Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis

Autores
Howard, Elizabeth J.; Xiong, Xu; Carlier, Yves; Sosa-estani, Sergio Alejandro; Buekens, Pierre
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
BACKGROUND: Chagas disease is caused by the parasite Trypanosoma cruzi and is endemic in much of Latin America. With increased globalisation and immigration, it is a risk in any country, partly through congenital transmission. The frequency of congenital transmission is unclear. OBJECTIVE: To assess the frequency of congenital transmission of T. cruzi. SEARCH STRATEGY: PubMed, Journals@Ovid Full Text, EMBASE, CINAHL, Fuente Academica and BIREME databases were searched using seven search terms related to Chagas disease or T. cruzi and congenital transmission. SELECTION CRITERIA: The inclusion criteria were the following: Dutch, English, French, Portuguese or Spanish language; case report, case series or observational study; original data on congenital T. cruzi infection in humans; congenital infection rate reported or it could be derived. This systematic review included 13 case reports/series and 51 observational studies. DATA COLLECTION AND ANALYSIS: Two investigators independently collected data on study characteristics, diagnosis and congenital infection rate. The principal summary measure - the congenital transmission rate - is defined as the number of congenitally infected infants divided by the number of infants born to infected mothers. A random effects model was used. MAIN RESULTS: The pooled congenital transmission rate was 4.7% (95% confidence interval: 3.9-5.6%). Countries where T. cruzi is endemic had a higher rate of congenital transmission compared with countries where it is not endemic (5.0% versus 2.7%). CONCLUSIONS: Congenital transmission of Chagas disease is a global problem. Overall risk of congenital infection in infants born to infected mothers is about 5%. The congenital mode of transmission requires targeted screening to prevent future cases of Chagas disease.
Fil: Howard, Elizabeth J.. University of Tulane; Estados Unidos
Fil: Xiong, Xu. University of Tulane; Estados Unidos
Fil: Carlier, Yves. Université Libre de Bruxelles; Bélgica
Fil: Sosa-estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
Materia
Trypanosoma cruzi
Chagas disease
Congenital infection
Meta-analysis
Systematic review
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/32613
Acceder
id CONICETDig_209bcf9924ac3db30a3e0170ca04dc58
oai_identifier_str oai:ri.conicet.gov.ar:11336/32613
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-AnalysisHoward, Elizabeth J.Xiong, XuCarlier, YvesSosa-estani, Sergio AlejandroBuekens, PierreTrypanosoma cruziChagas diseaseCongenital infectionMeta-analysisSystematic reviewhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3BACKGROUND: Chagas disease is caused by the parasite Trypanosoma cruzi and is endemic in much of Latin America. With increased globalisation and immigration, it is a risk in any country, partly through congenital transmission. The frequency of congenital transmission is unclear. OBJECTIVE: To assess the frequency of congenital transmission of T. cruzi. SEARCH STRATEGY: PubMed, Journals@Ovid Full Text, EMBASE, CINAHL, Fuente Academica and BIREME databases were searched using seven search terms related to Chagas disease or T. cruzi and congenital transmission. SELECTION CRITERIA: The inclusion criteria were the following: Dutch, English, French, Portuguese or Spanish language; case report, case series or observational study; original data on congenital T. cruzi infection in humans; congenital infection rate reported or it could be derived. This systematic review included 13 case reports/series and 51 observational studies. DATA COLLECTION AND ANALYSIS: Two investigators independently collected data on study characteristics, diagnosis and congenital infection rate. The principal summary measure - the congenital transmission rate - is defined as the number of congenitally infected infants divided by the number of infants born to infected mothers. A random effects model was used. MAIN RESULTS: The pooled congenital transmission rate was 4.7% (95% confidence interval: 3.9-5.6%). Countries where T. cruzi is endemic had a higher rate of congenital transmission compared with countries where it is not endemic (5.0% versus 2.7%). CONCLUSIONS: Congenital transmission of Chagas disease is a global problem. Overall risk of congenital infection in infants born to infected mothers is about 5%. The congenital mode of transmission requires targeted screening to prevent future cases of Chagas disease.Fil: Howard, Elizabeth J.. University of Tulane; Estados UnidosFil: Xiong, Xu. University of Tulane; Estados UnidosFil: Carlier, Yves. Université Libre de Bruxelles; BélgicaFil: Sosa-estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Buekens, Pierre. University of Tulane; Estados UnidosWiley2013-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/32613Buekens, Pierre; Sosa-estani, Sergio Alejandro; Carlier, Yves; Xiong, Xu; Howard, Elizabeth J.; Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis; Wiley; BJOG - An International Journal of Obstetrics and Gynaecology; 121; 1; 8-2013; 22-331470-03281471-0528CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.12396/abstractinfo:eu-repo/semantics/altIdentifier/doi/10.1111/1471-0528.12396info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914719/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:41Zoai:ri.conicet.gov.ar:11336/32613instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:41.339CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis
title Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis
spellingShingle Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis
Howard, Elizabeth J.
Trypanosoma cruzi
Chagas disease
Congenital infection
Meta-analysis
Systematic review
title_short Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis
title_full Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis
title_fullStr Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis
title_full_unstemmed Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis
title_sort Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis
dc.creator.none.fl_str_mv Howard, Elizabeth J.
