Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study
- Autores
- Chowdhury, Piklu Roy; Ingold, Ana; Vanegas, Natasha; Martínez, Elena; Merlino, John; Merkier, Andrea Karina; Castro, Mercedes; Rocha, Gerardo González; Borthagaray, Graciela; Centron, Daniela; Toledo, Helia Bello; Márquez, Carolina M.; Stokes, H. W.
- Año de publicación
- 2011
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- A comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum β-lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiotic resistance among Gram-negative pathogens. It was found that the class 1 integrons in this cohort were located in a number of different genetic contexts with clear regional differences. In Sydney, IS26-associated Tn21-like transposons on IncL/M plasmids contribute greatly to the dispersal of integron-associated multiple-drug-resistant (MDR) loci. In contrast, in the South American countries, Tn1696-like transposons on an IncA/C plasmid(s) appeared to be disseminating a characteristic MDR region. A range of mobile genetic elements is clearly being recruited by clinically important mobile class 1 integrons, and these elements appear to be becoming more common with time. This in turn is driving the evolution of complex and laterally mobile MDR units and may further complicate antibiotic therapy.
Fil: Chowdhury, Piklu Roy. University of Technology; Australia
Fil: Ingold, Ana. Universidad de la República; Uruguay
Fil: Vanegas, Natasha. University of Technology; Australia. Universidad El Bosque; Colombia
Fil: Martínez, Elena. University of Technology; Australia. Universidad de la República; Uruguay
Fil: Merlino, John. Concord Hospital; Australia. University of Sydney; Australia
Fil: Merkier, Andrea Karina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Castro, Mercedes. Servicio de Sanidad de las Fuerzas Armadas; Uruguay
Fil: Rocha, Gerardo González. Universidad de Concepción; Chile
Fil: Borthagaray, Graciela. Universidad de la República; Uruguay
Fil: Centron, Daniela. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Toledo, Helia Bello. Universidad de Concepción; Chile
Fil: Márquez, Carolina M.. Universidad de la República; Uruguay
Fil: Stokes, H. W.. University of Technology; Australia - Materia
-
Class 1 Integrons
Klebsiella Pneumoniae
Iscr1
Ctx-M-2 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/67676
Ver los metadatos del registro completo
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CONICET Digital (CONICET) |
spelling |
Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative studyChowdhury, Piklu RoyIngold, AnaVanegas, NatashaMartínez, ElenaMerlino, JohnMerkier, Andrea KarinaCastro, MercedesRocha, Gerardo GonzálezBorthagaray, GracielaCentron, DanielaToledo, Helia BelloMárquez, Carolina M.Stokes, H. W.Class 1 IntegronsKlebsiella PneumoniaeIscr1Ctx-M-2https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1A comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum β-lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiotic resistance among Gram-negative pathogens. It was found that the class 1 integrons in this cohort were located in a number of different genetic contexts with clear regional differences. In Sydney, IS26-associated Tn21-like transposons on IncL/M plasmids contribute greatly to the dispersal of integron-associated multiple-drug-resistant (MDR) loci. In contrast, in the South American countries, Tn1696-like transposons on an IncA/C plasmid(s) appeared to be disseminating a characteristic MDR region. A range of mobile genetic elements is clearly being recruited by clinically important mobile class 1 integrons, and these elements appear to be becoming more common with time. This in turn is driving the evolution of complex and laterally mobile MDR units and may further complicate antibiotic therapy.Fil: Chowdhury, Piklu Roy. University of Technology; AustraliaFil: Ingold, Ana. Universidad de la República; UruguayFil: Vanegas, Natasha. University of Technology; Australia. Universidad El Bosque; ColombiaFil: Martínez, Elena. University of Technology; Australia. Universidad de la República; UruguayFil: Merlino, John. Concord Hospital; Australia. University of Sydney; AustraliaFil: Merkier, Andrea Karina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Castro, Mercedes. Servicio de Sanidad de las Fuerzas Armadas; UruguayFil: Rocha, Gerardo González. Universidad de Concepción; ChileFil: Borthagaray, Graciela. Universidad de la República; UruguayFil: Centron, Daniela. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Toledo, Helia Bello. Universidad de Concepción; ChileFil: Márquez, Carolina M.. Universidad de la República; UruguayFil: Stokes, H. W.. University of Technology; AustraliaAmerican Society for Microbiology2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67676Chowdhury, Piklu Roy; Ingold, Ana; Vanegas, Natasha; Martínez, Elena; Merlino, John; et al.; Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 55; 7; 7-2011; 3140-31490066-4804CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.01529-10info:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/55/7/3140info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:00Zoai:ri.conicet.gov.ar:11336/67676instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:00.516CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study |
