A formal total synthesis of the marine alkaloid aaptamine
- Autores
- Larghi, Enrique Leandro; Obrist, Blaise V.; Kaufman, Teodoro Saul
- Año de publicación
- 2008
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A new strategy for the synthesis of benzo[de][1,6]naphthyridine derivative 2,3,3a,4,5,6-hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2,3,3a,4,5,6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural product.
Fil: Larghi, Enrique Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina
Fil: Obrist, Blaise V.. École Polytechnique Fédérale de Lausanne; Suiza
Fil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina - Materia
-
2,3,3A,4,5,6-HEXAHYDROAAPTAMINE
AAPTAMINE
BENZO[DE][1,6]NAPHTHYRIDINE ALKALOIDS
FORMAL TOTAL SYNTHESIS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/136903
Ver los metadatos del registro completo
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A formal total synthesis of the marine alkaloid aaptamineLarghi, Enrique LeandroObrist, Blaise V.Kaufman, Teodoro Saul2,3,3A,4,5,6-HEXAHYDROAAPTAMINEAAPTAMINEBENZO[DE][1,6]NAPHTHYRIDINE ALKALOIDSFORMAL TOTAL SYNTHESIShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A new strategy for the synthesis of benzo[de][1,6]naphthyridine derivative 2,3,3a,4,5,6-hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2,3,3a,4,5,6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural product.Fil: Larghi, Enrique Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaFil: Obrist, Blaise V.. École Polytechnique Fédérale de Lausanne; SuizaFil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; ArgentinaPergamon-Elsevier Science Ltd2008-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/136903Larghi, Enrique Leandro; Obrist, Blaise V.; Kaufman, Teodoro Saul; A formal total synthesis of the marine alkaloid aaptamine; Pergamon-Elsevier Science Ltd; Tetrahedron; 64; 22; 5-2008; 5236-52450040-4020CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0040402008005486info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tet.2008.03.036info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:40:51Zoai:ri.conicet.gov.ar:11336/136903instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:40:51.973CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
A formal total synthesis of the marine alkaloid aaptamine |
title |
A formal total synthesis of the marine alkaloid aaptamine |
spellingShingle |
A formal total synthesis of the marine alkaloid aaptamine Larghi, Enrique Leandro 2,3,3A,4,5,6-HEXAHYDROAAPTAMINE AAPTAMINE BENZO[DE][1,6]NAPHTHYRIDINE ALKALOIDS FORMAL TOTAL SYNTHESIS |
title_short |
A formal total synthesis of the marine alkaloid aaptamine |
title_full |
A formal total synthesis of the marine alkaloid aaptamine |
title_fullStr |
A formal total synthesis of the marine alkaloid aaptamine |
title_full_unstemmed |
A formal total synthesis of the marine alkaloid aaptamine |
title_sort |
A formal total synthesis of the marine alkaloid aaptamine |
dc.creator.none.fl_str_mv |
Larghi, Enrique Leandro Obrist, Blaise V. Kaufman, Teodoro Saul |
author |
Larghi, Enrique Leandro |
author_facet |
Larghi, Enrique Leandro Obrist, Blaise V. Kaufman, Teodoro Saul |
author_role |
author |
author2 |
Obrist, Blaise V. Kaufman, Teodoro Saul |
author2_role |
author author |
dc.subject.none.fl_str_mv |
2,3,3A,4,5,6-HEXAHYDROAAPTAMINE AAPTAMINE BENZO[DE][1,6]NAPHTHYRIDINE ALKALOIDS FORMAL TOTAL SYNTHESIS |
topic |
2,3,3A,4,5,6-HEXAHYDROAAPTAMINE AAPTAMINE BENZO[DE][1,6]NAPHTHYRIDINE ALKALOIDS FORMAL TOTAL SYNTHESIS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
A new strategy for the synthesis of benzo[de][1,6]naphthyridine derivative 2,3,3a,4,5,6-hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2,3,3a,4,5,6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural product. Fil: Larghi, Enrique Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina Fil: Obrist, Blaise V.. École Polytechnique Fédérale de Lausanne; Suiza Fil: Kaufman, Teodoro Saul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Química Rosario. Universidad Nacional de Rosario. Facultad de Ciencias Bioquímicas y Farmacéuticas. Instituto de Química Rosario; Argentina |
description |
A new strategy for the synthesis of benzo[de][1,6]naphthyridine derivative 2,3,3a,4,5,6-hexahydroaaptamine, which involves the construction of the isoquinoline ring after elaboration of the quinoline moiety, is described. Since 2,3,3a,4,5,6-hexahydroaaptamine has been previously synthesized as a key intermediate en route to the marine alkaloid aaptamine, access to this compound represents a formal total synthesis of the natural product. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/136903 Larghi, Enrique Leandro; Obrist, Blaise V.; Kaufman, Teodoro Saul; A formal total synthesis of the marine alkaloid aaptamine; Pergamon-Elsevier Science Ltd; Tetrahedron; 64; 22; 5-2008; 5236-5245 0040-4020 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/136903 |
identifier_str_mv |
Larghi, Enrique Leandro; Obrist, Blaise V.; Kaufman, Teodoro Saul; A formal total synthesis of the marine alkaloid aaptamine; Pergamon-Elsevier Science Ltd; Tetrahedron; 64; 22; 5-2008; 5236-5245 0040-4020 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0040402008005486 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.tet.2008.03.036 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
publisher.none.fl_str_mv |
Pergamon-Elsevier Science Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844614438057934848 |
score |
13.070432 |