International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood

Autores
Hokken Koelega, Anita C. S.; van der Steen, Manouk; Boguszewski, Margaret C. S.; Cianfarani, Stefano; Dahlgren, Jovanna; Horikawa, Reiko; Mericq, Veronica; Rapaport, Robert; Alherbish, Abdullah; Braslavsky, Debora Giselle; Charmandari, Evangelia; Chernausek, Steven D.; Cutfield, Wayne S.; Dauber, Andrew; Deeb, Asma; Goedegebuure, Wesley J.; Hofman, Paul L.; Isganatis, Elvira; Jorge, Alexander A.; Kanaka Gantenbein, Christina; Kashimada, Kenichi; Khadilkar, Vaman; Luo, Xiao Ping; Mathai, Sarah; Nakano, Yuya; Yau, Mabel
Año de publicación
2023
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations. The guideline gives new and clinically relevant insights into the etiology of short stature after SGA birth, including novel knowledge about (epi)genetic causes. Further, it presents long-term consequences of SGA birth and also reviews new treatment options, including treatment with gonadotropin-releasing hormone agonist (GnRHa) in addition to growth hormone (GH) treatment, as well as the metabolic and cardiovascular health of young adults born SGA after cessation of childhood GH treatment in comparison with appropriate control groups.To diagnose SGA, accurate anthropometry and use of national growth charts are recommended. Follow-up in early life is warranted and neurodevelopment evaluation in those at risk. Excessive postnatal weight gain should be avoided, as this is associated with an unfavorable cardiometabolic health profile in adulthood. Children born SGA with persistent short stature < −2.5 SDS at age 2 years or < −2 SDS at 3 to 4 years of age, should be referred for diagnostic workup. In case of dysmorphic features, major malformations, microcephaly, developmental delay, intellectual disability, and/or signs of skeletal dysplasia, genetic testing should be considered. Treatment with 0.033 to 0.067 mg GH/kg/day is recommended in case of persistent short stature at age of 3 to 4 years. Adding GnRHa treatment could be considered when short adult height is expected at pubertal onset. All young adults born SGA require counseling to adopt a healthy lifestyle.
Fil: Hokken Koelega, Anita C. S.. Erasmus University (erasmus University);
Fil: van der Steen, Manouk. Erasmus University (erasmus University);
Fil: Boguszewski, Margaret C. S.. Universidade Federal do Paraná; Brasil
Fil: Cianfarani, Stefano. Universita Tor Vergata; Italia. IRCCS “Bambino Gesù” Children's Hospital; Italia
Fil: Dahlgren, Jovanna. University of Gothenburg; Suecia
Fil: Horikawa, Reiko. National Center for Child Health and Development; Japón
Fil: Mericq, Veronica. Universidad de Chile; Chile
Fil: Rapaport, Robert. Mount Sinai Kravis Children's Hospital; Estados Unidos
Fil: Alherbish, Abdullah. Al Habib Medical Group; Arabia Saudita
Fil: Braslavsky, Debora Giselle. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Charmandari, Evangelia. Biomedical Research Foundation of the Academy of Athens; Grecia. Universidad Nacional y Kapodistriaca de Atenas; Grecia
Fil: Chernausek, Steven D.. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Cutfield, Wayne S.. University of Auckland; Nueva Zelanda
Fil: Dauber, Andrew. Children's National Hospital; Estados Unidos
Fil: Deeb, Asma. Khalifa University; Emiratos Arabes Unidos
Fil: Goedegebuure, Wesley J.. Erasmus University (erasmus University);
Fil: Hofman, Paul L.. University of Auckland; Nueva Zelanda
Fil: Isganatis, Elvira. Harvard Medical School; Estados Unidos
Fil: Jorge, Alexander A.. Universidade de Sao Paulo; Brasil
Fil: Kanaka Gantenbein, Christina. Universidad Nacional y Kapodistriaca de Atenas; Grecia
Fil: Kashimada, Kenichi. Tokyo Medical and Dental University; Japón
Fil: Khadilkar, Vaman. Jehangir Hospital; India
Fil: Luo, Xiao Ping. Huazhong University of Science and Technology; China
Fil: Mathai, Sarah. Christian Medical College; India
Fil: Nakano, Yuya. Showa University School of Medicine; Japón
Fil: Yau, Mabel. Mount Sinai Kravis Children's Hospital; Estados Unidos
Materia
SGA
SHORT STATURE
GH
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/256663

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network_name_str CONICET Digital (CONICET)
