Deterministic Limit of Intracellular Calcium Spikes

Autores
Voorsluijs, V.; Ponce Dawson, Silvina Martha; De Decker, Y.; Dupont, G.
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In nonexcitable cells, global Ca2+ spikes emerge from the collective dynamics of clusters of Ca2+ channels that are coupled by diffusion. Current modeling approaches have opposed stochastic descriptions of these systems to purely deterministic models, while both paradoxically appear compatible with experimental data. Combining fully stochastic simulations and mean-field analyses, we demonstrate that these two approaches can be reconciled. Our fully stochastic model generates spike sequences that can be seen as noise-perturbed oscillations of deterministic origin, while displaying statistical properties in agreement with experimental data. These underlying deterministic oscillations arise from a phenomenological spike nucleation mechanism.
Fil: Voorsluijs, V.. Université Libre de Bruxelles; Bélgica
Fil: Ponce Dawson, Silvina Martha. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: De Decker, Y.. Université Libre de Bruxelles; Bélgica
Fil: Dupont, G.. Université Libre de Bruxelles; Bélgica
Materia
CALCIUM
OSCILLATIONS
SPIKES
DETERMINISM
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/147504
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/147504
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Deterministic Limit of Intracellular Calcium SpikesVoorsluijs, V.Ponce Dawson, Silvina MarthaDe Decker, Y.Dupont, G.CALCIUMOSCILLATIONSSPIKESDETERMINISMhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1In nonexcitable cells, global Ca2+ spikes emerge from the collective dynamics of clusters of Ca2+ channels that are coupled by diffusion. Current modeling approaches have opposed stochastic descriptions of these systems to purely deterministic models, while both paradoxically appear compatible with experimental data. Combining fully stochastic simulations and mean-field analyses, we demonstrate that these two approaches can be reconciled. Our fully stochastic model generates spike sequences that can be seen as noise-perturbed oscillations of deterministic origin, while displaying statistical properties in agreement with experimental data. These underlying deterministic oscillations arise from a phenomenological spike nucleation mechanism.Fil: Voorsluijs, V.. Université Libre de Bruxelles; BélgicaFil: Ponce Dawson, Silvina Martha. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; ArgentinaFil: De Decker, Y.. Université Libre de Bruxelles; BélgicaFil: Dupont, G.. Université Libre de Bruxelles; BélgicaAmerican Physical Society2019-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/147504Voorsluijs, V.; Ponce Dawson, Silvina Martha; De Decker, Y.; Dupont, G.; Deterministic Limit of Intracellular Calcium Spikes; American Physical Society; Physical Review Letters; 122; 8; 2-2019; 1-60031-9007CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.aps.org/doi/10.1103/PhysRevLett.122.088101info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevLett.122.088101info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:21:23Zoai:ri.conicet.gov.ar:11336/147504instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:21:24.224CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Deterministic Limit of Intracellular Calcium Spikes
title Deterministic Limit of Intracellular Calcium Spikes
spellingShingle Deterministic Limit of Intracellular Calcium Spikes
Voorsluijs, V.
CALCIUM
OSCILLATIONS
SPIKES
DETERMINISM
title_short Deterministic Limit of Intracellular Calcium Spikes
title_full Deterministic Limit of Intracellular Calcium Spikes
title_fullStr Deterministic Limit of Intracellular Calcium Spikes
title_full_unstemmed Deterministic Limit of Intracellular Calcium Spikes
title_sort Deterministic Limit of Intracellular Calcium Spikes
dc.creator.none.fl_str_mv Voorsluijs, V.
Ponce Dawson, Silvina Martha
De Decker, Y.
Dupont, G.
author Voorsluijs, V.
author_facet Voorsluijs, V.
Ponce Dawson, Silvina Martha
De Decker, Y.
Dupont, G.
author_role author
author2 Ponce Dawson, Silvina Martha
De Decker, Y.
Dupont, G.
author2_role author
author
author
dc.subject.none.fl_str_mv CALCIUM
OSCILLATIONS
SPIKES
DETERMINISM
topic CALCIUM
OSCILLATIONS
SPIKES
DETERMINISM
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In nonexcitable cells, global Ca2+ spikes emerge from the collective dynamics of clusters of Ca2+ channels that are coupled by diffusion. Current modeling approaches have opposed stochastic descriptions of these systems to purely deterministic models, while both paradoxically appear compatible with experimental data. Combining fully stochastic simulations and mean-field analyses, we demonstrate that these two approaches can be reconciled. Our fully stochastic model generates spike sequences that can be seen as noise-perturbed oscillations of deterministic origin, while displaying statistical properties in agreement with experimental data. These underlying deterministic oscillations arise from a phenomenological spike nucleation mechanism.
Fil: Voorsluijs, V.. Université Libre de Bruxelles; Bélgica
Fil: Ponce Dawson, Silvina Martha. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Física; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Física de Buenos Aires. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Física de Buenos Aires; Argentina
Fil: De Decker, Y.. Université Libre de Bruxelles; Bélgica
Fil: Dupont, G.. Université Libre de Bruxelles; Bélgica
description In nonexcitable cells, global Ca2+ spikes emerge from the collective dynamics of clusters of Ca2+ channels that are coupled by diffusion. Current modeling approaches have opposed stochastic descriptions of these systems to purely deterministic models, while both paradoxically appear compatible with experimental data. Combining fully stochastic simulations and mean-field analyses, we demonstrate that these two approaches can be reconciled. Our fully stochastic model generates spike sequences that can be seen as noise-perturbed oscillations of deterministic origin, while displaying statistical properties in agreement with experimental data. These underlying deterministic oscillations arise from a phenomenological spike nucleation mechanism.
publishDate 2019
dc.date.none.fl_str_mv 2019-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/147504
Voorsluijs, V.; Ponce Dawson, Silvina Martha; De Decker, Y.; Dupont, G.; Deterministic Limit of Intracellular Calcium Spikes; American Physical Society; Physical Review Letters; 122; 8; 2-2019; 1-6
0031-9007
CONICET Digital
CONICET
url http://hdl.handle.net/11336/147504
identifier_str_mv Voorsluijs, V.; Ponce Dawson, Silvina Martha; De Decker, Y.; Dupont, G.; Deterministic Limit of Intracellular Calcium Spikes; American Physical Society; Physical Review Letters; 122; 8; 2-2019; 1-6
0031-9007
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.aps.org/doi/10.1103/PhysRevLett.122.088101
info:eu-repo/semantics/altIdentifier/doi/10.1103/PhysRevLett.122.088101
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv American Physical Society
publisher.none.fl_str_mv American Physical Society
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.982451

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