Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth

Autores
Pizzolitto, Romina Paola; Barberis, Carla Lorena; Dambolena, Jose Sebastian; Herrera, Jimena María; Zunino, María Paula; Magnoli, Carina Elizabeth; Rubinstein, Héctor R.; Zygadlo, Julio Alberto; Dalcero, Ana Maria
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Considering the impact of Aspergillus species on crops, it appears to be highly desirable to apply strategies to prevent their growth, as well as to eliminate or reduce their presence in food products. For this reason, the aims of this investigation were to evaluate the effects of ten natural phenolic compounds on the Aspergillus parasiticus growth and to determine which physicochemical properties are involved in the antifungal activity. According to the results of minimum inhibitory concentration (MIC) values of the individual compounds, isoeugenol, carvacrol, and thymol were the most active phenolic components (1.26 mM, 1.47 mM,and 1.50 mM, resp.), followed by eugenol (2.23 mM). On the other hand, creosol, p-cresol, o-cresol, m-cresol, vanillin, and phenol had no effects on fungal development. Logarithm of the octanol/water partition coefficient (log P), refractivity index (RI), and molar volume (MV) were demonstrated to be the descriptors that best explained the antifungal activity correlated to lipophilicity, reactivity of the components, and steric aspect. These findings make an important contribution to the search for new compounds with antifungal activity
Fil: Pizzolitto, Romina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Barberis, Carla Lorena. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología E Inmunología; Argentina
Fil: Dambolena, Jose Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Herrera, Jimena María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Magnoli, Carina Elizabeth. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología E Inmunología. Cátedra de Micología; Argentina
Fil: Rubinstein, Héctor R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Bioquímica Clínica E Inmunología; Argentina
Fil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Dalcero, Ana Maria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología E Inmunología. Cátedra de Micología; Argentina
Materia
ASPERGILLUS PARASITICUS, , ,
NATURAL PHENOLIC COMPOUNDS
ESSENTIAL OILS
LIPOPHILICITY
MOLAR VOLUME
REFRACTIVITY INDEX
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/15759
Acceder
id CONICETDig_2c95d210ef54a3cac13c68aeba150ff1
oai_identifier_str oai:ri.conicet.gov.ar:11336/15759
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus GrowthPizzolitto, Romina PaolaBarberis, Carla LorenaDambolena, Jose SebastianHerrera, Jimena MaríaZunino, María PaulaMagnoli, Carina ElizabethRubinstein, Héctor R.Zygadlo, Julio AlbertoDalcero, Ana MariaASPERGILLUS PARASITICUS, , ,NATURAL PHENOLIC COMPOUNDSESSENTIAL OILSLIPOPHILICITYMOLAR VOLUMEREFRACTIVITY INDEXhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Considering the impact of Aspergillus species on crops, it appears to be highly desirable to apply strategies to prevent their growth, as well as to eliminate or reduce their presence in food products. For this reason, the aims of this investigation were to evaluate the effects of ten natural phenolic compounds on the Aspergillus parasiticus growth and to determine which physicochemical properties are involved in the antifungal activity. According to the results of minimum inhibitory concentration (MIC) values of the individual compounds, isoeugenol, carvacrol, and thymol were the most active phenolic components (1.26 mM, 1.47 mM,and 1.50 mM, resp.), followed by eugenol (2.23 mM). On the other hand, creosol, p-cresol, o-cresol, m-cresol, vanillin, and phenol had no effects on fungal development. Logarithm of the octanol/water partition coefficient (log P), refractivity index (RI), and molar volume (MV) were demonstrated to be the descriptors that best explained the antifungal activity correlated to lipophilicity, reactivity of the components, and steric aspect. These findings make an important contribution to the search for new compounds with antifungal activityFil: Pizzolitto, Romina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Barberis, Carla Lorena. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología E Inmunología; ArgentinaFil: Dambolena, Jose Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Herrera, Jimena María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Magnoli, Carina Elizabeth. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología E Inmunología. Cátedra de Micología; ArgentinaFil: Rubinstein, Héctor R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Bioquímica Clínica E Inmunología; ArgentinaFil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); ArgentinaFil: Dalcero, Ana Maria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología E Inmunología. Cátedra de Micología; ArgentinaHindawi Publishing Corporation2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/15759Pizzolitto, Romina Paola; Barberis, Carla Lorena; Dambolena, Jose Sebastian; Herrera, Jimena María; Zunino, María Paula; et al.; Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth; Hindawi Publishing Corporation; E-journal Of Chemistry; 2015; 3-2015; 7-140973-49452090-9810enginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jchem/2015/547925/info:eu-repo/semantics/altIdentifier/doi/10.1155/2015/547925info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:55:38Zoai:ri.conicet.gov.ar:11336/15759instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:55:39.163CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth
title Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth
spellingShingle Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth
Pizzolitto, Romina Paola
ASPERGILLUS PARASITICUS, , ,
NATURAL PHENOLIC COMPOUNDS
ESSENTIAL OILS
LIPOPHILICITY
MOLAR VOLUME
REFRACTIVITY INDEX
title_short Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth
title_full Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth
title_fullStr Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth
title_full_unstemmed Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth
title_sort Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth
dc.creator.none.fl_str_mv Pizzolitto, Romina Paola
Barberis, Carla Lorena
Dambolena, Jose Sebastian
Herrera, Jimena María
Zunino, María Paula
Magnoli, Carina Elizabeth
Rubinstein, Héctor R.
