Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multic...

Autores
Hibberd, Patricia L.; Hansen, Nellie I.; Wang, Marie E.; Goudar, Shivaprasad S.; Pasha, Omrana; Esamai, Fabian; Chomba, Elwyn; Garces, Ana; Althabe, Fernando; Derman, Richard J.; Goldenberg, Robert L.; Liechty, Edward A.; Carlo, Waldemar A.; Hambidge, K. Michael; Krebs, Nancy F.; Buekens, Pierre; McClure, Elizabeth M.; Koso Thomas, Marion; Patel, Archana B.
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: Possible severe bacterial infections (pSBI) continue to be a leading cause of global neonatal mortality annually. With the recent publications of simplified antibiotic regimens for treatment of pSBI where referral is not possible, it is important to know how and where to target these regimens, but data on the incidence and outcomes of pSBI are limited. METHODS: We used data prospectively collected at 7 rural community-based sites in 6 low and middle income countries participating in the NICHD Global Network's Maternal and Newborn Health Registry, between January 1, 2010 and December 31, 2013. Participants included pregnant women and their live born neonates followed for 6 weeks after delivery and assessed for maternal and infant outcomes. RESULTS: In a cohort of 248,539 infants born alive between 2010 and 2013, 32,088 (13 %) neonates met symptomatic criteria for pSBI. The incidence of pSBI during the first 6 weeks of life varied 10 fold from 3 % (Zambia) to 36 % (Pakistan), and overall case fatality rates varied 8 fold from 5 % (Kenya) to 42 % (Zambia). Significant variations in incidence of pSBI during the study period, with proportions decreasing in 3 sites (Argentina, Kenya and Nagpur, India), remaining stable in 3 sites (Zambia, Guatemala, Belgaum, India) and increasing in 1 site (Pakistan), cannot be explained solely by changing rates of facility deliveries. Case fatality rates did not vary over time. CONCLUSIONS: In a prospective population based registry with trained data collectors, there were wide variations in the incidence and case fatality of pSBI in rural communities and in trends over time. Regardless of these variations, the burden of pSBI is still high and strategies to implement timely diagnosis and treatment are still urgently needed to reduce neonatal mortality.
Fil: Hibberd, Patricia L.. Massachusetts General Hospital for Children; Estados Unidos
Fil: Hansen, Nellie I.. Research Triangle Park. RTI International; Estados Unidos
Fil: Wang, Marie E.. Massachusetts General Hospital for Children; Estados Unidos
Fil: Goudar, Shivaprasad S.. Jawaharlal Nehru Medical College; India
Fil: Pasha, Omrana. Aga Khan University; Pakistán
Fil: Esamai, Fabian. Moi University; Kenia
Fil: Chomba, Elwyn. University of Zambia; Zambia
Fil: Garces, Ana. Instituto de Nutrición de Centro América y Panamá; Guatemala
Fil: Althabe, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Derman, Richard J.. Christiana Health Care; Estados Unidos
Fil: Goldenberg, Robert L.. Columbia University; Estados Unidos
Fil: Liechty, Edward A.. Indiana University; Estados Unidos
Fil: Carlo, Waldemar A.. University of Alabama at Birmingahm; Estados Unidos
Fil: Hambidge, K. Michael. University of Colorado. Health Sciences Center; Argentina
Fil: Krebs, Nancy F.. University of Colorado. Health Sciences Center; Argentina
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
Fil: McClure, Elizabeth M.. Research Triangle Park. RTI International; Estados Unidos
Fil: Koso Thomas, Marion. Eunice Kennedy Shriver National Institute of Child Health and Human Development; Estados Unidos
Fil: Patel, Archana B.. Lata Medical Research Foundation; India
Materia
Neonatal sepsis
Rural communities
Low middle income countries
Possible severe bacterial infections
Incidence of neonatal sepsis
Case fatality rates from neonatal sepsis
Global health
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/45253
Acceder
id CONICETDig_2be4f5b1d9ed2977cbebced7625a2482
oai_identifier_str oai:ri.conicet.gov.ar:11336/45253