Xiong, Xu
Carlier, Yves
Sosa-estani, Sergio Alejandro
Buekens, Pierre
author Howard, Elizabeth J.
author_facet Howard, Elizabeth J.
Xiong, Xu
Carlier, Yves
Sosa-estani, Sergio Alejandro
Buekens, Pierre
author_role author
author2 Xiong, Xu
Carlier, Yves
Sosa-estani, Sergio Alejandro
Buekens, Pierre
author2_role author
author
author
author
dc.subject.none.fl_str_mv Trypanosoma cruzi
Chagas disease
Congenital infection
Meta-analysis
Systematic review
topic Trypanosoma cruzi
Chagas disease
Congenital infection
Meta-analysis
Systematic review
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv BACKGROUND: Chagas disease is caused by the parasite Trypanosoma cruzi and is endemic in much of Latin America. With increased globalisation and immigration, it is a risk in any country, partly through congenital transmission. The frequency of congenital transmission is unclear. OBJECTIVE: To assess the frequency of congenital transmission of T. cruzi. SEARCH STRATEGY: PubMed, Journals@Ovid Full Text, EMBASE, CINAHL, Fuente Academica and BIREME databases were searched using seven search terms related to Chagas disease or T. cruzi and congenital transmission. SELECTION CRITERIA: The inclusion criteria were the following: Dutch, English, French, Portuguese or Spanish language; case report, case series or observational study; original data on congenital T. cruzi infection in humans; congenital infection rate reported or it could be derived. This systematic review included 13 case reports/series and 51 observational studies. DATA COLLECTION AND ANALYSIS: Two investigators independently collected data on study characteristics, diagnosis and congenital infection rate. The principal summary measure - the congenital transmission rate - is defined as the number of congenitally infected infants divided by the number of infants born to infected mothers. A random effects model was used. MAIN RESULTS: The pooled congenital transmission rate was 4.7% (95% confidence interval: 3.9-5.6%). Countries where T. cruzi is endemic had a higher rate of congenital transmission compared with countries where it is not endemic (5.0% versus 2.7%). CONCLUSIONS: Congenital transmission of Chagas disease is a global problem. Overall risk of congenital infection in infants born to infected mothers is about 5%. The congenital mode of transmission requires targeted screening to prevent future cases of Chagas disease.
Fil: Howard, Elizabeth J.. University of Tulane; Estados Unidos
Fil: Xiong, Xu. University of Tulane; Estados Unidos
Fil: Carlier, Yves. Université Libre de Bruxelles; Bélgica
Fil: Sosa-estani, Sergio Alejandro. Dirección Nacional de Instituto de Investigación. Administración Nacional de Laboratorio e Instituto de Salud. Instituto Nacional de Parasitología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Buekens, Pierre. University of Tulane; Estados Unidos
description BACKGROUND: Chagas disease is caused by the parasite Trypanosoma cruzi and is endemic in much of Latin America. With increased globalisation and immigration, it is a risk in any country, partly through congenital transmission. The frequency of congenital transmission is unclear. OBJECTIVE: To assess the frequency of congenital transmission of T. cruzi. SEARCH STRATEGY: PubMed, Journals@Ovid Full Text, EMBASE, CINAHL, Fuente Academica and BIREME databases were searched using seven search terms related to Chagas disease or T. cruzi and congenital transmission. SELECTION CRITERIA: The inclusion criteria were the following: Dutch, English, French, Portuguese or Spanish language; case report, case series or observational study; original data on congenital T. cruzi infection in humans; congenital infection rate reported or it could be derived. This systematic review included 13 case reports/series and 51 observational studies. DATA COLLECTION AND ANALYSIS: Two investigators independently collected data on study characteristics, diagnosis and congenital infection rate. The principal summary measure - the congenital transmission rate - is defined as the number of congenitally infected infants divided by the number of infants born to infected mothers. A random effects model was used. MAIN RESULTS: The pooled congenital transmission rate was 4.7% (95% confidence interval: 3.9-5.6%). Countries where T. cruzi is endemic had a higher rate of congenital transmission compared with countries where it is not endemic (5.0% versus 2.7%). CONCLUSIONS: Congenital transmission of Chagas disease is a global problem. Overall risk of congenital infection in infants born to infected mothers is about 5%. The congenital mode of transmission requires targeted screening to prevent future cases of Chagas disease.
publishDate 2013
dc.date.none.fl_str_mv 2013-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/32613
Buekens, Pierre; Sosa-estani, Sergio Alejandro; Carlier, Yves; Xiong, Xu; Howard, Elizabeth J.; Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis; Wiley; BJOG - An International Journal of Obstetrics and Gynaecology; 121; 1; 8-2013; 22-33
1470-0328
1471-0528
CONICET Digital
CONICET
url http://hdl.handle.net/11336/32613
identifier_str_mv Buekens, Pierre; Sosa-estani, Sergio Alejandro; Carlier, Yves; Xiong, Xu; Howard, Elizabeth J.; Frequency of the Congenital Transmission of Trypanosoma cruzi: A Systematic Review and Meta-Analysis; Wiley; BJOG - An International Journal of Obstetrics and Gynaecology; 121; 1; 8-2013; 22-33
1470-0328
1471-0528
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.12396/abstract
info:eu-repo/semantics/altIdentifier/doi/10.1111/1471-0528.12396
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3914719/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269300599029760
score 13.13397

Publicaciones similares