Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study

Autores
Chowdhury, Piklu Roy; Ingold, Ana; Vanegas, Natasha; Martínez, Elena; Merlino, John; Merkier, Andrea Karina; Castro, Mercedes; Rocha, Gerardo González; Borthagaray, Graciela; Centron, Daniela; Toledo, Helia Bello; Márquez, Carolina M.; Stokes, H. W.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum β-lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiotic resistance among Gram-negative pathogens. It was found that the class 1 integrons in this cohort were located in a number of different genetic contexts with clear regional differences. In Sydney, IS26-associated Tn21-like transposons on IncL/M plasmids contribute greatly to the dispersal of integron-associated multiple-drug-resistant (MDR) loci. In contrast, in the South American countries, Tn1696-like transposons on an IncA/C plasmid(s) appeared to be disseminating a characteristic MDR region. A range of mobile genetic elements is clearly being recruited by clinically important mobile class 1 integrons, and these elements appear to be becoming more common with time. This in turn is driving the evolution of complex and laterally mobile MDR units and may further complicate antibiotic therapy.
Fil: Chowdhury, Piklu Roy. University of Technology; Australia
Fil: Ingold, Ana. Universidad de la República; Uruguay
Fil: Vanegas, Natasha. University of Technology; Australia. Universidad El Bosque; Colombia
Fil: Martínez, Elena. University of Technology; Australia. Universidad de la República; Uruguay
Fil: Merlino, John. Concord Hospital; Australia. University of Sydney; Australia
Fil: Merkier, Andrea Karina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Castro, Mercedes. Servicio de Sanidad de las Fuerzas Armadas; Uruguay
Fil: Rocha, Gerardo González. Universidad de Concepción; Chile
Fil: Borthagaray, Graciela. Universidad de la República; Uruguay
Fil: Centron, Daniela. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Toledo, Helia Bello. Universidad de Concepción; Chile
Fil: Márquez, Carolina M.. Universidad de la República; Uruguay
Fil: Stokes, H. W.. University of Technology; Australia
Materia
Class 1 Integrons
Klebsiella Pneumoniae
Iscr1
Ctx-M-2
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/67676

id CONICETDig_264fc54d3fb6e76671228a4ab1daa1a4
oai_identifier_str oai:ri.conicet.gov.ar:11336/67676
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative studyChowdhury, Piklu RoyIngold, AnaVanegas, NatashaMartínez, ElenaMerlino, JohnMerkier, Andrea KarinaCastro, MercedesRocha, Gerardo GonzálezBorthagaray, GracielaCentron, DanielaToledo, Helia BelloMárquez, Carolina M.Stokes, H. W.Class 1 IntegronsKlebsiella PneumoniaeIscr1Ctx-M-2https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1A comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum β-lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiotic resistance among Gram-negative pathogens. It was found that the class 1 integrons in this cohort were located in a number of different genetic contexts with clear regional differences. In Sydney, IS26-associated Tn21-like transposons on IncL/M plasmids contribute greatly to the dispersal of integron-associated multiple-drug-resistant (MDR) loci. In contrast, in the South American countries, Tn1696-like transposons on an IncA/C plasmid(s) appeared to be disseminating a characteristic MDR region. A range of mobile genetic elements is clearly being recruited by clinically important mobile class 1 integrons, and these elements appear to be becoming more common with time. This in turn is driving the evolution of complex and laterally mobile MDR units and may further complicate antibiotic therapy.Fil: Chowdhury, Piklu Roy. University of Technology; AustraliaFil: Ingold, Ana. Universidad de la República; UruguayFil: Vanegas, Natasha. University of Technology; Australia. Universidad El Bosque; ColombiaFil: Martínez, Elena. University of Technology; Australia. Universidad de la República; UruguayFil: Merlino, John. Concord Hospital; Australia. University of Sydney; AustraliaFil: Merkier, Andrea Karina. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Castro, Mercedes. Servicio de Sanidad de las Fuerzas Armadas; UruguayFil: Rocha, Gerardo González. Universidad de Concepción; ChileFil: Borthagaray, Graciela. Universidad de la República; UruguayFil: Centron, Daniela. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; ArgentinaFil: Toledo, Helia Bello. Universidad de Concepción; ChileFil: Márquez, Carolina M.. Universidad de la República; UruguayFil: Stokes, H. W.. University of Technology; AustraliaAmerican Society for Microbiology2011-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/67676Chowdhury, Piklu Roy; Ingold, Ana; Vanegas, Natasha; Martínez, Elena; Merlino, John; et al.; Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 55; 7; 7-2011; 3140-31490066-4804CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.01529-10info:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/55/7/3140info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:02:00Zoai:ri.conicet.gov.ar:11336/67676instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:02:00.516CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study
title Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study
spellingShingle Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study
Chowdhury, Piklu Roy
Class 1 Integrons
Klebsiella Pneumoniae
Iscr1
Ctx-M-2
title_short Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study
title_full Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study
title_fullStr Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study
title_full_unstemmed Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study
title_sort Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study
dc.creator.none.fl_str_mv Chowdhury, Piklu Roy
Ingold, Ana
Vanegas, Natasha
Martínez, Elena
Merlino, John
Merkier, Andrea Karina
Castro, Mercedes
Rocha, Gerardo González
Borthagaray, Graciela
Centron, Daniela
Toledo, Helia Bello
Márquez, Carolina M.
