Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors

Autores
Barroso, Paola Andrea; Marco, Jorge Diego; Locatelli, Fabricio M.; Cardozo, Rubén Marino; Hoyos, Carlos Lorenzo; Mora, Maria Celia; Garcia Bustos, Maria Fernanda; López Quiroga, Inés; Mimori, Tatsuyuki; Gentile, Alberto G.; Barrio, Alejandra B.; Korenaga, Masataka; Hashiguchi, Yoshihisha; Basombrio, Miguel Angel Manuel
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cases of human visceral leishmaniasis (HVL) were not recorded until recently in the Chaco region of northwestern Argentina. Dogs were surveyed at the sites of infection of two HVL index cases in the Chaco region of Salta province. Canine cases (CanL) were diagnosed by two parasitological methods, two molecular methods targeting mini- and maxicircle DNA, and immunochromatographic dipstick. Among 77 dogs studied, 10 (13%) were found infected with Leishmania spp. In seven dogs and two humans, the infecting species was typed as Leishmania (Leishmania) infantum. The same genotype was detected in the human and two of the CanL. Although several diagnostic methods displayed weak or moderate agreement, the concordance values for serology versus maxicircle PCR were very good (Kappa index = 0.84). Sandflies captured in the area were identified as Lutzomyia migonei and Lu. cortelezzii/Lu. sallesi (cortelezzii complex). The focal appearance of leishmaniasis in dogs and humans in a sylvatic region and its relatively low prevalence of infection suggests that L. (L.) infantum transmission to dogs and humans may, in this region, stem from sylvatic reservoirs.
Fil: Barroso, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Marco, Jorge Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Locatelli, Fabricio M.. Kochi University. Kochi Medical School. Dept.of Parasitology; Japón
Fil: Cardozo, Rubén Marino. Provincia de Salta. Ministerio de Salud Publica; Argentina
Fil: Hoyos, Carlos Lorenzo. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina
Fil: Mora, Maria Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Garcia Bustos, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: López Quiroga, Inés. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biología. Cátedra de Química Biologica; Argentina
Fil: Mimori, Tatsuyuki. Kochi University. Kochi Medical School. Dept.of Parasitology; Japón
Fil: Gentile, Alberto G.. Provincia de Salta. Ministerio de Salud Publica; Argentina
Fil: Barrio, Alejandra B.. Universidad Nacional de Salta. Facultad de Cs.de la Salud. Cátedra de Microbiología; Argentina
Fil: Korenaga, Masataka. Kochi University. Kochi Medical School. Dept.of Parasitology; Japón
Fil: Hashiguchi, Yoshihisha. Kochi University. Kochi Medical School; Japón
Fil: Basombrio, Miguel Angel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Materia
Leishmaniasis
Visceral
Reservoirs
Vectors
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/27715
Acceder
id CONICETDig_2ec66151f932ea22b2203632df6d836a
oai_identifier_str oai:ri.conicet.gov.ar:11336/27715
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectorsBarroso, Paola AndreaMarco, Jorge DiegoLocatelli, Fabricio M.Cardozo, Rubén MarinoHoyos, Carlos LorenzoMora, Maria CeliaGarcia Bustos, Maria FernandaLópez Quiroga, InésMimori, TatsuyukiGentile, Alberto G.Barrio, Alejandra B.Korenaga, MasatakaHashiguchi, YoshihishaBasombrio, Miguel Angel ManuelLeishmaniasisVisceralReservoirsVectorshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Cases of human visceral leishmaniasis (HVL) were not recorded until recently in the Chaco region of northwestern Argentina. Dogs were surveyed at the sites of infection of two HVL index cases in the Chaco region of Salta province. Canine cases (CanL) were diagnosed by two parasitological methods, two molecular methods targeting mini- and maxicircle DNA, and immunochromatographic dipstick. Among 77 dogs studied, 10 (13%) were found infected with Leishmania spp. In seven dogs and two humans, the infecting species was typed as Leishmania (Leishmania) infantum. The same genotype was detected in the human and two of the CanL. Although several diagnostic methods displayed weak or moderate agreement, the concordance values for serology versus maxicircle PCR were very good (Kappa index = 0.84). Sandflies captured in the area were identified as Lutzomyia migonei and Lu. cortelezzii/Lu. sallesi (cortelezzii complex). The focal appearance of leishmaniasis in dogs and humans in a sylvatic region and its relatively low prevalence of infection suggests that L. (L.) infantum transmission to dogs and humans may, in this region, stem from sylvatic reservoirs.Fil: Barroso, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Marco, Jorge Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Locatelli, Fabricio M.. Kochi University. Kochi Medical School. Dept.of Parasitology; JapónFil: Cardozo, Rubén Marino. Provincia de Salta. Ministerio de Salud Publica; ArgentinaFil: Hoyos, Carlos Lorenzo. