European 1: A globally important clonal complex of Mycobacterium bovis

• Autores: Smith, Noel H.; Berg, Stefan; Dale, James; Allen, Adrian; Rodriguez, Sabrina; Romero, Beatriz; Matos, Filipa; Ghebremichael, Solomon; Karoui, Claudine; Donati, Chiara; Milian Suazo, Feliciano; Andrievskaia, Olga; Projahn, Michaela; Barandiaran, Soledad; Macías, Analia Florencia; Müller, Borna; Santos Zanini, Marcos; Ikuta, Cassia Yumi; Rosales Rodríguez, Cesar Alejandro; Pinheiro, Sônia Regina; Cataldi, Ángel Adrián; Gordon, Stephen V.; Jeon, Bo-Young; Källenius, Gunilla; Niemann, Stefan; Boniotti, M. Beatrice; van Helden, Paul D.; Harris, Beth; Zumárraga, Martín José; Kremer, Kristin
• Año de publicación: 2011
• Idioma: inglés
• Tipo de recurso: artículo
• Materia: M. bovis; Phylogeography; Localisation; Clonal complex
• Institución: Consejo Nacional de Investigaciones Científicas y Técnicas

We have identified a globally important clonal complex of Mycobacterium bovis by deletion analysis of over one thousand strains from over 30 countries. We initially show that over 99% of the strains of M. bovis, the cause of bovine tuberculosis, isolated from cattle in the Republic of Ireland and the UK are closely related and are members of a single clonal complex marked by the deletion of chromosomal region RDEu1 and we named this clonal complex European 1 (Eu1). Eu1 strains were present at less than 14% of French, Portuguese and Spanish isolates of M. bovis but are rare in other mainland European countries and Iran. However, strains of the Eu1 clonal complex were found at high frequency in former trading partners of the UK (USA, South Africa, New Zealand, Australia and Canada). The Americas, with the exception of Brazil, are dominated by the Eu1 clonal complex which was at high frequency in Argentina, Chile, Ecuador and Mexico as well as North America. Eu1 was rare or absent in the African countries surveyed except South Africa. A small sample of strains from Taiwan were non-Eu1 but, surprisingly, isolates from Korea and Kazakhstan were members of the Eu1 clonal complex. The simplest explanation for much of the current distribution of the Eu1 clonal complex is that it was spread in infected cattle, such as Herefords, from the UK to former trading partners, although there is evidence of secondary dispersion since. This is the first identification of a globally dispersed clonal complex M. bovis and indicates that much of the current global distribution of this important veterinary pathogen has resulted from relatively recent International trade in cattle.
Fil: Smith, Noel H.. University of Sussex; Reino Unido
Fil: Berg, Stefan. Animal Health and Veterinary Laboratories Agency; Reino Unido
Fil: Dale, James. Animal Health and Veterinary Laboratories Agency; Reino Unido
Fil: Allen, Adrian. Agri Food and Biosciences Institute; Reino Unido
Fil: Rodriguez, Sabrina. Universidad Complutense de Madrid; España
Fil: Romero, Beatriz. Universidad Complutense de Madrid; España
Fil: Matos, Filipa. Laboratório Nacional de Investigação Veterinária; Portugal
Fil: Ghebremichael, Solomon. Swedish Institute for Infectious Disease Control; Suecia
Fil: Karoui, Claudine. Agencia Francesa de Seguridad Sanitaria de los Alimentos; Francia
Fil: Donati, Chiara. Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia; Italia
Fil: Milian Suazo, Feliciano. Instituto Nacional de Investigaciones Forestales Agrícolas y Pecuarias; México
Fil: Andrievskaia, Olga. Canadian Food Inspection Agency; Canadá
Fil: Projahn, Michaela. Research Center Borstel; Alemania
Fil: Barandiaran, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Macías, Analia Florencia. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Müller, Borna. Stellenbosch University; Sudáfrica
Fil: Santos Zanini, Marcos. Universidade Federal do Espírito Santo; Brasil
Fil: Ikuta, Cassia Yumi. Universidade de Sao Paulo; Brasil
Fil: Rosales Rodríguez, Cesar Alejandro. Universidade de Sao Paulo; Brasil
Fil: Pinheiro, Sônia Regina. Universidade de Sao Paulo; Brasil
Fil: Cataldi, Ángel Adrián. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina
Fil: Gordon, Stephen V.. University College London; Estados Unidos
Fil: Jeon, Bo-Young. Yonsei University; Japón
Fil: Källenius, Gunilla. Karolinska Institutet; Suecia
Fil: Niemann, Stefan. Karolinska Institutet; Suecia
Fil: Boniotti, M. Beatrice. Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia; Italia
Fil: van Helden, Paul D.. Universidad de Buenos Aires. Facultad de Ciencias Veterinarias; Argentina
Fil: Harris, Beth. United States Department of Agriculture; Estados Unidos
Fil: Zumárraga, Martín José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto Nacional de Tecnología Agropecuaria. Centro de Investigación en Ciencias Veterinarias y Agronómicas. Instituto de Biotecnología; Argentina
Fil: Kremer, Kristin. National Institute for Public Health and the Environment; Países Bajos