Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549

Autores
Silva, Izabella T.; Geller, Fabiana Cristina; Persich, Lara; Dudek, Sabine E.; Lang, Karen L.; Caro, Miguel S. B.; Duran, Fernando Javier; Schenkel, Eloir P.; Ludwig, Stephan; Simoes, Cláudia M. O.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cucurbitacins and their derivatives are triterpenoids that are found in various plant families, and are known for their pharmacological and biological activities, including anti-cancer effects. Lung cancer represents a major public health problem, with non-small-cell lung cancer (NSCLC) being the most frequent and aggressive type of lung cancer. The objective of this work was to evaluate four cucurbitacins (CUCs) for their cytotoxic activity, effects on apoptosis induction, cell cycle progression, anti-migratory, and anti-invasive effects on the human NSCLC cell line (A549 cells). Our findings showed that these CUCs could suppress human NSCLC cell growth in vitro through their effects on the PI3Kinase and MAPK pathways, which lead to programmed cell death induction, as well as inhibition of cell migration and cell invasion. Additionally, these effects culminate in apoptosis induction and G2/M cell cycle arrest by modulating cyclin B1 expression, and in the mitigation of strategic steps of lung cancer metastasis, including migration and invasion of A549 cells. These results suggest that two natural (DDCB and CB) and two novel semisynthetic derivatives of cucurbitacin B (ACB and DBCB) could be considered as promising compounds with antitumor potential.
Fil: Silva, Izabella T.. Universidade Federal Da Santa Catarina; Brasil
Fil: Geller, Fabiana Cristina. Universidade Federal Da Santa Catarina; Brasil
Fil: Persich, Lara. Universidade Federal Da Santa Catarina; Brasil
Fil: Dudek, Sabine E.. Westfalische Wilhelms Universitat; Alemania
Fil: Lang, Karen L.. Universidade Federal Da Santa Catarina; Brasil
Fil: Caro, Miguel S. B.. Universidade Federal Da Santa Catarina; Brasil
Fil: Duran, Fernando Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Schenkel, Eloir P.. Universidade Federal Da Santa Catarina; Brasil
Fil: Ludwig, Stephan. Westfalische Wilhelms Universitat; Alemania
Fil: Simoes, Cláudia M. O.. Universidade Federal Da Santa Catarina; Brasil
Materia
Cucurbitacinas
Apoptosis
Invasion
Metastasis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/18721
Acceder
id CONICETDig_2eac450c7d63a9d0a6644ecb845050bc
oai_identifier_str oai:ri.conicet.gov.ar:11336/18721
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549Silva, Izabella T.Geller, Fabiana CristinaPersich, LaraDudek, Sabine E.Lang, Karen L.Caro, Miguel S. B.Duran, Fernando JavierSchenkel, Eloir P.Ludwig, StephanSimoes, Cláudia M. O.CucurbitacinasApoptosisInvasionMetastasishttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Cucurbitacins and their derivatives are triterpenoids that are found in various plant families, and are known for their pharmacological and biological activities, including anti-cancer effects. Lung cancer represents a major public health problem, with non-small-cell lung cancer (NSCLC) being the most frequent and aggressive type of lung cancer. The objective of this work was to evaluate four cucurbitacins (CUCs) for their cytotoxic activity, effects on apoptosis induction, cell cycle progression, anti-migratory, and anti-invasive effects on the human NSCLC cell line (A549 cells). Our findings showed that these CUCs could suppress human NSCLC cell growth in vitro through their effects on the PI3Kinase and MAPK pathways, which lead to programmed cell death induction, as well as inhibition of cell migration and cell invasion. Additionally, these effects culminate in apoptosis induction and G2/M cell cycle arrest by modulating cyclin B1 expression, and in the mitigation of strategic steps of lung cancer metastasis, including migration and invasion of A549 cells. These results suggest that two natural (DDCB and CB) and two novel semisynthetic derivatives of cucurbitacin B (ACB and DBCB) could be considered as promising compounds with antitumor potential.Fil: Silva, Izabella T.. Universidade Federal Da Santa Catarina; BrasilFil: Geller, Fabiana Cristina. Universidade Federal Da Santa Catarina; BrasilFil: Persich, Lara. Universidade Federal Da Santa Catarina; BrasilFil: Dudek, Sabine E.. Westfalische Wilhelms Universitat; AlemaniaFil: Lang, Karen L.. Universidade Federal Da Santa Catarina; BrasilFil: Caro, Miguel S. B.. Universidade Federal Da Santa Catarina; BrasilFil: Duran, Fernando Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; ArgentinaFil: Schenkel, Eloir P.. Universidade Federal Da Santa Catarina; BrasilFil: Ludwig, Stephan. Westfalische Wilhelms Universitat; AlemaniaFil: Simoes, Cláudia M. O.. Universidade Federal Da Santa Catarina; BrasilSpringer2016-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/18721Silva, Izabella T.; Geller, Fabiana Cristina; Persich, Lara; Dudek, Sabine E.; Lang, Karen L.; et al.; Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549; Springer; Investigational New Drugs; 34; 2; 4-2016; 139-1480167-69971573-0646CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s10637-015-0317-4info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10637-015-0317-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:39:37Zoai:ri.conicet.gov.ar:11336/18721instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:39:38.26CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549
title Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549
spellingShingle Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549
Silva, Izabella T.