spelling International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early AdulthoodHokken Koelega, Anita C. S.van der Steen, ManoukBoguszewski, Margaret C. S.Cianfarani, StefanoDahlgren, JovannaHorikawa, ReikoMericq, VeronicaRapaport, RobertAlherbish, AbdullahBraslavsky, Debora GiselleCharmandari, EvangeliaChernausek, Steven D.Cutfield, Wayne S.Dauber, AndrewDeeb, AsmaGoedegebuure, Wesley J.Hofman, Paul L.Isganatis, ElviraJorge, Alexander A.Kanaka Gantenbein, ChristinaKashimada, KenichiKhadilkar, VamanLuo, Xiao PingMathai, SarahNakano, YuyaYau, MabelSGASHORT STATUREGHhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations. The guideline gives new and clinically relevant insights into the etiology of short stature after SGA birth, including novel knowledge about (epi)genetic causes. Further, it presents long-term consequences of SGA birth and also reviews new treatment options, including treatment with gonadotropin-releasing hormone agonist (GnRHa) in addition to growth hormone (GH) treatment, as well as the metabolic and cardiovascular health of young adults born SGA after cessation of childhood GH treatment in comparison with appropriate control groups.To diagnose SGA, accurate anthropometry and use of national growth charts are recommended. Follow-up in early life is warranted and neurodevelopment evaluation in those at risk. Excessive postnatal weight gain should be avoided, as this is associated with an unfavorable cardiometabolic health profile in adulthood. Children born SGA with persistent short stature < −2.5 SDS at age 2 years or < −2 SDS at 3 to 4 years of age, should be referred for diagnostic workup. In case of dysmorphic features, major malformations, microcephaly, developmental delay, intellectual disability, and/or signs of skeletal dysplasia, genetic testing should be considered. Treatment with 0.033 to 0.067 mg GH/kg/day is recommended in case of persistent short stature at age of 3 to 4 years. Adding GnRHa treatment could be considered when short adult height is expected at pubertal onset. All young adults born SGA require counseling to adopt a healthy lifestyle.Fil: Hokken Koelega, Anita C. S.. Erasmus University (erasmus University);Fil: van der Steen, Manouk. Erasmus University (erasmus University);Fil: Boguszewski, Margaret C. S.. Universidade Federal do Paraná; BrasilFil: Cianfarani, Stefano. Universita Tor Vergata; Italia. IRCCS “Bambino Gesù” Children's Hospital; ItaliaFil: Dahlgren, Jovanna. University of Gothenburg; SueciaFil: Horikawa, Reiko. National Center for Child Health and Development; JapónFil: Mericq, Veronica. Universidad de Chile; ChileFil: Rapaport, Robert. Mount Sinai Kravis Children's Hospital; Estados UnidosFil: Alherbish, Abdullah. Al Habib Medical Group; Arabia SauditaFil: Braslavsky, Debora Giselle. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; ArgentinaFil: Charmandari, Evangelia. Biomedical Research Foundation of the Academy of Athens; Grecia. Universidad Nacional y Kapodistriaca de Atenas; GreciaFil: Chernausek, Steven D.. Oklahoma Medical Research Foundation; Estados UnidosFil: Cutfield, Wayne S.. University of Auckland; Nueva ZelandaFil: Dauber, Andrew. Children's National Hospital; Estados UnidosFil: Deeb, Asma. Khalifa University; Emiratos Arabes UnidosFil: Goedegebuure, Wesley J.. Erasmus University (erasmus University);Fil: Hofman, Paul L.. University of Auckland; Nueva ZelandaFil: Isganatis, Elvira. Harvard Medical School; Estados UnidosFil: Jorge, Alexander A.. Universidade de Sao Paulo; BrasilFil: Kanaka Gantenbein, Christina. Universidad Nacional y Kapodistriaca de Atenas; GreciaFil: Kashimada, Kenichi. Tokyo Medical and Dental University; JapónFil: Khadilkar, Vaman. Jehangir Hospital; IndiaFil: Luo, Xiao Ping. Huazhong University of Science and Technology; ChinaFil: Mathai, Sarah. Christian Medical College; IndiaFil: Nakano, Yuya. Showa University School of Medicine; JapónFil: Yau, Mabel. Mount Sinai Kravis Children's Hospital; Estados UnidosEndocrine Society2023-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/256663Hokken Koelega, Anita C. S.; van der Steen, Manouk; Boguszewski, Margaret C. S.; Cianfarani, Stefano; Dahlgren, Jovanna; et al.; International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood; Endocrine Society; Endocrine Reviews; 44; 3; 6-2023; 539-5650163-769XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/edrv/article/44/3/539/6986592info:eu-repo/semantics/altIdentifier/doi/10.1210/endrev/bnad002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:11:52Zoai:ri.conicet.gov.ar:11336/256663instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:11:52.71CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
title International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
spellingShingle International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
Hokken Koelega, Anita C. S.
