Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice

Autores
Karadayian, A. G.; Mc Laughlin, M. A.; Cutrera, Rodolfo Angel
Año de publicación
2012
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Melatonin has antioxidant and neuroprotective properties in human beings and experimental models, as well as 'anti-estrogenic' effects. Ethanol (EtOH) affects various behavioral parameters during a period known as ethanol-induced hangover. Our study evaluated the neuroprotective effect of melatonin on motor performance during ethanol hangover in male and female Swiss mice. The females were subjected to specific hormonal states: ovariectomized (OVX) and OVX estrogenized (OVX-E2). Mice received melatonin (25μg/ml) or vehicle in their drinking water for seven days and were given intraperitoneal (i.p.) injections of EtOH (3.8g/kg) or saline on the morning of the eighth day. Motor performance was evaluated by the tightrope test 6h after EtOH exposure (hangover onset). During ethanol hangover, males exhibited lower motor performance than controls (p<0.01) but pretreatment with melatonin significantly improved performance during hangover (p<0.05). In females, melatonin treatment before ethanol-induced hangover led to a better motor performance in OVX compared with intact females (p<0.01) and a lower performance in OVX-E2 compared with not-estrogenized OVX (p<0.05). Consequently, estrogen reversed the motor performance enhancement afforded by melatonin. We conclude that estrogen interferes with the protective action of melatonin on motor performance during ethanol hangover.
Fil: Karadayian, A. G.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Mc Laughlin, M. A.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Cutrera, Rodolfo Angel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Materia
ESTROGEN
ETHANOL HANGOVER
MELATONIN
MOTOR PERFORMANCE
OVX
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/198420
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/198420
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in miceKaradayian, A. G.Mc Laughlin, M. A.Cutrera, Rodolfo AngelESTROGENETHANOL HANGOVERMELATONINMOTOR PERFORMANCEOVXhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Melatonin has antioxidant and neuroprotective properties in human beings and experimental models, as well as 'anti-estrogenic' effects. Ethanol (EtOH) affects various behavioral parameters during a period known as ethanol-induced hangover. Our study evaluated the neuroprotective effect of melatonin on motor performance during ethanol hangover in male and female Swiss mice. The females were subjected to specific hormonal states: ovariectomized (OVX) and OVX estrogenized (OVX-E2). Mice received melatonin (25μg/ml) or vehicle in their drinking water for seven days and were given intraperitoneal (i.p.) injections of EtOH (3.8g/kg) or saline on the morning of the eighth day. Motor performance was evaluated by the tightrope test 6h after EtOH exposure (hangover onset). During ethanol hangover, males exhibited lower motor performance than controls (p<0.01) but pretreatment with melatonin significantly improved performance during hangover (p<0.05). In females, melatonin treatment before ethanol-induced hangover led to a better motor performance in OVX compared with intact females (p<0.01) and a lower performance in OVX-E2 compared with not-estrogenized OVX (p<0.05). Consequently, estrogen reversed the motor performance enhancement afforded by melatonin. We conclude that estrogen interferes with the protective action of melatonin on motor performance during ethanol hangover.Fil: Karadayian, A. G.. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Mc Laughlin, M. A.. Universidad de Buenos Aires. Facultad de Medicina; ArgentinaFil: Cutrera, Rodolfo Angel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaPergamon-Elsevier Science Ltd2012-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/198420Karadayian, A. G.; Mc Laughlin, M. A.; Cutrera, Rodolfo Angel; Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 107; 2; 9-2012; 181-1860031-9384CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0031938412002508info:eu-repo/semantics/altIdentifier/doi/10.1016/j.physbeh.2012.07.003info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:47:29Zoai:ri.conicet.gov.ar:11336/198420instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:47:29.976CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice
title Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice
spellingShingle Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice
Karadayian, A. G.
ESTROGEN
ETHANOL HANGOVER
MELATONIN
MOTOR PERFORMANCE
OVX
title_short Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice
title_full Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice
title_fullStr Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice
title_full_unstemmed Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice
title_sort Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice
dc.creator.none.fl_str_mv Karadayian, A. G.