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; ArgentinaFil: Mora, Maria Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: Garcia Bustos, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaFil: López Quiroga, Inés. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biología. Cátedra de Química Biologica; ArgentinaFil: Mimori, Tatsuyuki. Kochi University. Kochi Medical School. Dept.of Parasitology; JapónFil: Gentile, Alberto G.. Provincia de Salta. Ministerio de Salud Publica; ArgentinaFil: Barrio, Alejandra B.. Universidad Nacional de Salta. Facultad de Cs.de la Salud. Cátedra de Microbiología; ArgentinaFil: Korenaga, Masataka. Kochi University. Kochi Medical School. Dept.of Parasitology; JapónFil: Hashiguchi, Yoshihisha. Kochi University. Kochi Medical School; JapónFil: Basombrio, Miguel Angel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; ArgentinaAmerican Society of Tropical Medicine and Hygiene2015-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/27715Barroso, Paola Andrea; Marco, Jorge Diego; Locatelli, Fabricio M.; Cardozo, Rubén Marino; Hoyos, Carlos Lorenzo; et al.; Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 93; 8-2015; 334-3390002-9637CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.ajtmh.org/content/journals/10.4269/ajtmh.14-0267info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.14-0267info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:49:44Zoai:ri.conicet.gov.ar:11336/27715instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:49:45.254CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors
title Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors
spellingShingle Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors
Barroso, Paola Andrea
Leishmaniasis
Visceral
Reservoirs
Vectors
title_short Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors
title_full Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors
title_fullStr Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors
title_full_unstemmed Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors
title_sort Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors
dc.creator.none.fl_str_mv Barroso, Paola Andrea
Marco, Jorge Diego
Locatelli, Fabricio M.
Cardozo, Rubén Marino
Hoyos, Carlos Lorenzo
Mora, Maria Celia
Garcia Bustos, Maria Fernanda
López Quiroga, Inés
Mimori, Tatsuyuki
Gentile, Alberto G.
Barrio, Alejandra B.
Korenaga, Masataka
Hashiguchi, Yoshihisha
Basombrio, Miguel Angel Manuel
author Barroso, Paola Andrea
author_facet Barroso, Paola Andrea
Marco, Jorge Diego
Locatelli, Fabricio M.
Cardozo, Rubén Marino
Hoyos, Carlos Lorenzo
Mora, Maria Celia
Garcia Bustos, Maria Fernanda
López Quiroga, Inés
Mimori, Tatsuyuki
Gentile, Alberto G.
Barrio, Alejandra B.
Korenaga, Masataka
Hashiguchi, Yoshihisha
Basombrio, Miguel Angel Manuel
author_role author
author2 Marco, Jorge Diego
Locatelli, Fabricio M.
Cardozo, Rubén Marino
Hoyos, Carlos Lorenzo
Mora, Maria Celia
Garcia Bustos, Maria Fernanda
López Quiroga, Inés
Mimori, Tatsuyuki
Gentile, Alberto G.
Barrio, Alejandra B.
Korenaga, Masataka
Hashiguchi, Yoshihisha
Basombrio, Miguel Angel Manuel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Leishmaniasis
Visceral
Reservoirs
Vectors
topic Leishmaniasis
Visceral
Reservoirs
Vectors
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cases of human visceral leishmaniasis (HVL) were not recorded until recently in the Chaco region of northwestern Argentina. Dogs were surveyed at the sites of infection of two HVL index cases in the Chaco region of Salta province. Canine cases (CanL) were diagnosed by two parasitological methods, two molecular methods targeting mini- and maxicircle DNA, and immunochromatographic dipstick. Among 77 dogs studied, 10 (13%) were found infected with Leishmania spp. In seven dogs and two humans, the infecting species was typed as Leishmania (Leishmania) infantum. The same genotype was detected in the human and two of the CanL. Although several diagnostic methods displayed weak or moderate agreement, the concordance values for serology versus maxicircle PCR were very good (Kappa index = 0.84). Sandflies captured in the area were identified as Lutzomyia migonei and Lu. cortelezzii/Lu. sallesi (cortelezzii complex). The focal appearance of leishmaniasis in dogs and humans in a sylvatic region and its relatively low prevalence of infection suggests that L. (L.) infantum transmission to dogs and humans may, in this region, stem from sylvatic reservoirs.
