Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents

Autores
Rodrigues, Bruno; Figueroa, Diego Mendrot Taboas; Fang, Jiao; Rosa, Kaleizu Teodoro; Llesuy, Susana Francisca; de Angelis, Kátia; Irigoyen, Maria Cláudia
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objectives: To investigate the effects of hyperglycemia on left ventricular dysfunction, morphometry, myocardial infarction area, hemodynamic parameters, oxidative stress profile, and mortality rate in rats that had undergone seven days of myocardial infarction. Introduction: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. Methods: Male Wistar rats were divided into four groups: control-sham, diabetes-sham, myocardial infarction, and diabetes + myocardial infarction. Myocardial infarction was induced 14 days after diabetes induction. Ventricular function and morphometry, as well as oxidative stress and hemodynamic parameters, were evaluated after seven days of myocardial infarction. Results: The myocardial infarction area, which was similar in the infarcted groups at the initial evaluation, was reduced in the diabetes + myocardial infarction animals (23 ± 3%) when compared with the myocardial infarction (42 ± 7%, p<0.001) animals at the final evaluation. The ejection fraction (22%, p = 0.003), velocity of circumferential fiber shortening (30%, p = 0.001), and left ventricular isovolumetric relaxation time (26%, p = 0.002) were increased in the diabetes + myocardial infarction group compared with the myocardial infarction group. The diabetes-sham and diabetes + myocardial infarction groups displayed increased catalase concentrations compared to the control-sham and myocardial infarction groups (diabetes-sham: 32± 3; diabetes + myocardial infarction: 35± 0.7; control-sham: 12 ± 2; myocardial infarction: 16 ± 0.1 pmol min -1 mg -1 protein). The levels of thiobarbituric acid-reactive substances were reduced in the diabetes-sham rats compared to the control-sham rats. These positive adaptations were reflected in a reduced mortality rate in the diabetes + myocardial infarction animals (18.5%) compared with the myocardial infarction animals (40.7%, p = 0.001). Conclusions: These data suggest that short-term hyperglycemia initiates compensatory mechanisms, as demonstrated by increased catalase levels, which culminate in improvements in the ventricular response, infarcted area, and mortality rate in diabetic rats exposed to ischemic injury.
Fil: Rodrigues, Bruno. Universidade São Judas Tadeu; Brasil. Universidade de Sao Paulo; Brasil
Fil: Figueroa, Diego Mendrot Taboas. Universidade de Sao Paulo; Brasil
Fil: Fang, Jiao. Universidade de Sao Paulo; Brasil
Fil: Rosa, Kaleizu Teodoro. Universidade de Sao Paulo; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: de Angelis, Kátia. Universidade Nove de Julho; Brasil
Fil: Irigoyen, Maria Cláudia. Universidade de Sao Paulo; Brasil
Materia
DIABETES
MORTALITY RATE
MYOCARDIAL INFARCTION
OXIDATIVE STRESS
VENTRICULAR FUNCTION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67798
Acceder
id CONICETDig_27c9ab42c0019120372383c96c087032
oai_identifier_str oai:ri.conicet.gov.ar:11336/67798
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodentsRodrigues, BrunoFigueroa, Diego Mendrot TaboasFang, JiaoRosa, Kaleizu TeodoroLlesuy, Susana Franciscade Angelis, KátiaIrigoyen, Maria CláudiaDIABETESMORTALITY RATEMYOCARDIAL INFARCTIONOXIDATIVE STRESSVENTRICULAR FUNCTIONhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Objectives: To investigate the effects of hyperglycemia on left ventricular dysfunction, morphometry, myocardial infarction area, hemodynamic parameters, oxidative stress profile, and mortality rate in rats that had undergone seven days of myocardial infarction. Introduction: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. Methods: Male Wistar rats were divided into four groups: control-sham, diabetes-sham, myocardial infarction, and diabetes + myocardial infarction. Myocardial infarction was induced 14 days after diabetes induction. Ventricular function and morphometry, as well as oxidative stress and hemodynamic parameters, were evaluated after seven days of myocardial infarction. Results: The myocardial infarction area, which was similar in the infarcted groups at the initial evaluation, was reduced in the diabetes + myocardial infarction animals (23 ± 3%) when compared with the myocardial infarction (42 ± 7%, p<0.001) animals at the final evaluation. The ejection fraction (22%, p = 0.003), velocity of circumferential fiber shortening (30%, p = 0.001), and left ventricular isovolumetric relaxation time (26%, p = 0.002) were increased in the diabetes + myocardial infarction group compared with the myocardial infarction group. The diabetes-sham and diabetes + myocardial infarction groups displayed increased catalase concentrations compared to the control-sham and myocardial infarction groups (diabetes-sham: 32± 3; diabetes + myocardial infarction: 35± 0.7; control-sham: 12 ± 2; myocardial infarction: 16 ± 0.1 pmol min -1 mg -1 protein). The levels of thiobarbituric acid-reactive substances were reduced in the diabetes-sham rats compared to the control-sham rats. These positive adaptations were