Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina

Autores
Alonso, Daniel Oscar; Iglesias, Ayelén Aluminé; Coelho, Rocío María; Periolo, Natalia; Bruno, Agostina; Córdoba, Maria Teresa; Filomarino, Noemi; Quipildor, Marcelo; Biondo, Emiliano; Fortunato, Eduardo; Bellomo, Carla María; Martínez, Valeria Paula
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Hantavirus pulmonary syndrome (HPS) is an endemic disease in Argentina, one of the most affected countries in the Americas. Andes virus (ANDV) is the main Orthohantavirus species causing HPS in Argentina. In this study, the geographical distribution, clinical presentation, and epidemiological features of HPS from all endemic regions of Argentina were analyzed. We focused on the clinical and epidemiological data from 533 HPS cases confirmed during the period 2009 to 2017 by the National Reference Laboratory for Hantavirus. A case-fatality rate of 21.4% was registered, and most of the cases presented a severe clinical picture requiring intensive care treatment (84%). Since HPS first detection in 1995 the case-fatality rate showed a general trend towards a decrease. After more than 22 years of experience in HPS diagnosis and surveillance, we discuss some possible factors implicated in this tendency. This clinical and epidemiological analysis gives a global perspective, being useful to detect trends and patterns, to update preventive actions at a national level, and evaluate their impact on public health.
Fil: Alonso, Daniel Oscar. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Iglesias, Ayelén Aluminé. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Coelho, Rocío María. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Periolo, Natalia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bruno, Agostina. Hospital San Vicente de Paul; Argentina
Fil: Córdoba, Maria Teresa. Hospital San Vicente de Paul; Argentina
Fil: Filomarino, Noemi. Hospital Señor Del Milagro; Argentina
Fil: Quipildor, Marcelo. Hospital San Vicente de Paul; Argentina
Fil: Biondo, Emiliano. Ministerio de Salud de la Provincia de Chubut; Argentina
Fil: Fortunato, Eduardo. Provincia de Buenos Aires. Ministerio de Salud; Argentina
Fil: Bellomo, Carla María. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Martínez, Valeria Paula. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Materia
ANDES VIRUS
EPIDEMIOLOGY
HANTAVIRUS
HANTAVIRUS PULMONARY SYNDROME
VIROLOGY
ZOONOTIC
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/132489
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/132489
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in ArgentinaAlonso, Daniel OscarIglesias, Ayelén AluminéCoelho, Rocío MaríaPeriolo, NataliaBruno, AgostinaCórdoba, Maria TeresaFilomarino, NoemiQuipildor, MarceloBiondo, EmilianoFortunato, EduardoBellomo, Carla MaríaMartínez, Valeria PaulaANDES VIRUSEPIDEMIOLOGYHANTAVIRUSHANTAVIRUS PULMONARY SYNDROMEVIROLOGYZOONOTIChttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Hantavirus pulmonary syndrome (HPS) is an endemic disease in Argentina, one of the most affected countries in the Americas. Andes virus (ANDV) is the main Orthohantavirus species causing HPS in Argentina. In this study, the geographical distribution, clinical presentation, and epidemiological features of HPS from all endemic regions of Argentina were analyzed. We focused on the clinical and epidemiological data from 533 HPS cases confirmed during the period 2009 to 2017 by the National Reference Laboratory for Hantavirus. A case-fatality rate of 21.4% was registered, and most of the cases presented a severe clinical picture requiring intensive care treatment (84%). Since HPS first detection in 1995 the case-fatality rate showed a general trend towards a decrease. After more than 22 years of experience in HPS diagnosis and surveillance, we discuss some possible factors implicated in this tendency. This clinical and epidemiological analysis gives a global perspective, being useful to detect trends and patterns, to update preventive actions at a national level, and evaluate their impact on public health.Fil: Alonso, Daniel Oscar. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; ArgentinaFil: Iglesias, Ayelén Aluminé. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Coelho, Rocío María. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; ArgentinaFil: Periolo, Natalia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bruno, Agostina. Hospital San Vicente de Paul; ArgentinaFil: Córdoba, Maria Teresa. Hospital San Vicente de Paul; ArgentinaFil: Filomarino, Noemi. Hospital Señor Del Milagro; ArgentinaFil: Quipildor, Marcelo. Hospital San Vicente de Paul; ArgentinaFil: Biondo, Emiliano. Ministerio de Salud de la Provincia de Chubut; ArgentinaFil: Fortunato, Eduardo. Provincia de Buenos Aires. Ministerio de Salud; ArgentinaFil: Bellomo, Carla María. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; ArgentinaFil: Martínez, Valeria Paula. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; ArgentinaWiley-liss, div John Wiley & Sons Inc.2019-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/132489Alonso, Daniel Oscar; Iglesias, Ayelén Aluminé; Coelho, Rocío María; Periolo, Natalia; Bruno, Agostina; et al.; Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina; Wiley-liss, div John Wiley & Sons Inc.; Journal of Medical Virology; 91; 7; 7-2019; 1173-11810146-6615CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25446info:eu-repo/semantics/altIdentifier/doi/10.1002/jmv.25446info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:45:23Zoai:ri.conicet.gov.ar:11336/132489instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:45:23.46CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina
title Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina
spellingShingle Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina
