Current Trends and Advancements in the Management of Hepatocellular Carcinoma

Autores
Teufel, Andreas; Kudo, Masatoshi; Qian, Yuquan; Daza, Jimmy; Rodriguez, Isaac; Reissfelder, Christoph; Ridruejo, Ezequiel; Ebert, Matthias P.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Hepatocellular carcinoma (HCC) remains a significant global health burden with a high mortality rate. Over the past 40 years, significant progress has been achieved in the prevention and management of HCC.Summary: Hepatitis B vaccination programs, the development of direct acting antiviral drugs for Hepatitis C, and effective surveillance strategies provide a profound basis for the prevention of HCC. Advanced surgery and liver transplantation along with local ablation techniques potentially offer cure for the disease. Also, just recently, the introduction of immunotherapy opened a new chapter in systemic treatment. Finally, the introduction of the BCLC classification system for HCC, clearly defining patient groups and assigning reasonable treatment options, has standardized treatment and become the basis of almost all clinical trials for HCC. With this review, we provide a comprehensive overview of the evolving landscape of HCC management and also touch on current challenges.Key message: A comprehensive and multidisciplinary approach is crucial for effective HCC management. Continued research and clinical trials are imperative to further enhance treatment options and will ultimately reduce the global burden of this devastating disease.
Fil: Teufel, Andreas. Heidelberg University; Alemania
Fil: Kudo, Masatoshi. Kindai University; Japón
Fil: Qian, Yuquan. Chinese Academy of Sciences; República de China
Fil: Daza, Jimmy. Heidelberg University; Alemania
Fil: Rodriguez, Isaac. Heidelberg University; Alemania
Fil: Reissfelder, Christoph. Heidelberg University; Alemania
Fil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Ebert, Matthias P.. Heidelberg University; Alemania
Materia
HCC
Tratamiento
Prevencion
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/260730
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Current Trends and Advancements in the Management of Hepatocellular CarcinomaTeufel, AndreasKudo, MasatoshiQian, YuquanDaza, JimmyRodriguez, IsaacReissfelder, ChristophRidruejo, EzequielEbert, Matthias P.HCCTratamientoPrevencionhttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Hepatocellular carcinoma (HCC) remains a significant global health burden with a high mortality rate. Over the past 40 years, significant progress has been achieved in the prevention and management of HCC.Summary: Hepatitis B vaccination programs, the development of direct acting antiviral drugs for Hepatitis C, and effective surveillance strategies provide a profound basis for the prevention of HCC. Advanced surgery and liver transplantation along with local ablation techniques potentially offer cure for the disease. Also, just recently, the introduction of immunotherapy opened a new chapter in systemic treatment. Finally, the introduction of the BCLC classification system for HCC, clearly defining patient groups and assigning reasonable treatment options, has standardized treatment and become the basis of almost all clinical trials for HCC. With this review, we provide a comprehensive overview of the evolving landscape of HCC management and also touch on current challenges.Key message: A comprehensive and multidisciplinary approach is crucial for effective HCC management. Continued research and clinical trials are imperative to further enhance treatment options and will ultimately reduce the global burden of this devastating disease.Fil: Teufel, Andreas. Heidelberg University; AlemaniaFil: Kudo, Masatoshi. Kindai University; JapónFil: Qian, Yuquan. Chinese Academy of Sciences; República de ChinaFil: Daza, Jimmy. Heidelberg University; AlemaniaFil: Rodriguez, Isaac. Heidelberg University; AlemaniaFil: Reissfelder, Christoph. Heidelberg University; AlemaniaFil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Ebert, Matthias P.. Heidelberg University; AlemaniaKarger2024-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/260730Teufel, Andreas; Kudo, Masatoshi; Qian, Yuquan; Daza, Jimmy; Rodriguez, Isaac; et al.; Current Trends and Advancements in the Management of Hepatocellular Carcinoma; Karger; Digestive Diseases; 42; 4; 5-2024; 349-3600257-2753CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://karger.com/doi/10.1159/000538815info:eu-repo/semantics/altIdentifier/doi/10.1159/000538815info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:06:30Zoai:ri.conicet.gov.ar:11336/260730instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:06:30.447CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Current Trends and Advancements in the Management of Hepatocellular Carcinoma
title Current Trends and Advancements in the Management of Hepatocellular Carcinoma
spellingShingle Current Trends and Advancements in the Management of Hepatocellular Carcinoma
Teufel, Andreas
HCC
Tratamiento
Prevencion
title_short Current Trends and Advancements in the Management of Hepatocellular Carcinoma
title_full Current Trends and Advancements in the Management of Hepatocellular Carcinoma
title_fullStr Current Trends and Advancements in the Management of Hepatocellular Carcinoma
title_full_unstemmed Current Trends and Advancements in the Management of Hepatocellular Carcinoma
title_sort Current Trends and Advancements in the Management of Hepatocellular Carcinoma
dc.creator.none.fl_str_mv Teufel, Andreas
Kudo, Masatoshi
Qian, Yuquan
Daza, Jimmy
Rodriguez, Isaac
Reissfelder, Christoph
Ridruejo, Ezequiel
Ebert, Matthias P.
