Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain

Autores
Zanin, Juan Pablo; Unsain, Nicolas; Anastasia Gonzalez, Agustin
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Most growth factors and hormones are synthesized as pre-pro-proteins which are processed to the biologically active mature protein. The pre- and prodomains are cleaved from the precursor protein in the secretory pathway or, in some cases, extracellularly. The canonical functions of these prodomains are to assist in folding and stabilization of the mature domain, to direct intra and extracellular localization, to facilitate storage, and to regulate bioavailability of their mature counterpart. Recently, exciting evidence has revealed that prodomains of certain growth factors, after cleaved from the precursor pro-protein, can act as independent active signaling molecules. In this review, we discuss the various classical functions of prodomains, and the biological consequences of these pro-peptides acting as ligands. We will focus our attention on the brain-derived neurotrophic factor prodomain (pBDNF), which has been recently described as a novel secreted ligand influencing neuronal morphology and physiology.
Fil: Zanin, Juan Pablo. Rutgers University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Unsain, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet -Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.; Argentina
Fil: Anastasia Gonzalez, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Materia
Active Prodomains
Biosynthetic Pathway
Pbdnf
Precursor Cleavage Peptides
Probdnf
Val66met Polymorphism
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/63518
Acceder
id CONICETDig_29f1f826203e9bd8acca136b8bbb33af
oai_identifier_str oai:ri.conicet.gov.ar:11336/63518
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomainZanin, Juan PabloUnsain, NicolasAnastasia Gonzalez, AgustinActive ProdomainsBiosynthetic PathwayPbdnfPrecursor Cleavage PeptidesProbdnfVal66met Polymorphismhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Most growth factors and hormones are synthesized as pre-pro-proteins which are processed to the biologically active mature protein. The pre- and prodomains are cleaved from the precursor protein in the secretory pathway or, in some cases, extracellularly. The canonical functions of these prodomains are to assist in folding and stabilization of the mature domain, to direct intra and extracellular localization, to facilitate storage, and to regulate bioavailability of their mature counterpart. Recently, exciting evidence has revealed that prodomains of certain growth factors, after cleaved from the precursor pro-protein, can act as independent active signaling molecules. In this review, we discuss the various classical functions of prodomains, and the biological consequences of these pro-peptides acting as ligands. We will focus our attention on the brain-derived neurotrophic factor prodomain (pBDNF), which has been recently described as a novel secreted ligand influencing neuronal morphology and physiology.Fil: Zanin, Juan Pablo. Rutgers University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Unsain, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet -Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.; ArgentinaFil: Anastasia Gonzalez, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaWiley Blackwell Publishing, Inc2017-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/63518Zanin, Juan Pablo; Unsain, Nicolas; Anastasia Gonzalez, Agustin; Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 141; 3; 5-2017; 330-3400022-30421471-4159CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/jnc.13993info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.13993info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:52Zoai:ri.conicet.gov.ar:11336/63518instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:53.892CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain
title Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain
spellingShingle Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain
Zanin, Juan Pablo
Active Prodomains
Biosynthetic Pathway
Pbdnf
Precursor Cleavage Peptides
Probdnf
Val66met Polymorphism
title_short Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain
title_full Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain
title_fullStr Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain
title_full_unstemmed Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain
title_sort Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain
dc.creator.none.fl_str_mv Zanin, Juan Pablo
Unsain, Nicolas
Anastasia Gonzalez, Agustin
author Zanin, Juan Pablo
author_facet Zanin, Juan Pablo
Unsain, Nicolas
Anastasia Gonzalez, Agustin
author_role author
author2 Unsain, Nicolas
Anastasia Gonzalez, Agustin
author2_role author
author
dc.subject.none.fl_str_mv Active Prodomains
Biosynthetic Pathway
Pbdnf
Precursor Cleavage Peptides
Probdnf
Val66met Polymorphism
topic Active Prodomains
Biosynthetic Pathway
Pbdnf
Precursor Cleavage Peptides
Probdnf
Val66met Polymorphism
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Most growth factors and hormones are synthesized as pre-pro-proteins which are processed to the biologically active mature protein. The pre- and prodomains are cleaved from the precursor protein in the secretory pathway or, in some cases, extracellularly. The canonical functions of these prodomains are to assist in folding and stabilization of the mature domain, to direct intra and extracellular localization, to facilitate storage, and to regulate bioavailability of their mature counterpart. Recently, exciting evidence has revealed that prodomains of certain growth factors, after cleaved from the precursor pro-protein, can act as independent active signaling molecules. In this review, we discuss the various classical functions of prodomains, and the biological consequences of these pro-peptides acting as ligands. We will focus our attention on the brain-derived neurotrophic factor prodomain (pBDNF), which has been recently described as a novel secreted ligand influencing neuronal morphology and physiology.
Fil: Zanin, Juan Pablo. Rutgers University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Unsain, Nicolas. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet -Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina.; Argentina
Fil: Anastasia Gonzalez, Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
description Most growth factors and hormones are synthesized as pre-pro-proteins which are processed to the biologically active mature protein. The pre- and prodomains are cleaved from the precursor protein in the secretory pathway or, in some cases, extracellularly. The canonical functions of these prodomains are to assist in folding and stabilization of the mature domain, to direct intra and extracellular localization, to facilitate storage, and to regulate bioavailability of their mature counterpart. Recently, exciting evidence has revealed that prodomains of certain growth factors, after cleaved from the precursor pro-protein, can act as independent active signaling molecules. In this review, we discuss the various classical functions of prodomains, and the biological consequences of these pro-peptides acting as ligands. We will focus our attention on the brain-derived neurotrophic factor prodomain (pBDNF), which has been recently described as a novel secreted ligand influencing neuronal morphology and physiology.
publishDate 2017
dc.date.none.fl_str_mv 2017-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/63518
Zanin, Juan Pablo; Unsain, Nicolas; Anastasia Gonzalez, Agustin; Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 141; 3; 5-2017; 330-340
0022-3042
1471-4159
CONICET Digital
CONICET
url http://hdl.handle.net/11336/63518
identifier_str_mv Zanin, Juan Pablo; Unsain, Nicolas; Anastasia Gonzalez, Agustin; Growth factors and hormones pro-peptides: the unexpected adventures of the BDNF prodomain; Wiley Blackwell Publishing, Inc; Journal of Neurochemistry; 141; 3; 5-2017; 330-340
0022-3042
1471-4159
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/jnc.13993
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1111/jnc.13993
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
publisher.none.fl_str_mv Wiley Blackwell Publishing, Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269880771936256
score 13.13397

Publicaciones similares