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort studyHibberd, Patricia L.Hansen, Nellie I.Wang, Marie E.Goudar, Shivaprasad S.Pasha, OmranaEsamai, FabianChomba, ElwynGarces, AnaAlthabe, FernandoDerman, Richard J.Goldenberg, Robert L.Liechty, Edward A.Carlo, Waldemar A.Hambidge, K. MichaelKrebs, Nancy F.Buekens, PierreMcClure, Elizabeth M.Koso Thomas, MarionPatel, Archana B.Neonatal sepsisRural communitiesLow middle income countriesPossible severe bacterial infectionsIncidence of neonatal sepsisCase fatality rates from neonatal sepsisGlobal healthhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3BACKGROUND: Possible severe bacterial infections (pSBI) continue to be a leading cause of global neonatal mortality annually. With the recent publications of simplified antibiotic regimens for treatment of pSBI where referral is not possible, it is important to know how and where to target these regimens, but data on the incidence and outcomes of pSBI are limited. METHODS: We used data prospectively collected at 7 rural community-based sites in 6 low and middle income countries participating in the NICHD Global Network's Maternal and Newborn Health Registry, between January 1, 2010 and December 31, 2013. Participants included pregnant women and their live born neonates followed for 6 weeks after delivery and assessed for maternal and infant outcomes. RESULTS: In a cohort of 248,539 infants born alive between 2010 and 2013, 32,088 (13 %) neonates met symptomatic criteria for pSBI. The incidence of pSBI during the first 6 weeks of life varied 10 fold from 3 % (Zambia) to 36 % (Pakistan), and overall case fatality rates varied 8 fold from 5 % (Kenya) to 42 % (Zambia). Significant variations in incidence of pSBI during the study period, with proportions decreasing in 3 sites (Argentina, Kenya and Nagpur, India), remaining stable in 3 sites (Zambia, Guatemala, Belgaum, India) and increasing in 1 site (Pakistan), cannot be explained solely by changing rates of facility deliveries. Case fatality rates did not vary over time. CONCLUSIONS: In a prospective population based registry with trained data collectors, there were wide variations in the incidence and case fatality of pSBI in rural communities and in trends over time. Regardless of these variations, the burden of pSBI is still high and strategies to implement timely diagnosis and treatment are still urgently needed to reduce neonatal mortality.Fil: Hibberd, Patricia L.. Massachusetts General Hospital for Children; Estados UnidosFil: Hansen, Nellie I.. Research Triangle Park. RTI International; Estados UnidosFil: Wang, Marie E.. Massachusetts General Hospital for Children; Estados UnidosFil: Goudar, Shivaprasad S.. Jawaharlal Nehru Medical College; IndiaFil: Pasha, Omrana. Aga Khan University; PakistánFil: Esamai, Fabian. Moi University; KeniaFil: Chomba, Elwyn. University of Zambia; ZambiaFil: Garces, Ana. Instituto de Nutrición de Centro América y Panamá; GuatemalaFil: Althabe, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Derman, Richard J.. Christiana Health Care; Estados UnidosFil: Goldenberg, Robert L.. Columbia University; Estados UnidosFil: Liechty, Edward A.. Indiana University; Estados UnidosFil: Carlo, Waldemar A.. University of Alabama at Birmingahm; Estados UnidosFil: Hambidge, K. Michael. University of Colorado. Health Sciences Center; ArgentinaFil: Krebs, Nancy F.. University of Colorado. Health Sciences Center; ArgentinaFil: Buekens, Pierre. University of Tulane; Estados UnidosFil: McClure, Elizabeth M.. Research Triangle Park. RTI International; Estados UnidosFil: Koso Thomas, Marion. Eunice Kennedy Shriver National Institute of Child Health and Human Development; Estados UnidosFil: Patel, Archana B.. Lata Medical Research Foundation; IndiaBioMed Central2016-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/45253Hibberd, Patricia L.; Hansen, Nellie I.; Wang, Marie E.; Goudar, Shivaprasad S.; Pasha, Omrana; et al.; Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study; BioMed Central; Reproductive Health Matters (print); 65; 5-2016; 1-131742-4755CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1186/s12978-016-0177-1info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877736/info:eu-repo/semantics/altIdentifier/url/https://reproductive-health-journal.biomedcentral.com/articles/10.1186/s12978-016-0177-1info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:07:46Zoai:ri.conicet.gov.ar:11336/45253instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:07:46.454CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study
title Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study
spellingShingle Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study
Hibberd, Patricia L.