Mc Laughlin, M. A.
Cutrera, Rodolfo Angel
author Karadayian, A. G.
author_facet Karadayian, A. G.
Mc Laughlin, M. A.
Cutrera, Rodolfo Angel
author_role author
author2 Mc Laughlin, M. A.
Cutrera, Rodolfo Angel
author2_role author
author
dc.subject.none.fl_str_mv ESTROGEN
ETHANOL HANGOVER
MELATONIN
MOTOR PERFORMANCE
OVX
topic ESTROGEN
ETHANOL HANGOVER
MELATONIN
MOTOR PERFORMANCE
OVX
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Melatonin has antioxidant and neuroprotective properties in human beings and experimental models, as well as 'anti-estrogenic' effects. Ethanol (EtOH) affects various behavioral parameters during a period known as ethanol-induced hangover. Our study evaluated the neuroprotective effect of melatonin on motor performance during ethanol hangover in male and female Swiss mice. The females were subjected to specific hormonal states: ovariectomized (OVX) and OVX estrogenized (OVX-E2). Mice received melatonin (25μg/ml) or vehicle in their drinking water for seven days and were given intraperitoneal (i.p.) injections of EtOH (3.8g/kg) or saline on the morning of the eighth day. Motor performance was evaluated by the tightrope test 6h after EtOH exposure (hangover onset). During ethanol hangover, males exhibited lower motor performance than controls (p<0.01) but pretreatment with melatonin significantly improved performance during hangover (p<0.05). In females, melatonin treatment before ethanol-induced hangover led to a better motor performance in OVX compared with intact females (p<0.01) and a lower performance in OVX-E2 compared with not-estrogenized OVX (p<0.05). Consequently, estrogen reversed the motor performance enhancement afforded by melatonin. We conclude that estrogen interferes with the protective action of melatonin on motor performance during ethanol hangover.
Fil: Karadayian, A. G.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Mc Laughlin, M. A.. Universidad de Buenos Aires. Facultad de Medicina; Argentina
Fil: Cutrera, Rodolfo Angel. Universidad de Buenos Aires. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
description Melatonin has antioxidant and neuroprotective properties in human beings and experimental models, as well as 'anti-estrogenic' effects. Ethanol (EtOH) affects various behavioral parameters during a period known as ethanol-induced hangover. Our study evaluated the neuroprotective effect of melatonin on motor performance during ethanol hangover in male and female Swiss mice. The females were subjected to specific hormonal states: ovariectomized (OVX) and OVX estrogenized (OVX-E2). Mice received melatonin (25μg/ml) or vehicle in their drinking water for seven days and were given intraperitoneal (i.p.) injections of EtOH (3.8g/kg) or saline on the morning of the eighth day. Motor performance was evaluated by the tightrope test 6h after EtOH exposure (hangover onset). During ethanol hangover, males exhibited lower motor performance than controls (p<0.01) but pretreatment with melatonin significantly improved performance during hangover (p<0.05). In females, melatonin treatment before ethanol-induced hangover led to a better motor performance in OVX compared with intact females (p<0.01) and a lower performance in OVX-E2 compared with not-estrogenized OVX (p<0.05). Consequently, estrogen reversed the motor performance enhancement afforded by melatonin. We conclude that estrogen interferes with the protective action of melatonin on motor performance during ethanol hangover.
publishDate 2012
dc.date.none.fl_str_mv 2012-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/198420
Karadayian, A. G.; Mc Laughlin, M. A.; Cutrera, Rodolfo Angel; Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 107; 2; 9-2012; 181-186
0031-9384
CONICET Digital
CONICET
url http://hdl.handle.net/11336/198420
identifier_str_mv Karadayian, A. G.; Mc Laughlin, M. A.; Cutrera, Rodolfo Angel; Estrogen blocks the protective action of melatonin in a behavioral model of ethanol-induced hangover in mice; Pergamon-Elsevier Science Ltd; Physiology And Behavior; 107; 2; 9-2012; 181-186
0031-9384
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0031938412002508
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.physbeh.2012.07.003
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
publisher.none.fl_str_mv Pergamon-Elsevier Science Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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