author Teufel, Andreas
author_facet Teufel, Andreas
Kudo, Masatoshi
Qian, Yuquan
Daza, Jimmy
Rodriguez, Isaac
Reissfelder, Christoph
Ridruejo, Ezequiel
Ebert, Matthias P.
author_role author
author2 Kudo, Masatoshi
Qian, Yuquan
Daza, Jimmy
Rodriguez, Isaac
Reissfelder, Christoph
Ridruejo, Ezequiel
Ebert, Matthias P.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv HCC
Tratamiento
Prevencion
topic HCC
Tratamiento
Prevencion
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Hepatocellular carcinoma (HCC) remains a significant global health burden with a high mortality rate. Over the past 40 years, significant progress has been achieved in the prevention and management of HCC.Summary: Hepatitis B vaccination programs, the development of direct acting antiviral drugs for Hepatitis C, and effective surveillance strategies provide a profound basis for the prevention of HCC. Advanced surgery and liver transplantation along with local ablation techniques potentially offer cure for the disease. Also, just recently, the introduction of immunotherapy opened a new chapter in systemic treatment. Finally, the introduction of the BCLC classification system for HCC, clearly defining patient groups and assigning reasonable treatment options, has standardized treatment and become the basis of almost all clinical trials for HCC. With this review, we provide a comprehensive overview of the evolving landscape of HCC management and also touch on current challenges.Key message: A comprehensive and multidisciplinary approach is crucial for effective HCC management. Continued research and clinical trials are imperative to further enhance treatment options and will ultimately reduce the global burden of this devastating disease.
Fil: Teufel, Andreas. Heidelberg University; Alemania
Fil: Kudo, Masatoshi. Kindai University; Japón
Fil: Qian, Yuquan. Chinese Academy of Sciences; República de China
Fil: Daza, Jimmy. Heidelberg University; Alemania
Fil: Rodriguez, Isaac. Heidelberg University; Alemania
Fil: Reissfelder, Christoph. Heidelberg University; Alemania
Fil: Ridruejo, Ezequiel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; Argentina
Fil: Ebert, Matthias P.. Heidelberg University; Alemania
description Background: Hepatocellular carcinoma (HCC) remains a significant global health burden with a high mortality rate. Over the past 40 years, significant progress has been achieved in the prevention and management of HCC.Summary: Hepatitis B vaccination programs, the development of direct acting antiviral drugs for Hepatitis C, and effective surveillance strategies provide a profound basis for the prevention of HCC. Advanced surgery and liver transplantation along with local ablation techniques potentially offer cure for the disease. Also, just recently, the introduction of immunotherapy opened a new chapter in systemic treatment. Finally, the introduction of the BCLC classification system for HCC, clearly defining patient groups and assigning reasonable treatment options, has standardized treatment and become the basis of almost all clinical trials for HCC. With this review, we provide a comprehensive overview of the evolving landscape of HCC management and also touch on current challenges.Key message: A comprehensive and multidisciplinary approach is crucial for effective HCC management. Continued research and clinical trials are imperative to further enhance treatment options and will ultimately reduce the global burden of this devastating disease.
publishDate 2024
dc.date.none.fl_str_mv 2024-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/260730
Teufel, Andreas; Kudo, Masatoshi; Qian, Yuquan; Daza, Jimmy; Rodriguez, Isaac; et al.; Current Trends and Advancements in the Management of Hepatocellular Carcinoma; Karger; Digestive Diseases; 42; 4; 5-2024; 349-360
0257-2753
CONICET Digital
CONICET
url http://hdl.handle.net/11336/260730
identifier_str_mv Teufel, Andreas; Kudo, Masatoshi; Qian, Yuquan; Daza, Jimmy; Rodriguez, Isaac; et al.; Current Trends and Advancements in the Management of Hepatocellular Carcinoma; Karger; Digestive Diseases; 42; 4; 5-2024; 349-360
0257-2753
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://karger.com/doi/10.1159/000538815
info:eu-repo/semantics/altIdentifier/doi/10.1159/000538815
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Karger
publisher.none.fl_str_mv Karger
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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