Preformulation: The use of FTIR in compatibility studies

Autores
Segall, Adriana Ines
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Studies of active pharmaceutical ingredient (API) - excipient compatibility represent an important study in the preformulation stage of the development of new dosage forms. The potential physical and chemical interactions between an API and the excipients can affect the chemical nature, the stability and bioavailability of the former and, consequently, its therapeutic efficacy and safety. Solid dosage forms are generally less stable than their API components. Despite the importance of API-excipient compatibility testing, there is no universally accepted protocol to assess such interactions. Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Isothermal Stress Testing-Fourier Transform Infrared Spectroscopy (IST-FT-IR), Isothermal Stress Testing-High Performance Liquid Chromatography (IST-HPLC), are commonly used as screening techniques for assessing the compatibility of an active pharmaceutical ingredient (API) with some currently employed excipients. Through the assignment of spectral bands, FTIR provides information on chemical reactions taking place between the API and the excipient. Thus, this procedure gives formulation scientists information on which chemical groups to avoid in the excipients, favoring the development of more stable blends.
Fil: Segall, Adriana Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
compatibility studies
preformulation
Fourier Transform Infrared Spectroscopy
Differential Scanning Calorimetry
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/134583
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/134583
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Preformulation: The use of FTIR in compatibility studiesSegall, Adriana Inescompatibility studiespreformulationFourier Transform Infrared SpectroscopyDifferential Scanning Calorimetryhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Studies of active pharmaceutical ingredient (API) - excipient compatibility represent an important study in the preformulation stage of the development of new dosage forms. The potential physical and chemical interactions between an API and the excipients can affect the chemical nature, the stability and bioavailability of the former and, consequently, its therapeutic efficacy and safety. Solid dosage forms are generally less stable than their API components. Despite the importance of API-excipient compatibility testing, there is no universally accepted protocol to assess such interactions. Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Isothermal Stress Testing-Fourier Transform Infrared Spectroscopy (IST-FT-IR), Isothermal Stress Testing-High Performance Liquid Chromatography (IST-HPLC), are commonly used as screening techniques for assessing the compatibility of an active pharmaceutical ingredient (API) with some currently employed excipients. Through the assignment of spectral bands, FTIR provides information on chemical reactions taking place between the API and the excipient. Thus, this procedure gives formulation scientists information on which chemical groups to avoid in the excipients, favoring the development of more stable blends.Fil: Segall, Adriana Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaSouth Asian Academic Publications2019-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/134583Segall, Adriana Ines; Preformulation: The use of FTIR in compatibility studies; South Asian Academic Publications; Journal of Innovations in Applied Pharmaceutical Science; 4; 7-2019; 1-62455-5177CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://jiapsonline.com/VolumeArticles/FullTextPDF/45_JIAPSV4I301.pdfinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:53:49Zoai:ri.conicet.gov.ar:11336/134583instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:53:49.982CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Preformulation: The use of FTIR in compatibility studies
title Preformulation: The use of FTIR in compatibility studies
spellingShingle Preformulation: The use of FTIR in compatibility studies
Segall, Adriana Ines
compatibility studies
preformulation
Fourier Transform Infrared Spectroscopy
Differential Scanning Calorimetry
title_short Preformulation: The use of FTIR in compatibility studies
title_full Preformulation: The use of FTIR in compatibility studies
title_fullStr Preformulation: The use of FTIR in compatibility studies
title_full_unstemmed Preformulation: The use of FTIR in compatibility studies
title_sort Preformulation: The use of FTIR in compatibility studies
dc.creator.none.fl_str_mv Segall, Adriana Ines
author Segall, Adriana Ines
author_facet Segall, Adriana Ines
author_role author
dc.subject.none.fl_str_mv compatibility studies
preformulation
Fourier Transform Infrared Spectroscopy
Differential Scanning Calorimetry
topic compatibility studies
preformulation
Fourier Transform Infrared Spectroscopy
Differential Scanning Calorimetry
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Studies of active pharmaceutical ingredient (API) - excipient compatibility represent an important study in the preformulation stage of the development of new dosage forms. The potential physical and chemical interactions between an API and the excipients can affect the chemical nature, the stability and bioavailability of the former and, consequently, its therapeutic efficacy and safety. Solid dosage forms are generally less stable than their API components. Despite the importance of API-excipient compatibility testing, there is no universally accepted protocol to assess such interactions. Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Isothermal Stress Testing-Fourier Transform Infrared Spectroscopy (IST-FT-IR), Isothermal Stress Testing-High Performance Liquid Chromatography (IST-HPLC), are commonly used as screening techniques for assessing the compatibility of an active pharmaceutical ingredient (API) with some currently employed excipients. Through the assignment of spectral bands, FTIR provides information on chemical reactions taking place between the API and the excipient. Thus, this procedure gives formulation scientists information on which chemical groups to avoid in the excipients, favoring the development of more stable blends.
Fil: Segall, Adriana Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Tecnología Farmacéutica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description Studies of active pharmaceutical ingredient (API) - excipient compatibility represent an important study in the preformulation stage of the development of new dosage forms. The potential physical and chemical interactions between an API and the excipients can affect the chemical nature, the stability and bioavailability of the former and, consequently, its therapeutic efficacy and safety. Solid dosage forms are generally less stable than their API components. Despite the importance of API-excipient compatibility testing, there is no universally accepted protocol to assess such interactions. Fourier Transform Infrared Spectroscopy (FT-IR), Differential Scanning Calorimetry (DSC), Isothermal Stress Testing-Fourier Transform Infrared Spectroscopy (IST-FT-IR), Isothermal Stress Testing-High Performance Liquid Chromatography (IST-HPLC), are commonly used as screening techniques for assessing the compatibility of an active pharmaceutical ingredient (API) with some currently employed excipients. Through the assignment of spectral bands, FTIR provides information on chemical reactions taking place between the API and the excipient. Thus, this procedure gives formulation scientists information on which chemical groups to avoid in the excipients, favoring the development of more stable blends.
publishDate 2019
dc.date.none.fl_str_mv 2019-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/134583
Segall, Adriana Ines; Preformulation: The use of FTIR in compatibility studies; South Asian Academic Publications; Journal of Innovations in Applied Pharmaceutical Science; 4; 7-2019; 1-6
2455-5177
CONICET Digital
CONICET
url http://hdl.handle.net/11336/134583
identifier_str_mv Segall, Adriana Ines; Preformulation: The use of FTIR in compatibility studies; South Asian Academic Publications; Journal of Innovations in Applied Pharmaceutical Science; 4; 7-2019; 1-6
2455-5177
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://jiapsonline.com/VolumeArticles/FullTextPDF/45_JIAPSV4I301.pdf
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv South Asian Academic Publications
publisher.none.fl_str_mv South Asian Academic Publications
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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