Cucurbitacinas
Apoptosis
Invasion
Metastasis
title_short Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549
title_full Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549
title_fullStr Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549
title_full_unstemmed Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549
title_sort Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549
dc.creator.none.fl_str_mv Silva, Izabella T.
Geller, Fabiana Cristina
Persich, Lara
Dudek, Sabine E.
Lang, Karen L.
Caro, Miguel S. B.
Duran, Fernando Javier
Schenkel, Eloir P.
Ludwig, Stephan
Simoes, Cláudia M. O.
author Silva, Izabella T.
author_facet Silva, Izabella T.
Geller, Fabiana Cristina
Persich, Lara
Dudek, Sabine E.
Lang, Karen L.
Caro, Miguel S. B.
Duran, Fernando Javier
Schenkel, Eloir P.
Ludwig, Stephan
Simoes, Cláudia M. O.
author_role author
author2 Geller, Fabiana Cristina
Persich, Lara
Dudek, Sabine E.
Lang, Karen L.
Caro, Miguel S. B.
Duran, Fernando Javier
Schenkel, Eloir P.
Ludwig, Stephan
Simoes, Cláudia M. O.
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Cucurbitacinas
Apoptosis
Invasion
Metastasis
topic Cucurbitacinas
Apoptosis
Invasion
Metastasis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cucurbitacins and their derivatives are triterpenoids that are found in various plant families, and are known for their pharmacological and biological activities, including anti-cancer effects. Lung cancer represents a major public health problem, with non-small-cell lung cancer (NSCLC) being the most frequent and aggressive type of lung cancer. The objective of this work was to evaluate four cucurbitacins (CUCs) for their cytotoxic activity, effects on apoptosis induction, cell cycle progression, anti-migratory, and anti-invasive effects on the human NSCLC cell line (A549 cells). Our findings showed that these CUCs could suppress human NSCLC cell growth in vitro through their effects on the PI3Kinase and MAPK pathways, which lead to programmed cell death induction, as well as inhibition of cell migration and cell invasion. Additionally, these effects culminate in apoptosis induction and G2/M cell cycle arrest by modulating cyclin B1 expression, and in the mitigation of strategic steps of lung cancer metastasis, including migration and invasion of A549 cells. These results suggest that two natural (DDCB and CB) and two novel semisynthetic derivatives of cucurbitacin B (ACB and DBCB) could be considered as promising compounds with antitumor potential.
Fil: Silva, Izabella T.. Universidade Federal Da Santa Catarina; Brasil
Fil: Geller, Fabiana Cristina. Universidade Federal Da Santa Catarina; Brasil
Fil: Persich, Lara. Universidade Federal Da Santa Catarina; Brasil
Fil: Dudek, Sabine E.. Westfalische Wilhelms Universitat; Alemania
Fil: Lang, Karen L.. Universidade Federal Da Santa Catarina; Brasil
Fil: Caro, Miguel S. B.. Universidade Federal Da Santa Catarina; Brasil
Fil: Duran, Fernando Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Unidad de Microanálisis y Métodos Físicos en Química Orgánica. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Unidad de Microanálisis y Métodos Físicos en Química Orgánica; Argentina
Fil: Schenkel, Eloir P.. Universidade Federal Da Santa Catarina; Brasil
Fil: Ludwig, Stephan. Westfalische Wilhelms Universitat; Alemania
Fil: Simoes, Cláudia M. O.. Universidade Federal Da Santa Catarina; Brasil
description Cucurbitacins and their derivatives are triterpenoids that are found in various plant families, and are known for their pharmacological and biological activities, including anti-cancer effects. Lung cancer represents a major public health problem, with non-small-cell lung cancer (NSCLC) being the most frequent and aggressive type of lung cancer. The objective of this work was to evaluate four cucurbitacins (CUCs) for their cytotoxic activity, effects on apoptosis induction, cell cycle progression, anti-migratory, and anti-invasive effects on the human NSCLC cell line (A549 cells). Our findings showed that these CUCs could suppress human NSCLC cell growth in vitro through their effects on the PI3Kinase and MAPK pathways, which lead to programmed cell death induction, as well as inhibition of cell migration and cell invasion. Additionally, these effects culminate in apoptosis induction and G2/M cell cycle arrest by modulating cyclin B1 expression, and in the mitigation of strategic steps of lung cancer metastasis, including migration and invasion of A549 cells. These results suggest that two natural (DDCB and CB) and two novel semisynthetic derivatives of cucurbitacin B (ACB and DBCB) could be considered as promising compounds with antitumor potential.
publishDate 2016
dc.date.none.fl_str_mv 2016-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/18721
Silva, Izabella T.; Geller, Fabiana Cristina; Persich, Lara; Dudek, Sabine E.; Lang, Karen L.; et al.; Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549; Springer; Investigational New Drugs; 34; 2; 4-2016; 139-148
0167-6997
1573-0646
CONICET Digital
CONICET
url http://hdl.handle.net/11336/18721
identifier_str_mv Silva, Izabella T.; Geller, Fabiana Cristina; Persich, Lara; Dudek, Sabine E.; Lang, Karen L.; et al.; Cytotoxic effects of natural and semisynthetic cucurbitacins on lung cancer cell line A549; Springer; Investigational New Drugs; 34; 2; 4-2016; 139-148
0167-6997
1573-0646
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s10637-015-0317-4
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs10637-015-0317-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613254519717888
score 13.070432

Publicaciones similares