Autophagic clearance of bacterial pathogens: molecular recognition of intracellular microorganisms

Authors
Mansilla Pareja, MARIA EUGENIA; Colombo, Maria Isabel
Publication Year
2013
Language
English
Format
article
Status
Published version
Description
Autophagy is involved in several physiological and pathological processes. One of the key roles of the autophagic pathway is to participate in the first line of defense against the invasion of pathogens, as part of the innate immune response. Targeting of intracellular bacteria by the autophagic machinery, either in the cytoplasm or within vacuolar compartments, helps to control bacterial proliferation in the host cell, controlling also the spreading of the infection. In this review we will describe the means used by diverse bacterial pathogens to survive intracellularly and how they are recognized by the autophagic molecular machinery, as well as the mechanisms used to avoid autophagic clearance.
Fil: Mansilla Pareja, MARIA EUGENIA. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "dr. M. Burgos"; Argentina
Fil: Colombo, Maria Isabel. Consejo Nacional de Investigaciones Cientiâ­ficas y Tecnicas. Centro Cientifico Tecnologico Mendoza. Instituto Histologia y Embriologia de Mendoza "dr. M. Burgos"; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Médicas; Argentina
Subject
AUTOPHAGY
INTRACELLULAR BACTERIA
PATHOGENS
PHAGOCYTOSIS
INTRACELLULAR PAHTOGENS
RECOGNITION
XENOPHAGY
Enfermedades Infecciosas
Ciencias de la Salud
CIENCIAS MÉDICAS Y DE LA SALUD
Access level
Open access
License
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repository
CONICET Digital (CONICET)
Institution
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identifier
oai:ri.conicet.gov.ar:11336/9830