Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse

Autores
Finocchiaro, Liliana Maria Elena; Riveros, María D.; Glikin, Gerardo Claudio
Año de publicación
2009
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We evaluated the safety, efficacy and anti-tumour effects of a surgery adjuvant treatment on an equine patient with metastatic malignant melanoma. This approach combined suicide gene therapy with a subcutaneous vaccine composed by formolized tumour cells and irradiated xenogeneic cells producing human interleukin-2 and granulocyte-macrophage colony-stimulating factor. The post-surgical margins of the cavities were infiltrated with lipid-complexed thymidine kinase suicide gene co-administrated with ganciclovir. In addition, subcutaneous lesions periodically treated with the suicide gene system objectively reduced their sizes or disappeared. Without any symptom of toxicity, this combined treatment abolished local recurrence and further metastatic spread of the disease. Therefore, this surgery adjuvant combined treatment controlled tumour growth and delayed or prevented post-surgical recurrence and distant metastasis while recovered the patient’s quality of life.
Fil: Finocchiaro, Liliana Maria Elena. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Riveros, María D.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Glikin, Gerardo Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Materia
suicide gene
cytokines
gene therapy
immunotherapy
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/117852
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horseFinocchiaro, Liliana Maria ElenaRiveros, María D.Glikin, Gerardo Claudiosuicide genecytokinesgene therapyimmunotherapyhttps://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3We evaluated the safety, efficacy and anti-tumour effects of a surgery adjuvant treatment on an equine patient with metastatic malignant melanoma. This approach combined suicide gene therapy with a subcutaneous vaccine composed by formolized tumour cells and irradiated xenogeneic cells producing human interleukin-2 and granulocyte-macrophage colony-stimulating factor. The post-surgical margins of the cavities were infiltrated with lipid-complexed thymidine kinase suicide gene co-administrated with ganciclovir. In addition, subcutaneous lesions periodically treated with the suicide gene system objectively reduced their sizes or disappeared. Without any symptom of toxicity, this combined treatment abolished local recurrence and further metastatic spread of the disease. Therefore, this surgery adjuvant combined treatment controlled tumour growth and delayed or prevented post-surgical recurrence and distant metastasis while recovered the patient’s quality of life.Fil: Finocchiaro, Liliana Maria Elena. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Riveros, María D.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Glikin, Gerardo Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaBritish Veterinary Association2009-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/117852Finocchiaro, Liliana Maria Elena; Riveros, María D.; Glikin, Gerardo Claudio; Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse; British Veterinary Association; Veterinary Record; 164; 9; 2-2009; 278-2790042-4900CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://veterinaryrecord.bmj.com/content/164/9/278info:eu-repo/semantics/altIdentifier/doi/10.1136/vr.164.9.278info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:58:46Zoai:ri.conicet.gov.ar:11336/117852instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:58:46.947CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse
title Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse
spellingShingle Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse
Finocchiaro, Liliana Maria Elena
suicide gene
cytokines
gene therapy
immunotherapy
title_short Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse
title_full Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse
title_fullStr Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse
title_full_unstemmed Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse
title_sort Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse
dc.creator.none.fl_str_mv Finocchiaro, Liliana Maria Elena
Riveros, María D.
Glikin, Gerardo Claudio
author Finocchiaro, Liliana Maria Elena
author_facet Finocchiaro, Liliana Maria Elena
Riveros, María D.
Glikin, Gerardo Claudio
author_role author
author2 Riveros, María D.
Glikin, Gerardo Claudio
author2_role author
author
dc.subject.none.fl_str_mv suicide gene
cytokines
gene therapy
immunotherapy
topic suicide gene
cytokines
gene therapy
immunotherapy
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv We evaluated the safety, efficacy and anti-tumour effects of a surgery adjuvant treatment on an equine patient with metastatic malignant melanoma. This approach combined suicide gene therapy with a subcutaneous vaccine composed by formolized tumour cells and irradiated xenogeneic cells producing human interleukin-2 and granulocyte-macrophage colony-stimulating factor. The post-surgical margins of the cavities were infiltrated with lipid-complexed thymidine kinase suicide gene co-administrated with ganciclovir. In addition, subcutaneous lesions periodically treated with the suicide gene system objectively reduced their sizes or disappeared. Without any symptom of toxicity, this combined treatment abolished local recurrence and further metastatic spread of the disease. Therefore, this surgery adjuvant combined treatment controlled tumour growth and delayed or prevented post-surgical recurrence and distant metastasis while recovered the patient’s quality of life.
Fil: Finocchiaro, Liliana Maria Elena. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Riveros, María D.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Glikin, Gerardo Claudio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
description We evaluated the safety, efficacy and anti-tumour effects of a surgery adjuvant treatment on an equine patient with metastatic malignant melanoma. This approach combined suicide gene therapy with a subcutaneous vaccine composed by formolized tumour cells and irradiated xenogeneic cells producing human interleukin-2 and granulocyte-macrophage colony-stimulating factor. The post-surgical margins of the cavities were infiltrated with lipid-complexed thymidine kinase suicide gene co-administrated with ganciclovir. In addition, subcutaneous lesions periodically treated with the suicide gene system objectively reduced their sizes or disappeared. Without any symptom of toxicity, this combined treatment abolished local recurrence and further metastatic spread of the disease. Therefore, this surgery adjuvant combined treatment controlled tumour growth and delayed or prevented post-surgical recurrence and distant metastasis while recovered the patient’s quality of life.
publishDate 2009
dc.date.none.fl_str_mv 2009-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/117852
Finocchiaro, Liliana Maria Elena; Riveros, María D.; Glikin, Gerardo Claudio; Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse; British Veterinary Association; Veterinary Record; 164; 9; 2-2009; 278-279
0042-4900
CONICET Digital
CONICET
url http://hdl.handle.net/11336/117852
identifier_str_mv Finocchiaro, Liliana Maria Elena; Riveros, María D.; Glikin, Gerardo Claudio; Cytokine-enhanced vaccine and suicide gene therapy as adjuvant treatments of metastatic melanoma in a horse; British Veterinary Association; Veterinary Record; 164; 9; 2-2009; 278-279
0042-4900
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://veterinaryrecord.bmj.com/content/164/9/278
info:eu-repo/semantics/altIdentifier/doi/10.1136/vr.164.9.278
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv British Veterinary Association
publisher.none.fl_str_mv British Veterinary Association
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269541003952128
score 13.13397

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