Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina

Autores
Siewert, Susana Elfrida; Márquez, Federico; Mendoza, Gisela Veronica; González, Irma; Ojeda, Marta S.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2) are recognized as thestrongest common genetic risk factors for Type 2 Diabetes Mellitus (T2DM) across multiple ethnicities.This study was conducted to evaluate an association between TCF7L2 variants and diabetessusceptibility in the population of Juana Koslay, San Luis, Argentina. We genotyped 2 singlenucleotide polymorphisms (SNP) rs7903146 and rs12255372 in controls and diabetic subjects.Association with T2DM was found for both SNPs rs7903146 and rs12255372 in the whole sample(under a dominant genetic model, the odds ratios (OR) were 3.43, 95% CI [1.879 - 6.255], p <0.0001 and OR = 4.40, 95% CI [2.318 - 8.351], p < 0.0001, respectively). The risk conferred by homozygotesis much higher than the heterozygote carriers and it is marked in case of rs7903146.The haplotype that consisted of two minor alleles (TT) or the haplotypes carrying at least one ofthe minor alleles at SNP rs7903146 or rs12255372 (i.e. CT or TG) were more frequent in the groupof T2DM. The impact of TCF7L2 variation on T2DM risk in Juana Koslay population is compatiblewith that demonstrated by a range of studies conducted in various ethnic groups.
Fil: Siewert, Susana Elfrida. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Márquez, Federico. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Mendoza, Gisela Veronica. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: González, Irma. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Ojeda, Marta S.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Materia
HAPLOTYPES
ALLELES
HOMOCYGOTES
TCF7L2
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67062
Acceder
id CONICETDig_270e01d5ffdb23b2861db3996bf7e945
oai_identifier_str oai:ri.conicet.gov.ar:11336/67062
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, ArgentinaSiewert, Susana ElfridaMárquez, FedericoMendoza, Gisela VeronicaGonzález, IrmaOjeda, Marta S.HAPLOTYPESALLELESHOMOCYGOTESTCF7L2https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2) are recognized as thestrongest common genetic risk factors for Type 2 Diabetes Mellitus (T2DM) across multiple ethnicities.This study was conducted to evaluate an association between TCF7L2 variants and diabetessusceptibility in the population of Juana Koslay, San Luis, Argentina. We genotyped 2 singlenucleotide polymorphisms (SNP) rs7903146 and rs12255372 in controls and diabetic subjects.Association with T2DM was found for both SNPs rs7903146 and rs12255372 in the whole sample(under a dominant genetic model, the odds ratios (OR) were 3.43, 95% CI [1.879 - 6.255], p <0.0001 and OR = 4.40, 95% CI [2.318 - 8.351], p < 0.0001, respectively). The risk conferred by homozygotesis much higher than the heterozygote carriers and it is marked in case of rs7903146.The haplotype that consisted of two minor alleles (TT) or the haplotypes carrying at least one ofthe minor alleles at SNP rs7903146 or rs12255372 (i.e. CT or TG) were more frequent in the groupof T2DM. The impact of TCF7L2 variation on T2DM risk in Juana Koslay population is compatiblewith that demonstrated by a range of studies conducted in various ethnic groups.Fil: Siewert, Susana Elfrida. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Márquez, Federico. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Mendoza, Gisela Veronica. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: González, Irma. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaFil: Ojeda, Marta S.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; ArgentinaScientific Research2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67062Siewert, Susana Elfrida; Márquez, Federico; Mendoza, Gisela Veronica; González, Irma; Ojeda, Marta S.; Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina; Scientific Research; Open Access Library Journal; 2; 3; 3-2015; 1-102333-9721CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.scirp.org/journal/PaperInformation.aspx?PaperID=68129info:eu-repo/semantics/altIdentifier/doi/10.4236/oalib.1101419info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:43:41Zoai:ri.conicet.gov.ar:11336/67062instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:43:41.475CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina
title Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina
spellingShingle Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina
Siewert, Susana Elfrida
HAPLOTYPES
ALLELES
HOMOCYGOTES
TCF7L2
title_short Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina
title_full Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina
title_fullStr Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina
title_full_unstemmed Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina
title_sort Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina
dc.creator.none.fl_str_mv Siewert, Susana Elfrida
Márquez, Federico
Mendoza, Gisela Veronica
González, Irma
Ojeda, Marta S.
