Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis

Autores
Morbidoni, Héctor Ricardo; de la Iglesia, Agustina Inés; Figueroa, Virginia; Di Capua, Cecilia Beatriz; Ioerger, Thomas R.; Parish, Tanya
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis. We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.
Fil: Morbidoni, Héctor Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentina
Fil: de la Iglesia, Agustina Inés. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentina
Fil: Figueroa, Virginia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentina
Fil: Di Capua, Cecilia Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentina
Fil: Ioerger, Thomas R.. Texas A&M University; Estados Unidos
Fil: Parish, Tanya. Infectious Disease Research Institute. TB Discovery Research; Estados Unidos
Materia
Mycobacterium smegmatis
Mycobacterium tuberculosis
econazole
RshA
Mycobacterium smegmatis
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/111754
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatisMorbidoni, Héctor Ricardode la Iglesia, Agustina InésFigueroa, VirginiaDi Capua, Cecilia BeatrizIoerger, Thomas R.Parish, TanyaMycobacterium smegmatisMycobacterium tuberculosiseconazoleRshAMycobacterium smegmatishttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis. We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.Fil: Morbidoni, Héctor Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; ArgentinaFil: de la Iglesia, Agustina Inés. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; ArgentinaFil: Figueroa, Virginia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; ArgentinaFil: Di Capua, Cecilia Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; ArgentinaFil: Ioerger, Thomas R.. Texas A&M University; Estados UnidosFil: Parish, Tanya. Infectious Disease Research Institute. TB Discovery Research; Estados UnidosMicrobiological Society Korea2019-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/111754Morbidoni, Héctor Ricardo; de la Iglesia, Agustina Inés; Figueroa, Virginia; Di Capua, Cecilia Beatriz; Ioerger, Thomas R.; et al.; Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis; Microbiological Society Korea; Access Microbiology; 1; 10; 12-2019; 1-72516-8290CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.microbiologyresearch.org/content/journal/acmi/10.1099/acmi.0.000070info:eu-repo/semantics/altIdentifier/doi/10.1099/acmi.0.000070info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:57:22Zoai:ri.conicet.gov.ar:11336/111754instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:57:23.15CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
title Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
spellingShingle Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
Morbidoni, Héctor Ricardo
Mycobacterium smegmatis
Mycobacterium tuberculosis
econazole
RshA
Mycobacterium smegmatis
title_short Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
title_full Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
title_fullStr Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
title_full_unstemmed Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
title_sort Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis
dc.creator.none.fl_str_mv Morbidoni, Héctor Ricardo
de la Iglesia, Agustina Inés
Figueroa, Virginia
Di Capua, Cecilia Beatriz
Ioerger, Thomas R.
Parish, Tanya
author Morbidoni, Héctor Ricardo
author_facet Morbidoni, Héctor Ricardo
de la Iglesia, Agustina Inés
Figueroa, Virginia
Di Capua, Cecilia Beatriz
Ioerger, Thomas R.
Parish, Tanya
author_role author
author2 de la Iglesia, Agustina Inés
Figueroa, Virginia
Di Capua, Cecilia Beatriz
Ioerger, Thomas R.
Parish, Tanya
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Mycobacterium smegmatis
Mycobacterium tuberculosis
econazole
RshA
Mycobacterium smegmatis
topic Mycobacterium smegmatis
Mycobacterium tuberculosis
econazole
RshA
Mycobacterium smegmatis
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis. We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.
Fil: Morbidoni, Héctor Ricardo. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentina
Fil: de la Iglesia, Agustina Inés. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentina
Fil: Figueroa, Virginia. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentina
Fil: Di Capua, Cecilia Beatriz. Universidad Nacional de Rosario. Facultad de Ciencias Médicas. Laboratorio de Microbiología Molecular; Argentina
Fil: Ioerger, Thomas R.. Texas A&M University; Estados Unidos
Fil: Parish, Tanya. Infectious Disease Research Institute. TB Discovery Research; Estados Unidos
description Azole drugs such as econazole, are active on Mycobacterium tuberculosis and Mycobacterium smegmatis; however, the identification of their target(s) is still pending. It has been reported that mutations in the non-essential system mmpL5-mmpS5 conferred resistance to econazole in M. tuberculosis. We herein report that an azole-resistant mutant screen in M. smegmatis rendered mutations in rshA, encoding a non-essential anti-sigma H protein.
publishDate 2019
dc.date.none.fl_str_mv 2019-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/111754
Morbidoni, Héctor Ricardo; de la Iglesia, Agustina Inés; Figueroa, Virginia; Di Capua, Cecilia Beatriz; Ioerger, Thomas R.; et al.; Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis; Microbiological Society Korea; Access Microbiology; 1; 10; 12-2019; 1-7
2516-8290
CONICET Digital
CONICET
url http://hdl.handle.net/11336/111754
identifier_str_mv Morbidoni, Héctor Ricardo; de la Iglesia, Agustina Inés; Figueroa, Virginia; Di Capua, Cecilia Beatriz; Ioerger, Thomas R.; et al.; Mutations in the anti-sigma H factor RshA confer resistance to econazole and clotrimazole in Mycobacterium smegmatis; Microbiological Society Korea; Access Microbiology; 1; 10; 12-2019; 1-7
2516-8290
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.microbiologyresearch.org/content/journal/acmi/10.1099/acmi.0.000070
info:eu-repo/semantics/altIdentifier/doi/10.1099/acmi.0.000070
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Microbiological Society Korea
publisher.none.fl_str_mv Microbiological Society Korea
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083112542404608
score 13.22299

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