IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression

Autores
Yeh, Celine; Li, Aiqun; Chuang, Jen Zen; Saito, Masaki; Caceres, Alfredo Oscar; Sung, Ching Hwa
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Primary cilia undergo cell-cycle-dependent assembly and disassembly. Emerging data suggest that ciliary resorption is a checkpoint for S phase reentry and that the activation of phospho(T94)Tctex-1 couples these two events. However, the environmental cues and molecular mechanisms that trigger these processes remain unknown. Here, we show that insulin-like growth-1 (IGF-1) accelerates G1-S progression by causing cilia to resorb. The mitogenic signals of IGF-1 are predominantly transduced through IGF-1 receptor (IGF-1R) on the cilia of fibroblasts and epithelial cells. At the base of the cilium, phosphorylated IGF-1R activates an AGS3-regulated Gβγ signaling pathway that subsequently recruits phospho(T94)Tctex-1 to the transition zone. Perturbing any component of this pathway in cortical progenitors induces premature neuronal differentiation at the expense of proliferation. These data suggest that during corticogenesis, a cilium-transduced, noncanonical IGF-1R-Gβγ-phospho(T94)Tctex-1 signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length.
Fil: Yeh, Celine. Cornell University; Estados Unidos
Fil: Li, Aiqun. Cornell University; Estados Unidos
Fil: Chuang, Jen Zen. Cornell University; Estados Unidos
Fil: Saito, Masaki. Cornell University; Estados Unidos. Tohoku University; Japón
Fil: Caceres, Alfredo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Sung, Ching Hwa. Cornell University; Estados Unidos
Materia
Igf1
Cilia
Dineina
Señalización
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/25460
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/25460
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progressionYeh, CelineLi, AiqunChuang, Jen ZenSaito, MasakiCaceres, Alfredo OscarSung, Ching HwaIgf1CiliaDineinaSeñalizaciónhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Primary cilia undergo cell-cycle-dependent assembly and disassembly. Emerging data suggest that ciliary resorption is a checkpoint for S phase reentry and that the activation of phospho(T94)Tctex-1 couples these two events. However, the environmental cues and molecular mechanisms that trigger these processes remain unknown. Here, we show that insulin-like growth-1 (IGF-1) accelerates G1-S progression by causing cilia to resorb. The mitogenic signals of IGF-1 are predominantly transduced through IGF-1 receptor (IGF-1R) on the cilia of fibroblasts and epithelial cells. At the base of the cilium, phosphorylated IGF-1R activates an AGS3-regulated Gβγ signaling pathway that subsequently recruits phospho(T94)Tctex-1 to the transition zone. Perturbing any component of this pathway in cortical progenitors induces premature neuronal differentiation at the expense of proliferation. These data suggest that during corticogenesis, a cilium-transduced, noncanonical IGF-1R-Gβγ-phospho(T94)Tctex-1 signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length.Fil: Yeh, Celine. Cornell University; Estados UnidosFil: Li, Aiqun. Cornell University; Estados UnidosFil: Chuang, Jen Zen. Cornell University; Estados UnidosFil: Saito, Masaki. Cornell University; Estados Unidos. Tohoku University; JapónFil: Caceres, Alfredo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaFil: Sung, Ching Hwa. Cornell University; Estados UnidosCell Press2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/25460Yeh, Celine; Li, Aiqun; Chuang, Jen Zen; Saito, Masaki; Caceres, Alfredo Oscar; et al.; IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression; Cell Press; Developmental Cell; 26; 4; 8-2013; 358-3681534-5807CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.devcel.2013.07.014info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S153458071300422Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:34Zoai:ri.conicet.gov.ar:11336/25460instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:35.089CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression
title IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression
spellingShingle IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression
Yeh, Celine
Igf1
Cilia
Dineina
Señalización