SGA
SHORT STATURE
GH
title_short International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
title_full International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
title_fullStr International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
title_full_unstemmed International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
title_sort International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
dc.creator.none.fl_str_mv Hokken Koelega, Anita C. S.
van der Steen, Manouk
Boguszewski, Margaret C. S.
Cianfarani, Stefano
Dahlgren, Jovanna
Horikawa, Reiko
Mericq, Veronica
Rapaport, Robert
Alherbish, Abdullah
Braslavsky, Debora Giselle
Charmandari, Evangelia
Chernausek, Steven D.
Cutfield, Wayne S.
Dauber, Andrew
Deeb, Asma
Goedegebuure, Wesley J.
Hofman, Paul L.
Isganatis, Elvira
Jorge, Alexander A.
Kanaka Gantenbein, Christina
Kashimada, Kenichi
Khadilkar, Vaman
Luo, Xiao Ping
Mathai, Sarah
Nakano, Yuya
Yau, Mabel
author Hokken Koelega, Anita C. S.
author_facet Hokken Koelega, Anita C. S.
van der Steen, Manouk
Boguszewski, Margaret C. S.
Cianfarani, Stefano
Dahlgren, Jovanna
Horikawa, Reiko
Mericq, Veronica
Rapaport, Robert
Alherbish, Abdullah
Braslavsky, Debora Giselle
Charmandari, Evangelia
Chernausek, Steven D.
Cutfield, Wayne S.
Dauber, Andrew
Deeb, Asma
Goedegebuure, Wesley J.
Hofman, Paul L.
Isganatis, Elvira
Jorge, Alexander A.
Kanaka Gantenbein, Christina
Kashimada, Kenichi
Khadilkar, Vaman
Luo, Xiao Ping
Mathai, Sarah
Nakano, Yuya
Yau, Mabel
author_role author
author2 van der Steen, Manouk
Boguszewski, Margaret C. S.
Cianfarani, Stefano
Dahlgren, Jovanna
Horikawa, Reiko
Mericq, Veronica
Rapaport, Robert
Alherbish, Abdullah
Braslavsky, Debora Giselle
Charmandari, Evangelia
Chernausek, Steven D.
Cutfield, Wayne S.
Dauber, Andrew
Deeb, Asma
Goedegebuure, Wesley J.
Hofman, Paul L.
Isganatis, Elvira
Jorge, Alexander A.
Kanaka Gantenbein, Christina
Kashimada, Kenichi
Khadilkar, Vaman
Luo, Xiao Ping
Mathai, Sarah
Nakano, Yuya
Yau, Mabel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SGA
SHORT STATURE
GH
topic SGA
SHORT STATURE
GH
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations. The guideline gives new and clinically relevant insights into the etiology of short stature after SGA birth, including novel knowledge about (epi)genetic causes. Further, it presents long-term consequences of SGA birth and also reviews new treatment options, including treatment with gonadotropin-releasing hormone agonist (GnRHa) in addition to growth hormone (GH) treatment, as well as the metabolic and cardiovascular health of young adults born SGA after cessation of childhood GH treatment in comparison with appropriate control groups.To diagnose SGA, accurate anthropometry and use of national growth charts are recommended. Follow-up in early life is warranted and neurodevelopment evaluation in those at risk. Excessive postnatal weight gain should be avoided, as this is associated with an unfavorable cardiometabolic health profile in adulthood. Children born SGA with persistent short stature < −2.5 SDS at age 2 years or < −2 SDS at 3 to 4 years of age, should be referred for diagnostic workup. In case of dysmorphic features, major malformations, microcephaly, developmental delay, intellectual disability, and/or signs of skeletal dysplasia, genetic testing should be considered. Treatment with 0.033 to 0.067 mg GH/kg/day is recommended in case of persistent short stature at age of 3 to 4 years. Adding GnRHa treatment could be considered when short adult height is expected at pubertal onset. All young adults born SGA require counseling to adopt a healthy lifestyle.