Fil: Barroso, Paola Andrea. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Marco, Jorge Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Locatelli, Fabricio M.. Kochi University. Kochi Medical School. Dept.of Parasitology; Japón
Fil: Cardozo, Rubén Marino. Provincia de Salta. Ministerio de Salud Publica; Argentina
Fil: Hoyos, Carlos Lorenzo. Universidad Nacional de Salta. Sede Regional Oran. Instituto de Investigación de Enfermedades Tropicales; Argentina
Fil: Mora, Maria Celia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: Garcia Bustos, Maria Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
Fil: López Quiroga, Inés. Universidad Nacional de Salta. Facultad de Cs.naturales. Escuela de Biología. Cátedra de Química Biologica; Argentina
Fil: Mimori, Tatsuyuki. Kochi University. Kochi Medical School. Dept.of Parasitology; Japón
Fil: Gentile, Alberto G.. Provincia de Salta. Ministerio de Salud Publica; Argentina
Fil: Barrio, Alejandra B.. Universidad Nacional de Salta. Facultad de Cs.de la Salud. Cátedra de Microbiología; Argentina
Fil: Korenaga, Masataka. Kochi University. Kochi Medical School. Dept.of Parasitology; Japón
Fil: Hashiguchi, Yoshihisha. Kochi University. Kochi Medical School; Japón
Fil: Basombrio, Miguel Angel Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Salta. Instituto de Patología Experimental. Universidad Nacional de Salta. Facultad de Ciencias de la Salud. Instituto de Patología Experimental; Argentina
description Cases of human visceral leishmaniasis (HVL) were not recorded until recently in the Chaco region of northwestern Argentina. Dogs were surveyed at the sites of infection of two HVL index cases in the Chaco region of Salta province. Canine cases (CanL) were diagnosed by two parasitological methods, two molecular methods targeting mini- and maxicircle DNA, and immunochromatographic dipstick. Among 77 dogs studied, 10 (13%) were found infected with Leishmania spp. In seven dogs and two humans, the infecting species was typed as Leishmania (Leishmania) infantum. The same genotype was detected in the human and two of the CanL. Although several diagnostic methods displayed weak or moderate agreement, the concordance values for serology versus maxicircle PCR were very good (Kappa index = 0.84). Sandflies captured in the area were identified as Lutzomyia migonei and Lu. cortelezzii/Lu. sallesi (cortelezzii complex). The focal appearance of leishmaniasis in dogs and humans in a sylvatic region and its relatively low prevalence of infection suggests that L. (L.) infantum transmission to dogs and humans may, in this region, stem from sylvatic reservoirs.
publishDate 2015
dc.date.none.fl_str_mv 2015-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/27715
Barroso, Paola Andrea; Marco, Jorge Diego; Locatelli, Fabricio M.; Cardozo, Rubén Marino; Hoyos, Carlos Lorenzo; et al.; Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 93; 8-2015; 334-339
0002-9637
CONICET Digital
CONICET
url http://hdl.handle.net/11336/27715
identifier_str_mv Barroso, Paola Andrea; Marco, Jorge Diego; Locatelli, Fabricio M.; Cardozo, Rubén Marino; Hoyos, Carlos Lorenzo; et al.; Visceral leishmaniasis caused by Leishmania infantum in Salta, Argentina: Possible reservoirs and vectors; American Society of Tropical Medicine and Hygiene; American Journal of Tropical Medicine and Hygiene; 93; 8-2015; 334-339
0002-9637
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
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info:eu-repo/semantics/altIdentifier/doi/10.4269/ajtmh.14-0267
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
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eu_rights_str_mv openAccess
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dc.format.none.fl_str_mv application/pdf
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dc.publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
publisher.none.fl_str_mv American Society of Tropical Medicine and Hygiene
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
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instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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