeostasis and the resolution of inflammation. Recent studies have highlighted the complex convergence of different pathways in the regulation of neutrophil survival. This review focuses on the mechanisms involved in the induction and regulation of neutrophil apoptosis.
publishDate 2009
dc.date.none.fl_str_mv 2009-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/55359
Maggini, Julian; Raiden, Silvina Claudia; Salamone, Gabriela Veronica; Trevani, Analía Silvina; Geffner, Jorge Raúl; Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors; Frontiers in Bioscience; Frontiers in Bioscience; 14; 6; 1-2009; 2372-2385
1093-9946
CONICET Digital
CONICET
url http://hdl.handle.net/11336/55359
identifier_str_mv Maggini, Julian; Raiden, Silvina Claudia; Salamone, Gabriela Veronica; Trevani, Analía Silvina; Geffner, Jorge Raúl; Regulation of neutrophil apoptosis by cytokines, pathogens and environmental stressors; Frontiers in Bioscience; Frontiers in Bioscience; 14; 6; 1-2009; 2372-2385
1093-9946
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2741/3384
info:eu-repo/semantics/altIdentifier/url/http://www.bioscience.org/2009/v14/af/3384/list.htm
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers in Bioscience
publisher.none.fl_str_mv Frontiers in Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981384972402688
score 12.48226

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