author Siewert, Susana Elfrida
author_facet Siewert, Susana Elfrida
Márquez, Federico
Mendoza, Gisela Veronica
González, Irma
Ojeda, Marta S.
author_role author
author2 Márquez, Federico
Mendoza, Gisela Veronica
González, Irma
Ojeda, Marta S.
author2_role author
author
author
author
dc.subject.none.fl_str_mv HAPLOTYPES
ALLELES
HOMOCYGOTES
TCF7L2
topic HAPLOTYPES
ALLELES
HOMOCYGOTES
TCF7L2
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2) are recognized as thestrongest common genetic risk factors for Type 2 Diabetes Mellitus (T2DM) across multiple ethnicities.This study was conducted to evaluate an association between TCF7L2 variants and diabetessusceptibility in the population of Juana Koslay, San Luis, Argentina. We genotyped 2 singlenucleotide polymorphisms (SNP) rs7903146 and rs12255372 in controls and diabetic subjects.Association with T2DM was found for both SNPs rs7903146 and rs12255372 in the whole sample(under a dominant genetic model, the odds ratios (OR) were 3.43, 95% CI [1.879 - 6.255], p <0.0001 and OR = 4.40, 95% CI [2.318 - 8.351], p < 0.0001, respectively). The risk conferred by homozygotesis much higher than the heterozygote carriers and it is marked in case of rs7903146.The haplotype that consisted of two minor alleles (TT) or the haplotypes carrying at least one ofthe minor alleles at SNP rs7903146 or rs12255372 (i.e. CT or TG) were more frequent in the groupof T2DM. The impact of TCF7L2 variation on T2DM risk in Juana Koslay population is compatiblewith that demonstrated by a range of studies conducted in various ethnic groups.
Fil: Siewert, Susana Elfrida. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Márquez, Federico. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Mendoza, Gisela Veronica. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: González, Irma. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
Fil: Ojeda, Marta S.. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia; Argentina
description Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2) are recognized as thestrongest common genetic risk factors for Type 2 Diabetes Mellitus (T2DM) across multiple ethnicities.This study was conducted to evaluate an association between TCF7L2 variants and diabetessusceptibility in the population of Juana Koslay, San Luis, Argentina. We genotyped 2 singlenucleotide polymorphisms (SNP) rs7903146 and rs12255372 in controls and diabetic subjects.Association with T2DM was found for both SNPs rs7903146 and rs12255372 in the whole sample(under a dominant genetic model, the odds ratios (OR) were 3.43, 95% CI [1.879 - 6.255], p <0.0001 and OR = 4.40, 95% CI [2.318 - 8.351], p < 0.0001, respectively). The risk conferred by homozygotesis much higher than the heterozygote carriers and it is marked in case of rs7903146.The haplotype that consisted of two minor alleles (TT) or the haplotypes carrying at least one ofthe minor alleles at SNP rs7903146 or rs12255372 (i.e. CT or TG) were more frequent in the groupof T2DM. The impact of TCF7L2 variation on T2DM risk in Juana Koslay population is compatiblewith that demonstrated by a range of studies conducted in various ethnic groups.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67062
Siewert, Susana Elfrida; Márquez, Federico; Mendoza, Gisela Veronica; González, Irma; Ojeda, Marta S.; Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina; Scientific Research; Open Access Library Journal; 2; 3; 3-2015; 1-10
2333-9721
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67062
identifier_str_mv Siewert, Susana Elfrida; Márquez, Federico; Mendoza, Gisela Veronica; González, Irma; Ojeda, Marta S.; Association of TCF7L2 Gene Polymorphisms with Type 2 Diabetes Mellitus in the Population of Juana Koslay, San Luis Province, Argentina; Scientific Research; Open Access Library Journal; 2; 3; 3-2015; 1-10
2333-9721
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.scirp.org/journal/PaperInformation.aspx?PaperID=68129
info:eu-repo/semantics/altIdentifier/doi/10.4236/oalib.1101419
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Scientific Research
publisher.none.fl_str_mv Scientific Research
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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