Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring

Autores
Rodríguez, Pablo E. A.; Sanchez, Monica Silvina
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Although significant progress has been made in studying how triclosan affects the male reproductive tract, it is unknown whether this potent antibacterial agent can affect pregnancy and female pubertal development. Maternal exposure to TRICLOSAN on thyroid homeostasis (TH) and reproductive tract development in female Wistar rats was studied. Dams were exposed daily to TRICLOSAN (0, 1, 10, or 50 mg/kg/day) from 8 days before mating to lactation day 21. Offspring were also exposed after weaning. In vivo TRICLOSAN estrogenic activity was screened by uterotrophic assay and vaginal opening (VO), with first estrus, uterus and ovary weight being analyzed in offspring. Dam blood samples were taken during pregnancy and lactation to determine the effect of TRICLOSAN on TH. No external signs of toxicity or differences in mean numbers of implantation sites were observed in treated-rats. Triclosan treatment decreased total serum T4 and T3 in pregnant rats and also decreased sex ratio, pup body weight on PND20 and delayed VO in offspring. In addition, the highest dose of TRICLOSAN significantly decreased the live birth index (%) and 6-day survival index. Results show that Triclosan impairs THYROID HOMEOSTASIS and reproductive toxicity in adult rats and produces fetal toxicity in offspring exposed in utero, lactation, and after weaning.
Fil: Rodríguez, Pablo E. A.. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina
Fil: Sanchez, Monica Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina
Materia
TRICLOSAN
REPRODUCTIVE TOXICITY
SEXUAL DEVELOPMENT
THYROID HOMEOSTASIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/284048
Acceder
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repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat OffspringRodríguez, Pablo E. A.Sanchez, Monica SilvinaTRICLOSANREPRODUCTIVE TOXICITYSEXUAL DEVELOPMENTTHYROID HOMEOSTASIShttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Although significant progress has been made in studying how triclosan affects the male reproductive tract, it is unknown whether this potent antibacterial agent can affect pregnancy and female pubertal development. Maternal exposure to TRICLOSAN on thyroid homeostasis (TH) and reproductive tract development in female Wistar rats was studied. Dams were exposed daily to TRICLOSAN (0, 1, 10, or 50 mg/kg/day) from 8 days before mating to lactation day 21. Offspring were also exposed after weaning. In vivo TRICLOSAN estrogenic activity was screened by uterotrophic assay and vaginal opening (VO), with first estrus, uterus and ovary weight being analyzed in offspring. Dam blood samples were taken during pregnancy and lactation to determine the effect of TRICLOSAN on TH. No external signs of toxicity or differences in mean numbers of implantation sites were observed in treated-rats. Triclosan treatment decreased total serum T4 and T3 in pregnant rats and also decreased sex ratio, pup body weight on PND20 and delayed VO in offspring. In addition, the highest dose of TRICLOSAN significantly decreased the live birth index (%) and 6-day survival index. Results show that Triclosan impairs THYROID HOMEOSTASIS and reproductive toxicity in adult rats and produces fetal toxicity in offspring exposed in utero, lactation, and after weaning.Fil: Rodríguez, Pablo E. A.. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; ArgentinaFil: Sanchez, Monica Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; ArgentinaTaylor & Francis2010-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/284048Rodríguez, Pablo E. A.; Sanchez, Monica Silvina; Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring; Taylor & Francis; Journal of Toxicology and Environmental Health-Part A-Current Issues; 73; 24; 11-2010; 1678-16881528-7394CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/15287394.2010.516241info:eu-repo/semantics/altIdentifier/doi/10.1080/15287394.2010.516241info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2026-06-17T09:38:34Zoai:ri.conicet.gov.ar:11336/284048instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982026-06-17 09:38:34.755CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring
title Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring
spellingShingle Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring
Rodríguez, Pablo E. A.
TRICLOSAN
REPRODUCTIVE TOXICITY
SEXUAL DEVELOPMENT
THYROID HOMEOSTASIS
title_short Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring
title_full Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring
title_fullStr Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring
title_full_unstemmed Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring
title_sort Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring
dc.creator.none.fl_str_mv Rodríguez, Pablo E. A.