title_short IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression
title_full IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression
title_fullStr IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression
title_full_unstemmed IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression
title_sort IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression
dc.creator.none.fl_str_mv Yeh, Celine
Li, Aiqun
Chuang, Jen Zen
Saito, Masaki
Caceres, Alfredo Oscar
Sung, Ching Hwa
author Yeh, Celine
author_facet Yeh, Celine
Li, Aiqun
Chuang, Jen Zen
Saito, Masaki
Caceres, Alfredo Oscar
Sung, Ching Hwa
author_role author
author2 Li, Aiqun
Chuang, Jen Zen
Saito, Masaki
Caceres, Alfredo Oscar
Sung, Ching Hwa
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Igf1
Cilia
Dineina
Señalización
topic Igf1
Cilia
Dineina
Señalización
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Primary cilia undergo cell-cycle-dependent assembly and disassembly. Emerging data suggest that ciliary resorption is a checkpoint for S phase reentry and that the activation of phospho(T94)Tctex-1 couples these two events. However, the environmental cues and molecular mechanisms that trigger these processes remain unknown. Here, we show that insulin-like growth-1 (IGF-1) accelerates G1-S progression by causing cilia to resorb. The mitogenic signals of IGF-1 are predominantly transduced through IGF-1 receptor (IGF-1R) on the cilia of fibroblasts and epithelial cells. At the base of the cilium, phosphorylated IGF-1R activates an AGS3-regulated Gβγ signaling pathway that subsequently recruits phospho(T94)Tctex-1 to the transition zone. Perturbing any component of this pathway in cortical progenitors induces premature neuronal differentiation at the expense of proliferation. These data suggest that during corticogenesis, a cilium-transduced, noncanonical IGF-1R-Gβγ-phospho(T94)Tctex-1 signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length.
Fil: Yeh, Celine. Cornell University; Estados Unidos
Fil: Li, Aiqun. Cornell University; Estados Unidos
Fil: Chuang, Jen Zen. Cornell University; Estados Unidos
Fil: Saito, Masaki. Cornell University; Estados Unidos. Tohoku University; Japón
Fil: Caceres, Alfredo Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Fil: Sung, Ching Hwa. Cornell University; Estados Unidos
description Primary cilia undergo cell-cycle-dependent assembly and disassembly. Emerging data suggest that ciliary resorption is a checkpoint for S phase reentry and that the activation of phospho(T94)Tctex-1 couples these two events. However, the environmental cues and molecular mechanisms that trigger these processes remain unknown. Here, we show that insulin-like growth-1 (IGF-1) accelerates G1-S progression by causing cilia to resorb. The mitogenic signals of IGF-1 are predominantly transduced through IGF-1 receptor (IGF-1R) on the cilia of fibroblasts and epithelial cells. At the base of the cilium, phosphorylated IGF-1R activates an AGS3-regulated Gβγ signaling pathway that subsequently recruits phospho(T94)Tctex-1 to the transition zone. Perturbing any component of this pathway in cortical progenitors induces premature neuronal differentiation at the expense of proliferation. These data suggest that during corticogenesis, a cilium-transduced, noncanonical IGF-1R-Gβγ-phospho(T94)Tctex-1 signaling pathway promotes the proliferation of neural progenitors through modulation of ciliary resorption and G1 length.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/25460
Yeh, Celine; Li, Aiqun; Chuang, Jen Zen; Saito, Masaki; Caceres, Alfredo Oscar; et al.; IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression; Cell Press; Developmental Cell; 26; 4; 8-2013; 358-368
1534-5807
CONICET Digital
CONICET
url http://hdl.handle.net/11336/25460
identifier_str_mv Yeh, Celine; Li, Aiqun; Chuang, Jen Zen; Saito, Masaki; Caceres, Alfredo Oscar; et al.; IGF-1 activates a Cilium-localized noncanonical Gβγ signaling pathway that regulates cell-cycle progression; Cell Press; Developmental Cell; 26; 4; 8-2013; 358-368
1534-5807
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.devcel.2013.07.014
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S153458071300422X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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