Neonatal sepsis
Rural communities
Low middle income countries
Possible severe bacterial infections
Incidence of neonatal sepsis
Case fatality rates from neonatal sepsis
Global health
title_short Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study
title_full Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study
title_fullStr Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study
title_full_unstemmed Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study
title_sort Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study
dc.creator.none.fl_str_mv Hibberd, Patricia L.
Hansen, Nellie I.
Wang, Marie E.
Goudar, Shivaprasad S.
Pasha, Omrana
Esamai, Fabian
Chomba, Elwyn
Garces, Ana
Althabe, Fernando
Derman, Richard J.
Goldenberg, Robert L.
Liechty, Edward A.
Carlo, Waldemar A.
Hambidge, K. Michael
Krebs, Nancy F.
Buekens, Pierre
McClure, Elizabeth M.
Koso Thomas, Marion
Patel, Archana B.
author Hibberd, Patricia L.
author_facet Hibberd, Patricia L.
Hansen, Nellie I.
Wang, Marie E.
Goudar, Shivaprasad S.
Pasha, Omrana
Esamai, Fabian
Chomba, Elwyn
Garces, Ana
Althabe, Fernando
Derman, Richard J.
Goldenberg, Robert L.
Liechty, Edward A.
Carlo, Waldemar A.
Hambidge, K. Michael
Krebs, Nancy F.
Buekens, Pierre
McClure, Elizabeth M.
Koso Thomas, Marion
Patel, Archana B.
author_role author
author2 Hansen, Nellie I.
Wang, Marie E.
Goudar, Shivaprasad S.
Pasha, Omrana
Esamai, Fabian
Chomba, Elwyn
Garces, Ana
Althabe, Fernando
Derman, Richard J.
Goldenberg, Robert L.
Liechty, Edward A.
Carlo, Waldemar A.
Hambidge, K. Michael
Krebs, Nancy F.
Buekens, Pierre
McClure, Elizabeth M.
Koso Thomas, Marion
Patel, Archana B.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Neonatal sepsis
Rural communities
Low middle income countries
Possible severe bacterial infections
Incidence of neonatal sepsis
Case fatality rates from neonatal sepsis
Global health
topic Neonatal sepsis
Rural communities
Low middle income countries
Possible severe bacterial infections
Incidence of neonatal sepsis
Case fatality rates from neonatal sepsis
Global health
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUND: Possible severe bacterial infections (pSBI) continue to be a leading cause of global neonatal mortality annually. With the recent publications of simplified antibiotic regimens for treatment of pSBI where referral is not possible, it is important to know how and where to target these regimens, but data on the incidence and outcomes of pSBI are limited. METHODS: We used data prospectively collected at 7 rural community-based sites in 6 low and middle income countries participating in the NICHD Global Network's Maternal and Newborn Health Registry, between January 1, 2010 and December 31, 2013. Participants included pregnant women and their live born neonates followed for 6 weeks after delivery and assessed for maternal and infant outcomes. RESULTS: In a cohort of 248,539 infants born alive between 2010 and 2013, 32,088 (13 %) neonates met symptomatic criteria for pSBI. The incidence of pSBI during the first 6 weeks of life varied 10 fold from 3 % (Zambia) to 36 % (Pakistan), and overall case fatality rates varied 8 fold from 5 % (Kenya) to 42 % (Zambia). Significant variations in incidence of pSBI during the study period, with proportions decreasing in 3 sites (Argentina, Kenya and Nagpur, India), remaining stable in 3 sites (Zambia, Guatemala, Belgaum, India) and increasing in 1 site (Pakistan), cannot be explained solely by changing rates of facility deliveries. Case fatality rates did not vary over time. CONCLUSIONS: In a prospective population based registry with trained data collectors, there were wide variations in the incidence and case fatality of pSBI in rural communities and in trends over time. Regardless of these variations, the burden of pSBI is still high and strategies to implement timely diagnosis and treatment are still urgently needed to reduce neonatal mortality.