Alonso, Daniel Oscar
ANDES VIRUS
EPIDEMIOLOGY
HANTAVIRUS
HANTAVIRUS PULMONARY SYNDROME
VIROLOGY
ZOONOTIC
title_short Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina
title_full Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina
title_fullStr Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina
title_full_unstemmed Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina
title_sort Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina
dc.creator.none.fl_str_mv Alonso, Daniel Oscar
Iglesias, Ayelén Aluminé
Coelho, Rocío María
Periolo, Natalia
Bruno, Agostina
Córdoba, Maria Teresa
Filomarino, Noemi
Quipildor, Marcelo
Biondo, Emiliano
Fortunato, Eduardo
Bellomo, Carla María
Martínez, Valeria Paula
author Alonso, Daniel Oscar
author_facet Alonso, Daniel Oscar
Iglesias, Ayelén Aluminé
Coelho, Rocío María
Periolo, Natalia
Bruno, Agostina
Córdoba, Maria Teresa
Filomarino, Noemi
Quipildor, Marcelo
Biondo, Emiliano
Fortunato, Eduardo
Bellomo, Carla María
Martínez, Valeria Paula
author_role author
author2 Iglesias, Ayelén Aluminé
Coelho, Rocío María
Periolo, Natalia
Bruno, Agostina
Córdoba, Maria Teresa
Filomarino, Noemi
Quipildor, Marcelo
Biondo, Emiliano
Fortunato, Eduardo
Bellomo, Carla María
Martínez, Valeria Paula
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ANDES VIRUS
EPIDEMIOLOGY
HANTAVIRUS
HANTAVIRUS PULMONARY SYNDROME
VIROLOGY
ZOONOTIC
topic ANDES VIRUS
EPIDEMIOLOGY
HANTAVIRUS
HANTAVIRUS PULMONARY SYNDROME
VIROLOGY
ZOONOTIC
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Hantavirus pulmonary syndrome (HPS) is an endemic disease in Argentina, one of the most affected countries in the Americas. Andes virus (ANDV) is the main Orthohantavirus species causing HPS in Argentina. In this study, the geographical distribution, clinical presentation, and epidemiological features of HPS from all endemic regions of Argentina were analyzed. We focused on the clinical and epidemiological data from 533 HPS cases confirmed during the period 2009 to 2017 by the National Reference Laboratory for Hantavirus. A case-fatality rate of 21.4% was registered, and most of the cases presented a severe clinical picture requiring intensive care treatment (84%). Since HPS first detection in 1995 the case-fatality rate showed a general trend towards a decrease. After more than 22 years of experience in HPS diagnosis and surveillance, we discuss some possible factors implicated in this tendency. This clinical and epidemiological analysis gives a global perspective, being useful to detect trends and patterns, to update preventive actions at a national level, and evaluate their impact on public health.
Fil: Alonso, Daniel Oscar. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Iglesias, Ayelén Aluminé. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Coelho, Rocío María. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Periolo, Natalia. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Bruno, Agostina. Hospital San Vicente de Paul; Argentina
Fil: Córdoba, Maria Teresa. Hospital San Vicente de Paul; Argentina
Fil: Filomarino, Noemi. Hospital Señor Del Milagro; Argentina
Fil: Quipildor, Marcelo. Hospital San Vicente de Paul; Argentina
Fil: Biondo, Emiliano. Ministerio de Salud de la Provincia de Chubut; Argentina
Fil: Fortunato, Eduardo. Provincia de Buenos Aires. Ministerio de Salud; Argentina
Fil: Bellomo, Carla María. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
Fil: Martínez, Valeria Paula. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio E Instituto de Salud "Dr. C. G. Malbran". Departamento Virus; Argentina
description Hantavirus pulmonary syndrome (HPS) is an endemic disease in Argentina, one of the most affected countries in the Americas. Andes virus (ANDV) is the main Orthohantavirus species causing HPS in Argentina. In this study, the geographical distribution, clinical presentation, and epidemiological features of HPS from all endemic regions of Argentina were analyzed. We focused on the clinical and epidemiological data from 533 HPS cases confirmed during the period 2009 to 2017 by the National Reference Laboratory for Hantavirus. A case-fatality rate of 21.4% was registered, and most of the cases presented a severe clinical picture requiring intensive care treatment (84%). Since HPS first detection in 1995 the case-fatality rate showed a general trend towards a decrease. After more than 22 years of experience in HPS diagnosis and surveillance, we discuss some possible factors implicated in this tendency. This clinical and epidemiological analysis gives a global perspective, being useful to detect trends and patterns, to update preventive actions at a national level, and evaluate their impact on public health.
publishDate 2019
dc.date.none.fl_str_mv 2019-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/132489
Alonso, Daniel Oscar; Iglesias, Ayelén Aluminé; Coelho, Rocío María; Periolo, Natalia; Bruno, Agostina; et al.; Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina; Wiley-liss, div John Wiley & Sons Inc.; Journal of Medical Virology; 91; 7; 7-2019; 1173-1181
0146-6615
CONICET Digital
CONICET
url http://hdl.handle.net/11336/132489
identifier_str_mv Alonso, Daniel Oscar; Iglesias, Ayelén Aluminé; Coelho, Rocío María; Periolo, Natalia; Bruno, Agostina; et al.; Epidemiological description, case-fatality rate, and trends of Hantavirus Pulmonary Syndrome: 9 years of surveillance in Argentina; Wiley-liss, div John Wiley & Sons Inc.; Journal of Medical Virology; 91; 7; 7-2019; 1173-1181
0146-6615
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/abs/10.1002/jmv.25446
info:eu-repo/semantics/altIdentifier/doi/10.1002/jmv.25446
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
publisher.none.fl_str_mv Wiley-liss, div John Wiley & Sons Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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