Autophagy: Eating Myself as a Requirement for the Skin Health

Autores
Rinflerch, Adriana Raquel; De Luca, David Aldo; Miretti, Marcos Mateo; Galimberti, Ricardo Luis
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cells recycle their components during starvation through aprocess called autophagy. It is a normal cellular mechanism related tophysiological actions such as nutrient and energy metabolism.In the skin as in other organs, one normal function of autophagyis related to the immune system as the control of mycotic, bacterialand viral infections. Genetic alterations cause amino acid substitutionsin proteins, when it?s involved to autophagy compounds, results inalterations of the defense mechanisms of the host. They have beenrecently involved in the pathogenesis of immunological disorderssuch as systemic lupus erythematosus, vitiligo and oral lichen planus.Furthermore, alterations in autophagy process induce a moreaggressive behavior and reduced life expectancy in squamouscell carcinoma and malignant melanoma. The aim of this review isdescribe the molecular process of autophagy and how alterations ofcomponents of this process are linked to the development of diversesskin pathologies.The understanding of molecular mechanisms involved inautophagy promises new diagnostic and treatment perspectives,mainly in autoimmune diseases and skin cancer.
Fil: Rinflerch, Adriana Raquel. Hospital Italiano; Argentina
Fil: De Luca, David Aldo. Hospital Italiano; Argentina
Fil: Miretti, Marcos Mateo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; Argentina
Fil: Galimberti, Ricardo Luis. Hospital Italiano; Argentina
Materia
AUTOPHAGY
AUTOIMMUNE
SKIN
VITILIGO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/46434
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Autophagy: Eating Myself as a Requirement for the Skin HealthRinflerch, Adriana RaquelDe Luca, David AldoMiretti, Marcos MateoGalimberti, Ricardo LuisAUTOPHAGYAUTOIMMUNESKINVITILIGOhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Cells recycle their components during starvation through aprocess called autophagy. It is a normal cellular mechanism related tophysiological actions such as nutrient and energy metabolism.In the skin as in other organs, one normal function of autophagyis related to the immune system as the control of mycotic, bacterialand viral infections. Genetic alterations cause amino acid substitutionsin proteins, when it?s involved to autophagy compounds, results inalterations of the defense mechanisms of the host. They have beenrecently involved in the pathogenesis of immunological disorderssuch as systemic lupus erythematosus, vitiligo and oral lichen planus.Furthermore, alterations in autophagy process induce a moreaggressive behavior and reduced life expectancy in squamouscell carcinoma and malignant melanoma. The aim of this review isdescribe the molecular process of autophagy and how alterations ofcomponents of this process are linked to the development of diversesskin pathologies.The understanding of molecular mechanisms involved inautophagy promises new diagnostic and treatment perspectives,mainly in autoimmune diseases and skin cancer.Fil: Rinflerch, Adriana Raquel. Hospital Italiano; ArgentinaFil: De Luca, David Aldo. Hospital Italiano; ArgentinaFil: Miretti, Marcos Mateo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; ArgentinaFil: Galimberti, Ricardo Luis. Hospital Italiano; ArgentinaAvens Publishing Group2017-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/46434Rinflerch, Adriana Raquel; De Luca, David Aldo; Miretti, Marcos Mateo; Galimberti, Ricardo Luis; Autophagy: Eating Myself as a Requirement for the Skin Health; Avens Publishing Group; Journal of Clinical and Investigative Dermatology; 5; 2; 12-2017; 1-72373-10442373-1044CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.13188/2373-1044.1000045info:eu-repo/semantics/altIdentifier/url/http://www.avensonline.org/fulltextarticles/JCID-2373-1044-05-0045.htmlinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:06:07Zoai:ri.conicet.gov.ar:11336/46434instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:06:07.702CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Autophagy: Eating Myself as a Requirement for the Skin Health
title Autophagy: Eating Myself as a Requirement for the Skin Health
spellingShingle Autophagy: Eating Myself as a Requirement for the Skin Health
Rinflerch, Adriana Raquel
AUTOPHAGY
AUTOIMMUNE
SKIN
VITILIGO
title_short Autophagy: Eating Myself as a Requirement for the Skin Health
title_full Autophagy: Eating Myself as a Requirement for the Skin Health
