Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes

Autores
Bobillo, Maria Cecilia; Navoni, Julio A.; Olmos, Valentina; Merini, Luciano Jose; Villaamil Lepori, Edda; Corach, Daniel
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Because the ratio between the two major arsenic metabolites is related to the adverse health effects of arsenic, numerous studies have been performed to establish a relationship between the ability to metabolically detoxify arsenic and other variables, including exposure level, gender, age and ethnicity. Because ethnicity may play a key role and provide relevant information for heterogeneous populations, we characterized a group of 70 children from rural schools in the Argentinean provinces of Chaco and Santiago del Estero who were exposed to high levels of arsenic. We used genetic markers for maternal, paternal and bi-parental ancestry to achieve this goal. Our results demonstrate that the Amerindian maternal linages are present in 100% of the samples, whereas the Amerindian component transmitted through the paternal line is less than 10%. Informative markers for autosomal ancestry show a predominantly European ancestry, in which 37% of the samples contained between 90 and 99% European ancestry. The native American component ranged from 50 to 80% in 15.7% of the samples, and in all but four samples, the African component was less than 10%. Correlation analysis demonstrated that the ethnicity and the ratio of the excreted arsenic metabolites monomethyl arsenic and dimethyl arsenic are not associated, dismissing a relationship between ethnic origin and differential metabolism.
Fil: Bobillo, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Navoni, Julio A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Olmos, Valentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Merini, Luciano Jose. Instituto Nacional de Tecnología Agropecuaria. Centro Regional la Pampa-San Luis. Estación Experimental Agropecuaria Anguil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villaamil Lepori, Edda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Arsenic
Children
Ethnic characterization
Ancestral informative markers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/16645
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processesBobillo, Maria CeciliaNavoni, Julio A.Olmos, ValentinaMerini, Luciano JoseVillaamil Lepori, EddaCorach, DanielArsenicChildrenEthnic characterizationAncestral informative markershttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Because the ratio between the two major arsenic metabolites is related to the adverse health effects of arsenic, numerous studies have been performed to establish a relationship between the ability to metabolically detoxify arsenic and other variables, including exposure level, gender, age and ethnicity. Because ethnicity may play a key role and provide relevant information for heterogeneous populations, we characterized a group of 70 children from rural schools in the Argentinean provinces of Chaco and Santiago del Estero who were exposed to high levels of arsenic. We used genetic markers for maternal, paternal and bi-parental ancestry to achieve this goal. Our results demonstrate that the Amerindian maternal linages are present in 100% of the samples, whereas the Amerindian component transmitted through the paternal line is less than 10%. Informative markers for autosomal ancestry show a predominantly European ancestry, in which 37% of the samples contained between 90 and 99% European ancestry. The native American component ranged from 50 to 80% in 15.7% of the samples, and in all but four samples, the African component was less than 10%. Correlation analysis demonstrated that the ethnicity and the ratio of the excreted arsenic metabolites monomethyl arsenic and dimethyl arsenic are not associated, dismissing a relationship between ethnic origin and differential metabolism.Fil: Bobillo, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Navoni, Julio A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Olmos, Valentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Merini, Luciano Jose. Instituto Nacional de Tecnología Agropecuaria. Centro Regional la Pampa-San Luis. Estación Experimental Agropecuaria Anguil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Villaamil Lepori, Edda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; ArgentinaFil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentinae-Century Publishing2014-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/16645Bobillo, Maria Cecilia; Navoni, Julio A.; Olmos, Valentina; Merini, Luciano Jose; Villaamil Lepori, Edda; et al.; Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes; e-Century Publishing; International Journal of Molecular Epidemiology and Genetics; 5; 1; 1-2014; 1-101948-1756enginfo:eu-repo/semantics/altIdentifier/url/http://www.ijmeg.org/IJMEG_V5N1.htmlinfo:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939002/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:09:45Zoai:ri.conicet.gov.ar:11336/16645instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:09:46.118CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes
title Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes
spellingShingle Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes
Bobillo, Maria Cecilia
Arsenic
Children
Ethnic characterization
Ancestral informative markers
title_short Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes
title_full Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes
title_fullStr Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes
title_full_unstemmed Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes
title_sort Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes
dc.creator.none.fl_str_mv Bobillo, Maria Cecilia
Navoni, Julio A.