Fil: Hibberd, Patricia L.. Massachusetts General Hospital for Children; Estados Unidos
Fil: Hansen, Nellie I.. Research Triangle Park. RTI International; Estados Unidos
Fil: Wang, Marie E.. Massachusetts General Hospital for Children; Estados Unidos
Fil: Goudar, Shivaprasad S.. Jawaharlal Nehru Medical College; India
Fil: Pasha, Omrana. Aga Khan University; Pakistán
Fil: Esamai, Fabian. Moi University; Kenia
Fil: Chomba, Elwyn. University of Zambia; Zambia
Fil: Garces, Ana. Instituto de Nutrición de Centro América y Panamá; Guatemala
Fil: Althabe, Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Derman, Richard J.. Christiana Health Care; Estados Unidos
Fil: Goldenberg, Robert L.. Columbia University; Estados Unidos
Fil: Liechty, Edward A.. Indiana University; Estados Unidos
Fil: Carlo, Waldemar A.. University of Alabama at Birmingahm; Estados Unidos
Fil: Hambidge, K. Michael. University of Colorado. Health Sciences Center; Argentina
Fil: Krebs, Nancy F.. University of Colorado. Health Sciences Center; Argentina
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
Fil: McClure, Elizabeth M.. Research Triangle Park. RTI International; Estados Unidos
Fil: Koso Thomas, Marion. Eunice Kennedy Shriver National Institute of Child Health and Human Development; Estados Unidos
Fil: Patel, Archana B.. Lata Medical Research Foundation; India
description BACKGROUND: Possible severe bacterial infections (pSBI) continue to be a leading cause of global neonatal mortality annually. With the recent publications of simplified antibiotic regimens for treatment of pSBI where referral is not possible, it is important to know how and where to target these regimens, but data on the incidence and outcomes of pSBI are limited. METHODS: We used data prospectively collected at 7 rural community-based sites in 6 low and middle income countries participating in the NICHD Global Network's Maternal and Newborn Health Registry, between January 1, 2010 and December 31, 2013. Participants included pregnant women and their live born neonates followed for 6 weeks after delivery and assessed for maternal and infant outcomes. RESULTS: In a cohort of 248,539 infants born alive between 2010 and 2013, 32,088 (13 %) neonates met symptomatic criteria for pSBI. The incidence of pSBI during the first 6 weeks of life varied 10 fold from 3 % (Zambia) to 36 % (Pakistan), and overall case fatality rates varied 8 fold from 5 % (Kenya) to 42 % (Zambia). Significant variations in incidence of pSBI during the study period, with proportions decreasing in 3 sites (Argentina, Kenya and Nagpur, India), remaining stable in 3 sites (Zambia, Guatemala, Belgaum, India) and increasing in 1 site (Pakistan), cannot be explained solely by changing rates of facility deliveries. Case fatality rates did not vary over time. CONCLUSIONS: In a prospective population based registry with trained data collectors, there were wide variations in the incidence and case fatality of pSBI in rural communities and in trends over time. Regardless of these variations, the burden of pSBI is still high and strategies to implement timely diagnosis and treatment are still urgently needed to reduce neonatal mortality.
publishDate 2016
dc.date.none.fl_str_mv 2016-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/45253
Hibberd, Patricia L.; Hansen, Nellie I.; Wang, Marie E.; Goudar, Shivaprasad S.; Pasha, Omrana; et al.; Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study; BioMed Central; Reproductive Health Matters (print); 65; 5-2016; 1-13
1742-4755
CONICET Digital
CONICET
url http://hdl.handle.net/11336/45253
identifier_str_mv Hibberd, Patricia L.; Hansen, Nellie I.; Wang, Marie E.; Goudar, Shivaprasad S.; Pasha, Omrana; et al.; Trends in the incidence of possible severe bacterial infection and case fatality rates in rural communities in Sub-Saharan Africa, South Asia and Latin America, 2010-2013: a multicenter prospective cohort study; BioMed Central; Reproductive Health Matters (print); 65; 5-2016; 1-13
1742-4755
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1186/s12978-016-0177-1
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4877736/
info:eu-repo/semantics/altIdentifier/url/https://reproductive-health-journal.biomedcentral.com/articles/10.1186/s12978-016-0177-1
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv BioMed Central
publisher.none.fl_str_mv BioMed Central
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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