title |
Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study |
spellingShingle |
Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study Chowdhury, Piklu Roy Class 1 Integrons Klebsiella Pneumoniae Iscr1 Ctx-M-2 |
title_short |
Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study |
title_full |
Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study |
title_fullStr |
Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study |
title_full_unstemmed |
Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study |
title_sort |
Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study |
dc.creator.none.fl_str_mv |
Chowdhury, Piklu Roy Ingold, Ana Vanegas, Natasha Martínez, Elena Merlino, John Merkier, Andrea Karina Castro, Mercedes Rocha, Gerardo González Borthagaray, Graciela Centron, Daniela Toledo, Helia Bello Márquez, Carolina M. Stokes, H. W. |
author |
Chowdhury, Piklu Roy |
author_facet |
Chowdhury, Piklu Roy Ingold, Ana Vanegas, Natasha Martínez, Elena Merlino, John Merkier, Andrea Karina Castro, Mercedes Rocha, Gerardo González Borthagaray, Graciela Centron, Daniela Toledo, Helia Bello Márquez, Carolina M. Stokes, H. W. |
author_role |
author |
author2 |
Ingold, Ana Vanegas, Natasha Martínez, Elena Merlino, John Merkier, Andrea Karina Castro, Mercedes Rocha, Gerardo González Borthagaray, Graciela Centron, Daniela Toledo, Helia Bello Márquez, Carolina M. Stokes, H. W. |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
Class 1 Integrons Klebsiella Pneumoniae Iscr1 Ctx-M-2 |
topic |
Class 1 Integrons Klebsiella Pneumoniae Iscr1 Ctx-M-2 |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
A comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum β-lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiotic resistance among Gram-negative pathogens. It was found that the class 1 integrons in this cohort were located in a number of different genetic contexts with clear regional differences. In Sydney, IS26-associated Tn21-like transposons on IncL/M plasmids contribute greatly to the dispersal of integron-associated multiple-drug-resistant (MDR) loci. In contrast, in the South American countries, Tn1696-like transposons on an IncA/C plasmid(s) appeared to be disseminating a characteristic MDR region. A range of mobile genetic elements is clearly being recruited by clinically important mobile class 1 integrons, and these elements appear to be becoming more common with time. This in turn is driving the evolution of complex and laterally mobile MDR units and may further complicate antibiotic therapy. Fil: Chowdhury, Piklu Roy. University of Technology; Australia Fil: Ingold, Ana. Universidad de la República; Uruguay Fil: Vanegas, Natasha. University of Technology; Australia. Universidad El Bosque; Colombia Fil: Martínez, Elena. University of Technology; Australia. Universidad de la República; Uruguay Fil: Merlino, John. Concord Hospital; Australia. University of Sydney; Australia Fil: Merkier, Andrea Karina. Universidad de Buenos Aires. Facultad de Medicina; Argentina Fil: Castro, Mercedes. Servicio de Sanidad de las Fuerzas Armadas; Uruguay Fil: Rocha, Gerardo González. Universidad de Concepción; Chile Fil: Borthagaray, Graciela. Universidad de la República; Uruguay Fil: Centron, Daniela. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina Fil: Toledo, Helia Bello. Universidad de Concepción; Chile Fil: Márquez, Carolina M.. Universidad de la República; Uruguay Fil: Stokes, H. W.. University of Technology; Australia |
description |
A comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum β-lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiotic resistance among Gram-negative pathogens. It was found that the class 1 integrons in this cohort were located in a number of different genetic contexts with clear regional differences. In Sydney, IS26-associated Tn21-like transposons on IncL/M plasmids contribute greatly to the dispersal of integron-associated multiple-drug-resistant (MDR) loci. In contrast, in the South American countries, Tn1696-like transposons on an IncA/C plasmid(s) appeared to be disseminating a characteristic MDR region. A range of mobile genetic elements is clearly being recruited by clinically important mobile class 1 integrons, and these elements appear to be becoming more common with time. This in turn is driving the evolution of complex and laterally mobile MDR units and may further complicate antibiotic therapy. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/67676 Chowdhury, Piklu Roy; Ingold, Ana; Vanegas, Natasha; Martínez, Elena; Merlino, John; et al.; Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 55; 7; 7-2011; 3140-3149 0066-4804 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/67676 |
identifier_str_mv |
Chowdhury, Piklu Roy; Ingold, Ana; Vanegas, Natasha; Martínez, Elena; Merlino, John; et al.; Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 55; 7; 7-2011; 3140-3149 0066-4804 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.01529-10 info:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/55/7/3140 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
American Society for Microbiology |
publisher.none.fl_str_mv |
American Society for Microbiology |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
_version_ |
1842269729702543360 |
score |
13.13397 |