Olmos, Valentina
Merini, Luciano Jose
Villaamil Lepori, Edda
Corach, Daniel
author Bobillo, Maria Cecilia
author_facet Bobillo, Maria Cecilia
Navoni, Julio A.
Olmos, Valentina
Merini, Luciano Jose
Villaamil Lepori, Edda
Corach, Daniel
author_role author
author2 Navoni, Julio A.
Olmos, Valentina
Merini, Luciano Jose
Villaamil Lepori, Edda
Corach, Daniel
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Arsenic
Children
Ethnic characterization
Ancestral informative markers
topic Arsenic
Children
Ethnic characterization
Ancestral informative markers
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Because the ratio between the two major arsenic metabolites is related to the adverse health effects of arsenic, numerous studies have been performed to establish a relationship between the ability to metabolically detoxify arsenic and other variables, including exposure level, gender, age and ethnicity. Because ethnicity may play a key role and provide relevant information for heterogeneous populations, we characterized a group of 70 children from rural schools in the Argentinean provinces of Chaco and Santiago del Estero who were exposed to high levels of arsenic. We used genetic markers for maternal, paternal and bi-parental ancestry to achieve this goal. Our results demonstrate that the Amerindian maternal linages are present in 100% of the samples, whereas the Amerindian component transmitted through the paternal line is less than 10%. Informative markers for autosomal ancestry show a predominantly European ancestry, in which 37% of the samples contained between 90 and 99% European ancestry. The native American component ranged from 50 to 80% in 15.7% of the samples, and in all but four samples, the African component was less than 10%. Correlation analysis demonstrated that the ethnicity and the ratio of the excreted arsenic metabolites monomethyl arsenic and dimethyl arsenic are not associated, dismissing a relationship between ethnic origin and differential metabolism.
Fil: Bobillo, Maria Cecilia. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Navoni, Julio A.. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Olmos, Valentina. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Merini, Luciano Jose. Instituto Nacional de Tecnología Agropecuaria. Centro Regional la Pampa-San Luis. Estación Experimental Agropecuaria Anguil; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Villaamil Lepori, Edda. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica; Argentina
Fil: Corach, Daniel. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Servicio de Huellas Digitales Genéticas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Because the ratio between the two major arsenic metabolites is related to the adverse health effects of arsenic, numerous studies have been performed to establish a relationship between the ability to metabolically detoxify arsenic and other variables, including exposure level, gender, age and ethnicity. Because ethnicity may play a key role and provide relevant information for heterogeneous populations, we characterized a group of 70 children from rural schools in the Argentinean provinces of Chaco and Santiago del Estero who were exposed to high levels of arsenic. We used genetic markers for maternal, paternal and bi-parental ancestry to achieve this goal. Our results demonstrate that the Amerindian maternal linages are present in 100% of the samples, whereas the Amerindian component transmitted through the paternal line is less than 10%. Informative markers for autosomal ancestry show a predominantly European ancestry, in which 37% of the samples contained between 90 and 99% European ancestry. The native American component ranged from 50 to 80% in 15.7% of the samples, and in all but four samples, the African component was less than 10%. Correlation analysis demonstrated that the ethnicity and the ratio of the excreted arsenic metabolites monomethyl arsenic and dimethyl arsenic are not associated, dismissing a relationship between ethnic origin and differential metabolism.
publishDate 2014
dc.date.none.fl_str_mv 2014-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/16645
Bobillo, Maria Cecilia; Navoni, Julio A.; Olmos, Valentina; Merini, Luciano Jose; Villaamil Lepori, Edda; et al.; Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes; e-Century Publishing; International Journal of Molecular Epidemiology and Genetics; 5; 1; 1-2014; 1-10
1948-1756
url http://hdl.handle.net/11336/16645
identifier_str_mv Bobillo, Maria Cecilia; Navoni, Julio A.; Olmos, Valentina; Merini, Luciano Jose; Villaamil Lepori, Edda; et al.; Ethnic characterization of a population of children exposed to high doses of arsenic via drinking water and a possible correlation with metabolic processes; e-Century Publishing; International Journal of Molecular Epidemiology and Genetics; 5; 1; 1-2014; 1-10
1948-1756
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.ijmeg.org/IJMEG_V5N1.html
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3939002/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv e-Century Publishing
publisher.none.fl_str_mv e-Century Publishing
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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