Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases

Autores
Ambasch, German; Coscia, Esteban; Tambini Díaz, Jorge Luis; Bueno, Germán David; Argañarás, Luis Alberto; Martínez Ríos, Nicolás; Porta, Daniela Josefina; Beltramo, Dante Miguel; Garcia, Nestor Horacio
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
No specific and effective antiviral treatment has been approved for COVID-19 so far. Systemic corticosteroid and remdesivir have shown to decrease mortality in COVID-19 patients, but mortality still is elevated. We propose that nebulized hypertonic ibuprofen solu- tion which has bactericidal, virucidal, mucolytic and anti-inflamma- tory properties to be used for COVID-19 pneumonia and prevent the classical evolution to respiratory failure and mechanical respiration. We report here the first two cases of the COVID-19 pneumonia suc- cessfully treated with nebulized hypertonic ibuprofen solution (NaI- HS). Rationale of the treatment is to mitigate the local inflammation with inhaled NIH that stays in the lung and may inhibit proliferation of the virus, inflammation and successfully reverts the hypoxia ob- served in these clinical cases. Mild adverse events were observed. Larger and further studies are warranted to confirm the result of these cases.
Fil: Ambasch, German. Sanatorio Privado Mayo; Argentina
Fil: Coscia, Esteban. Sanatorio Privado Mayo; Argentina
Fil: Tambini Díaz, Jorge Luis. Sanatorio Privado Mayo; Argentina
Fil: Bueno, Germán David. Sanatorio Privado Mayo; Argentina
Fil: Argañarás, Luis Alberto. Quimica Luar SRL; Argentina
Fil: Martínez Ríos, Nicolás. Quimica Luar SRL; Argentina
Fil: Porta, Daniela Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Beltramo, Dante Miguel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garcia, Nestor Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Materia
severe acute respiratory syndrome coronavirus
hypertonic ibuprofen solution
inhalation
coronavirus disease 2019
COVID-19
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147888
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/147888
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first casesAmbasch, GermanCoscia, EstebanTambini Díaz, Jorge LuisBueno, Germán DavidArgañarás, Luis AlbertoMartínez Ríos, NicolásPorta, Daniela JosefinaBeltramo, Dante MiguelGarcia, Nestor Horaciosevere acute respiratory syndrome coronavirushypertonic ibuprofen solutioninhalationcoronavirus disease 2019COVID-19https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3No specific and effective antiviral treatment has been approved for COVID-19 so far. Systemic corticosteroid and remdesivir have shown to decrease mortality in COVID-19 patients, but mortality still is elevated. We propose that nebulized hypertonic ibuprofen solu- tion which has bactericidal, virucidal, mucolytic and anti-inflamma- tory properties to be used for COVID-19 pneumonia and prevent the classical evolution to respiratory failure and mechanical respiration. We report here the first two cases of the COVID-19 pneumonia suc- cessfully treated with nebulized hypertonic ibuprofen solution (NaI- HS). Rationale of the treatment is to mitigate the local inflammation with inhaled NIH that stays in the lung and may inhibit proliferation of the virus, inflammation and successfully reverts the hypoxia ob- served in these clinical cases. Mild adverse events were observed. Larger and further studies are warranted to confirm the result of these cases.Fil: Ambasch, German. Sanatorio Privado Mayo; ArgentinaFil: Coscia, Esteban. Sanatorio Privado Mayo; ArgentinaFil: Tambini Díaz, Jorge Luis. Sanatorio Privado Mayo; ArgentinaFil: Bueno, Germán David. Sanatorio Privado Mayo; ArgentinaFil: Argañarás, Luis Alberto. Quimica Luar SRL; ArgentinaFil: Martínez Ríos, Nicolás. Quimica Luar SRL; ArgentinaFil: Porta, Daniela Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaFil: Beltramo, Dante Miguel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia, Nestor Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; ArgentinaJournal of Clinical Images and Medical Case Reports2021-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147888Ambasch, German; Coscia, Esteban; Tambini Díaz, Jorge Luis; Bueno, Germán David; Argañarás, Luis Alberto; et al.; Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases; Journal of Clinical Images and Medical Case Reports; Journal of Clinical Images and Medical Case Reports; 2; 5; 10-2021; 1-52766-7820CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jcimcr.org/pdfs/JCIMCR-v2-1336.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:28Zoai:ri.conicet.gov.ar:11336/147888instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:28.949CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases
title Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases
spellingShingle Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases
Ambasch, German
severe acute respiratory syndrome coronavirus
hypertonic ibuprofen solution
inhalation
coronavirus disease 2019
COVID-19
title_short Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases
title_full Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases
title_fullStr Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases
title_full_unstemmed Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases
title_sort Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases
dc.creator.none.fl_str_mv Ambasch, German
Coscia, Esteban
Tambini Díaz, Jorge Luis
Bueno, Germán David
Argañarás, Luis Alberto
Martínez Ríos, Nicolás
Porta, Daniela Josefina
Beltramo, Dante Miguel
Garcia, Nestor Horacio
author Ambasch, German
author_facet Ambasch, German
Coscia, Esteban
Tambini Díaz, Jorge Luis
Bueno, Germán David
Argañarás, Luis Alberto
Martínez Ríos, Nicolás
Porta, Daniela Josefina
Beltramo, Dante Miguel
Garcia, Nestor Horacio
author_role author
author2 Coscia, Esteban
Tambini Díaz, Jorge Luis
Bueno, Germán David
Argañarás, Luis Alberto
Martínez Ríos, Nicolás
Porta, Daniela Josefina
Beltramo, Dante Miguel
Garcia, Nestor Horacio
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv severe acute respiratory syndrome coronavirus
hypertonic ibuprofen solution
inhalation
coronavirus disease 2019
COVID-19
topic severe acute respiratory syndrome coronavirus
hypertonic ibuprofen solution
inhalation
coronavirus disease 2019
COVID-19
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv No specific and effective antiviral treatment has been approved for COVID-19 so far. Systemic corticosteroid and remdesivir have shown to decrease mortality in COVID-19 patients, but mortality still is elevated. We propose that nebulized hypertonic ibuprofen solu- tion which has bactericidal, virucidal, mucolytic and anti-inflamma- tory properties to be used for COVID-19 pneumonia and prevent the classical evolution to respiratory failure and mechanical respiration. We report here the first two cases of the COVID-19 pneumonia suc- cessfully treated with nebulized hypertonic ibuprofen solution (NaI- HS). Rationale of the treatment is to mitigate the local inflammation with inhaled NIH that stays in the lung and may inhibit proliferation of the virus, inflammation and successfully reverts the hypoxia ob- served in these clinical cases. Mild adverse events were observed. Larger and further studies are warranted to confirm the result of these cases.
Fil: Ambasch, German. Sanatorio Privado Mayo; Argentina
Fil: Coscia, Esteban. Sanatorio Privado Mayo; Argentina
Fil: Tambini Díaz, Jorge Luis. Sanatorio Privado Mayo; Argentina
Fil: Bueno, Germán David. Sanatorio Privado Mayo; Argentina
Fil: Argañarás, Luis Alberto. Quimica Luar SRL; Argentina
Fil: Martínez Ríos, Nicolás. Quimica Luar SRL; Argentina
Fil: Porta, Daniela Josefina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
Fil: Beltramo, Dante Miguel. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Garcia, Nestor Horacio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Ciencias de la Salud. Universidad Nacional de Córdoba. Instituto de Investigaciones en Ciencias de la Salud; Argentina
description No specific and effective antiviral treatment has been approved for COVID-19 so far. Systemic corticosteroid and remdesivir have shown to decrease mortality in COVID-19 patients, but mortality still is elevated. We propose that nebulized hypertonic ibuprofen solu- tion which has bactericidal, virucidal, mucolytic and anti-inflamma- tory properties to be used for COVID-19 pneumonia and prevent the classical evolution to respiratory failure and mechanical respiration. We report here the first two cases of the COVID-19 pneumonia suc- cessfully treated with nebulized hypertonic ibuprofen solution (NaI- HS). Rationale of the treatment is to mitigate the local inflammation with inhaled NIH that stays in the lung and may inhibit proliferation of the virus, inflammation and successfully reverts the hypoxia ob- served in these clinical cases. Mild adverse events were observed. Larger and further studies are warranted to confirm the result of these cases.
publishDate 2021
dc.date.none.fl_str_mv 2021-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147888
Ambasch, German; Coscia, Esteban; Tambini Díaz, Jorge Luis; Bueno, Germán David; Argañarás, Luis Alberto; et al.; Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases; Journal of Clinical Images and Medical Case Reports; Journal of Clinical Images and Medical Case Reports; 2; 5; 10-2021; 1-5
2766-7820
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147888
identifier_str_mv Ambasch, German; Coscia, Esteban; Tambini Díaz, Jorge Luis; Bueno, Germán David; Argañarás, Luis Alberto; et al.; Therapeutic potential of ibuprofen inhalation for COVID-19 pneumonia: Report of two first cases; Journal of Clinical Images and Medical Case Reports; Journal of Clinical Images and Medical Case Reports; 2; 5; 10-2021; 1-5
2766-7820
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jcimcr.org/pdfs/JCIMCR-v2-1336.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Journal of Clinical Images and Medical Case Reports
publisher.none.fl_str_mv Journal of Clinical Images and Medical Case Reports
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269522592006144
score 13.13397

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