Regulation of spine density and morphology by IQGAP1 protein domains

Autores
Jausoro, Ignacio; Mestres Lascano, Ivan; Quassollo Infanzon, Gonzalo Emiliano; Masseroni, Maria Luján; Heredia, María Florencia; Caceres, Alfredo Oscar
Año de publicación
2013
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
IQGAP1 is a scaffolding protein that regulates spine number. We now show a differential role for IQGAP1 domains in spine morphogenesis, in which a region of the N-terminus that promotes Arp2/3-mediated actin polymerization and branching stimulates spine head formation while a region that binds to Cdc42 and Rac is required for stalk extension. Conversely, IQGAP1 rescues spine deficiency induced by expression of dominant negative Cdc42 by stimulating formation of stubby spines. Together, our observations place IQGAP1 as a crucial regulator of spine number and shape acting through the N-Wasp Arp2/3 complex, as well as upstream and downstream of Cdc42.
Fil: Jausoro, Ignacio. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
Fil: Mestres Lascano, Ivan. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
Fil: Quassollo Infanzon, Gonzalo Emiliano. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
Fil: Masseroni, Maria Luján. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
Fil: Heredia, María Florencia. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
Fil: Caceres, Alfredo Oscar. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
Materia
IQGAP
NEURON
SPINES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/604
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Regulation of spine density and morphology by IQGAP1 protein domainsJausoro, IgnacioMestres Lascano, IvanQuassollo Infanzon, Gonzalo EmilianoMasseroni, Maria LujánHeredia, María FlorenciaCaceres, Alfredo OscarIQGAPNEURONSPINEShttps://purl.org/becyt/ford/1https://purl.org/becyt/ford/1.6IQGAP1 is a scaffolding protein that regulates spine number. We now show a differential role for IQGAP1 domains in spine morphogenesis, in which a region of the N-terminus that promotes Arp2/3-mediated actin polymerization and branching stimulates spine head formation while a region that binds to Cdc42 and Rac is required for stalk extension. Conversely, IQGAP1 rescues spine deficiency induced by expression of dominant negative Cdc42 by stimulating formation of stubby spines. Together, our observations place IQGAP1 as a crucial regulator of spine number and shape acting through the N-Wasp Arp2/3 complex, as well as upstream and downstream of Cdc42.Fil: Jausoro, Ignacio. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;Fil: Mestres Lascano, Ivan. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;Fil: Quassollo Infanzon, Gonzalo Emiliano. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;Fil: Masseroni, Maria Luján. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;Fil: Heredia, María Florencia. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;Fil: Caceres, Alfredo Oscar. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;Public Library Science2013-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/604Jausoro, Ignacio; Mestres Lascano, Ivan; Quassollo Infanzon, Gonzalo Emiliano; Masseroni, Maria Luján; Heredia, María Florencia; Caceres, Alfredo Oscar; Regulation of spine density and morphology by IQGAP1 protein domains; Public Library Science; Plos One; 8; 2; 2-2013; e56574;1932-6203enginfo:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0056574info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:14:55Zoai:ri.conicet.gov.ar:11336/604instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:14:56.201CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Regulation of spine density and morphology by IQGAP1 protein domains
title Regulation of spine density and morphology by IQGAP1 protein domains
spellingShingle Regulation of spine density and morphology by IQGAP1 protein domains
Jausoro, Ignacio
IQGAP
NEURON
SPINES
title_short Regulation of spine density and morphology by IQGAP1 protein domains
title_full Regulation of spine density and morphology by IQGAP1 protein domains
title_fullStr Regulation of spine density and morphology by IQGAP1 protein domains
title_full_unstemmed Regulation of spine density and morphology by IQGAP1 protein domains
title_sort Regulation of spine density and morphology by IQGAP1 protein domains
dc.creator.none.fl_str_mv Jausoro, Ignacio
Mestres Lascano, Ivan
Quassollo Infanzon, Gonzalo Emiliano
Masseroni, Maria Luján
Heredia, María Florencia
Caceres, Alfredo Oscar
author Jausoro, Ignacio
author_facet Jausoro, Ignacio
Mestres Lascano, Ivan
Quassollo Infanzon, Gonzalo Emiliano
Masseroni, Maria Luján
Heredia, María Florencia
Caceres, Alfredo Oscar
author_role author
author2 Mestres Lascano, Ivan
Quassollo Infanzon, Gonzalo Emiliano
Masseroni, Maria Luján
Heredia, María Florencia
Caceres, Alfredo Oscar
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv IQGAP
NEURON
SPINES
topic IQGAP
NEURON
SPINES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/1.6
dc.description.none.fl_txt_mv IQGAP1 is a scaffolding protein that regulates spine number. We now show a differential role for IQGAP1 domains in spine morphogenesis, in which a region of the N-terminus that promotes Arp2/3-mediated actin polymerization and branching stimulates spine head formation while a region that binds to Cdc42 and Rac is required for stalk extension. Conversely, IQGAP1 rescues spine deficiency induced by expression of dominant negative Cdc42 by stimulating formation of stubby spines. Together, our observations place IQGAP1 as a crucial regulator of spine number and shape acting through the N-Wasp Arp2/3 complex, as well as upstream and downstream of Cdc42.
Fil: Jausoro, Ignacio. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
Fil: Mestres Lascano, Ivan. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
Fil: Quassollo Infanzon, Gonzalo Emiliano. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
Fil: Masseroni, Maria Luján. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
Fil: Heredia, María Florencia. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
Fil: Caceres, Alfredo Oscar. Consejo Nacional de Invest.cientif.y Tecnicas. Centro Cientifico Tecnol.conicet - Cordoba. Instituto de Inv. Medicas Mercedes y Martin Ferreyra; Universidad Nacional de Cordoba;
description IQGAP1 is a scaffolding protein that regulates spine number. We now show a differential role for IQGAP1 domains in spine morphogenesis, in which a region of the N-terminus that promotes Arp2/3-mediated actin polymerization and branching stimulates spine head formation while a region that binds to Cdc42 and Rac is required for stalk extension. Conversely, IQGAP1 rescues spine deficiency induced by expression of dominant negative Cdc42 by stimulating formation of stubby spines. Together, our observations place IQGAP1 as a crucial regulator of spine number and shape acting through the N-Wasp Arp2/3 complex, as well as upstream and downstream of Cdc42.
publishDate 2013
dc.date.none.fl_str_mv 2013-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/604
Jausoro, Ignacio; Mestres Lascano, Ivan; Quassollo Infanzon, Gonzalo Emiliano; Masseroni, Maria Luján; Heredia, María Florencia; Caceres, Alfredo Oscar; Regulation of spine density and morphology by IQGAP1 protein domains; Public Library Science; Plos One; 8; 2; 2-2013; e56574;
1932-6203
url http://hdl.handle.net/11336/604
identifier_str_mv Jausoro, Ignacio; Mestres Lascano, Ivan; Quassollo Infanzon, Gonzalo Emiliano; Masseroni, Maria Luján; Heredia, María Florencia; Caceres, Alfredo Oscar; Regulation of spine density and morphology by IQGAP1 protein domains; Public Library Science; Plos One; 8; 2; 2-2013; e56574;
1932-6203
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0056574
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Public Library Science
publisher.none.fl_str_mv Public Library Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781575906197504
score 12.982451

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