Stokes, H. W.
author Chowdhury, Piklu Roy
author_facet Chowdhury, Piklu Roy
Ingold, Ana
Vanegas, Natasha
Martínez, Elena
Merlino, John
Merkier, Andrea Karina
Castro, Mercedes
Rocha, Gerardo González
Borthagaray, Graciela
Centron, Daniela
Toledo, Helia Bello
Márquez, Carolina M.
Stokes, H. W.
author_role author
author2 Ingold, Ana
Vanegas, Natasha
Martínez, Elena
Merlino, John
Merkier, Andrea Karina
Castro, Mercedes
Rocha, Gerardo González
Borthagaray, Graciela
Centron, Daniela
Toledo, Helia Bello
Márquez, Carolina M.
Stokes, H. W.
author2_role author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Class 1 Integrons
Klebsiella Pneumoniae
Iscr1
Ctx-M-2
topic Class 1 Integrons
Klebsiella Pneumoniae
Iscr1
Ctx-M-2
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum β-lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiotic resistance among Gram-negative pathogens. It was found that the class 1 integrons in this cohort were located in a number of different genetic contexts with clear regional differences. In Sydney, IS26-associated Tn21-like transposons on IncL/M plasmids contribute greatly to the dispersal of integron-associated multiple-drug-resistant (MDR) loci. In contrast, in the South American countries, Tn1696-like transposons on an IncA/C plasmid(s) appeared to be disseminating a characteristic MDR region. A range of mobile genetic elements is clearly being recruited by clinically important mobile class 1 integrons, and these elements appear to be becoming more common with time. This in turn is driving the evolution of complex and laterally mobile MDR units and may further complicate antibiotic therapy.
Fil: Chowdhury, Piklu Roy. University of Technology; Australia
Fil: Ingold, Ana. Universidad de la República; Uruguay
Fil: Vanegas, Natasha. University of Technology; Australia. Universidad El Bosque; Colombia
Fil: Martínez, Elena. University of Technology; Australia. Universidad de la República; Uruguay
Fil: Merlino, John. Concord Hospital; Australia. University of Sydney; Australia
Fil: Merkier, Andrea Karina. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Castro, Mercedes. Servicio de Sanidad de las Fuerzas Armadas; Uruguay
Fil: Rocha, Gerardo González. Universidad de Concepción; Chile
Fil: Borthagaray, Graciela. Universidad de la República; Uruguay
Fil: Centron, Daniela. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones en Microbiología y Parasitología Médica. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones en Microbiología y Parasitología Médica; Argentina
Fil: Toledo, Helia Bello. Universidad de Concepción; Chile
Fil: Márquez, Carolina M.. Universidad de la República; Uruguay
Fil: Stokes, H. W.. University of Technology; Australia
description A comparative genetic analysis of 42 clinical Klebsiella pneumoniae isolates, resistant to two or more antibiotics belonging to the broad-spectrum β-lactam group, sourced from Sydney, Australia, and three South American countries is presented. The study focuses on the genetic contexts of class 1 integrons, mobilizable genetic elements best known for their role in the rapid evolution of antibiotic resistance among Gram-negative pathogens. It was found that the class 1 integrons in this cohort were located in a number of different genetic contexts with clear regional differences. In Sydney, IS26-associated Tn21-like transposons on IncL/M plasmids contribute greatly to the dispersal of integron-associated multiple-drug-resistant (MDR) loci. In contrast, in the South American countries, Tn1696-like transposons on an IncA/C plasmid(s) appeared to be disseminating a characteristic MDR region. A range of mobile genetic elements is clearly being recruited by clinically important mobile class 1 integrons, and these elements appear to be becoming more common with time. This in turn is driving the evolution of complex and laterally mobile MDR units and may further complicate antibiotic therapy.
publishDate 2011
dc.date.none.fl_str_mv 2011-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/67676
Chowdhury, Piklu Roy; Ingold, Ana; Vanegas, Natasha; Martínez, Elena; Merlino, John; et al.; Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 55; 7; 7-2011; 3140-3149
0066-4804
CONICET Digital
CONICET
url http://hdl.handle.net/11336/67676
identifier_str_mv Chowdhury, Piklu Roy; Ingold, Ana; Vanegas, Natasha; Martínez, Elena; Merlino, John; et al.; Dissemination of multiple drug resistance genes by class 1 integrons in Klebsiella pneumoniae isolates from four countries: A comparative study; American Society for Microbiology; Antimicrobial Agents and Chemotherapy; 55; 7; 7-2011; 3140-3149
0066-4804
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1128/AAC.01529-10
info:eu-repo/semantics/altIdentifier/url/https://aac.asm.org/content/55/7/3140
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Society for Microbiology
publisher.none.fl_str_mv American Society for Microbiology
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269729702543360
score 13.13397