13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes

Autores
Ferreira, M. João G.; García, Agustina; Leonardi, Darío; Salomon, Claudio Javier; Lamas, Maria Celina; Nunes, T. G.
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
13C and 15N solid-state nuclear magnetic resonance (NMR) spectra were recorded from albendazole (ABZ) and from ABZ:β-cyclodextrin, ABZ:methyl-β-cyclodextrin, ABZ:hydroxypropyl-β-cyclodextrin and ABZ:citrate-β-cyclodextrin, which were prepared by the spray-drying technique. ABZ signals were typical of a crystalline solid for the pure drug and of an amorphous compound obtained from ABZ:cyclodextrin samples. Relevant spectral differences were correlated with chemical interaction between ABZ and cyclodextrins. The number and type of complexes revealed a strong dependence on the cyclodextrin group substituent. Solid-state NMR data were consistent with the presence of stable inclusion complexes.
Fil: Ferreira, M. João G.. Universidade de Lisboa. Instituto Superior Técnico; Portugal
Fil: García, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Lamas, Maria Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Nunes, T. G.. Universidade de Lisboa. Instituto Superior Técnico; Portugal
Materia
Albendazole
Cyclodextrins
Solid State Nmr
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5992
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/5992
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexesFerreira, M. João G.García, AgustinaLeonardi, DaríoSalomon, Claudio JavierLamas, Maria CelinaNunes, T. G.AlbendazoleCyclodextrinsSolid State Nmrhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/113C and 15N solid-state nuclear magnetic resonance (NMR) spectra were recorded from albendazole (ABZ) and from ABZ:β-cyclodextrin, ABZ:methyl-β-cyclodextrin, ABZ:hydroxypropyl-β-cyclodextrin and ABZ:citrate-β-cyclodextrin, which were prepared by the spray-drying technique. ABZ signals were typical of a crystalline solid for the pure drug and of an amorphous compound obtained from ABZ:cyclodextrin samples. Relevant spectral differences were correlated with chemical interaction between ABZ and cyclodextrins. The number and type of complexes revealed a strong dependence on the cyclodextrin group substituent. Solid-state NMR data were consistent with the presence of stable inclusion complexes.Fil: Ferreira, M. João G.. Universidade de Lisboa. Instituto Superior Técnico; PortugalFil: García, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Lamas, Maria Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; ArgentinaFil: Nunes, T. G.. Universidade de Lisboa. Instituto Superior Técnico; PortugalElsevier2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5992Ferreira, M. João G.; García, Agustina; Leonardi, Darío; Salomon, Claudio Javier; Lamas, Maria Celina; et al.; 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes; Elsevier; Carbohydrate Polymers; 123; 1-2015; 130-1350144-8617enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0144861715000557info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carbpol.2015.01.031info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:07Zoai:ri.conicet.gov.ar:11336/5992instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:07.459CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes
title 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes
spellingShingle 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes
Ferreira, M. João G.
Albendazole
Cyclodextrins
Solid State Nmr
title_short 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes
title_full 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes
title_fullStr 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes
title_full_unstemmed 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes
title_sort 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes
dc.creator.none.fl_str_mv Ferreira, M. João G.
García, Agustina
Leonardi, Darío
Salomon, Claudio Javier
Lamas, Maria Celina
Nunes, T. G.
author Ferreira, M. João G.
author_facet Ferreira, M. João G.
García, Agustina
Leonardi, Darío
Salomon, Claudio Javier
Lamas, Maria Celina
Nunes, T. G.
author_role author
author2 García, Agustina
Leonardi, Darío
Salomon, Claudio Javier
Lamas, Maria Celina
Nunes, T. G.
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Albendazole
Cyclodextrins
Solid State Nmr
topic Albendazole
Cyclodextrins
Solid State Nmr
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv 13C and 15N solid-state nuclear magnetic resonance (NMR) spectra were recorded from albendazole (ABZ) and from ABZ:β-cyclodextrin, ABZ:methyl-β-cyclodextrin, ABZ:hydroxypropyl-β-cyclodextrin and ABZ:citrate-β-cyclodextrin, which were prepared by the spray-drying technique. ABZ signals were typical of a crystalline solid for the pure drug and of an amorphous compound obtained from ABZ:cyclodextrin samples. Relevant spectral differences were correlated with chemical interaction between ABZ and cyclodextrins. The number and type of complexes revealed a strong dependence on the cyclodextrin group substituent. Solid-state NMR data were consistent with the presence of stable inclusion complexes.
Fil: Ferreira, M. João G.. Universidade de Lisboa. Instituto Superior Técnico; Portugal
Fil: García, Agustina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Leonardi, Darío. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Salomon, Claudio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Lamas, Maria Celina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Rosario. Instituto de Química Rosario; Argentina
Fil: Nunes, T. G.. Universidade de Lisboa. Instituto Superior Técnico; Portugal
description 13C and 15N solid-state nuclear magnetic resonance (NMR) spectra were recorded from albendazole (ABZ) and from ABZ:β-cyclodextrin, ABZ:methyl-β-cyclodextrin, ABZ:hydroxypropyl-β-cyclodextrin and ABZ:citrate-β-cyclodextrin, which were prepared by the spray-drying technique. ABZ signals were typical of a crystalline solid for the pure drug and of an amorphous compound obtained from ABZ:cyclodextrin samples. Relevant spectral differences were correlated with chemical interaction between ABZ and cyclodextrins. The number and type of complexes revealed a strong dependence on the cyclodextrin group substituent. Solid-state NMR data were consistent with the presence of stable inclusion complexes.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5992
Ferreira, M. João G.; García, Agustina; Leonardi, Darío; Salomon, Claudio Javier; Lamas, Maria Celina; et al.; 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes; Elsevier; Carbohydrate Polymers; 123; 1-2015; 130-135
0144-8617
url http://hdl.handle.net/11336/5992
identifier_str_mv Ferreira, M. João G.; García, Agustina; Leonardi, Darío; Salomon, Claudio Javier; Lamas, Maria Celina; et al.; 13C and 15N solid-state NMR studies on albendazole and cyclodextrin albendazole complexes; Elsevier; Carbohydrate Polymers; 123; 1-2015; 130-135
0144-8617
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0144861715000557
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.carbpol.2015.01.031
info:eu-repo/semantics/altIdentifier/doi/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268954557415424
score 13.13397

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