Fil: Hokken Koelega, Anita C. S.. Erasmus University (erasmus University);
Fil: van der Steen, Manouk. Erasmus University (erasmus University);
Fil: Boguszewski, Margaret C. S.. Universidade Federal do Paraná; Brasil
Fil: Cianfarani, Stefano. Universita Tor Vergata; Italia. IRCCS “Bambino Gesù” Children's Hospital; Italia
Fil: Dahlgren, Jovanna. University of Gothenburg; Suecia
Fil: Horikawa, Reiko. National Center for Child Health and Development; Japón
Fil: Mericq, Veronica. Universidad de Chile; Chile
Fil: Rapaport, Robert. Mount Sinai Kravis Children's Hospital; Estados Unidos
Fil: Alherbish, Abdullah. Al Habib Medical Group; Arabia Saudita
Fil: Braslavsky, Debora Giselle. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Charmandari, Evangelia. Biomedical Research Foundation of the Academy of Athens; Grecia. Universidad Nacional y Kapodistriaca de Atenas; Grecia
Fil: Chernausek, Steven D.. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Cutfield, Wayne S.. University of Auckland; Nueva Zelanda
Fil: Dauber, Andrew. Children's National Hospital; Estados Unidos
Fil: Deeb, Asma. Khalifa University; Emiratos Arabes Unidos
Fil: Goedegebuure, Wesley J.. Erasmus University (erasmus University);
Fil: Hofman, Paul L.. University of Auckland; Nueva Zelanda
Fil: Isganatis, Elvira. Harvard Medical School; Estados Unidos
Fil: Jorge, Alexander A.. Universidade de Sao Paulo; Brasil
Fil: Kanaka Gantenbein, Christina. Universidad Nacional y Kapodistriaca de Atenas; Grecia
Fil: Kashimada, Kenichi. Tokyo Medical and Dental University; Japón
Fil: Khadilkar, Vaman. Jehangir Hospital; India
Fil: Luo, Xiao Ping. Huazhong University of Science and Technology; China
Fil: Mathai, Sarah. Christian Medical College; India
Fil: Nakano, Yuya. Showa University School of Medicine; Japón
Fil: Yau, Mabel. Mount Sinai Kravis Children's Hospital; Estados Unidos
description This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations. The guideline gives new and clinically relevant insights into the etiology of short stature after SGA birth, including novel knowledge about (epi)genetic causes. Further, it presents long-term consequences of SGA birth and also reviews new treatment options, including treatment with gonadotropin-releasing hormone agonist (GnRHa) in addition to growth hormone (GH) treatment, as well as the metabolic and cardiovascular health of young adults born SGA after cessation of childhood GH treatment in comparison with appropriate control groups.To diagnose SGA, accurate anthropometry and use of national growth charts are recommended. Follow-up in early life is warranted and neurodevelopment evaluation in those at risk. Excessive postnatal weight gain should be avoided, as this is associated with an unfavorable cardiometabolic health profile in adulthood. Children born SGA with persistent short stature < −2.5 SDS at age 2 years or < −2 SDS at 3 to 4 years of age, should be referred for diagnostic workup. In case of dysmorphic features, major malformations, microcephaly, developmental delay, intellectual disability, and/or signs of skeletal dysplasia, genetic testing should be considered. Treatment with 0.033 to 0.067 mg GH/kg/day is recommended in case of persistent short stature at age of 3 to 4 years. Adding GnRHa treatment could be considered when short adult height is expected at pubertal onset. All young adults born SGA require counseling to adopt a healthy lifestyle.
publishDate 2023
dc.date.none.fl_str_mv 2023-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/256663
Hokken Koelega, Anita C. S.; van der Steen, Manouk; Boguszewski, Margaret C. S.; Cianfarani, Stefano; Dahlgren, Jovanna; et al.; International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood; Endocrine Society; Endocrine Reviews; 44; 3; 6-2023; 539-565
0163-769X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/256663
identifier_str_mv Hokken Koelega, Anita C. S.; van der Steen, Manouk; Boguszewski, Margaret C. S.; Cianfarani, Stefano; Dahlgren, Jovanna; et al.; International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood; Endocrine Society; Endocrine Reviews; 44; 3; 6-2023; 539-565
0163-769X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/edrv/article/44/3/539/6986592
info:eu-repo/semantics/altIdentifier/doi/10.1210/endrev/bnad002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Endocrine Society
publisher.none.fl_str_mv Endocrine Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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