Zygadlo, Julio Alberto
Dalcero, Ana Maria
author Pizzolitto, Romina Paola
author_facet Pizzolitto, Romina Paola
Barberis, Carla Lorena
Dambolena, Jose Sebastian
Herrera, Jimena María
Zunino, María Paula
Magnoli, Carina Elizabeth
Rubinstein, Héctor R.
Zygadlo, Julio Alberto
Dalcero, Ana Maria
author_role author
author2 Barberis, Carla Lorena
Dambolena, Jose Sebastian
Herrera, Jimena María
Zunino, María Paula
Magnoli, Carina Elizabeth
Rubinstein, Héctor R.
Zygadlo, Julio Alberto
Dalcero, Ana Maria
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ASPERGILLUS PARASITICUS, , ,
NATURAL PHENOLIC COMPOUNDS
ESSENTIAL OILS
LIPOPHILICITY
MOLAR VOLUME
REFRACTIVITY INDEX
topic ASPERGILLUS PARASITICUS, , ,
NATURAL PHENOLIC COMPOUNDS
ESSENTIAL OILS
LIPOPHILICITY
MOLAR VOLUME
REFRACTIVITY INDEX
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Considering the impact of Aspergillus species on crops, it appears to be highly desirable to apply strategies to prevent their growth, as well as to eliminate or reduce their presence in food products. For this reason, the aims of this investigation were to evaluate the effects of ten natural phenolic compounds on the Aspergillus parasiticus growth and to determine which physicochemical properties are involved in the antifungal activity. According to the results of minimum inhibitory concentration (MIC) values of the individual compounds, isoeugenol, carvacrol, and thymol were the most active phenolic components (1.26 mM, 1.47 mM,and 1.50 mM, resp.), followed by eugenol (2.23 mM). On the other hand, creosol, p-cresol, o-cresol, m-cresol, vanillin, and phenol had no effects on fungal development. Logarithm of the octanol/water partition coefficient (log P), refractivity index (RI), and molar volume (MV) were demonstrated to be the descriptors that best explained the antifungal activity correlated to lipophilicity, reactivity of the components, and steric aspect. These findings make an important contribution to the search for new compounds with antifungal activity
Fil: Pizzolitto, Romina Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Barberis, Carla Lorena. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología E Inmunología; Argentina
Fil: Dambolena, Jose Sebastian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Herrera, Jimena María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Zunino, María Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Magnoli, Carina Elizabeth. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología E Inmunología. Cátedra de Micología; Argentina
Fil: Rubinstein, Héctor R.. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Centro de Investigaciones En Bioquímica Clínica E Inmunología; Argentina
Fil: Zygadlo, Julio Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Córdoba. Instituto Multidisciplinario de Biología Vegetal (p); Argentina
Fil: Dalcero, Ana Maria. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas, Fisicoquímicas y Naturales. Departamento de Microbiología E Inmunología. Cátedra de Micología; Argentina
description Considering the impact of Aspergillus species on crops, it appears to be highly desirable to apply strategies to prevent their growth, as well as to eliminate or reduce their presence in food products. For this reason, the aims of this investigation were to evaluate the effects of ten natural phenolic compounds on the Aspergillus parasiticus growth and to determine which physicochemical properties are involved in the antifungal activity. According to the results of minimum inhibitory concentration (MIC) values of the individual compounds, isoeugenol, carvacrol, and thymol were the most active phenolic components (1.26 mM, 1.47 mM,and 1.50 mM, resp.), followed by eugenol (2.23 mM). On the other hand, creosol, p-cresol, o-cresol, m-cresol, vanillin, and phenol had no effects on fungal development. Logarithm of the octanol/water partition coefficient (log P), refractivity index (RI), and molar volume (MV) were demonstrated to be the descriptors that best explained the antifungal activity correlated to lipophilicity, reactivity of the components, and steric aspect. These findings make an important contribution to the search for new compounds with antifungal activity
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/15759
Pizzolitto, Romina Paola; Barberis, Carla Lorena; Dambolena, Jose Sebastian; Herrera, Jimena María; Zunino, María Paula; et al.; Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth; Hindawi Publishing Corporation; E-journal Of Chemistry; 2015; 3-2015; 7-14
0973-4945
2090-9810
url http://hdl.handle.net/11336/15759
identifier_str_mv Pizzolitto, Romina Paola; Barberis, Carla Lorena; Dambolena, Jose Sebastian; Herrera, Jimena María; Zunino, María Paula; et al.; Inhibitory Effect of Natural Phenolic Compounds on Aspergillus parasiticus Growth; Hindawi Publishing Corporation; E-journal Of Chemistry; 2015; 3-2015; 7-14
0973-4945
2090-9810
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/jchem/2015/547925/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2015/547925
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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