Sanchez, Monica Silvina
author Rodríguez, Pablo E. A.
author_facet Rodríguez, Pablo E. A.
Sanchez, Monica Silvina
author_role author
author2 Sanchez, Monica Silvina
author2_role author
dc.subject.none.fl_str_mv TRICLOSAN
REPRODUCTIVE TOXICITY
SEXUAL DEVELOPMENT
THYROID HOMEOSTASIS
topic TRICLOSAN
REPRODUCTIVE TOXICITY
SEXUAL DEVELOPMENT
THYROID HOMEOSTASIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Although significant progress has been made in studying how triclosan affects the male reproductive tract, it is unknown whether this potent antibacterial agent can affect pregnancy and female pubertal development. Maternal exposure to TRICLOSAN on thyroid homeostasis (TH) and reproductive tract development in female Wistar rats was studied. Dams were exposed daily to TRICLOSAN (0, 1, 10, or 50 mg/kg/day) from 8 days before mating to lactation day 21. Offspring were also exposed after weaning. In vivo TRICLOSAN estrogenic activity was screened by uterotrophic assay and vaginal opening (VO), with first estrus, uterus and ovary weight being analyzed in offspring. Dam blood samples were taken during pregnancy and lactation to determine the effect of TRICLOSAN on TH. No external signs of toxicity or differences in mean numbers of implantation sites were observed in treated-rats. Triclosan treatment decreased total serum T4 and T3 in pregnant rats and also decreased sex ratio, pup body weight on PND20 and delayed VO in offspring. In addition, the highest dose of TRICLOSAN significantly decreased the live birth index (%) and 6-day survival index. Results show that Triclosan impairs THYROID HOMEOSTASIS and reproductive toxicity in adult rats and produces fetal toxicity in offspring exposed in utero, lactation, and after weaning.
Fil: Rodríguez, Pablo E. A.. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina
Fil: Sanchez, Monica Silvina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Provincia de Córdoba. Ministerio de Ciencia y Técnica. Centro de Excelencia en Productos y Procesos de Córdoba; Argentina
description Although significant progress has been made in studying how triclosan affects the male reproductive tract, it is unknown whether this potent antibacterial agent can affect pregnancy and female pubertal development. Maternal exposure to TRICLOSAN on thyroid homeostasis (TH) and reproductive tract development in female Wistar rats was studied. Dams were exposed daily to TRICLOSAN (0, 1, 10, or 50 mg/kg/day) from 8 days before mating to lactation day 21. Offspring were also exposed after weaning. In vivo TRICLOSAN estrogenic activity was screened by uterotrophic assay and vaginal opening (VO), with first estrus, uterus and ovary weight being analyzed in offspring. Dam blood samples were taken during pregnancy and lactation to determine the effect of TRICLOSAN on TH. No external signs of toxicity or differences in mean numbers of implantation sites were observed in treated-rats. Triclosan treatment decreased total serum T4 and T3 in pregnant rats and also decreased sex ratio, pup body weight on PND20 and delayed VO in offspring. In addition, the highest dose of TRICLOSAN significantly decreased the live birth index (%) and 6-day survival index. Results show that Triclosan impairs THYROID HOMEOSTASIS and reproductive toxicity in adult rats and produces fetal toxicity in offspring exposed in utero, lactation, and after weaning.
publishDate 2010
dc.date.none.fl_str_mv 2010-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/284048
Rodríguez, Pablo E. A.; Sanchez, Monica Silvina; Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring; Taylor & Francis; Journal of Toxicology and Environmental Health-Part A-Current Issues; 73; 24; 11-2010; 1678-1688
1528-7394
CONICET Digital
CONICET
url http://hdl.handle.net/11336/284048
identifier_str_mv Rodríguez, Pablo E. A.; Sanchez, Monica Silvina; Maternal Exposure to Triclosan Impairs Thyroid Homeostasis and Female Pubertal Development in Wistar Rat Offspring; Taylor & Francis; Journal of Toxicology and Environmental Health-Part A-Current Issues; 73; 24; 11-2010; 1678-1688
1528-7394
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.tandfonline.com/doi/abs/10.1080/15287394.2010.516241
info:eu-repo/semantics/altIdentifier/doi/10.1080/15287394.2010.516241
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.040872

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