reflected in a reduced mortality rate in the diabetes + myocardial infarction animals (18.5%) compared with the myocardial infarction animals (40.7%, p = 0.001). Conclusions: These data suggest that short-term hyperglycemia initiates compensatory mechanisms, as demonstrated by increased catalase levels, which culminate in improvements in the ventricular response, infarcted area, and mortality rate in diabetic rats exposed to ischemic injury.Fil: Rodrigues, Bruno. Universidade São Judas Tadeu; Brasil. Universidade de Sao Paulo; BrasilFil: Figueroa, Diego Mendrot Taboas. Universidade de Sao Paulo; BrasilFil: Fang, Jiao. Universidade de Sao Paulo; BrasilFil: Rosa, Kaleizu Teodoro. Universidade de Sao Paulo; BrasilFil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: de Angelis, Kátia. Universidade Nove de Julho; BrasilFil: Irigoyen, Maria Cláudia. Universidade de Sao Paulo; BrasilUniversidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas2011-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67798Rodrigues, Bruno; Figueroa, Diego Mendrot Taboas; Fang, Jiao; Rosa, Kaleizu Teodoro; Llesuy, Susana Francisca; et al.; Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas; Clinics; 66; 8; 11-2011; 1437-14421807-59321980-5322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1590/S1807-59322011000800022info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161225/info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/z8gc4pinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:57:21Zoai:ri.conicet.gov.ar:11336/67798instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:57:21.82CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
title Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
spellingShingle Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
Rodrigues, Bruno
DIABETES
MORTALITY RATE
MYOCARDIAL INFARCTION
OXIDATIVE STRESS
VENTRICULAR FUNCTION
title_short Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
title_full Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
title_fullStr Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
title_full_unstemmed Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
title_sort Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents
dc.creator.none.fl_str_mv Rodrigues, Bruno
Figueroa, Diego Mendrot Taboas
Fang, Jiao
Rosa, Kaleizu Teodoro
Llesuy, Susana Francisca
de Angelis, Kátia
Irigoyen, Maria Cláudia
author Rodrigues, Bruno
author_facet Rodrigues, Bruno
Figueroa, Diego Mendrot Taboas
Fang, Jiao
Rosa, Kaleizu Teodoro
Llesuy, Susana Francisca
de Angelis, Kátia
Irigoyen, Maria Cláudia
author_role author
author2 Figueroa, Diego Mendrot Taboas
Fang, Jiao
Rosa, Kaleizu Teodoro
Llesuy, Susana Francisca
de Angelis, Kátia
Irigoyen, Maria Cláudia
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv DIABETES
MORTALITY RATE
MYOCARDIAL INFARCTION
OXIDATIVE STRESS
VENTRICULAR FUNCTION
topic DIABETES
MORTALITY RATE
MYOCARDIAL INFARCTION
OXIDATIVE STRESS
VENTRICULAR FUNCTION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objectives: To investigate the effects of hyperglycemia on left ventricular dysfunction, morphometry, myocardial infarction area, hemodynamic parameters, oxidative stress profile, and mortality rate in rats that had undergone seven days of myocardial infarction. Introduction: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. Methods: Male Wistar rats were divided into four groups: control-sham, diabetes-sham, myocardial infarction, and diabetes + myocardial infarction. Myocardial infarction was induced 14 days after diabetes induction. Ventricular function and morphometry, as well as oxidative stress and hemodynamic parameters, were evaluated after seven days of myocardial infarction. Results: The myocardial infarction area, which was similar in the infarcted groups at the initial evaluation, was reduced in the diabetes + myocardial infarction animals (23 ± 3%) when compared with the myocardial infarction (42 ± 7%, p<0.001) animals at the final evaluation. The ejection fraction (22%, p = 0.003), velocity of circumferential fiber shortening (30%, p = 0.001), and left ventricular isovolumetric relaxation time (26%, p = 0.002) were increased in the diabetes + myocardial infarction group compared with the myocardial infarction group. The diabetes-sham and diabetes + myocardial infarction groups displayed increased catalase concentrations compared to the control-sham and myocardial infarction groups (diabetes-sham: 32± 3; diabetes + myocardial infarction: 35± 0.7; control-sham: 12 ± 2; myocardial infarction: 16 ± 0.1 pmol min -1 mg -1 protein). The levels of thiobarbituric acid-reactive substances were reduced in the diabetes-sham rats compared to the control-sham rats. These positive adaptations were reflected in a reduced mortality rate in the diabetes + myocardial infarction animals (18.5%) compared with the myocardial infarction animals (40.7%, p = 0.001). Conclusions: These data suggest that short-term hyperglycemia initiates compensatory mechanisms, as demonstrated by increased catalase levels, which culminate in improvements in the ventricular response, infarcted area, and mortality rate in diabetic rats exposed to ischemic injury.