title_fullStr Autophagy: Eating Myself as a Requirement for the Skin Health
title_full_unstemmed Autophagy: Eating Myself as a Requirement for the Skin Health
title_sort Autophagy: Eating Myself as a Requirement for the Skin Health
dc.creator.none.fl_str_mv Rinflerch, Adriana Raquel
De Luca, David Aldo
Miretti, Marcos Mateo
Galimberti, Ricardo Luis
author Rinflerch, Adriana Raquel
author_facet Rinflerch, Adriana Raquel
De Luca, David Aldo
Miretti, Marcos Mateo
Galimberti, Ricardo Luis
author_role author
author2 De Luca, David Aldo
Miretti, Marcos Mateo
Galimberti, Ricardo Luis
author2_role author
author
author
dc.subject.none.fl_str_mv AUTOPHAGY
AUTOIMMUNE
SKIN
VITILIGO
topic AUTOPHAGY
AUTOIMMUNE
SKIN
VITILIGO
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Cells recycle their components during starvation through aprocess called autophagy. It is a normal cellular mechanism related tophysiological actions such as nutrient and energy metabolism.In the skin as in other organs, one normal function of autophagyis related to the immune system as the control of mycotic, bacterialand viral infections. Genetic alterations cause amino acid substitutionsin proteins, when it?s involved to autophagy compounds, results inalterations of the defense mechanisms of the host. They have beenrecently involved in the pathogenesis of immunological disorderssuch as systemic lupus erythematosus, vitiligo and oral lichen planus.Furthermore, alterations in autophagy process induce a moreaggressive behavior and reduced life expectancy in squamouscell carcinoma and malignant melanoma. The aim of this review isdescribe the molecular process of autophagy and how alterations ofcomponents of this process are linked to the development of diversesskin pathologies.The understanding of molecular mechanisms involved inautophagy promises new diagnostic and treatment perspectives,mainly in autoimmune diseases and skin cancer.
Fil: Rinflerch, Adriana Raquel. Hospital Italiano; Argentina
Fil: De Luca, David Aldo. Hospital Italiano; Argentina
Fil: Miretti, Marcos Mateo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas | Universidad Nacional de Misiones. Instituto de Biología Subtropical. Instituto de Biología Subtropical - Nodo Posadas; Argentina
Fil: Galimberti, Ricardo Luis. Hospital Italiano; Argentina
description Cells recycle their components during starvation through aprocess called autophagy. It is a normal cellular mechanism related tophysiological actions such as nutrient and energy metabolism.In the skin as in other organs, one normal function of autophagyis related to the immune system as the control of mycotic, bacterialand viral infections. Genetic alterations cause amino acid substitutionsin proteins, when it?s involved to autophagy compounds, results inalterations of the defense mechanisms of the host. They have beenrecently involved in the pathogenesis of immunological disorderssuch as systemic lupus erythematosus, vitiligo and oral lichen planus.Furthermore, alterations in autophagy process induce a moreaggressive behavior and reduced life expectancy in squamouscell carcinoma and malignant melanoma. The aim of this review isdescribe the molecular process of autophagy and how alterations ofcomponents of this process are linked to the development of diversesskin pathologies.The understanding of molecular mechanisms involved inautophagy promises new diagnostic and treatment perspectives,mainly in autoimmune diseases and skin cancer.
publishDate 2017
dc.date.none.fl_str_mv 2017-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/46434
Rinflerch, Adriana Raquel; De Luca, David Aldo; Miretti, Marcos Mateo; Galimberti, Ricardo Luis; Autophagy: Eating Myself as a Requirement for the Skin Health; Avens Publishing Group; Journal of Clinical and Investigative Dermatology; 5; 2; 12-2017; 1-7
2373-1044
2373-1044
CONICET Digital
CONICET
url http://hdl.handle.net/11336/46434
identifier_str_mv Rinflerch, Adriana Raquel; De Luca, David Aldo; Miretti, Marcos Mateo; Galimberti, Ricardo Luis; Autophagy: Eating Myself as a Requirement for the Skin Health; Avens Publishing Group; Journal of Clinical and Investigative Dermatology; 5; 2; 12-2017; 1-7
2373-1044
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.13188/2373-1044.1000045
info:eu-repo/semantics/altIdentifier/url/http://www.avensonline.org/fulltextarticles/JCID-2373-1044-05-0045.html
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Avens Publishing Group
publisher.none.fl_str_mv Avens Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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