International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood

• Autores: Hokken Koelega, Anita C. S.; van der Steen, Manouk; Boguszewski, Margaret C. S.; Cianfarani, Stefano; Dahlgren, Jovanna; Horikawa, Reiko; Mericq, Veronica; Rapaport, Robert; Alherbish, Abdullah; Braslavsky, Debora Giselle; Charmandari, Evangelia; Chernausek, Steven D.; Cutfield, Wayne S.; Dauber, Andrew; Deeb, Asma; Goedegebuure, Wesley J.; Hofman, Paul L.; Isganatis, Elvira; Jorge, Alexander A.; Kanaka Gantenbein, Christina; Kashimada, Kenichi; Khadilkar, Vaman; Luo, Xiao Ping; Mathai, Sarah; Nakano, Yuya; Yau, Mabel
• Año de publicación: 2023
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: SGA; SHORT STATURE; GH
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations. The guideline gives new and clinically relevant insights into the etiology of short stature after SGA birth, including novel knowledge about (epi)genetic causes. Further, it presents long-term consequences of SGA birth and also reviews new treatment options, including treatment with gonadotropin-releasing hormone agonist (GnRHa) in addition to growth hormone (GH) treatment, as well as the metabolic and cardiovascular health of young adults born SGA after cessation of childhood GH treatment in comparison with appropriate control groups.To diagnose SGA, accurate anthropometry and use of national growth charts are recommended. Follow-up in early life is warranted and neurodevelopment evaluation in those at risk. Excessive postnatal weight gain should be avoided, as this is associated with an unfavorable cardiometabolic health profile in adulthood. Children born SGA with persistent short stature < −2.5 SDS at age 2 years or < −2 SDS at 3 to 4 years of age, should be referred for diagnostic workup. In case of dysmorphic features, major malformations, microcephaly, developmental delay, intellectual disability, and/or signs of skeletal dysplasia, genetic testing should be considered. Treatment with 0.033 to 0.067 mg GH/kg/day is recommended in case of persistent short stature at age of 3 to 4 years. Adding GnRHa treatment could be considered when short adult height is expected at pubertal onset. All young adults born SGA require counseling to adopt a healthy lifestyle.
Fil: Hokken Koelega, Anita C. S.. Erasmus University (erasmus University);
Fil: van der Steen, Manouk. Erasmus University (erasmus University);
Fil: Boguszewski, Margaret C. S.. Universidade Federal do Paraná; Brasil
Fil: Cianfarani, Stefano. Universita Tor Vergata; Italia. IRCCS “Bambino Gesù” Children's Hospital; Italia
Fil: Dahlgren, Jovanna. University of Gothenburg; Suecia
Fil: Horikawa, Reiko. National Center for Child Health and Development; Japón
Fil: Mericq, Veronica. Universidad de Chile; Chile
Fil: Rapaport, Robert. Mount Sinai Kravis Children's Hospital; Estados Unidos
Fil: Alherbish, Abdullah. Al Habib Medical Group; Arabia Saudita
Fil: Braslavsky, Debora Giselle. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Gobierno de la Ciudad de Buenos Aires. Centro de Investigaciones Endocrinológicas "Dr. César Bergada". Fundación de Endocrinología Infantil. Centro de Investigaciones Endocrinológicas "Dr. César Bergada"; Argentina
Fil: Charmandari, Evangelia. Biomedical Research Foundation of the Academy of Athens; Grecia. Universidad Nacional y Kapodistriaca de Atenas; Grecia
Fil: Chernausek, Steven D.. Oklahoma Medical Research Foundation; Estados Unidos
Fil: Cutfield, Wayne S.. University of Auckland; Nueva Zelanda
Fil: Dauber, Andrew. Children's National Hospital; Estados Unidos
Fil: Deeb, Asma. Khalifa University; Emiratos Arabes Unidos
Fil: Goedegebuure, Wesley J.. Erasmus University (erasmus University);
Fil: Hofman, Paul L.. University of Auckland; Nueva Zelanda
Fil: Isganatis, Elvira. Harvard Medical School; Estados Unidos
Fil: Jorge, Alexander A.. Universidade de Sao Paulo; Brasil
Fil: Kanaka Gantenbein, Christina. Universidad Nacional y Kapodistriaca de Atenas; Grecia
Fil: Kashimada, Kenichi. Tokyo Medical and Dental University; Japón
Fil: Khadilkar, Vaman. Jehangir Hospital; India
Fil: Luo, Xiao Ping. Huazhong University of Science and Technology; China
Fil: Mathai, Sarah. Christian Medical College; India
Fil: Nakano, Yuya. Showa University School of Medicine; Japón
Fil: Yau, Mabel. Mount Sinai Kravis Children's Hospital; Estados Unidos