Fil: Rodrigues, Bruno. Universidade São Judas Tadeu; Brasil. Universidade de Sao Paulo; Brasil
Fil: Figueroa, Diego Mendrot Taboas. Universidade de Sao Paulo; Brasil
Fil: Fang, Jiao. Universidade de Sao Paulo; Brasil
Fil: Rosa, Kaleizu Teodoro. Universidade de Sao Paulo; Brasil
Fil: Llesuy, Susana Francisca. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: de Angelis, Kátia. Universidade Nove de Julho; Brasil
Fil: Irigoyen, Maria Cláudia. Universidade de Sao Paulo; Brasil
description Objectives: To investigate the effects of hyperglycemia on left ventricular dysfunction, morphometry, myocardial infarction area, hemodynamic parameters, oxidative stress profile, and mortality rate in rats that had undergone seven days of myocardial infarction. Introduction: Previous research has demonstrated that hyperglycemia may protect the heart against ischemic injury. Methods: Male Wistar rats were divided into four groups: control-sham, diabetes-sham, myocardial infarction, and diabetes + myocardial infarction. Myocardial infarction was induced 14 days after diabetes induction. Ventricular function and morphometry, as well as oxidative stress and hemodynamic parameters, were evaluated after seven days of myocardial infarction. Results: The myocardial infarction area, which was similar in the infarcted groups at the initial evaluation, was reduced in the diabetes + myocardial infarction animals (23 ± 3%) when compared with the myocardial infarction (42 ± 7%, p<0.001) animals at the final evaluation. The ejection fraction (22%, p = 0.003), velocity of circumferential fiber shortening (30%, p = 0.001), and left ventricular isovolumetric relaxation time (26%, p = 0.002) were increased in the diabetes + myocardial infarction group compared with the myocardial infarction group. The diabetes-sham and diabetes + myocardial infarction groups displayed increased catalase concentrations compared to the control-sham and myocardial infarction groups (diabetes-sham: 32± 3; diabetes + myocardial infarction: 35± 0.7; control-sham: 12 ± 2; myocardial infarction: 16 ± 0.1 pmol min -1 mg -1 protein). The levels of thiobarbituric acid-reactive substances were reduced in the diabetes-sham rats compared to the control-sham rats. These positive adaptations were reflected in a reduced mortality rate in the diabetes + myocardial infarction animals (18.5%) compared with the myocardial infarction animals (40.7%, p = 0.001). Conclusions: These data suggest that short-term hyperglycemia initiates compensatory mechanisms, as demonstrated by increased catalase levels, which culminate in improvements in the ventricular response, infarcted area, and mortality rate in diabetic rats exposed to ischemic injury.
publishDate 2011
dc.date.none.fl_str_mv 2011-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67798
Rodrigues, Bruno; Figueroa, Diego Mendrot Taboas; Fang, Jiao; Rosa, Kaleizu Teodoro; Llesuy, Susana Francisca; et al.; Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas; Clinics; 66; 8; 11-2011; 1437-1442
1807-5932
1980-5322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67798
identifier_str_mv Rodrigues, Bruno; Figueroa, Diego Mendrot Taboas; Fang, Jiao; Rosa, Kaleizu Teodoro; Llesuy, Susana Francisca; et al.; Short-term diabetes attenuates left ventricular dysfunction and mortality rates after myocardial infarction in rodents; Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas; Clinics; 66; 8; 11-2011; 1437-1442
1807-5932
1980-5322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1590/S1807-59322011000800022
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3161225/
info:eu-repo/semantics/altIdentifier/url/http://ref.scielo.org/z8gc4p
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas
publisher.none.fl_str_mv Universidade de São Paulo. Faculdade de Medicina. Hospital das Clínicas
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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